| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Poley, L., et al.
(författare)
-
The ABC130 barrel module prototyping programme for the ATLAS strip tracker
- 2020
-
Ingår i: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 15:9
-
Tidskriftsartikel (refereegranskat)abstract
- For the Phase-II Upgrade of the ATLAS Detector [1], its Inner Detector, consisting of silicon pixel, silicon strip and transition radiation sub-detectors, will be replaced with an all new 100% silicon tracker, composed of a pixel tracker at inner radii and a strip tracker at outer radii. The future ATLAS strip tracker will include 11,000 silicon sensor modules in the central region (barrel) and 7,000 modules in the forward region (end-caps), which are foreseen to be constructed over a period of 3.5 years. The construction of each module consists of a series of assembly and quality control steps, which were engineered to be identical for all production sites. In order to develop the tooling and procedures for assembly and testing of these modules, two series of major prototyping programs were conducted: an early program using readout chips designed using a 250 nm fabrication process (ABCN-250) [2, 3] and a subsequent program using a follow-up chip set made using 130 nm processing (ABC130 and HCC130 chips). This second generation of readout chips was used for an extensive prototyping program that produced around 100 barrel-type modules and contributed significantly to the development of the final module layout. This paper gives an overview of the components used in ABC130 barrel modules, their assembly procedure and findings resulting from their tests.
|
|
| 5. |
|
|
| 6. |
- Dion, G., et al.
(författare)
-
Change management : Blended learning adoption in a large network of European universities
- 2018
-
Ingår i: Proceedings of the International Conference on e-Learning, ICEL. - : Academic Conferences Limited. - 9781911218906 ; , s. 77-83
-
Konferensbidrag (refereegranskat)abstract
- We report in this paper on a multiyear endeavour within the EIT (European Institute of Innovation and Technology) Digital community, during which EIT Digital built an international community of Innovation and Entrepreneurship (“I&E”) teachers at Master level by implementing a blended learning strategy. We see this challenge as a case in change management, which could offer relevant insight to run similar initiatives of blending learning adoption as an enabler to developing pedagogical cooperation in networks of universities with real impact on practices. Through the lenses of change management theory, we describe and analyse the methods that allowed EIT Digital to create and enhance a community of “teacher-producers” in order to develop and deploy blended education from scratch. EIT Digital, a Knowledge and Innovation Community of the European Institute of Innovation and Technology (EIT), provides IT education at Master’s level since 2013 and in association with its around 20 member universities, including a strong “Innovation & Entrepreneurship” (“I&E”) education component. EIT Digital developed a blended learning strategy whose originality came from the fact that some of the teachers are also producers on behalf of the entire community, receiving associated co-funding and technical support from EIT Digital. More specifically, teachers actively took part to the production agenda, according to which producers were chosen within the community to create and deliver the agreed online contents. EIT Digital library now encompasses more than 500 basic online contents (“nuggets”) covering most topics relevant for I&E education at the graduate level, from basic business model introductions to complex technology transfer strategies. This amounts to more than 45 hours’ worth of videos along with dozens of written cases, quizzes and other forms of online/offline assignments. Depending on the various universities’ contexts, different blending strategies were deployed, which had practical consequences on the global EIT Digital development. The heterogeneity of the universities’ profiles probably significantly increased the value of the EIT Digital network which proved relevant with regards to blended learning adoption, while EIT Digital’s change management strategy contributed significantly to uplifting the I&E education offered at the member universities, notably giving momentum to its I&E teacher community.
|
|
| 7. |
- Gruhl, T., et al.
(författare)
-
Ultrafast structural changes direct the first molecular events of vision
- 2023
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 615, s. 939-944
-
Tidskriftsartikel (refereegranskat)abstract
- Vision is initiated by the rhodopsin family of light-sensitive G protein-coupled receptors (GPCRs)(1). A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which isomerizes within 200 femtoseconds to the all-trans conformation(2), thereby initiating the cellular signal transduction processes that ultimately lead to vision. However, the intramolecular mechanism by which the photoactivated retinal induces the activation events inside rhodopsin remains experimentally unclear. Here we use ultrafast time-resolved crystallography at room temperature(3) to determine how an isomerized twisted all-trans retinal stores the photon energy that is required to initiate the protein conformational changes associated with the formation of the G protein-binding signalling state. The distorted retinal at a 1-ps time delay after photoactivation has pulled away from half of its numerous interactions with its binding pocket, and the excess of the photon energy is released through an anisotropic protein breathing motion in the direction of the extracellular space. Notably, the very early structural motions in the protein side chains of rhodopsin appear in regions that are involved in later stages of the conserved class A GPCR activation mechanism. Our study sheds light on the earliest stages of vision in vertebrates and points to fundamental aspects of the molecular mechanisms of agonist-mediated GPCR activation.
|
|
