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| 3. |
- Matsuda, Satoru, et al.
(författare)
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Evaluation of endoscopic response using deep neural network in esophageal cancer patients who received neoadjuvant chemotherapy
- 2023
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Ingår i: Annals of Surgical Oncology. - : Springer Nature. - 1068-9265 .- 1534-4681. ; 30:6, s. 3733-3742
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Tidskriftsartikel (refereegranskat)abstract
- Background: We previously reported that endoscopic response evaluation can preoperatively predict the prognosis and distribution of residual tumors after neoadjuvant chemotherapy (NAC). In this study, we developed artificial intelligence (AI)-guided endoscopic response evaluation using a deep neural network to discriminate endoscopic responders (ERs) in patients with esophageal squamous cell carcinoma (ESCC) after NAC.Method: Surgically resectable ESCC patients who underwent esophagectomy following NAC were retrospectively analyzed in this study. Endoscopic images of the tumors were analyzed using a deep neural network. The model was validated with a test data set using 10 newly collected ERs and 10 newly collected non-ER images. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the endoscopic response evaluation by AI and endoscopists were calculated and compared.Results: Of 193 patients, 40 (21%) were diagnosed as ERs. The median sensitivity, specificity, PPV, and NPV values for ER detection in 10 models were 60%, 100%, 100%, and 71%, respectively. Similarly, the median values by the endoscopist were 80%, 80%, 81%, and 81%, respectively.Conclusion: This proof-of-concept study using a deep learning algorithm demonstrated that the constructed AI-guided endoscopic response evaluation after NAC could identify ER with high specificity and PPV. It would appropriately guide an individualized treatment strategy that includes an organ preservation approach in ESCC patients.
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- Diaz, Sandra, et al.
(författare)
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The IPBES Conceptual Framework - connecting nature and people
- 2015
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Ingår i: Current Opinion in Environmental Sustainability. - : Elsevier BV. - 1877-3435 .- 1877-3443. ; 14, s. 1-16
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Tidskriftsartikel (refereegranskat)abstract
- The first public product of the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) is its Conceptual Framework. This conceptual and analytical tool, presented here in detail, will underpin all IPBES functions and provide structure and comparability to the syntheses that IPBES will produce at different spatial scales, on different themes, and in different regions. Salient innovative aspects of the IPBES Conceptual Framework are its transparent and participatory construction process and its explicit consideration of diverse scientific disciplines, stakeholders, and knowledge systems, including indigenous and local knowledge. Because the focus on co-construction of integrative knowledge is shared by an increasing number of initiatives worldwide, this framework should be useful beyond IPBES, for the wider research and knowledge-policy communities working on the links between nature and people, such as natural, social and engineering scientists, policy-makers at different levels, and decision-makers in different sectors of society.
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- Elmqvist, Thomas, et al.
(författare)
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Sustainability and resilience for transformation in the urban century
- 2019
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Ingår i: Nature Sustainability. - : Springer Science and Business Media LLC. - 2398-9629. ; 2:4, s. 267-273
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Forskningsöversikt (refereegranskat)abstract
- We have entered the urban century and addressing a broad suite of sustainability challenges in urban areas is increasingly key for our chances to transform the entire planet towards sustainability. For example, cities are responsible for 70% of global greenhouse gas emissions and, at the same time, 90% of urban areas are situated on coastlines, making the majority of the world's population increasingly vulnerable to climate change. While urbanization accelerates, meeting the challenges will require unprecedented transformative solutions for sustainability with a careful consideration of resilience in their implementation. However, global and local policy processes often use vague or narrow definitions of the concepts of 'urban sustainability' and 'urban resilience', leading to deep confusion, particularly in instances when the two are used interchangeably. Confusion and vagueness slow down needed transformation processes, since resilience can be undesirable and many sustainability goals contrast, or even challenge efforts to improve resilience. Here, we propose a new framework that resolves current contradictions and tensions; a framework that we believe will significantly help urban policy and implementation processes in addressing new challenges and contributing to global sustainability in the urban century.
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| 6. |
- Elmqvist, Thomas, et al.
