1. |
- Tran, K. B., et al.
(författare)
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The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet. - 0140-6736. ; 400:10352, s. 563-591
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Tidskriftsartikel (refereegranskat)abstract
- Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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2. |
- Alvarez, E. M., et al.
(författare)
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The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet Oncology. - : Elsevier BV. - 1470-2045. ; 23:1, s. 27-52
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Tidskriftsartikel (refereegranskat)abstract
- Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.
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3. |
- Sheena, B. S., et al.
(författare)
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Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet Gastroenterology & Hepatology. - : Elsevier BV. - 2468-1253. ; 7:9, s. 796-829
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Tidskriftsartikel (refereegranskat)abstract
- Background Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods The primary data sources were population-based serosurveys, claims and hospital discharges, cancer registries, vital registration systems, and published case series. We estimated chronic HBV infection and the burden of HBV-related diseases, defined as an aggregate of cirrhosis due to hepatitis B, liver cancer due to hepatitis B, and acute hepatitis B. We used DisMod-MR 2.1, a Bayesian mixed-effects meta-regression tool, to estimate the prevalence of chronic HBV infection, cirrhosis, and aetiological proportions of cirrhosis. We used mortality-to-incidence ratios modelled with spatiotemporal Gaussian process regression to estimate the incidence of liver cancer. We used the Cause of Death Ensemble modelling (CODEm) model, a tool that selects models and covariates on the basis of out-ofsample performance, to estimate mortality due to cirrhosis, liver cancer, and acute hepatitis B. Findings In 2019, the estimated global, all-age prevalence of chronic HBV infection was 4 center dot 1% (95% uncertainty interval [UI] 3 center dot 7 to 4 center dot 5), corresponding to 316 million (284 to 351) infected people. There was a 31 center dot 3% (29 center dot 0 to 33 center dot 9) decline in all-age prevalence between 1990 and 2019, with a more marked decline of 76 center dot 8% (76 center dot 2 to 77 center dot 5) in prevalence in children younger than 5 years. HBV-related diseases resulted in 555 000 global deaths (487 000 to 630 000) in 2019. The number of HBV-related deaths increased between 1990 and 2019 (by 5 center dot 9% [-5 center dot 6 to 19 center dot 2]) and between 2015 and 2019 (by 2 center dot 9% [-5 center dot 9 to 11 center dot 3]). By contrast, all-age and age-standardised death rates due to HBV-related diseases decreased during these periods. We compared estimates for 2019 in 194 WHO locations to WHO-GHSS 2020 targets, and found that four countries achieved a 10% reduction in deaths, 15 countries achieved a 30% reduction in new cases, and 147 countries achieved a 1% prevalence in children younger than 5 years. As of 2019, 68 of 194 countries had already achieved the 2030 target proposed in WHO Interim Guidance of an all-age HBV-related death rate of four per 100 000. Interpretation The prevalence of chronic HBV infection declined over time, particularly in children younger than 5 years, since the introduction of hepatitis B vaccination. HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and cohort effects. By 2019, many countries had met the interim seroprevalence target for children younger than 5 years, but few countries had met the WHO-GHSS interim targets for deaths and new cases. Progress according to all indicators must be accelerated to meet 2030 targets, and there are marked disparities in burden and progress across the world. HBV interventions, such as vaccination, testing, and treatment, must be strategically supported and scaled up to achieve elimination.
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6. |
- Obers, Niels A., et al.
(författare)
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Quantum gravity phenomenology at the dawn of the multi-messenger era—A review
- 2022
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Ingår i: Progress in Particle and Nuclear Physics. - : Elsevier BV. - 0146-6410 .- 1873-2224. ; 125
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Forskningsöversikt (refereegranskat)abstract
- The exploration of the universe has recently entered a new era thanks to the multi-messenger paradigm, characterized by a continuous increase in the quantity and quality of experimental data that is obtained by the detection of the various cosmic messengers (photons, neutrinos, cosmic rays and gravitational waves) from numerous origins. They give us information about their sources in the universe and the properties of the intergalactic medium. Moreover, multi-messenger astronomy opens up the possibility to search for phenomenological signatures of quantum gravity. On the one hand, the most energetic events allow us to test our physical theories at energy regimes which are not directly accessible in accelerators; on the other hand, tiny effects in the propagation of very high energy particles could be amplified by cosmological distances. After decades of merely theoretical investigations, the possibility of obtaining phenomenological indications of Planck-scale effects is a revolutionary step in the quest for a quantum theory of gravity, but it requires cooperation between different communities of physicists (both theoretical and experimental). This review, prepared within the COST Action CA18108 “Quantum gravity phenomenology in the multi-messenger approach”, is aimed at promoting this cooperation by giving a state-of-the art account of the interdisciplinary expertise that is needed in the effective search of quantum gravity footprints in the production, propagation and detection of cosmic messengers.
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7. |
- Marcouille, O., et al.
