| 1. |
- Campbell, PJ, et al.
(författare)
-
Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 2. |
- Asano, H., et al.
(författare)
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Spectroscopic study of the Λ(1405) resonance via the d (K-, n) reaction at J-PARC
- 2019
-
Ingår i: 13th International Conference on Hypernuclear and Strange Particle Physics, HYP 2018. - : AIP Publishing. - 9780735418721 ; 2130
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Konferensbidrag (refereegranskat)abstract
- The structure of the Λ(1405) hyperon is an important and long-standing issue related to the K̄-nucleus interaction. The J-PARC E31 experiment has been performed to investigate the Λ(1405) spectrum shape. Because it is hard to form the Λ(1405) directly by a K̄N scattering in free space, E31 uses the d(K-, n) reaction with an incident kaon momentum of 1 GeV/c. We will identify three final states - ς-π+, ς+π-, ς0π0-so that the isospin structure of hyperon resonance states produced can be decomposed. The first physics run of the E31 experiment was performed in 2016. To enhance the statistics of the data set, we have performed the second physics run in the beginning of 2018. During the second run of E31, around 3.9×1010 kaons impacted on the deuteron target.
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| 3. |
- Yamaga, Takumi, et al.
(författare)
-
Study of the elementary (K -, n) reactions to search for the K NN bound state via the 3He (K -, n) reaction at J-PARC
- 2016
-
Ingår i: XVIth International Conference on Hadron Spectroscopy, Hadron 2015. - : Author(s). - 9780735413894 ; 1735
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Konferensbidrag (refereegranskat)abstract
- We have searched for the simplest kaonic nuclear state, K̄NN, using the in-flight 3He (K-, n) reaction at the J-PARC hadron experimental facility. In the semi-inclusive neutron missing-mass spectrum at θnlab=0°, an excess of yield was observed just below the K- pp mass-threshold, which cannot be explained by any elementary reactions [PTEP 2015, 061D01]. To understand the missing-mass spectrum of 3He (K-, n) X, we investigated the elementary (K-, n) reactions using hydrogen and deuterium targets. The p (K-, n) X missing-mass spectrum was well described by the charge-exchange reaction. However, in the d (K-, n) X spectrum, we observed an excess of yield just below the K- p mass-threshold, which was similar to that in the 3He (K-, n) X spectrum.
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| 4. |
- Hashimoto, T., et al.
(författare)
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Beamline test of a transition-edge-sensor spectrometer in preparation for kaonic-atom measurements
- 2017
-
Ingår i: IEEE Transactions on Applied Superconductivity. - 1051-8223. ; 27:4
-
Tidskriftsartikel (refereegranskat)abstract
- We are developing a new technique to apply transition-edge sensors (TESs) to X-ray spectroscopy of exotic atoms, especially of kaonic atoms. To demonstrate the feasibility of this pioneering project, performance of a TES-based X-ray detector was evaluated in pion- and kaon-beam environments at particle accelerators.We successfully observed X-rays from pionic-carbon atoms with a resolution as good as 7 eV FWHM at 6 keV. Also at a kaon beamline, we confirmed that the TES spectrometer will be able to achieve our resolution goal, 6 eV, in our first scientific campaign to measure X-rays from kaonic-helium atoms.
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| 5. |
- Hashimoto, T., et al.
(författare)
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Kaonic-Atom X-ray Spectroscopy with Superconducting Microcalorimeters
- 2017
-
Ingår i: Proceedings of the 12th International Conference on Hypernuclear and Strange Particle Physics (HYP2015). - 9784890271221 ; 17
-
Konferensbidrag (refereegranskat)abstract
- We will measure kaonic helium X-rays using transition-edge-sensor microcalorimeters, TES, in the J-PARC hadron experimental facility. To demonstrate the feasibility of the experiment, we performed a measurement of pionic carbon X-rays at PSI, where an excellent FWHM energy resolution of 7 eV at 6.4 keV was achieved. We also evaluated the expected TES performance in the kaon beam at J-PARC. The simulation results show that the TES spectrometer would work with a good energy resolution, and clear peaks of kaonic helium X-rays would be observed on a reasonably suppressed background.
