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- Alme, J., et al.
(författare)
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RCU2-The ALICE TPC readout electronics consolidation for Run2
- 2013
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the solution for optimization of the ALICE TPC readout for running at full energy in the Run2 period after 2014. For the data taking with heavy ion beams an event readout rate of 400 Hz with a low dead time is envisaged for the ALICE central barrel detectors during these three years. A new component, the Readout Control Unit 2 (RCU2), is being designed to increase the present readout rate by a factor of up to 2.6. The immunity to radiation induced errors will also be significantly improved by the new design.
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- Nahse, Viola, et al.
(författare)
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ATPase activity of DFCP1 controls selective autophagy
- 2023
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- The endoplasmic reticulum protein DFCP1 is found on omegasomes implicated in autophagosome biogenesis, but its function has remained unknown. Here, Nahse et al. show that DFCP1 is an ATPase that mediates selective autophagy by promoting constriction of large omegasomes. Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER) known as omegasomes, which are characterized by the presence of the ER protein DFCP1/ZFYVE1. The function of DFCP1 is unknown, as are the mechanisms of omegasome formation and constriction. Here, we demonstrate that DFCP1 is an ATPase that is activated by membrane binding and dimerizes in an ATP-dependent fashion. Whereas depletion of DFCP1 has a minor effect on bulk autophagic flux, DFCP1 is required to maintain the autophagic flux of p62 under both fed and starved conditions, and this is dependent on its ability to bind and hydrolyse ATP. While DFCP1 mutants defective in ATP binding or hydrolysis localize to forming omegasomes, these omegasomes fail to constrict properly in a size-dependent manner. Consequently, the release of nascent autophagosomes from large omegasomes is markedly delayed. While knockout of DFCP1 does not affect bulk autophagy, it inhibits selective autophagy, including aggrephagy, mitophagy and micronucleophagy. We conclude that DFCP1 mediates ATPase-driven constriction of large omegasomes to release autophagosomes for selective autophagy.
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- Berg, CK, et al.
(författare)
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Psychosocial factors associated with broadly defined bulimia nervosa during early pregnancy: findings from the Norwegian Mother and Child Cohort Study
- 2008
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Ingår i: The Australian and New Zealand journal of psychiatry. - : SAGE Publications. - 1440-1614 .- 0004-8674. ; 42:5, s. 396-404
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The purpose of the present study was to investigate the relationship between psychosocial characteristics and broadly defined bulimia nervosa during early pregnancy, including factors associated with continuation, incidence and remission. Method: A total of 41 157 women completed questionnaires at approximately gestation week 18, including items on eating disorders and psychosocial characteristics as a part of Norwegian Mother and Child Cohort Study conducted by the Norwegian Institute of Public Health. Results: Incident bulimia nervosa during the first trimester was significantly associated with symptoms of anxiety and depression and low self-esteem and life satisfaction, whereas remission was significantly associated with higher self-esteem and life satisfaction. Continuation was not significantly related to any of the psychosocial variables tested. Conclusion: Onset of bulimia nervosa during pregnancy is associated with mood and anxiety symptoms. Remission of bulimic symptoms and new onset of bulimia nervosa are associated with opposite profiles of self-esteem, and life satisfaction measures.
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| 8. |
- Bingen, B., et al.
(författare)
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Geochronology of the Palaeoproterozoic Kautokeino Greenstone Belt, Finnmark, Norway: Tectonic implications in a Fennoscandia context.
- 2015
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Ingår i: Norwegian Journal of Geology. - : Geological Society of Norway. - 2387-5844 .- 2387-5852. ; 95, s. 365-396
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Tidskriftsartikel (refereegranskat)abstract
- Zircon U–Pb geochronological data in 18 samples from Finnmarksvidda and one sample from the Repparfjord Tectonic Window, northern Norway, constrain the evolution of the Palaeoproterozoic Kautokeino Greenstone Belt and neighbouring units in a Fennoscandia context. The Jergul Complex is an Archaean cratonic block of Karelian affinity, made of variably gneissic, tonalite–trondhjemite–granodiorite–granite plutonic rocks formed between 2975 ± 10 and 2776 ± 6 Ma. It is associated with the Archaean Goldenvárri greenstone–schist formation. At the base of the Kautokeino Greenstone Belt, the Masi Formation is a typical Jatulian quartzite, hosting a Haaskalehto-type, albite–magnetite-rich, mafic sill dated at 2220 ± 7 Ma. The Likčá and Čáskejas formations represent the main event of basaltic magmatism. A synvolcanic metagabbro dates this magmatism at 2137 ± 5 Ma. The geochemical and Nd isotopic signature of the Čáskejas Formation (eNd = +2.2 ± 1.7) is remarkably similar to coeval dykes intruding the Archaean Karelian Craton in Finland and Russia (eNd = +2.5 ± 1.0). The Čáskejas Formation can be correlated with the Kvenvik Formation in the Alta–Kvænangen Tectonic Window. Two large granite plutons yield ages of 1888 ± 7 and 1865 ± 8 Ma, and provide a maximum age for shearing along two prominent NNW–SSE-oriented shear zones recording Svecokarelian transpression. The Bidjovagge Au–Cu deposit formed around 1886 to 1837 Ma and is also related to this NNW–SSE-oriented shear system. The Ráiseatnu Complex is mainly composed of granitic gneisses formed between 1868 ± 13 and 1828 ± 5 Ma, and containing metasediment rafts and zircon xenocrysts ranging from c. 3100 to 2437 Ma. The Kautokeino Greenstone Belt and Ráiseatnu Complex are interpreted as Palaeoproterozoic, pericontinental, lithospheric domains formed during rifting between Archaean cratonic domains. They accommodated oblique convergence between the Karelian and the Norrbotten Archaean cratons during the Svecokarelian orogeny.