(författare)
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Production of high energy photons with in vacuum wigglers : From SOLEIL wiggler to MAXIV wiggler
- 2019
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Ingår i: Proceedings of the 13th International Conference on Synchrotron Radiation Instrumentation, SRI 2018. - : Author(s). - 9780735417823 ; 2054
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Konferensbidrag (refereegranskat)abstract
- Small gap wigglers become more and more attractive to produce high photon fluxes in the hard X-ray photon range. They use magnet blocks of high magnetization which resists much better to heating (baking, synchrotron radiation) than in the past, produce high magnetic field with numerous periods and are very compact. They also are a very good alternative to superconducting technology which requires special infrastructure, heavy maintenance and is not running cost free. SOLEIL, operating presently at 2.75 GeV has designed and built an in-vacuum wiggler of 38 periods of 50 mm producing 2.1 T at a minimum gap of 5.5 mm to delivered photon beam between 20 keV and 50 keV. Already in operation, further improvements are presently in progress to push photons towards higher energy, in particular thanks to the operation at lower gap (4.5 mm). MAX IV and SOLEIL, in the frame of collaboration, ave built an upgraded version of the existing SOLEIL wiggler with the target to extend the spectral range at high energy (above 50 keV) but also at low energy (4 keV) with the same insertion device. The design of the existing magnetic system has been modified to reach 2.4 T at a minimum gap of 4.2 mm and includes taper operation to avoid undulator structure in the radiated spectrum at low energy.
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8. |
- Khorrami, F., et al.
(författare)
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An up-to-date block model and strain rate map of Iran using integrated campaign-mode and permanent GPS velocities
- 2019
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Ingår i: 27th IUGG General Assembly.
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Konferensbidrag (refereegranskat)abstract
- Iran accommodates a large part of the ongoing Arabia-Eurasia collision deformation. Because of such active tectonics, the country suffers from intensive seismicity and frequent destructive earthquakes in different locations.To study further the crustal deformation in Iran, we processed the data collected during 10 years (2006-2015) from the Iranian Permanent GNSS Network and combined them with previously published velocity solutions from GPS survey measurements during 1997–2013. We analysed this velocity field using a continuum approach to compute a new strain rate map for this region and we designed a block model based on the main geological, morphological, and seismic structures. Comparison between both approaches suggests similar results and allow us to present the first comprehensive first order fault slip rate estimates for the whole of Iran. Our results confirm most of the results from previous geodetic studies. Moreover, we also show a trade-off between the coupling ratio of the Iranian Makran subduction interface and the kinematic of the faults north of the Makran in the Jazmurian depression. Although too scarce to accurately estimate a coupling ratio, we show that coupling higher than 0.4 on the plate interface down to a depth of 25 km will induce extension on the E-W faults in the Jazmurian region. However, the sites close to the shoreline suggest a low coupling ratio, hence the coupling on this plate interface is probably more complicated than previously described and the Iranian Makran subduction interface mechanical behaviour might be similar to that on the Hellenic subduction zone.
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9. |
- Dashtimanesh, Abbas, et al.
(författare)
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Numerical study on a heeled one-stepped boat moving forward in planing regime
- 2020
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Ingår i: Applied Ocean Research. - : Elsevier BV. - 0141-1187 .- 1879-1549. ; 96
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Tidskriftsartikel (refereegranskat)abstract
- Stepped planing hulls have the potential to reach high-speeds in the sea. The step on the bottom of these vessels influence the pressure distribution and thus stability of the vessel, especially in transverse plane. Understanding the behavior of these vessels in a non-zero heel condition is fundamental in the early stage design. In the current paper, numerical simulation of the viscous flow field around a heeled one-stepped planing hull is performed to evaluate influences of the asymmetric planing on the performance of the vessel. The numerical model is validated in two steps. At the first step, performance of a heeled stepless planing hull operating in calm water is simulated using the numerical model, and the computed data are compared against experimental data. At the second step, the numerical model is used to compute resisatnce anad running attitudes of a one-stepped planing hull in symmetric condition, and the obtained results are compared against experimental measurements. Numerically computed results are in good quantitative agreement with laboratory measurements, showing that the numerical model has reasonable accuracy. On the whole, it has been found that a heeled condition manages a one-stepped vessel to settle at a smaller trim angle. But, unlike stepless boats, large heel angles have less effects on the trim angle at high-speeds since significant negative pressure is caused behind the step by the air, triggering negative pitching moment. It is shown that the resistance of a one-stepped planing hull is increased up to 25% at most of speeds and heel angles when the vessel advances in asymmetric condition. Moreover, this study shows that, the heeling moment of a one-stepped vessel decreases as the speed increases. The extent of reduction in the heeling moment gets more significant by the increase in heel angle at high-speeds, and, as a result, the heeling moment required to keep the vessel at large heel angle is observed to converge to the heeling moment correspanding to small heel angles.
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10. |
- Rowe, AD, et al.
(författare)
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A Novel Approach to Improve Newborn Screening for Congenital Hypothyroidism by Integrating Covariate-Adjusted Results of Different Tests into CLIR Customized Interpretive Tools
- 2021
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Ingår i: International journal of neonatal screening. - : MDPI AG. - 2409-515X. ; 7:2
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Tidskriftsartikel (refereegranskat)abstract
- Newborn screening for congenital hypothyroidism remains challenging decades after broad implementation worldwide. Testing protocols are not uniform in terms of targets (TSH and/or T4) and protocols (parallel vs. sequential testing; one or two specimen collection times), and specificity (with or without collection of a second specimen) is overall poor. The purpose of this retrospective study is to investigate the potential impact of multivariate pattern recognition software (CLIR) to improve the post-analytical interpretation of screening results. Seven programs contributed reference data (N = 1,970,536) and two sets of true (TP, N = 1369 combined) and false (FP, N = 15,201) positive cases for validation and verification purposes, respectively. Data were adjusted for age at collection, birth weight, and location using polynomial regression models of the fifth degree to create three-dimensional regression surfaces. Customized Single Condition Tools and Dual Scatter Plots were created using CLIR to optimize the differential diagnosis between TP and FP cases in the validation set. Verification testing correctly identified 446/454 (98%) of the TP cases, and could have prevented 1931/5447 (35%) of the FP cases, with variable impact among locations (range 4% to 50%). CLIR tools either as made here or preferably standardized to the recommended uniform screening panel could improve performance of newborn screening for congenital hypothyroidism.