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| 6. |
- Sada, Y., et al.
(författare)
-
Structure near the K- + p + p threshold in the in-flight 3He(K-, Λp)n reaction
- 2016
-
Ingår i: Progress of Theoretical and Experimental Physics. - : Oxford University Press (OUP). - 2050-3911. ; 2016:5
-
Tidskriftsartikel (refereegranskat)abstract
- To search for an S = -1 di-baryonic state which decays toΛp, the 3He(K-,Λp)nmissing reaction was studied at 1.0 GeV/c. Unobserved neutrons were kinematically identified from the missing mass MX of the 3He (K-,Λp) X reaction in order to have a large acceptance for the Λpn final state. The observed Λpn events, distributed widely over the kinematically allowed region of the Dalitz plot, establish that the major component comes from a three-nucleon absorption process. A concentration of events at a specific neutron kinetic energy was observed in a region of low momentum transfer to the Λp. To account for the observed peak structure, the simplest S-wave polewas assumed to exist in the reaction channel, having a Breit-Wigner formin energy and with a Gaussian form factor. A minimum X2 method was applied to deduce its mass, MX = 2355+6 -8 (stat.) ±12 (syst.)MeV/c2, and decay width, γX = 110+19 -17 (stat.) ±27 (syst.)MeV/c2, respectively. The form factor parameter QX ∼ 400MeV/c implies that the range of the interaction is about 0.5 fm.
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| 7. |
- Okada, S., et al.
(författare)
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First application of superconducting transition-edge sensor microcalorimeters to hadronic atom X-ray spectroscopy
- 2016
-
Ingår i: Progress of Theoretical and Experimental Physics. - : Oxford University Press (OUP). - 2050-3911. ; 2016:9
-
Tidskriftsartikel (refereegranskat)abstract
- High-resolution pionic atom X-ray spectroscopy was performed with an X-ray spectrometer based on a 240 pixel array of superconducting transition-edge sensor (TES) microcalorimeters at the φM1 beam line of the Paul Scherrer Institute. X-rays emitted by pionic carbon via the 4f → 3d transition and the parallel 4d → 3p transition were observed with a full width at half maximum energy resolution of 6.8 eV at 6.4 keV. The measured X-ray energies are consistent with calculated electromagnetic values which considered the strong interaction effect assessed via the Seki-Masutani potential for the 3p energy level, and favor the electronic population of two filled 1s electrons in the K-shell. Absolute energy calibration with an uncertainty of 0.1 eV was demonstrated under a high-rate hadron beam condition of 1.45 MHz. This is the first application of a TES spectrometer to hadronic atom X-ray spectroscopy and is an important milestone towards next-generation high-resolution kaonic atom X-ray spectroscopy.
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| 8. |
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| 9. |
- Isobe, T, et al.
(författare)
-
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia
- 2022
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 4501-
-
Tidskriftsartikel (refereegranskat)abstract
- KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) represents the most refractory type of childhood leukemia. To uncover the molecular heterogeneity of this disease, we perform RNA sequencing, methylation array analysis, whole exome and targeted deep sequencing on 84 infants with KMT2A-rearranged leukemia. Our multi-omics clustering followed by single-sample and single-cell inference of hematopoietic differentiation establishes five robust integrative clusters (ICs) with different master transcription factors, fusion partners and corresponding stages of B-lymphopoietic and early hemato-endothelial development: IRX-type differentiated (IC1), IRX-type undifferentiated (IC2), HOXA-type MLLT1 (IC3), HOXA-type MLLT3 (IC4), and HOXA-type AFF1 (IC5). Importantly, our deep mutational analysis reveals that the number of RAS pathway mutations predicts prognosis and that the most refractory subgroup of IC2 possesses 100% frequency and the heaviest burden of RAS pathway mutations. Our findings highlight the previously under-appreciated intra- and inter-patient heterogeneity of KMT2A-rearranged infant ALL and provide a rationale for the future development of genomics-guided risk stratification and individualized therapy.