(författare)
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Urban tinkering
- 2018
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Ingår i: Sustainability Science. - : Springer Science and Business Media LLC. - 1862-4065 .- 1862-4057. ; 13:6, s. 1549-1564
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Tidskriftsartikel (refereegranskat)abstract
- Cities are currently experiencing serious, multifaceted impacts from global environmental change, especially climate change, and the degree to which they will need to cope with and adapt to such challenges will continue to increase. A complex systems approach inspired by evolutionary theory can inform strategies for policies and interventions to deal with growing urban vulnerabilities. Such an approach would guide the design of new (and redesign of existing) urban structures, while promoting innovative integration of grey, green and blue infrastructure in service of environmental and health objectives. Moreover, it would contribute to more flexible, effective policies for urban management and the use of urban space. Four decades ago, in a seminal paper in Science, the French evolutionary biologist and philosopher Francois Jacob noted that evolution differs significantly in its characteristic modes of action from processes that are designed and engineered de novo (Jacob in Science 196(4295):1161-1166, 1977). He labeled the evolutionary process tinkering, recognizing its foundation in the modification and molding of existing traits and forms, with occasional dramatic shifts in function in the context of changing conditions. This contrasts greatly with conventional engineering and design approaches that apply tailor-made materials and tools to achieve well-defined functions that are specified a priori. We here propose that urban tinkering is the application of evolutionary thinking to urban design, engineering, ecological restoration, management and governance. We define urban tinkering as:A mode of operation, encompassing policy, planning and management processes, that seeks to transform the use of existing and design of new urban systems in ways that diversify their functions, anticipate new uses and enhance adaptability, to better meet the social, economic and ecological needs of cities under conditions of deep uncertainty about the future.This approach has the potential to substantially complement and augment conventional urban development, replacing predictability, linearity and monofunctional design with anticipation of uncertainty and non-linearity and design for multiple, potentially shifting functions. Urban tinkering can function by promoting a diversity of small-scale urban experiments that, in aggregate, lead to large-scale often playful innovative solutions to the problems of sustainable development. Moreover, the tinkering approach is naturally suited to exploring multi-functional uses and approaches (e.g., bricolage) for new and existing urban structures and policies through collaborative engagement and analysis. It is thus well worth exploring as a means of delivering co-benefits for environment and human health and wellbeing. Indeed, urban tinkering has close ties to systems approaches, which often are recognized as critical to sustainable development. We believe this concept can help forge much-closer, much-needed ties among engineers, architects, evolutionary ecologists, health specialists, and numerous other urban stakeholders in developing innovative, widely beneficial solutions for society and contribute to successful implementation of SDG11 and the New Urban Agenda.
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- Hahn, Thomas, 1964-, et al.
(författare)
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Insurance value of biodiversity in the Anthropocene is the full resilience value
- 2023
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Ingår i: Ecological Economics. - : Elsevier BV. - 0921-8009 .- 1873-6106. ; 208
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Tidskriftsartikel (refereegranskat)abstract
- Recently two distinctly different conceptualisations of insurance value of biodiversity/ ecosystems have been developed. The ecosystem framing addresses the full resilience value without singling out subjective risk pref-erences. Conversely, the economic framing focuses exactly on this subjective value of risk aversion, implying that the insurance value is zero for risk neutral persons. Here we analyse the differences conceptually and empirically, and relate this to the broader socio-cultural dimensions of social-ecological resilience. The uncertainty of the Anthropocene blurs the distinction between subjective/objective. We show that the economic framing has been operationalised only in specific cases while the broader literature on resilience, disaster risk reduction, and nature-based solutions tend to address the full value of resilience. Yet, the empirical literature that relates to insurance value of biodiversity is hardly consistent with resilience theory because the slow underlying variables defining resilience are rarely addressed. We suggest how the empirical literature on insurance value can be better aligned with resilience theory. Since the ecosystem framing of insurance value captures the essence of the resilience, we propose using the concept resilience value as it may reduce the present ambiguity in terminology and conceptualisation of insurance value of biodiversity.