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14. |
- Armengaud, E., et al.
(författare)
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Model-based toolchain for the efficient development of safety-relevant automotive embedded systems
- 2011
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Ingår i: SAE technical paper series. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191.
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Tidskriftsartikel (refereegranskat)abstract
- Advanced functionalities unthinkable a few decades ago are now being introduced into automotive vehicles through embedded systems for reasons like emission control, vehicle connectivity, safety and cooperative behaviors. As the development often involves stakeholders from different engineering disciplines and organizations, the complexity due to shared requirements, interdependencies of data, functions, and resources, as well as tight constraints in regards to timing, safety, and resource efficiency makes the system integration, quality control and assurance, reuse and change management increasingly more difficult. This calls for a more rigorous approach to the development of automotive embedded systems and components. This paper describes the CESAR reference technology platform (RTP) that supports the formalization of various engineering concerns in the development of safety-relevant embedded systems and thereby a model-based integration of various tools and methods to form seamless environments or toolchains for the development of such systems.
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15. |
- Bilandi, R. N., et al.
(författare)
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A numerical and analytical way for double-stepped planing hull in regular wave
- 2019
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Ingår i: 8th International Conference on Computational Methods in Marine Engineering, MARINE 2019. - : International Center for Numerical Methods in Engineering. ; , s. 417-427
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Konferensbidrag (refereegranskat)abstract
- The paper presents a comparison analysis between numerical method and nonlinear mathematical model for the prediction of the vertical motions of a double stepped planing hull in regular wave. The numerical method is to Unsteady Reynolds Averaged Navier-Stokes (URANS) equations solution via moving mesh techniques (overset/chimera), performed at different model speeds, wavelengths, and wave heights using the commercial software Siemens PLM Star-CCM+. Instead, the analytical solution is obtained using nonlinear mathematical model. The presented non-linear mathematical model is developed using a combined approach based on 2D+T theory, momentum theory, and linear wake profile. Under such assumption, the double stepped planing hull is divided into three planing surfaces, and hydrodynamic forces acting on each planing surface is found by extension of simulation of symmetric water entry of two-dimensional wedge section bodies. Then, each sub-problem is solved by extending the mathematical simulation of wedge penetrating water. Final vertical force and pitching moment are found and substituted in motion equation. The mathematical model is able to compute heave and pitch motion in calm water and regular waves. Results of numerical method and novel 2D+T analytical method are compared against each other.
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16. |
- Bilandi, R. N., et al.
(författare)
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Calm-water performance of a boat with two swept steps at high-speeds : Laboratory measurements and mathematical modeling
- 2020
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Ingår i: Procedia Manufacturing. - : Elsevier B.V.. - 2351-9789. ; , s. 467-474
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Konferensbidrag (refereegranskat)abstract
- Laboratory measurements are performed to find the performance in calm water of a planing hull with two swept steps. Furthermore, a mathematical model, based on the 2D+T theory, is adapted to provide a fast and accurate simulation for performance prediction of this craft. The trim angle of the vessel is seen to reach to two peaks, one in pre-planing and on in the early planing speed, then converges to a small value around 2 degrees. A small wetted area is seen to appear near the chine of the middle body of the vessel at early planing speed. Laboratory measurements and mathematical computations are seen to be in good agreement, especially at very high-speeds. Overall, the mathematical model is found to be a useful tool for performance prediction of boats with swept steps, which can have different, but better performance in comparison with stepless and boats with transverse steps.
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17. |
- Dashtimanesh, Abbas, et al.
(författare)
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Effects of step configuration on hydrodynamic performance of one- and doubled-stepped planing flat plates : A numerical simulation
- 2020
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Ingår i: Proceedings of the Institution of Mechanical Engineers Part M: Journal of Engineering for the Maritime Environment. - : SAGE Publications. - 1475-0902 .- 2041-3084. ; 234:1, s. 181-195
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Tidskriftsartikel (refereegranskat)abstract
- Categorized as one of high-speed marine vehicles, stepped planing hulls have the potential to reach relatively high speed in the sea by decreasing wetted surface. There were and still are some challenges in modeling of these vessels and design of ideal situation of steps. In the current study, a numerical-based method has been used to provide understanding about the effect of step height and its location on hydrodynamic characteristics of double-stepped planing plates. At the first step, one-stepped planing plate is numerically simulated. Results are compared against exiting numerical data, suggesting that results of the current numerical simulation are similar to results of previous numerical simulations. Then, double-stepped planing plates are modeled and pressure distribution, wetted length, free surface elevation and drag over lift ratio are computed. It is seen that, ventilation length behind the step and pressure coefficient are increased when step height of one- and a double-stepped planing plates are increased. It has been shown that, unlike an one-stepped planing plate, drag coefficient of a double-stepped planing plate can be increased when the step height is increased. The effects of the location of the second step on the performance of the planing plate have been explored, showing that this position plays a critical role on hydrodynamic forces. It is demonstrated that when the smallest possible lift force is produced by the middle-body, the plate shows the best performance (highest lift over drag ratio).
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18. |
- Esfandiari, A., et al.