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| 10. |
- Curceanu, C., et al.
(författare)
-
Kaonic deuterium measurement with Siddharta-2 on daΦNE
- 2020
-
Ingår i: Acta Physica Polonica B. - 0587-4254. ; 51:1, s. 251-257
-
Tidskriftsartikel (refereegranskat)abstract
- The interaction of antikaons with nucleons and nuclei in the low-energy regime represents an active research field in hadron physics with still many important open questions. The investigation of light kaonic atoms is, in this context, a unique tool to obtain precise information on this interaction. The most precise kaonic hydrogen measurement to date, together with an exploratory measurement of kaonic deuterium, were carried out by the SIDDHARTA Collaboration at the DAΦNE electron–positron collider of LNF-INFN, by combining the excellent quality kaon beam delivered by the collider with new experimental techniques, as fast and precise Silicon-Drift X-ray detectors. The measurement of kaonic deuterium will be realized in the near future by SIDDHARTA-2, a major upgrade of SIDDHARTA.
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| 11. |
- Curceanu, C., et al.
(författare)
-
Low-energy kaon-nuclei interaction studies at DAΦNE : Siddharta-2 and amadeus
- 2017
-
Ingår i: Acta Physica Polonica B. - 0587-4254. ; 48:10, s. 1855-1860
-
Tidskriftsartikel (refereegranskat)abstract
- The DAΦNE electron-positron collider of the Laboratori Nazionali di Frascati of INFN has made available a unique quality low-energy negatively charged kaons "beam", which is being used to study the kaon-nucleon/nuclei interactions by the SIDDHARTA-2 experiment and the AMADEUS Collaboration. The dynamics of the strong interaction processes in the nonperturbative regime is approached by lattice calculations and effective field theories (ChPT) which are still lacking experimental results in the lowenergy regime, fundamental for their good understanding. The studies of kaonic atoms and of the kaonic nuclear processes performed by SIDDHARTA- 2 and AMADEUS play in this context a key-role.
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| 12. |
- Curceanu, C., et al.
(författare)
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The kaonic atoms research program at DAΦNE : Overview and perspectives
- 2018
-
Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 1138:1
-
Tidskriftsartikel (refereegranskat)abstract
- The interaction of antikaons with nucleons and nuclei in the low-energy regime represents an active research field in hadron physics with still many important open questions. The investigation of light kaonic atoms is, in this context, a unique tool to obtain precise information on this interaction. The energy shift and broadening of the lowest-lying states of such atoms, induced by the kaon-nucleus strong interaction, can be determined with high precision from atomic X-ray spectroscopy. This experimental method provides unique information to understand the low energy kaon-nucleus interaction at threshold. The lightest atomic systems, kaonic hydrogen and kaonic deuterium, deliver the isospin-dependent kaon-nucleon scattering lengths. The most precise kaonic hydrogen measurement to date, together with an exploratory measurement of kaonic deuterium, were carried out by the SIDDHARTA collaboration at the DAΦNE electron-positron collider of LNF-INFN, by combining the excellent quality kaon beam delivered by the collider with new experimental techniques, as fast and precise X-ray detectors: Silicon Drift Detectors. The measurement of kaonic deuterium will be realized in the near future by SIDDHARTA-2, a major upgrade of SIDDHARTA. In this paper an overview of the main results obtained by SIDDHARTA together with the future plans, are given.
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| 13. |
- De Paolis, L., et al.
