| 1. |
- Ernst, Aurélie, et al.
(författare)
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Neurogenesis in the Striatum of the Adult Human Brain
- 2014
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Ingår i: Cell. - Cambridge, MA 02139, USA : Elsevier. - 0092-8674 .- 1097-4172. ; 156:5, s. 1072-1083
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Tidskriftsartikel (refereegranskat)abstract
- Neurons are added throughout life in the hippocampus and olfactory bulb in most mammals, although humans represent an exception without detectable olfactory bulb neurogenesis. Nevertheless, neuroblasts are generated in the lateral ventricle wall in humans, the neurogenic niche for olfactory bulb neurons in other mammals. We show that, in humans, new neurons integrate adjacent to this neurogenic niche, in the striatum. The neuronal turnover in the striatum appears restricted to interneurons and we show that postnatally generated striatal neurons are preferentially depleted in Huntington’s disease. This demonstrates a unique pattern of neurogenesis in the adult human brain.
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| 2. |
- Reu, Pedro, et al.
(författare)
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The Lifespan and Turnover of Microglia in the Human Brain
- 2017
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Ingår i: Cell Reports. - Cambridge, MA 02139, USA : Elsevier BV. - 2211-1247. ; 20:4, s. 779-784
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Tidskriftsartikel (refereegranskat)abstract
- The hematopoietic system seeds the CNS with microglial progenitor cells during the fetal period, but the subsequent cell generation dynamics and maintenance of this population have been poorly understood. We report that microglia, unlike most other hematopoietic lineages, renew slowly at a median rate of 28% per year, and some microglia last for more than two decades. Furthermore, we find no evidence for the existence of a substantial population of quiescent long-lived cells, meaning that the microglia population in the human brain is sustained by continuous slow turnover throughout adult life.
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| 3. |
- Tisdale, John, et al.
(författare)
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A Multiple UAV System for Vision-Based Search and Localization
- 2008
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Ingår i: Proceedings of the '08 American Control Conference. - Linköping : IEEE. - 9781424420797 - 9781424420780 ; , s. 1985-1990
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Konferensbidrag (refereegranskat)abstract
- The contribution of this paper is an experimentally verified real-time algorithm for combined probabilistic search and track using multiple unmanned aerial vehicles (UAVs). Distributed data fusion provides a framework for multiple sensors to search for a target and accurately estimate its position. Vision based sensing is employed, using fixed downward-looking cameras. These sensors are modeled to include vehicle state uncertainty and produce an estimate update regardless of whether the target is detected in the frame or not. This allows for a single framework for searching or tracking, and requires non-linear representations of the target position probability density function (PDF) and the sensor model. While a grid-based system for Bayesian estimation was used for the flight demonstrations, the use of a particle filter solution has also been examined.Multi-aircraft flight experiments demonstrate vision-based localization of a stationary target with estimated error covariance on the order of meters. This capability for real-time distributed estimation will be a necessary component for future research in information-theoretic control.
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| 4. |
- Yeung, Maggie, et al.
(författare)
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Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain
- 2014
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Ingår i: Cell. - Maryland Heights : Elsevier. - 0092-8674 .- 1097-4172. ; 159:4, s. 766-774
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Tidskriftsartikel (refereegranskat)abstract
- The myelination of axons by oligodendrocytes has been suggested to be modulated by experience, which could mediate neural plasticity by optimizing the performance of the circuitry. We have assessed the dynamics of oligodendrocyte generation and myelination in the human brain. The number of oligodendrocytes in the corpus callosum is established in childhood and remains stable after that. Analysis of the integration of nuclear bomb test-derived 14C revealed that myelin is exchanged at a high rate, whereas the oligodendrocyte population in white matter is remarkably stable in humans, with an annual exchange of 1/300 oligodendrocytes. We conclude that oligodendrocyte turnover contributes minimally to myelin remodeling in human white matter and that this instead may be carried out by mature oligodendrocytes, which may facilitate rapid neural plasticity.
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