(författare)
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Comparison between the dynamic behavior of the non-stepped and double-stepped planing hulls in rough water : A numerical study
- 2020
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Ingår i: Journal of Ship Production and Design. - : The Society of Naval Architects and Marine Engineers. - 2158-2866 .- 2158-2874. ; 36:1, s. 52-66
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Tidskriftsartikel (refereegranskat)abstract
- Reducing vertical motions of high-speed planing hulls in rough water is one of the most important factors that help a boat to becomemore operable, andwill benefit the structure of the boat and the crew on board. In the recent decade, stepped planing hulls have been investigated with emphasis on their better performance in calm water than that of nonstepped planing hulls. However, there are still doubts about their performance in rough water. In this study, we investigate this problem by providing numerical simulations for motions of a double-stepped and a non-stepped planing hull in a vertical plane when they encounter head waves. The problem will be solved using the finite volume method and volume of fluidmethod. To this end, anumerical computational fluid dynamics code (STARCCM1) has been used. Accuracy of the numerical simulations is evaluated by comparing their outcome with available experimental data. The dynamic response of the investigated hulls has been numerically modeled for two different wave lengths, one of which is smaller than the boat length and the other which is larger than the boat length. Using the numerical simulations, heave and pitch motions as well as vertical acceleration are found. It has been found that at wave lengths larger than the boat length, heave amplitude decreases by 10-40%when twosteps are added to the bottom of a vessel. It has also been observed that pitch of a planing hull is reduced by 18-32% in the presence of the two steps on its bottom. Finally, it has been observed that forwave lengths larger than the boat length, the maximum vertical acceleration decreases by a gravitational acceleration of about .2-.7.
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19. |
- Ghadimi, P., et al.
(författare)
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Developing a computer program for detailed study of planing hull’s spray based on Morabito’s approach
- 2014
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Ingår i: Journal of Marine Science and Application. - : Springer Nature. - 1671-9433 .- 1993-5048. ; 13:4, s. 402-415
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Tidskriftsartikel (refereegranskat)abstract
- Recently, Morabito (2010) has studied the water spray phenomena in planing hulls and presented new analytical equations. However, these equations have not been used for detailed parametric studies of water spray around planing hulls. In this paper, a straight forward analysis is conducted to apply these analytical equations for finding the spray geometry profile by developing a computer program based on presented computational process. The obtained results of the developed computer program are compared against existing data in the literature and favorable accuracy is achieved. Parametric studies have been conducted for different physical parameters. Positions of spray apex are computed and three dimensional profiles of spray are examined. It is concluded that spray height increases by an increase in the speed coefficient or the deadrise angle. Ultimately, a computational process is added to Savitsky’s method and variations of spray apex are computed for different velocities. It is shown that vertical, lateral, and longitudinal positions of spray increase as the craft speed increases. On the other hand, two new angles are defined in top view and it is concluded that they have direct relation with the trim angle. However, they show inverse relation with the deadrise angle.
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20. |
- Ghadimi, P., et al.
(författare)
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Introducing a particular mathematicalmodel for predicting the resistance and performance of prismatic planing hulls in calm water by means of total pressure distribution
- 2015
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Ingår i: Journal of Naval Architecture and Marine Engineering. - : Department of Naval Architecture and Marine Engineering. - 1813-8535 .- 2070-8998. ; 12:2, s. 73-94
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Tidskriftsartikel (refereegranskat)abstract
- Mathematical modeling of planing hulls and determination of their characteristics are the most important subjects in hydrodynamic study of planing vessels. In this paper, a new mathematical model has been developed based on pressure distribution. This model has been provided for two different situations: (1) for a situation in which all forces pass through the center of gravity and (2) for a situation in which forces don not necessarily pass through the center of gravity. Two algorithms have been designed for the governing equations. Computational results have been presented in the form of trim angle, total pressure, hydrodynamic and hydrostatic lift coefficients, spray apex and total resistance which includes frictional, spray and induced resistances. Accuracy of the model has been verified by comparing the numerical findings against the results of Savitsky's method and available experimental data. Good accuracy is displayed. Furthermore, effects of deadrise angle on trim angle of the craft, position of spray apex and resistance have been investigated.
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21. |
- Hosseini, A., et al.
(författare)
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Performance prediction of a hard-chine planing hull by employing different cfd models
- 2021
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Ingår i: Journal of Marine Science and Engineering. - : MDPI AG. - 2077-1312. ; 9:5
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents CFD (Computational Fluid Dynamics) simulations of the performance of a planing hull in a calm-water condition, aiming to evaluate similarities and differences between results of different CFDmodels. The key differences between thesemodels are the ways they use to compute the turbulent flow and simulate themotion of the vessel. The planingmotion of a vessel on water leads to a strong turbulent fluid flowmotion, and themovement of the vessel fromits initial position can be relatively significant, which makes the simulation of the problem challenging. Two different frameworks including k-" and DES (Detached Eddy Simulation) methods are employed to model the turbulence behavior of the fluid motion of the air–water flow around the boat. Vertical motions of the rigid solid body in the fluid domain, which eventually converge to steady linear and angular displacements, are numerically modeled by using two approaches, including morphing and overset techniques. All simulations are performed with a similar mesh structure which allows us to evaluate the differences between results of the applied mesh motions in terms of computation of turbulent air–water flow around the vessel. Through quantitative comparisons, themorphing technique has been seen to result in smaller errors in the prediction of the running trim angle at high speeds. Numerical observations suggest that a DES model can modify the accuracy of the morphing mesh simulations in the prediction of the trim angle, especially at high-speeds. The DES model has been seen to increase the accuracy of the model in the computation of the resistance of the vessel in a high-speed operation, as well. This better level of accuracy in the prediction of resistance is a result of the calculation of the turbulent eddies emerging in the water flow in the downstream zone, which are not captured when a k-" framework is employed. The morphing approach itself can also increase the accuracy of the resistance prediction. The oversetmethod, however, overpredicts the resistance force. This overprediction is caused by the larger vorticity, computed in the direction of the waves, generated under the bow of the vessel. Furthermore, the overset technique is observed to result in larger hydrodynamic pressure on the stagnation line, which is linked to the greater trimangle, predicted by this approach. The DESmodel is seen to result in extra-damping of the second and third crests of transomwaves as it calculates the stronger eddies in the wake of the boat. Overall, a combination of themorphing and DESmodels is recommended to be used for CFDmodeling of a planing hull at high-speeds. This combined CFD model might be relatively slower in terms of computational time, but it provides a greater level of accuracy in the performance prediction, and can predict the energy damping, developed in the surrounding water. Finally, the results of the present paper demonstrate that a better level of accuracy in the performance prediction of the vessel might also be achieved when an oversetmeshmotion is used. This can be attained in future bymodifying themesh structure in such away that vorticity is not overpredicted and the generated eddies, emerging when a DESmodel is employed, are captured properly.