(författare)
-
Kaonic atoms measurement at DA Φ NE : SIDDHARTA and SIDDHARTA-2
- 2019
-
Ingår i: Basic Concepts in Nuclear Physics : Theory, Experiments and Applications - 2018 La Rábida International Scientific Meeting on Nuclear Physics - Theory, Experiments and Applications - 2018 La Rábida International Scientific Meeting on Nuclear Physics. - Cham : Springer International Publishing. - 9783030222031 ; 225, s. 191-195
-
Konferensbidrag (refereegranskat)abstract
- Light kaonic atoms studies provide the unique opportunity to perform experiments equivalent to scattering at threshold, being their atomic binding energies in the keV range. High precision atomic X-rays spectroscopy ensures that the energy shift and broadening of the lowest-lying states of the kaonic atoms, induced by the strong interaction between the kaon and nucleus, can be detected. Kaonic hydrogen and kaonic deuterium are the lightest atomic systems and their study deliver the isospin-dependent kaon-nucleon scattering lengths. The SIDDHARTA collaboration was able to perform the most precise kaonic hydrogen measurement to date, together with an exploratory measurement of kaonic deuterium. The measurement of the kaonic deuterium will be realized in the near future by a major upgrade of SIDDHARTA: SIDDHARTA-2. In this paper an overview of the main results obtained by SIDDHARTA together with the future plans are presented.
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| 14. |
- Marton, J., et al.
(författare)
-
Spectroscopy of kaonic atoms at DAFNE and J-PARC
- 2019
-
Ingår i: Proceedings - 15th International Workshop on Meson Physics, MESON 2018. - : EDP Sciences.
-
Konferensbidrag (refereegranskat)abstract
- The interaction of antikaons (K) with nucleons and nuclei in the low-energy regime represents a very active research field in hadron physics. A unique and rather direct experimental access to the antikaon-nucleon scattering lengths is provided by precision X-ray spectroscopy of transitions in low-lying states in the lightest kaonic atoms (i.e. kaonic hydrogen and deuterium). In the SIDDHARTA experiment at the electron-positron collider DAFNE of LNFINFN we measured the most precise values of the strong interaction observables in conic hydrogen. The strong interaction on the 1s ground state of the electromagnetically bound K-p atom causes an energy shift and broadening of the 1s state. SIDDHARTA will extend the spectroscopy to kaonic deuterium to get access to the antikaon-neutron interaction and thus the isospin dependent scattering lengths. At J-PARC a kaon beam is used in a complementary experiment with a different setup for spectroscopy of kaonic deuterium atoms. The talk will give an overview of the of the upcoming experiments SIDDHARTA and the complementary experiment at J-PARC.Furthermore, the implications of the experiments for the theory of low-energy strong interaction with strangeness will be discussed.
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| 15. |
- Miliucci, M., et al.
(författare)
-
Kaonic Deuterium Precision Measurement at DA Φ NE : The SIDDHARTA-2 Experiment
- 2020
-
Ingår i: Recent Progress in Few-Body Physics : Proceedings of the 22nd International Conference on Few-Body Problems in Physics, FB22 2018 - Proceedings of the 22nd International Conference on Few-Body Problems in Physics, FB22 2018. - Cham : Springer International Publishing. - 0930-8989 .- 1867-4941. - 9783030323561 - 9783030323578 ; 238, s. 965-969
-
Bokkapitel (refereegranskat)abstract
- Light kaonic atoms spectroscopy offers the unique opportunity to perform experiments equivalent to scattering at vanishing relative energies. This allows the determination of the antikaon-nucleus interaction at threshold, without the need of extrapolation to zero energy, as in the case of scattering experiments. In this framework, the SIDDHARTA-2 collaboration aims to perform the first measurement of kaonic deuterium transition to the fundamental level, which is mandatory to extract the isospin dependent antikaon—nucleon scattering lengths. The experiment will be carried out at the DA(formula presented)NE collider of LNF-INFN in 2019–2020.
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| 16. |
- Scordo, A., et al.
