| 1. |
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| 2. |
- Amato, Elisabetta, et al.
(författare)
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A Resource Sharing Method for Reliable Slice as a Service Provisioning in 5G Metro Networks
- 2021
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Ingår i: 2021 25th Conference On Optical Network Design And Modelling, ONDM 2021. - 9783903176331 ; , s. 1-3
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Konferensbidrag (refereegranskat)abstract
- This paper proposes a dynamic slice provisioning analysis in a 5G metro network with reliability guarantees and possible sharing of backup resources. Performance of dedicated (DP) and shared (SP) protection solutions are evaluated with respect to slice resource allocation (i.e., bandwidth and processing units). The main results show a remarkable saving, in terms of slice acceptance rate, by applying SP solutions with respect to conventional DP ones.
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| 3. |
- Amato, Elisabetta, et al.
(författare)
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Differentiated protection in 5G vehicular networks
- 2020
-
Ingår i: 2020 AEIT International Conference of Electrical and Electronic Technologies for Automotive, AEIT AUTOMOTIVE 2020.
-
Konferensbidrag (refereegranskat)abstract
- Automotive applications need high reliability and service continuity to support self-driving and safety in smart city environments. Suitable allocation of network functions is studied and optimal solutions based on Integer Linear Programming methodology are found. Differentiated reliability concept is applied in the presence of two different 5G classes of service, namely eMBB and URLLC. Saving of processing and bandwidth resources is numerically evaluated by combining service-based shared and dedicated protection in a reference scenario. Scalability aspects of the approach are also discussed.
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| 4. |
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| 5. |
- Ambros, Inge M, et al.
(författare)
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A multilocus technique for risk evaluation of patients with neuroblastoma.
- 2011
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Ingår i: Clinical cancer research : an official journal of the American Association for Cancer Research. - 1078-0432. ; 17:4, s. 792-804
-
Tidskriftsartikel (refereegranskat)abstract
- Precise and comprehensive analysis of neuroblastoma genetics is essential for accurate risk evaluation and only pangenomic/multilocus approaches fulfill the present-day requirements. We present the establishment and validation of the PCR-based multiplex ligation-dependent probe amplification (MLPA) technique for neuroblastoma.
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| 6. |
- Ambros, I. M., et al.
(författare)
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Age Dependency of the Prognostic Impact of Tumor Genomics in Localized Resectable MYCN-Nonamplified Neuroblastomas. Report From the SIOPEN Biology Group on the LNESG Trials and a COG Validation Group
- 2020
-
Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology (ASCO). - 0732-183X .- 1527-7755. ; 38:31
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSEFor localized, resectable neuroblastoma without MYCN amplification, surgery only is recommended even if incomplete. However, it is not known whether the genomic background of these tumors may influence outcome.PATIENTS AND METHODSDiagnostic samples were obtained from 317 tumors, International Neuroblastoma Staging System stages 1/2A/2B, from 3 cohorts: Localized Neuroblastoma European Study Group I/II and Children's Oncology Group. Genomic data were analyzed using multi- and pangenomic techniques and fluorescence in-situ hybridization in 2 age groups (cutoff age, 18 months) and were quality controlled by the International Society of Pediatric Oncology European Neuroblastoma (SIOPEN) Biology Group.RESULTSPatients with stage 1 tumors had an excellent outcome (5-year event-free survival [EFS] standard deviation [SD], 95% +/- 2%; 5-year overall survival [OS], 99% +/- 1%). In contrast, patients with stage 2 tumors had a reduced EFS in both age groups (5-year EFS +/- SD, 84% +/- 3% in patients < 18 months of age and 75% 7% in patients >= 18 months of age). However, OS was significantly decreased only in the latter group (5-year OS +/- SD in < 18months and 18months, 96% +/- 2% and 81% +/- 7%, respectively; P = .001). In < 18months, relapses occurred independent of segmental chromosome aberrations (SCAs); only 1p loss decreased EFS (5-year EFS SD in patients 1p loss and no 1p loss, 62% +/- 13% and 87% +/- 3%, respectively; P = .019) but not OS (5-year OS +/- SD, 92% +/- 8% and 97% +/- 2%, respectively). In patients >= 18 months, only SCAs led to relapse and death, with 11q loss as the strongest marker (11q loss and no 11q loss: 5-year EFS +/- SD, 48% +/- 16% and 85% +/- 7%, P = .033; 5-year OS +/- SD, 46% +/- 22% and 92% +/- 6%, P = .038).CONCLUSIONGenomic aberrations of resectable non-MYCN-amplified stage 2 neuroblastomas have a distinct age-dependent prognostic impact. Chromosome 1p loss is a risk factor for relapse but not for diminished OS in patients < 18 months, SCAs (especially 11q loss) are risk factors for reduced EFS and OS in those > 18months. In older patients with SCA, a randomized trial of postoperative chemotherapy compared with observation alone may be indicated.
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| 7. |
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| 8. |
- Andreasi Bassi, Susanna, et al.