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22. |
- Huang, Luofeng, et al.
(författare)
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Offshore COVID-19 risk assessment based on a fishing vessel
- 2023
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Ingår i: Ocean Engineering. - 0029-8018. ; 285
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Tidskriftsartikel (refereegranskat)abstract
- Offshore crews often work near each other due to limited space, signifying a complex environment for the airborne transmission of the coronavirus (COVID-19). During offshore operations, a fishing vessel can be subjected to miscellaneous airflow conditions and will respond dynamically to ocean waves. To understand the risk of COVID-19 contagion, this research establishes a new computational model to analyse the airborne transmission of COVID-19 and develops effective mitigation strategies where possible. The concentration and coverage of coronavirus are scrutinised, considering typical airflows and wave-induced vessel motions. Furthermore, the COVID-19 infection risk is quantified using a probability index. The results show that the overall infection risk of a ship in tailwind is lower than in head or beam wind. Structural motions are for the first time coupled with the virus transmission, and it was found that the vessel's oscillating movement in waves can reinforce the virus concentration in close proximity to the infected person and may help diffuse the virus outside the proximal region. The presented findings can inform the airborne contagion risks and corresponding hygienic measures for maritime and offshore operations, facilitating long-term human health in seas.i
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23. |
- Kari, OK, et al.
(författare)
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Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System
- 2020
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Ingår i: Pharmaceutics. - : MDPI AG. - 1999-4923. ; 12:8
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Tidskriftsartikel (refereegranskat)abstract
- Light-activated liposomes permit site and time-specific drug delivery to ocular and systemic targets. We combined a light activation technology based on indocyanine green with a hyaluronic acid (HA) coating by synthesizing HA–lipid conjugates. HA is an endogenous vitreal polysaccharide and a potential targeting moiety to cluster of differentiation 44 (CD44)-expressing cells. Light-activated drug release from 100 nm HA-coated liposomes was functional in buffer, plasma, and vitreous samples. The HA-coating improved stability in plasma compared to polyethylene glycol (PEG)-coated liposomes. Liposomal protein coronas on HA- and PEG-coated liposomes after dynamic exposure to undiluted human plasma and porcine vitreous samples were hydrophilic and negatively charged, thicker in plasma (~5 nm hard, ~10 nm soft coronas) than in vitreous (~2 nm hard, ~3 nm soft coronas) samples. Their compositions were dependent on liposome formulation and surface charge in plasma but not in vitreous samples. Compared to the PEG coating, the HA-coated liposomes bound more proteins in vitreous samples and enriched proteins related to collagen interactions, possibly explaining their slightly reduced vitreal mobility. The properties of the most abundant proteins did not correlate with liposome size or charge, but included proteins with surfactant and immune system functions in plasma and vitreous samples. The HA-coated light-activated liposomes are a functional and promising alternative for intravenous and ocular drug delivery.
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24. |
- Khojasteh, D., et al.
(författare)
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Numerical analysis of shipping water impacting a step structure
- 2020
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Ingår i: Ocean Engineering. - : Elsevier Ltd. - 0029-8018 .- 1873-5258. ; 209
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Tidskriftsartikel (refereegranskat)abstract
- Shipping water, the flow washing over and impacting the upper decks of ships and offshore structures, occurs frequently during their service life and often causes structural problems. For engineers to design safe floating structures subjected to shipping water it is essential to gain an in-depth understanding of its depth and flow field, and the resulting impact forces. In this work, Computational Fluid Dynamics (CFD) is applied to understand the physics of shipping water washing over a stepped platform. We find that the most accurate solutions are obtained with the k−ε turbulence closure. The hydrodynamic load generated by the shipping water is found to strongly depends on the kinematic energy of the water hitting the step. It is shown that with smaller values of the freeboard a more dynamic flow ensues, with a stronger vortex and larger velocity gradient resulting in deeper shipping water and a larger impact force.
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25. |
- Lagali, Neil, et al.