(författare)
-
The kaonic atoms research program at DAΦNE : From SIDDHARTA to SIDDHARTA-2
- 2018
-
Ingår i: EPJ Web of Conferences. - : EDP Sciences. - 2101-6275 .- 2100-014X. ; 181
-
Tidskriftsartikel (refereegranskat)abstract
- The interaction of antikaons with nucleons and nuclei in the low-energy regime represents an active research field in hadron physics with still many important open questions. The investigation of light kaonic atoms, in which one electron is replaced by a negatively charged kaon, is a unique tool to provide precise information on this interaction; the energy shift and the broadening of the low-lying states of such atoms, induced by the kaon-nucleus hadronic interaction, can be determined with high precision from the atomic X-ray spectroscopy, and this experimental method provides unique information to understand the low energy kaon-nucleus interaction at the production threshold. The lightest atomic systems, like the kaonic hydrogen and the kaonic deuterium deliver, in a model-independent way, the isospin-dependent kaon-nucleon scattering lengths. The most precise kaonic hydrogen measurement to-date, together with an exploratory measurement of kaonic deuterium, were carried out in 2009 by the SIDDHARTA collaboration at the DAΦNE electron-positron collider of LNF-INFN, combining the excellent quality kaon beam delivered by the collider with new experimental techniques, as fast and very precise X-ray detectors, like the Silicon Drift Detectors. The SIDDHARTA results triggered new theoretical work, which achieved major progress in the understanding of the low-energy strong interaction with strangeness reflected by the antikaon-nucleon scattering lengths calculated with the antikaon-proton amplitudes constrained by the SIDDHARTA data. The most important open question is the experimental determination of the hadronic energy shift and width of kaonic deuterium; presently, a major upgrade of the setup, SIDDHARTA-2, is being realized to reach this goal. In this paper, the results obtained in 2009 and the proposed SIDDHARTA-2 upgrades are presented.
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| 17. |
- Sirghi, D., et al.
(författare)
-
Experiments with low-energy kaons at the DAΦNE Collider
- 2019. - 1
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Ingår i: XIII International Conference on Beauty, Charm and Hyperon Hadrons (BEACH 2018) 17–23 June 2018, Peniche, Portugal. - : IOP Publishing. - 1742-6588. ; 1137
-
Konferensbidrag (refereegranskat)abstract
- The investigations of light kaonic atoms offer the unique opportunity to perform experiments equivalent to scattering at vanishing relative energies, being their atomic binding energies in the keV range. This allows the determination of the hadron-nucleus interaction at threshold without the need of an extrapolation to zero relative energy. The energy shift and broadening of the lowest-lying states of such atoms, induced by the kaon-nucleus strong interaction, can be determined with high precision from atomic X-ray spectroscopy. The lightest atomic systems, kaonic hydrogen and kaonic deuterium, deliver the isospin-dependent kaon-nucleon scattering lengths. The most precise kaonic hydrogen measurement to date, together with an exploratory measurement of kaonic deuterium, were carried out by the SIDDHARTA collaboration at the DAΦNE electron-positron collider of LNF-INFN. The measurement of kaonic deuterium will be realized in the near future by SIDDHARTA-2, a major upgrade of SIDDHARTA. A correlated study of the kaon-nuclei interaction at momenta below 130 MeV/c is carried out by the AMADEUS collaboration, using the KLOE detector and dedicated targets inserted near the collider interaction point. In this paper an overview of the main results obtained by SIDDHARTA together with the future plans, the SIDDHARTA-2 experiment and with the preliminary results of the study of charged antikaons interacting with nuclei by the AMADEUS collaboration, are shown.
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| 18. |
- Sirghi, D., et al.