(författare)
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A life cycle assessment framework for large-scale changes in material circularity
- 2021
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Ingår i: Waste Management. - : Elsevier BV. - 0956-053X .- 1879-2456. ; 135, s. 360-371
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Tidskriftsartikel (refereegranskat)abstract
- Increasing material circularity is high on the agenda of the European Union in order to decouple environmental impacts and economic growth. While life cycle assessment (LCA) is useful for quantifying the associated environmental impacts, consistent LCA modeling of the large-scale changes arising from policy targets addressing material circularity (i.e., recycled content and recycling rate) is challenging. In response to this, we propose an assessment framework addressing key steps in LCA, namely, goal definition, functional unit, baseline versus alternative scenario definition, and modeling of system responses. Regulatory and economic aspects (e.g., trends in consumption patterns, market responses, market saturation, and legislative side-policies affecting waste management) are emphasized as critical for the identification of potential system responses and for supporting regulatory interventions required to reach the intended environmental benefits. The framework is recommended for LCA studies focusing on system-wide consequences where allocation between product life cycles is not relevant; however, the framework can be adapted to include allocation. The application of the framework was illustrated by an example of implementing a policy target for 2025 of 70% recycled content in PET trays in EU27+1. It was demonstrated that neglecting large-scale market responses and saturation lead to an overestimation of the environmental benefits from the policy target and that supplementary initiatives are required to achieve the full benefits at system level.
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| 9. |
- Azevedo, Josué, et al.
(författare)
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Museums and cradles of diversity are geographically coincident for narrowly distributed Neotropical snakes
- 2020
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Ingår i: Ecography. - : Wiley. - 0906-7590 .- 1600-0587. ; 43:2, s. 328-339
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Tidskriftsartikel (refereegranskat)abstract
- Factors driving the spatial configuration of centres of endemism have long been a topic of broad interest and debate. Due to different eco-evolutionary processes, these highly biodiverse areas may harbour different amounts of ancient and recently diverged organisms (paleo- and neo-endemism, respectively). Patterns of endemism still need to be measured at distinct phylogenetic levels for most clades and, consequently, little is known about the distribution, the age and the causes of such patterns. Here we tested for the presence of centres with high phylogenetic endemism (PE) in the highly diverse Neotropical snakes, testing the age of these patterns (paleo- or neo-endemism), and the presence of PE centres with distinct phylogenetic composition. We then tested whether PE is predicted by topography, by climate (seasonality, stability, buffering and relictualness), or biome size. We found that most areas of high PE for Neotropical snakes present a combination of both ancient and recently diverged diversity, which is distributed mostly in the Caribbean region, Central America, the Andes, the Atlantic Forest and on scattered highlands in central Brazil. Turnover of lineages is higher across Central America, resulting in more phylogenetically distinct PE centres compared to South America, which presents a more phylogenetically uniform snake fauna. Finally, we found that elevational range (topographic roughness) is the main predictor of PE, especially for paleo-endemism, whereas low paleo-endemism levels coincide with areas of high climatic seasonality. Our study highlights the importance of mountain systems to both ancient and recent narrowly distributed diversity. Mountains are both museums and cradles of snake diversity in the Neotropics, which has important implications for conservation in this region.
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| 10. |
- Borsatti, Davide, et al.
(författare)
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From IoT to Cloud: Applications and Performance of the MQTT Protocol
- 2020
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Ingår i: International Conference on Transparent Optical Networks. - 2162-7339. ; 2020-July, s. 1-4
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Konferensbidrag (refereegranskat)abstract
- A study of the MQTT publish/subscribe protocol with different QoS levels is presented with the aim to extend the Internet of Things (IoT) concept across access, edge and transport networks and reach cloud computing facilities. A simple testbed is set up with related software components to measure the end-to-end delivery latency between the publisher and the subscribers and the impact of the network delay caused by network configurations with different service deployments. In particular, the latency is shown to rise up to more than 7 times the average network delay when the QoS 2 level is applied, thus indicating that its adoption must be carefully considered.
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| 11. |
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| 12. |
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| 13. |
- Defferrari, R., et al.
(författare)
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Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplification
- 2015
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 112:2, s. 290-295
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Tidskriftsartikel (refereegranskat)abstract
- Background: The prognostic impact of segmental chromosome alterations (SCAs) in children older than 1 year, diagnosed with localised unresectable neuroblastoma (NB) without MYCN amplification enrolled in the European Unresectable Neuroblastoma (EUNB) protocol is still to be clarified, while, for other group of patients, the presence of SCAs is associated with poor prognosis. Methods: To understand the role of SCAs we performed multilocus/pangenomic analysis of 98 tumour samples from patients enrolled in the EUNB protocol. Results: Age at diagnosis was categorised into two groups using 18 months as the age cutoff. Significant difference in the presence of SCAs was seen in tumours of patients between 12 and 18 months and over 18 months of age at diagnosis, respectively (P = 0.04). A significant correlation (P = 0.03) was observed between number of SCAs per tumour and age. Event-free (EFS) and overall survival (OS) were calculated in both age groups, according to both the presence and number of SCAs. In older patients, a poorer survival was associated with the presence of SCAs (EFS = 46% vs 75%, P = 0.023; OS = 66.8% vs 100%, P = 0.003). Moreover, OS of older patients inversely correlated with number of SCAs (P = 0.002). Finally, SCAs provided additional prognostic information beyond histoprognosis, as their presence was associated with poorer OS in patients over 18 months with unfavourable International Neuroblastoma Pathology Classification (INPC) histopathology (P = 0.018). Conclusions: The presence of SCAs is a negative prognostic marker that impairs outcome of patients over the age of 18 months with localised unresectable NB without MYCN amplification, especially when more than one SCA is present. Moreover, in older patients with unfavourable INPC tumour histoprognosis, the presence of SCAs significantly affects OS.
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| 14. |
- Di Cicco, Nicola, et al.