(författare)
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Focused Tortuosity Definitions Based on Expert Clinical Assessment of Corneal Subbasal Nerves
- 2015
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Ingår i: Investigative Ophthalmology and Visual Science. - : ASSOC RESEARCH VISION OPHTHALMOLOGY INC. - 0146-0404 .- 1552-5783. ; 56:9, s. 5102-5109
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE. We examined agreement among experts in the assessment of corneal subbasal nerve tortuosity. METHODS. Images of corneal subbasal nerves were obtained from investigators at seven sites (Auckland, Boston, Linkoping, Manchester, Oslo, Rostock, and Sydney) using laser-scanning in vivo confocal microscopy. A set of 30 images was assembled and ordered by increasing tortuosity by 10 expert graders from the seven sites. In a first experiment, graders assessed tortuosity without a specific definition and performed grading three times, with at least 1 week between sessions. In a second experiment, graders assessed the same image set using four focused tortuosity definitions. Intersession and intergrader repeatability for the experiments were determined using the Spearman rank correlation. RESULTS. Expert graders without a specific tortuosity definition had high intersession (Spearman correlation coefficient 0.80), but poor intergrader (0.62) repeatability. Specific definitions improved intergrader repeatability to 0.79. In particular, tortuosity defined by frequent small-amplitude directional changes (short range tortuosity) or by infrequent large-amplitude directional changes (long range tortuosity), indicated largely independent measures and resulted in improved repeatability across the graders. A further refinement, grading only the most tortuous nerve in a given image, improved the average correlation of a given graders ordering of images with the group average to 0.86 to 0.90. CONCLUSIONS. Definitions of tortuosity specifying short or long-range tortuosity and considering only the most tortuous nerve in an image improved the agreement in tortuosity grading among a group of expert observers. These definitions could improve accuracy and consistency in quantifying subbasal nerve tortuosity in clinical studies.
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26. |
- Law, Andrew M. K., et al.
(författare)
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ALTEN: A High‐Fidelity Primary Tissue‐Engineering Platform to Assess Cellular Responses Ex Vivo
- 2022
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Ingår i: Advanced Science. - : John Wiley & Sons. - 2198-3844. ; 9:21
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Tidskriftsartikel (refereegranskat)abstract
- To fully investigate cellular responses to stimuli and perturbations within tissues, it is essential to replicate the complex molecular interactions within the local microenvironment of cellular niches. Here, the authors introduce Alginate-based tissue engineering (ALTEN), a biomimetic tissue platform that allows ex vivo analysis of explanted tissue biopsies. This method preserves the original characteristics of the source tissue's cellular milieu, allowing multiple and diverse cell types to be maintained over an extended period of time. As a result, ALTEN enables rapid and faithful characterization of perturbations across specific cell types within a tissue. Importantly, using single-cell genomics, this approach provides integrated cellular responses at the resolution of individual cells. ALTEN is a powerful tool for the analysis of cellular responses upon exposure to cytotoxic agents and immunomodulators. Additionally, ALTEN's scalability using automated microfluidic devices for tissue encapsulation and subsequent transport, to enable centralized high-throughput analysis of samples gathered by large-scale multicenter studies, is shown.
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27. |
- Mousavi, Z., et al.
(författare)
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Global Positioning System constraints on the active tectonics of NE Iran and the South Caspian region
- 2013
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Ingår i: Earth and Planetary Science Letters. - : Elsevier. - 0012-821X .- 1385-013X. ; 377-378, s. 287-298
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Tidskriftsartikel (refereegranskat)abstract
- We present a velocity field compiled from a network of 27 permanent and 20 campaign GPS stations across NE Iran. This new GPS velocity field helps to investigate how Arabia-Eurasia collision deformation is accommodated at the northern boundary of the deforming zone. The present-day northward motion decreases eastward from 11 mm/yr at Tehran (~52°E) to 1.5 mm/yr at Mashhad (~60°E). N-S shortening across the Kopeh Dagh, Binalud and Kuh-e-Surkh ranges sums to 4.5±0.5 mm/yr at longitude 59°E. The available GPS velocities allow us to describe the rigid-body rotation of the South Caspian about an Euler pole that is located further away than previously thought. We suggest that two new stations (MAVT and MAR2), which are sited far from the block boundaries, are most likely to indicate the full motion of the South Caspian basin. These stations suggest that NW motion is accommodated by right-lateral slip on the Ashkabad fault (at a rate of up to 7 mm/yr) and by up to 4-6 mm/yr of summed left-lateral slip across the Shahroud left-lateral strike-slip system. Our new GPS results are important for assessing seismic hazard in NE Iran, which contains numerous large population centers and possesses an abundant historical earthquake record. Our results suggest that the fault zones along the eastern Alborz and western Kopeh Dagh may accommodate slip at much faster rates than previously thought. Fully assessing the role of these faults, and the hazard that they represent, requires independent verification of their slip-rates through additional GPS measurements and geological fieldwork.
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28. |
- Nilforoushan, Faramarz, et al.
(författare)
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GPS network monitors the Arabia-Eurasia collision deformation in Iran
- 2003
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Ingår i: Journal of Geodesy. - : Springer Science and Business Media LLC. - 0949-7714 .- 1432-1394. ; 77, s. 411-422
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Tidskriftsartikel (refereegranskat)abstract
- The rate of crustal deformation in Iran due to the Arabia–Eurasia collision is estimated. The results are based on new global positioning system (GPS) data. In order to address the problem of the distribution of the deformation in Iran, Iranian and French research organizations have carried out the first large-scale GPS survey of Iran. A GPS network of 28 sites (25 in Iran, two in Oman and one in Uzbekistan) has been installed and surveyed twice, in September 1999 and October 2001. Each site has been surveyed for a minimum observation of 4 days. GPS data processing has been done using the GAMIT-GLOBK software package. The solution displays horizontal repeatabilities of about 1.2 mm in 1999 and 2001. The resulting velocities allow us to constrain the kinematics of the Iranian tectonic blocks. These velocities are given in ITRF2000 and also relative to Eurasia. This last kinematic model demonstrates that (1) the north–south shortening from Arabia to Eurasia is 2–2.5 cm/year, less than previously estimated, and (2) the transition from subduction (Makran) to collision (Zagros) is very sharp and governs the different styles of deformation observed in Iran. In the eastern part of Iran, most of the shortening is accommodated in the Gulf of Oman, while in the western part the shortening is more distributed from south to north. The large faults surrounding the Lut block accommodate most of the subduction–collision transition.