(författare)
-
Kaonic atoms measurements at the DAΦNE Collider
- 2018
-
Ingår i: Proceedings of Science. - 1824-8039. ; 336
-
Konferensbidrag (refereegranskat)abstract
- The DAΦNE electron-positron collider of the Laboratori Nazionali di Frascati of INFN is a worldwide unique low-energy kaon source, which is being used to produce and to study kaonic atoms by the SIDDHARTA collaboration. The X-ray measurements of kaonic atoms play an important role for understanding the low-energy QCD in the strangeness sector. Significant achievements have been obtained by the SIDDHARTA experiment, among which: the most precise kaonic hydrogen measurement of the 1s level shift and width induced by the presence of the strong interaction; an upper limit of the X-ray yield for kaonic deuterium K-series; the accurate measurement of the 2p level shift and width of kaonic helium-4 and kaonic helium-3; yields of various light kaonic atoms transitions. Using the experience gained with SIDDHARTA experiment, the first kaonic deuterium measurement is in preparation in the framework of the SIDDHARTA-2 experiment, with the goal to determine the antikaon-nucleon isospin dependent scattering lengths, which is possible only by combining the K−p and the upcoming K−d results. An overview of the experimental results of SIDDHARTA and an outlook to SIDDHARTA-2 experiments are given in this paper.
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| 19. |
- Aikawa, S., et al.
(författare)
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Pole position of Λ(1405) measured in d(K−,n)πΣ reactions
- 2023
-
Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 837
-
Tidskriftsartikel (refereegranskat)abstract
- We measured a set of π±Σ∓, π0Σ0, and π−Σ0 invariant mass spectra below and above the K¯N mass threshold in K−-induced reactions on deuteron. The measured πΣ mass spectral shape is well reproduced via the two-step mechanism, i.e., a neutron knocked out at a forward angle from a deuteron by an incident K−, with the K¯ recoiled backward reacting with the residual nucleon to produce π and Σ. We deduced the S-wave K¯N→πΣ and K¯N→K¯N scattering amplitudes in the isospin 0 channel in the framework of a K¯N and πΣ coupled channel. We find that a resonance pole corresponding to Λ(1405) is located at 1417.7−7.4+6.0 (fitting errors)−1.0+1.1 (systematic errors) + [−26.1−7.9+6.0 (fitting errors)−2.0+1.7 (systematic errors)] i MeV/c2, closer to the K¯N mass threshold than the value determined by the Particle Data Group. © 2022 The Author
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| 20. |
- Ajimura, S., et al.
(författare)
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“K−pp” a K‾-meson nuclear bound state, observed in 3He(K−,Λp)n reactions
- 2019
-
Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 789, s. 620-625
-
Tidskriftsartikel (refereegranskat)abstract
- We observed a distinct peak in the Λp invariant mass spectrum of He3(K−,Λp)n, well below mK+2mp, i.e., the mass threshold of the K− to be bound to two protons. By selecting a relatively large momentum-transfer region q=350∼650 MeV/c, one can kinematically separate the peak from the quasi-free process, K‾N→K‾N followed by the non-resonant absorption by the two spectator-nucleons K‾NN→ΛN. We found that the simplest fit to the observed peak gives us a Breit–Wigner pole position at BKpp=47±3(stat.)−6 +3(sys.) MeV having a width ΓKpp=115±7(stat.)−20 +10(sys.) MeV, and the S-wave Gaussian reaction form-factor parameter QKpp=381±14(stat.)−0 +57(sys.) MeV/c, as a new form of the nuclear bound system with strangeness – “K−pp”.
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| 21. |
- Doriese, W B, et al.