(författare)
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Optimization over time of reliable 5G-RAN with network function migrations
- 2022
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Ingår i: Computer Networks. - : Elsevier BV. - 1389-1286. ; 215
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Tidskriftsartikel (refereegranskat)abstract
- Resource optimization in 5G Radio Access Networks (5G-RAN) has to face the dynamics over time in networks with increasing numbers of nodes and virtual network functions. In this context, multiple objectives need to be jointly optimized, and key application requirements such as latency must be enforced. In addition, virtual network functions realizing baseband processing are subject to failures of the cloud infrastructure, requiring an additional level of reliability. Overall, this is a complex problem to solve, requiring fast algorithms to cope with dynamic networks while avoiding resource overprovisioning. This paper considers the problem of optimal virtual function placement in 5G-RAN with reliability against a single DU Hotel failure and proposes a solution that takes service dynamics into account. Firstly, the joint optimization of the total number of DU Hotels, of the RU–DU latency and of the backup DU sharing in a static traffic scenario is considered, and the DUOpt algorithm, based on Lexicographic Optimization, is proposed for solving efficiently this multi-objective problem. DUOpt splits the multi-objective problem into smaller Integer Linear Programming (ILP) subproblems that are sequentially solved, adopting for each one the most effective methodology to reduce the total execution time. The proposed DUOpt algorithm is extensively benchmarked to show its effectiveness in optimization of medium to large size networks: in particular, it is shown to greatly outperform an aggregate multi-objective approach, being able to compute optimal or close to optimal solutions for networks of several tens of nodes in computing times of a few seconds. Then, the problem is extended to a dynamic traffic scenario in which optimization is performed over time. In this context, in addition to the aforementioned objectives, the total number of network function migrations induced by multiple reoptimizations must be kept to the minimum. For solving efficiently this problem the DUMig algorithm is proposed, which extends and improves DUOpt. Reoptimization over a time horizon of one day in an illustrative dynamic traffic scenario is performed to evaluate the proposed DUMig algorithm against DUOpt, the latter being oblivious of the traffic dynamics. DUMig shows remarkable savings in the total number of migrations (above 86.1% for primary virtual functions and 83% for backup virtual functions) compared to DUOpt, while preserving near-optimal resource assignment.
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| 15. |
- Di Saverio, Salomone, et al.
(författare)
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WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis
- 2016
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Ingår i: World Journal of Emergency Surgery. - : BIOMED CENTRAL LTD. - 1749-7922. ; 11:34
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Forskningsöversikt (refereegranskat)abstract
- Acute appendicitis (AA) is among the most common cause of acute abdominal pain. Diagnosis of AA is challenging; a variable combination of clinical signs and symptoms has been used together with laboratory findings in several scoring systems proposed for suggesting the probability of AA and the possible subsequent management pathway. The role of imaging in the diagnosis of AA is still debated, with variable use of US, CT and MRI in different settings worldwide. Up to date, comprehensive clinical guidelines for diagnosis and management of AA have never been issued. In July 2015, during the 3rd World Congress of the WSES, held in Jerusalem (Israel), a panel of experts including an Organizational Committee and Scientific Committee and Scientific Secretariat, participated to a Consensus Conference where eight panelists presented a number of statements developed for each of the eight main questions about diagnosis and management of AA. The statements were then voted, eventually modified and finally approved by the participants to The Consensus Conference and lately by the board of co-authors. The current paper is reporting the definitive Guidelines Statements on each of the following topics: 1) Diagnostic efficiency of clinical scoring systems, 2) Role of Imaging, 3) Non-operative treatment for uncomplicated appendicitis, 4) Timing of appendectomy and in-hospital delay, 5) Surgical treatment 6) Scoring systems for intra-operative grading of appendicitis and their clinical usefulness 7) Non-surgical treatment for complicated appendicitis: abscess or phlegmon 8) Pre-operative and post-operative antibiotics.
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| 16. |
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| 17. |
- Fernandes, Andre L.P., et al.
(författare)
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A Cost Assessment Methodology for User-Centric Distributed Massive MIMO Architectures
- 2024
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Ingår i: IEEE Open Journal of the Communications Society. - 2644-125X. ; 5, s. 3517-3543
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Tidskriftsartikel (refereegranskat)abstract
- User-centric (UC) distributed massive multiple-input multiple-output (D-mMIMO), also known as cell-free mMIMO, is a pivotal technology for enabling future mobile communication systems. While UC D-mMIMO intrinsically follows a distributed architecture, its processing can be implemented in a distributed or centralized fashion. This paper proposes a comprehensive cost assessment methodology for UC D-mMIMO, capturing its total cost of ownership and factoring in the deployment configuration, processing implementation, computational demands, and fronthaul signaling. The methodology considers two transmission reception point (TRP) deployment strategies. The first focuses only on supporting user equipment (UE) demands, while the other fulfills these requirements and also actively strives to provide a fairer service among UEs. The proposed methodology is then used to perform a techno-economic assessment of the feasibility of centralized versus distributed processing functional splits while varying key costs and TRP capabilities, like antenna and served UE count. Results suggest that with the TRP deployment that only supports the required UE rate, distributed processing is usually the most feasible option for UE demands of up to 50 Mbps, and centralized processing is more cost-effective in other cases. Additionally, when considering the actively fairer TRP deployment, centralized processing becomes cheaper for any UE demands.
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| 18. |
- Gamble, LD, et al.