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29. |
- Piveteau, Amélie, et al.
(författare)
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Weak entanglement improves quantum communication using only product measurements
- 2024
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Ingår i: Physical Review Applied. - 2331-7019. ; 21:3
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Tidskriftsartikel (refereegranskat)abstract
- We show that weakly entangled states can improve communication over a qubit channel using only separate, interference-free, measurements of individual photons. We introduce a communication task corresponding to the cryptographic primitive known as secret sharing and show that all steerable two-qubit isotropic states provide a quantum advantage in the success rate using only product measurements. Furthermore, we show that such measurements can even reveal communication advantages from noisy partially entangled states that admit no quantum steering. We then go further and consider a stochastic variant of secret sharing based on more-sophisticated, yet standard, partial Bell-state analyzers, and show that this reveals advantages also for a range of unsteerable isotropic states. By preparing polarization qubits in unsteerable states, we experimentally demonstrate increased success rates of both secret-sharing tasks beyond the best entanglement-unassisted qubit protocol. Our results reveal the capability of simple and scalable measurements in entanglement-assisted quantum communication to overcome large amounts of noise.
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30. |
- Piveteau, Amélie, 1994-, et al.
(författare)
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Weak entanglement improves quantum communication using only product measurements
- 2024
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Ingår i: Physical Review Applied. - 2331-7019. ; 21:3
-
Tidskriftsartikel (refereegranskat)abstract
- We show that weakly entangled states can improve communication over a qubit channel using only separate, interference-free, measurements of individual photons. We introduce a communication task corresponding to the cryptographic primitive known as secret sharing and show that all steerable two-qubit isotropic states provide a quantum advantage in the success rate using only product measurements. Furthermore, we show that such measurements can even reveal communication advantages from noisy partially entangled states that admit no quantum steering. We then go further and consider a stochastic variant of secret sharing based on more-sophisticated, yet standard, partial Bell-state analyzers, and show that this reveals advantages also for a range of unsteerable isotropic states. By preparing polarization qubits in unsteerable states, we experimentally demonstrate increased success rates of both secret-sharing tasks beyond the best entanglement-unassisted qubit protocol. Our results reveal the capability of simple and scalable measurements in entanglement-assisted quantum communication to overcome large amounts of noise.
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31. |
- Tavakoli, Assad A, et al.
(författare)
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The effect of traffic flow improvements on driver attitudes towards pavement markings and other traffic control devices and pedestrian safety
- 2001
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Ingår i: Proceedings of the conference Traffic Safety on Three Continents. - Linköping : Statens väg- och transportforskningsinstitut. ; , s. 584-592
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The author notes that many drivers today, especially those outside of major metropolitan areas, have not ever been pedestrians in the usual way. They may walk to their cars or through parking lots to mall entrances, but they rarely walk on public streets. Since they are not used to being pedestrians, many of them do not know how to behave towards pedestrians when they are behind the wheel of a car. In addition, some of the current traffic flow improvements provide the driver with more choices to make, sometimes leaving the pedestrian to the bottom choice. Right turn on red laws and arrows (and in some states left turn on red is permitted) frequently encourage the pedestrians to race for the curb in order to avoid being hit by the turning vehicle. Radios, cell phones, on board computers, and other amenities available in today's cars further distract the drivers from paying attention to pedestrian pavement markings and the pedestrians in them.
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32. |
- Tavakoli, F., et al.
(författare)
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Distribution of the right-lateral strike-slip motion from the Main Recent Fault to the Kazerun Fault System (Zagros, Iran): Evidence from present-day GPS velocities
- 2008
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Ingår i: Earth and Planetary Science Letters. - : Elsevier BV. - 0012-821X .- 1385-013X. ; 275, s. 342-375
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Tidskriftsartikel (refereegranskat)abstract
- GPS measurements across the Kazerun Fault System in the Zagros mountain belt provide first instantaneous velocities on the different segments. These results are closely consistent with the geological fault slip rates (over 150 ka), implying stable velocities over a longer period. The present-day strike–slip motion is distributed from the Main Recent Fault to the N-trending Kazerun Fault System along a preferential en-echelon fault zone included in a more distributed fan-shape fault pattern. The Hormuz salt decoupling layer cannot be the only cause of a sedimentary spreading because seismicity attests these faults are rooted in the basement. The Dena fault (3.7 mm/yr) transfers the MRF fault slip mainly to the Kazerun (3.6 mm/yr) and slightly to the High Zagros and Sabz Pushan faults (1.5 mm/yr), and the Kazerun fault further to the Kareh Bas fault (3.4 mm/yr). Total geological horizontal offsets associated with GPS slip rates help inferring precise fault slip onset ages. The successive onsets deduced by this approach imply that the right-lateral strike-slip activity of the MRF has propagated in time southeastward to the Dena segment, and then to the Kazerun segment and to the Kareh Bas fault.
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33. |
- Tavakoli, S., et al.
