| 1. |
|
|
| 2. |
|
|
| 3. |
- Bravo, L, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 4. |
- Tabiri, S, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 5. |
|
|
| 6. |
- Hildahl, Jon, 1976, et al.
(författare)
-
CHARACTERIZATION OF THE GROWTH HORMONE – INSULIN-LIKE GROWTH FACTOR I SYSTEM DURING ATLANTIC HALIBUT METAMORPHOSIS
- 2006
-
Ingår i: 7th International Congress on the Biology of Fish, Book of Abstracts.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The GH-IGF-I system is critical for proper growth and development in fish and thus is likely to play a role in the control of flatfish metamorphosis.. In order to characterize the role of GH and IGF-I in Atlantic halibut development, hormonal content (GH and IGF-I RIA) and receptor gene expression (GHR and IGF-IR QPCR) was assessed during normal and abnormal metamorphosis GH larval head content increases throughout normal metamorphosis in parallel with larval weight. The full-length GH receptor (hhGHRfl) mRNA and IGF-I protein levels change in parallel and in a stage-specific manner, with an increase at the onset of metamorphosis followed by down-regulation. Two isoforms of the IGF-I receptor are regulated differently; isoform one (hhIGF-IR1) mRNA increases from pre-metamorphosis to the post-metamorphic juvenile stage, while isoform 2 (hhIGF-IR2) mRNA is highest at early pre-metamorphosis and decreases prior to the onset of metamorphosis. In larvae experiencing arrested development, mRNA levels for hhGHRfl and hhIGF-IR1 and IGF-I larval content are depressed relative to normal individuals, whereas GH content, hhIGF-IR2 mRNA levels and weight are not changed. Increased hhGHRfl mRNA and IGF-I protein levels at the onset of metamorphosis suggest that tissue sensitivity to GH increases during metamorphosis while tissue sensitivity to IGF-I does not change. The data provide new evidence suggesting that GHR and IGF-IR levels may be of critical importance for metamorphic success in Atlantic halibut. Funded by the EU and FORMAS.
|
|
| 7. |
- Khatri, C, et al.
(författare)
-
Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
-
Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
-
Tidskriftsartikel (refereegranskat)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
|
|
| 8. |
- Power, DM, et al.
(författare)
-
Thyroid hormones in growth and development of fish
- 2001
-
Ingår i: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. - 1532-0456. ; 130:4, s. 447-459
-
Tidskriftsartikel (refereegranskat)abstract
- The thyroid hormones (THs), thyroxine (T-4) and triiodothyronine (T-3) are products of the thyroid gland in all vertebrates. Their role in early development and metamorphosis is well established in mammals and amphibians, respectively, and recently several studies in fish have highlighted the importance of THs during flatfish metamorphosis. THs are present in high quantities in fish eggs and are presumably of maternal origin. During embryogenesis the concentration of T-4 and T-3 in the eggs decrease until endogenous production starts. Thyroid hormone receptors (TR) have been isolated from several teleosts and in common with tetrapods two receptor isoforms have been identified, TR alpha and TR beta. Both the receptors are expressed in early embryos and larvae of the Japanese flounder (Paralichthys olivaceus), zebrafish (Danio rerio) and seabream (Sparus aurata) although a different temporal pattern is apparent. The role of THs and TRs in fish embryogenesis, larval development and during metamorphosis will be discussed. (C) 2001 Elsevier Science Inc. All rights reserved.
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