(författare)
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A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma
- 2021
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 13:8
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Tidskriftsartikel (refereegranskat)abstract
- Ornithine decarboxylase (ODC1), a critical regulatory enzyme in polyamine biosynthesis, is a direct transcriptional target of MYCN, amplification of which is a powerful marker of aggressive neuroblastoma. A single nucleotide polymorphism (SNP), G316A, within the first intron of ODC1, results in genotypes wildtype GG, and variants AG/AA. CRISPR-cas9 technology was used to investigate the effects of AG clones from wildtype MYCN-amplified SK-N-BE(2)-C cells and the effect of the SNP on MYCN binding, and promoter activity was investigated using EMSA and luciferase assays. AG clones exhibited decreased ODC1 expression, growth rates, and histone acetylation and increased sensitivity to ODC1 inhibition. MYCN was a stronger transcriptional regulator of the ODC1 promoter containing the G allele, and preferentially bound the G allele over the A. Two neuroblastoma cohorts were used to investigate the clinical impact of the SNP. In the study cohort, the minor AA genotype was associated with improved survival, while poor prognosis was associated with the GG genotype and AG/GG genotypes in MYCN-amplified and non-amplified patients, respectively. These effects were lost in the GWAS cohort. We have demonstrated that the ODC1 G316A polymorphism has functional significance in neuroblastoma and is subject to allele-specific regulation by the MYCN oncoprotein.
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| 19. |
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| 20. |
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| 21. |
- Horton, Paul, et al.
(författare)
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Contesting heteronormativity : The fight for lesbian, gay, bisexual and transgender recognition in India and Vietnam
- 2015
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Ingår i: Culture, Health and Sexuality. - : Taylor & Francis. - 1369-1058 .- 1464-5351. ; 17:9, s. 1059-1073
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Tidskriftsartikel (refereegranskat)abstract
- Recent public debates about sexuality in India and Vietnam have brought the rights of lesbian, gay, bisexual and transgender people sharply into focus. Drawing on legal documents, secondary sources and ethnographic fieldwork conducted in the urban centres of Delhi and Hanoi, this article shows how the efforts of civil society organisations dedicated to the fight for lesbian, gay, bisexual and transgender rights have had different consequences in these two Asian contexts. The paper considers how these organisations navigated government regulations about their formation and activities, as well as the funding priorities of national and international agencies. The HIV epidemic has had devastating consequences for gay men and other men who have sex with men, and has been highly stigmatising. As a sad irony, the epidemic has provided at the same time a strategic entry point for organisations to struggle for lesbian, gay, bisexual and transgender recognition. This paper examines how the fight for lesbian, gay, bisexual and transgender recognition has been doubly framed through health-based and rights-based approaches and how the struggle for recognition has positioned lesbian, gay, bisexual and transgender people in India and Vietnam differently.
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| 22. |
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| 23. |
- Iurilli, Giuliano, et al.
(författare)
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Sound-Driven Synaptic Inhibition in Primary Visual Cortex
- 2012
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Ingår i: Neuron. - : Elsevier BV. - 0896-6273 .- 1097-4199. ; 73:4, s. 814-28
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Tidskriftsartikel (refereegranskat)abstract
- Multimodal objects and events activate many sensory cortical areas simultaneously. This is possibly reflected in reciprocal modulations of neuronal activity, even at the level of primary cortical areas. However, the synaptic character of these interareal interactions, and their impact on synaptic and behavioral sensory responses are unclear. Here, we found that activation of auditory cortex by a noise burst drove local GABAergic inhibition on supragranular pyramids of the mouse primary visual cortex, via cortico-cortical connections. This inhibition was generated by sound-driven excitation of a limited number of cells in infragranular visual cortical neurons. Consequently, visually driven synaptic and spike responses were reduced upon bimodal stimulation. Also, acoustic stimulation suppressed conditioned behavioral responses to a dim flash, an effect that was prevented by acute blockade of GABAergic transmission in visual cortex. Thus, auditory cortex activation by salient stimuli degrades potentially distracting sensory processing in visual cortex by recruiting local, translaminar, inhibitory circuits.
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| 24. |
- John, Wolfgang, et al.
(författare)
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ANIARA Project - Automation of Network Edge Infrastructure and Applications with Artificial Intelligence
- 2023
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Ingår i: Ada User Journal. - 1381-6551. ; 42:2, s. 92-95
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Tidskriftsartikel (refereegranskat)abstract
- Emerging use-cases like smart manufacturing and smart cities pose challenges in terms of latency, which cannot be satisfied by traditional centralized infrastructure. Edge networks, which bring computational capacity closer to the users/clients, are a promising solution for supporting these critical low latency services. Different from traditional centralized networks, the edge is distributed by nature and is usually equipped with limited compute capacity. This creates a complex network to handle, subject to failures of different natures, that requires novel solutions to work in practice. To reduce complexity, edge application technology enablers, advanced infrastructure and application orchestration techniques need to be in place where AI and ML are key players.
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| 25. |
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| 26. |
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| 27. |
- Lashgari, Maryam, 1991, et al.
(författare)
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Designing and Operating Optical Transport Networks in 5G and Beyond Scenarios
- 2023
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Ingår i: Photonic Networks and Devices in Proceedings Advanced Photonics Congress 2023 - Part of Advanced Photonics Congress 2023.
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Konferensbidrag (refereegranskat)abstract
- Deploying and operating optical transport networks is a complex task. This paper presents a few challenges operators must tackle when considering 5G and beyond scenarios and the lesson learned by addressing them.
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| 28. |
- Lashgari, Maryam, 1991, et al.
(författare)
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Fiber- vs. Microwave-based 5G Transport: a Total Cost of Ownership Analysis
- 2022
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Ingår i: European Conference on Optical Communication, ECOC.
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Konferensbidrag (refereegranskat)abstract
- Answering a key question from operators, the paper compares the techno-economic performance of fiber and microwave-based 5G transport deployments using vendor’s inventories and real-life field deployment scenarios. Results highlight how microwave gains vary based on the geo-types, the fiber trenching, and microwave equipment costs.
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| 29. |
- Lashgari, Maryam, 1991, et al.