(författare)
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Effects of vertical motions on roll of planing hulls
- 2021
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Ingår i: Journal of Offshore Mechanics and Arctic Engineering-Transactions of The Asme. - : ASME International. - 0892-7219 .- 1528-896X. ; 143:4
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Tidskriftsartikel (refereegranskat)abstract
- Roll motion of a planing hull can be easily triggered at high speeds, causing a significant change in hydrodynamic pressure pattern, which can threaten the stability of the vessel. Modeling and investigating roll motion of a planing vessel may require a strong coupling between motions in vertical and transverse planes. In the present paper, we have used a mathematical model to analyze the roll of a planing hull by coupling surge, heave, pitch, and roll motions using 2D+T theory to study the effects of roll-induced vertical motions on roll coefficients and response. Mathematically computed forces and moments as well as roll dynamic response of the vessel are seen to be in fair quantitative agreement with experimentally measured values of previously published data. Using the 2D+T method, it has been shown that to model the roll of a planing hull at high speeds, we need to consider the effects of heave, pitch, and surge motions. Through our mathematical modeling, it is found that freedom in vertical motions increases time-dependent roll damping and added mass coefficients, especially at early planing speeds. The results of dynamic response simulations suggest that freedom in the vertical plane can decrease the roll response.
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34. |
- Tavakoli, Shima, et al.
(författare)
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Immunomodulation of Skin Repair : Cell-Based Therapeutic Strategies for Skin Replacement (A Comprehensive Review)
- 2022
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Ingår i: Biomedicines. - : MDPI AG. - 2227-9059. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- The immune system has a crucial role in skin wound healing and the application of specific cell-laden immunomodulating biomaterials emerged as a possible treatment option to drive skin tissue regeneration. Cell-laden tissue-engineered skin substitutes have the ability to activate immune pathways, even in the absence of other immune-stimulating signals. In particular, mesenchymal stem cells with their immunomodulatory properties can create a specific immune microenvironment to reduce inflammation, scarring, and support skin regeneration. This review presents an overview of current wound care techniques including skin tissue engineering and biomaterials as a novel and promising approach. We highlight the plasticity and different roles of immune cells, in particular macrophages during various stages of skin wound healing. These aspects are pivotal to promote the regeneration of nonhealing wounds such as ulcers in diabetic patients. We believe that a better understanding of the intrinsic immunomodulatory features of stem cells in implantable skin substitutes will lead to new translational opportunities. This, in turn, will improve skin tissue engineering and regenerative medicine applications.
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35. |
- Vernant, P, et al.
(författare)
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Present-day crustal deformation and plate kinematics in the Middle East constrained by GPS measurements in Iran and northern Oman
- 2004
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Ingår i: Geophysical Journal International. - 0956-540X .- 1365-246X. ; 157:1, s. 381-398
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Tidskriftsartikel (refereegranskat)abstract
- A network of 27 GPS sites was implemented in Iran and northern Oman to measure displacements in this part of the Alpine–Himalayan mountain belt. We present and interpret the results of two surveys performed in 1999 September and 2001 October. GPS sites in Oman show northward motion of the Arabian Plate relative to Eurasia slower than the NUVEL-1A estimates (e.g. 22 ± 2 mm yr−1 at N8°± 5°E instead of 30.5 mm yr−1 at N6°E at Bahrain longitude). We define a GPS Arabia–Eurasia Euler vector of 27.9°± 0.5°N, 19.5°± 1.4°E, 0.41°± 0.1° Myr−1. The Arabia–Eurasia convergence is accommodated differently in eastern and western Iran. East of 58°E, most of the shortening is accommodated by the Makran subduction zone (19.5 ± 2 mm yr−1) and less by the Kopet-Dag (6.5 ± 2 mm yr−1). West of 58°E, the deformation is distributed in separate fold and thrust belts. At the longitude of Tehran, the Zagros and the Alborz mountain ranges accommodate 6.5 ± 2 mm yr−1 and 8 ± 2 mm yr−1 respectively. The right-lateral displacement along the Main Recent Fault in the northern Zagros is about 3 ± 2 mm yr−1, smaller than what was generally expected. By contrast, large right-lateral displacement takes place in northwestern Iran (up to 8 ± mm yr−1). The Central Iranian Block is characterized by coherent plate motion (internal deformation <2 mm yr−1). Sites east of 61°E show very low displacements relative to Eurasia. The kinematic contrast between eastern and western Iran is accommodated by strike-slip motions along the Lut Block. To the south, the transition zone between Zagros and Makran is under transpression with right-lateral displacements of 11 ± 2 mm yr−1.
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36. |
- Walpersdorf, A, et al.
(författare)
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Difference in the GPS deformation pattern of North and Central Zagros (Iran)
- 2006
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Ingår i: Geophysical Journal International. - 0956-540X .- 1365-246X. ; 167:3, s. 1077-1088
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Tidskriftsartikel (refereegranskat)abstract
- Measurements on either side of the Kazerun fault system in the Zagros Mountain Belt, Iran, show that the accommodation of the convergence of the Arabian and Eurasian Plates differs across the region. In northwest Zagros, the deformation is partitioned as 3–6 mm yr−1 of shortening perpendicular to the axis of the mountain belt, and 4–6 mm yr−1 of dextral strike-slip motion on northwest–southeast trending faults. No individual strike-slip fault seems to slip at a rate higher than ∼2 mm yr−1. In southeast Zagros, the deformation is pure shortening of 8 ± 2 mm yr−1 occurring perpendicular to the simple folded belt and restricted to the Persian Gulf shore. The fact that most of the deformation is located in front of the simple folded belt, close to the Persian Gulf, while seismicity is more widely spread across the mountain belt, confirms the decoupling of the surface sedimentary layers from the seismogenic basement. A comparison with the folding and topography corroborates a southwestward propagation of the surface deformation. The difference in deformation between the two regions suggests that right-lateral shear cumulates on the north–south trending Kazerun strike-slip fault system to 6 ± 2 mm yr−1.
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