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| 9. |
- Jarzebski, Marcin Pawel, et al.
(författare)
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Ageing and population shrinking : implications for sustainability in the urban century
- 2021
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Ingår i: npj Urban Sustainability. - : Springer Nature. - 2661-8001. ; 1:1
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Tidskriftsartikel (refereegranskat)abstract
- Population ageing and shrinking are demographic phenomena with far-reaching implications for sustainability in the current context of extensive and rapid urbanization. This Perspective rationalizes their interface by (a) identifying the challenges and opportunities that ageing and shrinking urban populations will have for implementing the sustainable development goals (SDGs), and (b) discussing some emerging interventions to capitalise on the opportunities and reduce the challenges to achieving sustainability. We argue that a diverse set of context-specific technological, socioeconomic, institutional and governance interventions would be needed to leverage effectively the opportunities and minimize the risks posed by ageing and shrinking urban populations for long-term sustainability.
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| 10. |
- Takeuchi, Kazuhiko, et al.
(författare)
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Satoyama landscape as social-ecological system : historical changes and future perspective
- 2016
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Ingår i: Current Opinion in Environmental Sustainability. - : Elsevier BV. - 1877-3435 .- 1877-3443. ; 19, s. 30-39
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Tidskriftsartikel (refereegranskat)abstract
- Many production landscapes around the world have been sustained through appropriate use and management of natural resources, but many are now facing overuse or underuse. This paper explores future perspectives on the satoyama landscape (traditional Japanese rural landscape) as a social-ecological system through an overview of its transformation. Two phases in the human-nature relationship are observed: before the fossil fuel revolution of the late 1950s, people maintained a direct relationship with nature, and the landscape was integrally managed through community cooperation to avoid overuse; then, after the late 1950s, inflow of goods and services from outside and outflow of the population resulted in underuse of natural resources, and the human-nature relationship became weakened and more indirect. Rebuilding the human-nature relationship in the present day calls for efforts that go beyond the local level toward cross-scale, connected and coupled social-ecological systems.
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| 11. |
- Warszawski, Lila, et al.
(författare)
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All options, not silver bullets, needed to limit global warming to 1.5 °C : a scenario appraisal
- 2021
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Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9326. ; 16:6
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Tidskriftsartikel (refereegranskat)abstract
- Climate science provides strong evidence of the necessity of limiting global warming to 1.5 °C, in line with the Paris Climate Agreement. The IPCC 1.5 °C special report (SR1.5) presents 414 emissions scenarios modelled for the report, of which around 50 are classified as '1.5 °C scenarios', with no or low temperature overshoot. These emission scenarios differ in their reliance on individual mitigation levers, including reduction of global energy demand, decarbonisation of energy production, development of land-management systems, and the pace and scale of deploying carbon dioxide removal (CDR) technologies. The reliance of 1.5 °C scenarios on these levers needs to be critically assessed in light of the potentials of the relevant technologies and roll-out plans. We use a set of five parameters to bundle and characterise the mitigation levers employed in the SR1.5 1.5 °C scenarios. For each of these levers, we draw on the literature to define 'medium' and 'high' upper bounds that delineate between their 'reasonable', 'challenging' and 'speculative' use by mid century. We do not find any 1.5 °C scenarios that stay within all medium upper bounds on the five mitigation levers. Scenarios most frequently 'over use' CDR with geological storage as a mitigation lever, whilst reductions of energy demand and carbon intensity of energy production are 'over used' less frequently. If we allow mitigation levers to be employed up to our high upper bounds, we are left with 22 of the SR1.5 1.5 °C scenarios with no or low overshoot. The scenarios that fulfil these criteria are characterised by greater coverage of the available mitigation levers than those scenarios that exceed at least one of the high upper bounds. When excluding the two scenarios that exceed the SR1.5 carbon budget for limiting global warming to 1.5 °C, this subset of 1.5 °C scenarios shows a range of 15–22 Gt CO2 (16–22 Gt CO2 interquartile range) for emissions in 2030. For the year of reaching net zero CO2 emissions the range is 2039–2061 (2049–2057 interquartile range).
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| 12. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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