(författare)
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Techno-economics of 5G transport deployments
- 2023
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 12429
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Konferensbidrag (refereegranskat)abstract
- Network densification is a crucial enabler for 5G, requiring the installation of a large number of devices and/or cables for the 5G transport network. This invited paper provides a techno-economic study focusing on adopting microwave and fiber equipment for 5G transport network deployments. Different architectures for low layer split supporting latency critical services are considered.
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| 30. |
- Lashgari, Maryam, 1991, et al.
(författare)
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Techno-economics of Fiber vs. Microwave for Mobile Transport Network Deployments [Invited]
- 2023
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Ingår i: Journal of Optical Communications and Networking. - 1943-0620 .- 1943-0639. ; 15:7, s. C74-C87
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Tidskriftsartikel (refereegranskat)abstract
- One of the challenges for network operators is to design and deploy cost-efficient transport networks (TNs) to meet the high capacity and strict latency/reliability requirements of today’s emerging services. Therefore, they need to consider different aspects, including the appropriate technology, the level of reconfigurability, and the functional split option. A crucial aspect of network design is assessing the impact of these aspects against the total cost of ownership (TCO), latency, and reliability performance of a given solution. For this reason, this paper proposes a framework to investigate the TCO, latency, and reliability performance of a set of fiber and microwave-based TN architectures. They are categorized based on their baseband functional split option and the reconfigurability capabilities of the equipment used. The results, based on real data from a non-incumbent operator, show that in most of the considered scenarios, a microwavebased TN exhibits lower TCO than a fiber-based one. The TCO gain may vary with the choice of the functional split option, geo-type, reconfigurability features, fiber trenching costs, and cost of microwave equipment, with a more significant impact in a dense urban geo-type, where for a low layer functional split option the fiber- and microwave-based architectures have a comparable TCO. Finally, it was found that the considered fiber and microwave architectures have almost similar average latency and connection availability performance. Both are suitable to meet the service requirements of 5G and beyond 5G services in most of the considered scenarios. Only in extreme latency-critical scenarios, a small number of the cells might not fully satisfy the latency requirements of a low layer split option due to multiple microwave hops in the microwave-based architecture.
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| 31. |
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| 32. |
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| 33. |
- Malgoyre, A, et al.
(författare)
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Aerobic performance improvment and mitochondrial adaptations after endurance training in hypoxia
- 2011
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Ingår i: Acta Physiologica. - : John Wiley & Sons. - 1748-1708 .- 1748-1716. ; 202:Suppl. 685
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Tidskriftsartikel (refereegranskat)abstract
- Aim: The aim of the present study was to examine the effects of hypoxic endurance training on both aerobic performance and mitochondrial changes within plantaris muscle, independently of hematopoietic modifications.Methods: Four groups of female rats were constituted either sedentary (S) or trained (T), in either hypoxia (H) or normoxia (N). H conditions corresponded to 14% O2 and the training program to 5 running sessions/week for 5 weeks. Duration and intensity reached progressively 75Õ up to 80% of individual maximal aerobic running velocity (MAV) in either H or N. Performances of each rat were analysed through MAV values and time to exhaustion at 65% MAV (T65). Mitochondrial oxidative capacities (Vmax) for pyruvate (pyr), palmitoyl-carnitine (PC) and palmitoyl-CoA (PCoA) were measured in plantaris skinned fibers. Citrate synthase (CS) and HAD activities were also measured.Results: MAV increased in both TN and TH rats (respectively +52%, +39%, P<0.001) without difference between H and N, whereas hypoxia specifically increased T65 (+ 39%, P<0.05) independently of training effect. The training-induced increase in CS activity (P<0.001) was more marked in TN than in TH group (+39% vs +26%, P<0.001) whereas HAD activity rose similarly in TN and TH (respectively +83%, +64%, P<0.05). Physical training increased Vmaxpyr only in N rats (+30%, P<0.001), while VmaxPCoA decreased in hypoxia (P<0.05) without change in VmaxPC. This suggests that LCFA transport by CPT-1 was limiting in hypoxia. As expected, training improved creatine kinase efficiency in N rats (+80%, P<0.005), but no change was shown in H rats.Conclusion: Regarding the modest changes in mitochondrial function, it is likely that other factors contribute to explain the improvement of physical performance after an endurance training in hypoxia.
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| 34. |
- Passariello, A., et al.
(författare)
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Constitutional 11q14-q22 chromosome deletion syndrome in a child with neuroblastoma MYCN single copy
- 2013
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Ingår i: European Journal of Medical Genetics. - : Elsevier BV. - 1769-7212. ; 56:11, s. 626-634
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Tidskriftsartikel (refereegranskat)abstract
- Constitutional 11q deletion is a chromosome imbalance possibly found in MCA/MR patients analyzed for chromosomal anomalies. Its role in determining the phenotype depends on extension and position of deleted region. Loss of heterozygosity of 11q (region 11q23) is also associated with neuroblastoma, the most frequent extra cranial cancer in children. It represents one of the most frequent cytogenetic abnormalities observed in the tumor of patients with high-risk disease even if germline deletion of 11q in neuroblastoma is rare. Hereby, we describe a 18 months old girl presenting with trigonocephaly and dysmorphic facial features, including hypotelorism, broad depressed nasal bridge, micrognathia, synophrys, epicanthal folds, and with a stage 4 neuroblastoma without MYCN amplification, carrying a germline 11q deletion (11q14.1-q22.3), outside from Jacobsen syndrome and from neuroblastoma 11q critical regions. The role of 11q deletion in determining the clinical phenotype and its association with neuroblastoma development in the patient are discussed. (C) 2013 Elsevier Masson SAS. All rights reserved.
