| 1. |
- Tehler, H., et al.
(författare)
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Using microworlds to study critical infrastructure protection—the effect of incentives on risk management
- 2018
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Ingår i: Safety and Reliability - Safe Societies in a Changing World - Proceedings of the 28th International European Safety and Reliability Conference, ESREL 2018. - London : CRC Press. - 9780815386827 ; , s. 1865-1872
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Konferensbidrag (refereegranskat)abstract
- A computer simulated microworld was used to study risk management in a critical infrastructure context. 36 students assumed the role of an electric distribution company Chief Executive Officer (CEO) making decision on how to spend resources between investments in risk reduction and other investments. We studied the effect of differences in terms of the incentives to invest in risk reduction and the extent that the participants had access to a risk assessment. We found that both independent variables influenced the total resources spent on risk reduction and total losses due to storms. If the company had to bear a larger part of the total losses due to a storm their propensity to invest in risk reduction increased. In addition, if the participants were provided with a simple risk assessment to support their decisions they invested more resources in risk reduction, and they were also more successful in limiting the total losses due to storms.
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| 2. |
- Häfner, Sophia J., et al.
(författare)
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Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions
- 2023
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Ingår i: Developmental Cell. - 1534-5807. ; 58:17, s. 9-1609
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Tidskriftsartikel (refereegranskat)abstract
- Translational regulation impacts both pluripotency maintenance and cell differentiation. To what degree the ribosome exerts control over this process remains unanswered. Accumulating evidence has demonstrated heterogeneity in ribosome composition in various organisms. 2′-O-methylation (2′-O-me) of rRNA represents an important source of heterogeneity, where site-specific alteration of methylation levels can modulate translation. Here, we examine changes in rRNA 2′-O-me during mouse brain development and tri-lineage differentiation of human embryonic stem cells (hESCs). We find distinct alterations between brain regions, as well as clear dynamics during cortex development and germ layer differentiation. We identify a methylation site impacting neuronal differentiation. Modulation of its methylation levels affects ribosome association of the fragile X mental retardation protein (FMRP) and is accompanied by an altered translation of WNT pathway-related mRNAs. Together, these data identify ribosome heterogeneity through rRNA 2′-O-me during early development and differentiation and suggest a direct role for ribosomes in regulating translation during cell fate acquisition.
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| 3. |
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| 4. |
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| 5. |
- Poengsungnoen, Vasun, et al.
(författare)
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Phylogenetic analysis reveals two morphologically unique new species in the genera Astrochapsa and Nitidochapsa (lichenized Ascomycota Graphidaceae)
- 2014
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Ingår i: Phytotaxa. - : Magnolia Press. - 1179-3163 .- 1179-3155. ; 189, s. 268-281
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Tidskriftsartikel (refereegranskat)abstract
- Graphidaceae is the largest family of tropical crustose lichens, with nearly 2,400 known species, and exhibits a large diversity of ascoma morphologies. Ascomata that open by triangular marginal lobules that become recurved to form geaster-like fruiting bodies, so-called chroodiscoid ascomata, were recently shown to have evolved independently several times within the family. A special type of such ascomata is the gyrotremoid form in which the hymenium and excipulum are organized in concentric rings. In the present study, we address the phylogenetic position of two chroodiscoid species collected in Thailand that form aggregate or gyrotremoid, chroodiscoid ascomata, using a molecular phylogeny of nuclear LSU and mitochondrial SSU rDNA sequences of 92 Graphidaceae. Our morphological, chemical and phylogenetic analyses show that one species is an undescribed species in the genus Astrochapsa, here newly described as A. kalbii Poengsungnoen, Lücking & Lumbsch, with a unique, gyrotremoid ascoma morphology. The second species belongs in the recently established genus Nitidochapsa, which is a close relative of Ocellularia, and is here described as new species N. siamensis Poengsungnoen, Lücking & Lumbsch. Based on these findings, three further new combinations are proposed in the genus Nitidochapsa, viz. N. aggregata (Hale) Poengsungnoen, Lücking & Lumbsch, N. phlyctidea (Vain.) Lücking & Lumbsch, and N. stictoides (Leight.) Tehler, Lücking & Lumbsch. A key to all five species is presented.
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| 6. |
- Scheidegger, C., Mayrhofer, H., Moberg, R. & Tehler, A.
(författare)
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Evolutionary trends in Physciaceae.
- 2001
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Ingår i: Lichenologist. ; 33, s. 25-45
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Tehler, Henrik, et al.
(författare)
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Standardization of disaster risk management - Challenges and opportunities
- 2019
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Ingår i: Standardization and Risk Governance : A Multi-Disciplinary Approach - A Multi-Disciplinary Approach. - London : Routledge. - 9780429290817 ; , s. 61-78
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Bokkapitel (refereegranskat)abstract
- This chapter discusses the question of whether increasing the level of standardization in a disaster risk management system will increase its effectiveness. Based on the results from several studies conducted in the context of the Swedish disaster risk management system, the authors argue that there are both positive and negative effects of increased standardization. More precisely, studies based on experiments indicate that increasing the extent of standardization of risk descriptions will probably facilitate the work of combining several sources of information in a risk assessment. But a study based on interviews and document reviews indicates that increasing the level of standardization might also lead to a reduction of motivation to conduct risk assessments. Thus, although increasing the level of standardization in a disaster risk management context might be an opportunity to facilitate the work of assessing risk, it might also result in new challenges.
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| 8. |
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| 9. |
- Tehler, Ulrika, et al.
(författare)
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Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice
- 2013
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 56:6, s. 2690-2694
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Tidskriftsartikel (refereegranskat)abstract
- Esterification was used to simultaneously increase solubility and permeability of ciprofloxacin, a biopharmaceutics classification system (BCS) class 4 drug (low solubility/low permeability) with solid-state limited solubility. Molecular flexibility was increased to disturb the crystal lattice, lower the melting point, and thereby improve the solubility, whereas lipophilicity was increased to enhance the intestinal permeability. These structural changes resulted in BCS class 1 analogues (high solubility/high permeability) emphasizing that simple medicinal chemistry may improve both these properties.
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