(författare)
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A practical superconducting-microcalorimeter X-ray spectrometer for beamline and laboratory science
- 2017
-
Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 88:5
-
Tidskriftsartikel (refereegranskat)abstract
- We describe a series of microcalorimeter X-ray spectrometers designed for a broad suite of measurement applications. The chief advantage of this type of spectrometer is that it can be orders of magnitude more efficient at collecting X-rays than more traditional high-resolution spectrometers that rely on wavelength-dispersive techniques. This advantage is most useful in applications that are traditionally photon-starved and/or involve radiation-sensitive samples. Each energy-dispersive spectrometer is built around an array of several hundred transition-edge sensors (TESs). TESs are superconducting thin films that are biased into their superconducting-to-normal-metal transitions. The spectrometers share a common readout architecture and many design elements, such as a compact, 65 mK detector package, 8-column time-division-multiplexed superconducting quantum-interference device readout, and a liquid-cryogen-free cryogenic system that is a two-stage adiabatic-demagnetization refrigerator backed by a pulse-tube cryocooler. We have adapted this flexible architecture to mate to a variety of sample chambers and measurement systems that encompass a range of observing geometries. There are two different types of TES pixels employed. The first, designed for X-ray energies below 10 keV, has a best demonstrated energy resolution of 2.1 eV (full-width-at-half-maximum or FWHM) at 5.9 keV. The second, designed for X-ray energies below 2 keV, has a best demonstrated resolution of 1.0 eV (FWHM) at 500 eV. Our team has now deployed seven of these X-ray spectrometers to a variety of light sources, accelerator facilities, and laboratory-scale experiments; these seven spectrometers have already performed measurements related to their applications. Another five of these spectrometers will come online in the near future. We have applied our TES spectrometers to the following measurement applications: synchrotron-based absorption and emission spectroscopy and energy-resolved scattering; accelerator-based spectroscopy of hadronic atoms and particle-induced-emission spectroscopy; laboratory-based time-resolved absorption and emission spectroscopy with a tabletop, broadband source; and laboratory-based metrology of X-ray-emission lines. Here, we discuss the design, construction, and operation of our TES spectrometers and show first-light measurements from the various systems. Finally, because X-ray-TES technology continues to mature, we discuss improvements to array size, energy resolution, and counting speed that we anticipate in our next generation of TES-X-ray spectrometers and beyond.
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| 22. |
- Hashimoto, T., et al.
(författare)
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Measurements of Strong-Interaction Effects in Kaonic-Helium Isotopes at Sub-eV Precision with X-Ray Microcalorimeters
- 2022
-
Ingår i: Physical Review Letters. - 1079-7114. ; 128:11
-
Tidskriftsartikel (refereegranskat)abstract
- We have measured the 3d→2p transition x rays of kaonic 3He and 4He atoms using superconducting transition-edge-sensor microcalorimeters with an energy resolution better than 6 eV (FWHM). We determined the energies to be 6224.5±0.4(stat)±0.2(syst) eV and 6463.7±0.3(stat)±0.1(syst) eV, and widths to be 2.5±1.0(stat)±0.4(syst) eV and 1.0±0.6(stat)±0.3(stat) eV, for kaonic 3He and 4He, respectively. These values are nearly 10 times more precise than in previous measurements. Our results exclude the large strong-interaction shifts and widths that are suggested by a coupled-channel approach and agree with calculations based on optical-potential models.
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| 23. |
- Tatsuno, H., et al.
(författare)
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Future projects of light kaonic atom X-ray spectroscopy
- 2016
-
Ingår i: EPJ Web of Conferences. - : EDP Sciences. - 2101-6275 .- 2100-014X. ; 130
-
Tidskriftsartikel (refereegranskat)abstract
- X-ray spectroscopy of light kaonic atoms is a unique tool to provide precise information on the fundamental KN interaction at the low-energy limit and the in-medium nuclear interaction of K-. The future experiments of kaonic deuterium strong-interaction shift and width (SIDDHARTA-2 and J-PARC E57) can extract the isospin dependent K-N interaction at threshold. The high-resolution X-ray spectroscopy of kaonic helium with microcalorimeters (J-PARC E62) has the possibility to solve the long-standing potential-strength problem of the attractive K--nucleus interaction. Here, the recent experimental results and the future projects of X-ray spectroscopy of light kaonic atoms are presented.
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