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| 35. |
- Raffaelli, Carla, et al.
(författare)
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Network Slicing
- 2020
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Ingår i: Network Programmability: a (r)evolutionary approach. - 9788894982428
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Network slicing is emerging as a key enabling technology to support new service needs, business cases, and the evolution of programmable networking. As an end-to-end concept involving network functions in different domains and administrations, network slicing calls for new standardization efforts, design methodologies, and deployment strategies. This chapter aims at addressing the main aspects of network slicing with relevant challenges and practical solutions.
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| 36. |
- Raffaelli, C., et al.
(författare)
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Optimization of Centralized Radio access networks in indoor areas
- 2016
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Ingår i: International Conference on Transparent Optical Networks. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781509014675
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Konferensbidrag (refereegranskat)abstract
- A Centralized Radio Architecture (CRA) allows for the coordination of the physical layer functions of macro and small cells. Efficient techniques can be introduced based on the CRA concept, but deployment cost could potentially increase if CRA networks are not carefully designed. This paper proposes a number of design strategies aimed at cost minimization for CRA networks in residential areas based on heuristics which easily scale with the number of indoor antennas. A few different algorithms, which aim at reducing the overall amount of equipment to cover the area, are described and compared.
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| 37. |
- Raffaelli, Carla, et al.
(författare)
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Reliable Slicing in Optical Metro Networks with Reconfigurable Backup Resources
- 2022
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Ingår i: 2022 13th International Symposium on Communication Systems, Networks and Digital Signal Processing, CSNDSP 2022. ; , s. 863-866
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Konferensbidrag (refereegranskat)abstract
- Network slicing enables resource sharing in high capacity network infrastructures. To support network flexibility in relation to dynamic application scenarios, slice configuration needs changes over time to maintain optimization in resource usage and meet performance constraints. Emerging services like autonomous driving or industrial contexts require critical low latency and high reliability referred to in 5G context as the Ultra Reliable Low Latency Communications (URLLC) service. With reference to this class of services, this paper introduces a methodology to manage slice dynamics in network operation to maintain optimal resource assignment. Simulation results show how slice dynamics impact performance in the presence of different reliability schemes. In particular, the shared protection scheme is shown to perform remarkably better than the dedicated protection one and allows a viable approach to dynamic resource management.
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| 38. |
- Spagnuolo, M. S., et al.
(författare)
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A Short-Term Western Diet Impairs Cholesterol Homeostasis and Key Players of Beta Amyloid Metabolism in Brain of Middle Aged Rats
- 2020
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Ingår i: Molecular Nutrition & Food Research. - : Wiley. - 1613-4125 .- 1613-4133. ; 64:16
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Tidskriftsartikel (refereegranskat)abstract
- Scope Cholesterol homeostasis is crucial for brain functioning. Unhealthy nutrition can influence cerebral physiology, but the effect of western diets on brain cholesterol homeostasis, particularly at middle age, is unknown. Given the link between brain cholesterol alteration and beta amyloid production, the aim is to evaluate whether a diet rich in fat and fructose affects the protein network implicated in cholesterol synthesis and shuttling between glial cells and neurons, as well as crucial markers of beta amyloid metabolism. Methods and results Middle aged rats are fed a high fat-high fructose (HFF) or a control diet for 4 weeks. Inflammatory markers and cholesterol levels significantly increase in hippocampus of HFF rats. A higher activation of 3-hydroxy 3-methylglutaryl coenzyme-A reductase, coupled with lower levels of apolipoprotein E, LXR-beta, and lipoproteins receptors is measured in hippocampus from HFF rats. The alteration of critical players of cholesterol homeostasis is associated with increased level of amyloid precursor protein, presenilin 1, and nicastrin, and decreased level of insulin degrading enzyme. Conclusions Overall these data show that a western diet is associated with perturbation of cholesterol homeostasis in middle aged rats, mostly in hippocampus. This might trigger molecular events involved in the onset of neurodegenerative diseases.
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| 39. |
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| 40. |
- Tonini, C., et al.
(författare)
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The fundamental manifold of spiral galaxies: ordered versus random motions and the morphology dependence of the Tully-Fisher relation
- 2014
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 438:4, s. 3332-3339
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the morphology dependence of the Tully-Fisher (TF) relation, and the expansion of the relation into a three-dimensional manifold defined by luminosity, total circular velocity and a third dynamical parameter, to fully characterize spiral galaxies across all morphological types. We use a full semi-analytic hierarchical model (based on Croton et al.), built on cosmological simulations of structure formation, to model galaxy evolution and build the theoretical TF relation. With this tool, we analyse a unique data set of galaxies for which we cross-match luminosity with total circular velocity and central velocity dispersion. We provide a theoretical framework to calculate such measurable quantities from hierarchical semi-analytic models. We establish the morphology dependence of the TF relation in both model and data. We analyse the dynamical properties of the model galaxies and determine that the parameter Sigma/V-C, i.e. the ratio between random and total motions defined by velocity dispersion and circular velocity, accurately characterizes the varying slope of the TF relation for different model galaxy types. We apply these dynamical cuts to the observed galaxies and find indeed that such selection produces a differential slope of the TF relation. The TF slope in different ranges of Sigma/V-C is consistent with that for the traditional photometric classification in Sa, Sb and Sc. We conclude that Sigma/V-C is a good parameter to classify galaxy type, and we argue that such classification based on dynamics more closely mirrors the physical properties of the observed galaxies, compared to visual (photometric) classification. We also argue that dynamical classification is useful for samples where eye inspection is not reliable or impractical. We conclude that Sigma/V-C is a suitable parameter to characterize the hierarchical assembly history that determines the disc-to-bulge ratio, and to expand the TF relation into a three-dimensional manifold, defined by luminosity, circular velocity and Sigma/V-C.
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| 41. |
- Tonini, Federico, 1990, et al.
(författare)
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A Service-Aware Autoscaling Strategy for Container Orchestration Platforms with Soft Resource Isolation
- 2023
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Ingår i: 2023 JOINT EUROPEAN CONFERENCE ON NETWORKS AND COMMUNICATIONS & 6G SUMMIT, EUCNC/6G SUMMIT. - 2575-4912 .- 2475-6490. - 9798350311020 ; , s. 454-459
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Konferensbidrag (refereegranskat)abstract
- Container orchestration platforms like Kubernetes (K8s) allow easy deployment and management of cloud native services. When deploying their services, service providers need to specify a proper amount of resources to K8s, so that the desired Quality of Service (QoS) to their users can be maintained. To cope with the varying traffic demand coming from users, they can rely on the K8s Horizontal Pod Autoscaling (HPA) mechanism. To ensure that enough resources are available when needed, the standard HPA mechanism relies on resource overprovisioning. In this way, the required QoS is achieved most of (or all) the time but at the expense of additional resources that are allocated (and charged for), while they may stay idle for significant periods of time. A way to reduce overprovisioning is provided by the soft resource isolation of K8s, which allows services to compensate for a temporary lack of resources with shared resources, i.e., idle resources of the machines where services are running. However, during traffic spikes, these idle resources may not be enough to serve the whole demand, degrading the QoS. The HPA, which is not aware of how much demand could not be served, is not always able to correctly estimate the required additional resources, further degrading the QoS. To overcome this, service providers need to leverage overprovisioning, limiting the use of shared resources. In this paper, we propose a novel mechanism for autoscaling resources in K8s that relies on service-related data to avoid the additional degradation introduced by the HPA. The proposed strategy also offers a way to tune overprovisioning and shared resources. Simulation results show that our approach can reduce idle resources by up to 60% compared with the HPA mechanism.
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| 42. |
- Tonini, F., et al.
(författare)
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Benefits of joint planning of small cells and fiber backhaul in 5G dense cellular networks
- 2017
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Ingår i: 2017 IEEE International Conference on Communications, ICC 2017. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781467389990
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Konferensbidrag (refereegranskat)abstract
- Base station (BS) densification is increasingly adopted by mobile operators in order to support increasing traffic demand. However, a large number of BSs requires many backhaul connections, which may be very expensive. For this reason, provisioning high speed backhaul connections to BSs in a cost-effective way is challenging, and it is important to efficiently utilize an existing fixed network infrastructure if possible. This paper proposes two optimized infrastructure-aware planning strategies for small cells and fiber backhaul. The first strategy is referred to as joint design (JD) and is based on the joint cost minimization of small cells and fiber backhaul. The JD strategy is compared to a traditional design (TD) solution based on a two-step optimization approach. In the latter a cost-optimal small cells placement is identified first, then the corresponding minimum cost fiber backhaul deployment is determined accordingly. A comparison between these two approaches in dense 5G urban scenarios shows that the relative performance of JD and TD largely depends on the expected traffic demand and on the existing infrastructure. In dense urban areas with the average traffic levels expected for the year 2020 and beyond, JD returns up to 50% lower deployment cost in a greenfield scenario, and up to 70% lower deployment cost in a brownfield scenario. Only in areas with extremely high traffic demand (e.g., open-air festivals and stadiums) JD returns deployment costs very similar to TD.
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| 43. |
- Tonini, Federico, 1990, et al.
(författare)
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Benefits of Pod dimensioning with best-effort resources in bare metal cloud native deployments
- 2023
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Ingår i: IEEE Networking Letters. - 2576-3156.
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Tidskriftsartikel (refereegranskat)abstract
- Container orchestration platforms automatically adjust resources to evolving traffic conditions. However, these scaling mechanisms are reactive and may lead to service degradation. Traditionally, resource dimensioning has been performed considering guaranteed (or request) resources. Recently, container orchestration platforms included the possibility of allocating idle (or limit) resources for a short time in a best-effort fashion. This paper analyzes the potential of using limit resources as a way to mitigate degradation while reducing the number of allocated request resources. Results show that a 25% CPU reduction can be achieved by relying on limit resources.
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| 44. |
- Tonini, Federico, et al.
(författare)
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Cost-Optimal Deployment of a C-RAN with Hybrid Fiber/FSO Fronthaul
- 2019
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Ingår i: Journal of Optical Communications and Networking. - 1943-0620 .- 1943-0639. ; 11:7, s. 397-408
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Tidskriftsartikel (refereegranskat)abstract
- Centralized radio access network (C-RAN) has been considered as an architectural solution able to reduce capital and operational expenditure in dense 5G cellular networks while allowing better network performance. The C-RAN approach decouples baseband units from antenna sites and places them in selected locations, connected by the so-called fronthaul links. These links require expensive high-capacity connections, thus calling for cost-efficient deployment. This paper presents a hybrid fronthaul solution for C-RAN based on both optical fibers and free-space optics (FSO) to enhance fronthaul flexibility and minimize deployment costs. Two design strategies based on integer linear programming are proposed for both greenfield and brownfield deployments. The first strategy is referred to as joint planning (JP) and is based on the joint minimization of the number of deployed remote radio heads (RRHs) and the cost of the hybrid fiber/FSO fronthaul. The second strategy is based on two-step disjoint planning (DP) that first identifies a cost-optimal RRH placement and then finds the corresponding minimum cost deployment for the fronthaul links. Results obtained with JP and DP are compared in dense urban area scenarios (i.e., with characteristics similar to festivals or concerts), highlighting the advantage of the JP approach compared to DP, both in terms of costs and an enhanced flexibility during the network design process.
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| 45. |
- Tonini, Federico, 1990, et al.
(författare)
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Demonstrating the Benefits of Service-Aware Pod Autoscaling with Shared Resources
- 2023
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Ingår i: 2023 IEEE 9th International Conference on Network Softwarization: Boosting Future Networks through Advanced Softwarization, NetSoft 2023 - Proceedings. - 9798350399806 ; , s. 305-307
-
Konferensbidrag (refereegranskat)abstract
- Service providers can leverage shared resources to reduce the overall amount of required resources while keeping acceptable Quality of Service (QoS) levels. Kubernetes (K8s) provides a Horizontal Pod Autoscaling (HPA) mechanism that allows to automatically adjust the number of Pods to closely follow the user demand variations over time. To properly leverage shared resources with HPA, service providers need to limit the use of dedicated resources and overprovisioning. However, in the case of traffic spikes, there may not be enough resources to satisfy the demand. The HPA, which relies on resource usage to drive the scaling, is unaware of how many requests could not be served with the required QoS. This might result in an underestimation of the number of required Pods to be added, leading to additional QoS degradation. This demonstration showcases the effectiveness of a new Pod autoscaling mechanism (i.e., Service Aware Pod Autoscaling (SAPA)) that relies on user request measurements from the service load balancer to better estimate the number of required Pods. SAPA allows selecting the amount of Pod resources (dedicated and shared) in a simple way. We demonstrate the benefits of SAPA by comparing it to a K8s cluster based on the traditional HPA in terms of resource usage and service latency.
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| 46. |
- Tonini, F., et al.
(författare)
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Minimum Cost Deployment of Radio and Transport Resources in Centralized Radio Architectures
- 2016
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Ingår i: 2016 INTERNATIONAL CONFERENCE ON COMPUTING, NETWORKING AND COMMUNICATIONS (ICNC). - : IEEE Computer Society. - 9781467385794
-
Konferensbidrag (refereegranskat)abstract
- The traffic in mobile access networks is increasing at an exponential rate, with the majority of this traffic being generated indoor. To cope with this trend, heterogeneous network (HetNet) architectures based on the centralized radio architecture (CRA) concept have been recently proposed. A CRA network is able to reach high wireless network performance by centralizing the radio physical layer functions of macro and small cells. On the other hand, a CRA network puts strict latency and capacity requirements on the transport segment, which usually comprises a mixture of fiber- and copper-based infrastructure. These strict constraints may translate into high deployment costs if not carefully addressed. This paper proposes an optimized deployment strategy for CRA networks in residential areas. The objective of the proposed strategy is to contain the total deployment cost by minimizing the number of wireless and transport resources required. We demonstrate that our deployment strategy allows for a significant reduction of the required amount of network components and the overall network cost compared to the existing deployment solutions.
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| 47. |
- Tonini, Federico, 1990, et al.
(författare)
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Network Slicing Automation: Challenges and Benefits
- 2020
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Ingår i: 2020 24th International Conference on Optical Network Design and Modeling, ONDM 2020.
-
Konferensbidrag (refereegranskat)abstract
- Network slicing is a technique widely used in 5G networks where multiple logical networks (i.e., slices) run over a single shared physical infrastructure. Each slice may realize one or multiple services, whose specific requirements are negotiated beforehand and regulated through Service Level Agreements (SLAs). In Beyond 5G (B5G) networks it is envisioned that slices should be created, deployed, and managed in an automated fashion (i.e., without human intervention) irrespective of the technological and administrative domains over which a slice may span. Achieving this vision requires a combination of novel physical layer technologies, artificial intelligence tools, standard interfaces, network function virtualization, and software-defined networking principles. This paper provides an overview of the challenges facing network slicing automation with a focus on transport networks. Results from a selected group of use cases show the benefits of applying conventional optimization tools and machine-learning-based techniques while addressing some slicing design and provisioning problems.
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| 48. |
- Tonini, Federico, et al.
(författare)
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Radio and Transport Planning of Centralized Radio Architectures in 5G Indoor Scenarios
- 2017
-
Ingår i: IEEE Journal on Selected Areas in Communications. - : IEEE. - 0733-8716 .- 1558-0008. ; 35:8, s. 1837-1848
-
Tidskriftsartikel (refereegranskat)abstract
- Providing high capacity to the end users is one of the main challenges for the fifth generation (5G) of mobile networks. The users' habit to consume online contents indoor makes the outdoor-to-indoor capacity provisioning impractical, especially when the high-frequency bands proposed for 5G are employed. The centralized radio architecture (CRA) is an inbuilding solution, which relies on the centralization of baseband processing functions, fully or partly allowing for centralized cell management while providing signals directly inside the buildings. On the other hand, the massive deployment of CRAs in urban areas may yield to unacceptably high installation costs, due to the radio network equipment to be activated. To make CRAs appealing to mobile operators, we propose different deployment strategies to minimize the CRA deployment cost. We define the remote radio unit placement (RRUP) problem and formulate it as an integer linear program, obtaining optimal deployment solutions in small urban residential scenarios. We prove the RRUP problem to be NP-hard, requiring heuristic approaches to solve large problem instances. To this end, we propose an effective and scalable heuristic for minimizing the amount of radio equipment required to deploy CRAs in large urban areas.
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| 49. |
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| 50. |
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