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- Sorensen, J. L., et al.
(författare)
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The Organizer Dilemma: Outcomes from a Collaboration Exercise
- 2019
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Ingår i: International Journal of Disaster Risk Science. - : Springer Science and Business Media LLC. - 2095-0055 .- 2192-6395. ; 10:2, s. 261-269
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Tidskriftsartikel (refereegranskat)abstract
- In crisis management, cross-sector collaboration exercises are perceived as improving preparedness and develop team-integration efforts. However, studies show that exercises may tend to produce results with limited learning and usefulness. The purpose of this nonexperimental, survey-based study was to measure the difference in perceived exercise effect between participants belonging to the exercise planning organizations and participants belonging to other participating groups. Surveys were distributed and collected from participants in a 2017 chemical oil-spill exercise set off the southern coast of Norway. The target population was operational staff, excluding exercise management and directing staff. The sample population consisted of operatives associated with the exercise organizer organization and others belonging to external public and nongovernmental emergency organizations. The data collection instrument was the Collaboration, Learning, and Utility Scale (CLU-scale). Findings indicated that the levels of CLU were higher among external participants than among those individuals who belong to the exercise planning organizations. This study recommends the development and adoption of a national maritime collaboration exercise framework. A practical implication is a recommendation to evaluate exercises to secure the outcome regarding collaboration skill using the same instrument.
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- Torgersen, T., et al.
(författare)
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Profiles and levels of fatty acid esters of okadaic acid group toxins and pectenotoxins during toxin depuration, Part I: Brown crab (Cancer pagurus)
- 2008
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Ingår i: Toxicon. - : Elsevier BV. - 0041-0101. ; 52:3, s. 407-417
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Tidskriftsartikel (refereegranskat)abstract
- In 2002, two outbreaks of diarrhetic shellfish poisoning (DSP) occurred in Norway, which was later confirmed to be caused by the consumption of brown crab (Cancer pagurus) contaminated predominantly by esters of okadaic acid (OA) after feeding on toxic blue mussels (Mytilus edulis). In addition to OA-group toxins, pectenotoxins (PTXs) are commonly detected in the toxin-producing algae (i.e. Dinophysis). In this paper, an experiment was set up to study the fatty acid ester profiles and depuration rates of OA-group toxins and PTXs from C. pagurus after feeding on M. edulis containing these toxin groups. CA, DTX1, DTX2 and PTX2 SA were all detected primarily in the form of fatty acid esters in the crab hepatopancreas (HP). Crabs preferentially assimilated toxins of the OA group after feeding on the mussels for 1 week. Detailed analysis of the fatty acid ester profile in crabs and mussels showed that the ester profiles in the crabs differed slightly from profiles of the fatty acid esters in M. edulis, but neither ester profile nor ester to free toxin ratio appeared to change in the crabs during the first 2 weeks of deputation. Calculations of deputation rates of the free forms of toxins resulted in similar reduction rates for OA and DTX2, whereas the depuration rate of DTX1, PTX2 and PTX2 SA was considerably faster. From the industrial perspective, the PTX-compounds are of minor importance compared to the OA group toxins in crabs, considering (1) the uncertainty regarding the oral toxicity of the PTXs, (2) the preferential ingestion of OA-group toxins compared to PTXs and (3) the faster depuration of PTXs. (C) 2008 Elsevier Ltd. All rights reserved.
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| 27. |
- Torgersen, T., et al.
(författare)
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Profiles and levels of fatty acid esters of okadaic acid group toxins and pectenotoxins during toxin depuration. Part II: Blue mussels (Mytilus edulis) and flat oyster (Ostrea edulis)
- 2008
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Ingår i: Toxicon. - : Elsevier BV. - 0041-0101. ; 52:3, s. 418-427
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Tidskriftsartikel (refereegranskat)abstract
- Bivalve molluscs accumulate toxins of the okadaic acid (OA) and pectenotoxin (PTX) groups, which are frequently found in Dinophysis spp. Transformation of the OA-group toxins into fatty acid ester derivatives (often designated "DTX3") is common in many bivalve species but the degree to which these toxins are transformed vary between species, and is also depending on the parent toxin involved. In this paper, detailed profiles and levels of fatty acid esters of OA, DTX1, DTX2 and PTX2 SA were studied in blue mussels (Mytilus edulis) and European flat oysters (Ostrea edulis), collected during a bloom of Dinophysis spp. and after 3 and 6 weeks of depuration. Analysis of samples by HPLC-MS/MS and HPLC-MS2 revealed some differences in identity and abundance of fatty acid moieties of the OA-group esters between species, but the 16:0 fatty acid esters dominated in both oysters and mussels, which is in accordance with the free fatty acid profiles in these species. A wider range of FM SA-esters were detected compared to esters of the CA-group toxins in both mussels and oysters, and in oysters, both 14:0, 18:4 and 20:5 fatty acid side chains were more common than 16:0. OA-group toxins were esterified to a larger degree in oysters (83-93%) compared to mussels (21-41%), and in mussels a higher proportion of OA was esterified compared to DTX1 and DTX2. Contrary to what was observed for CA-group toxins, PTX2 SA was esterified to a larger degree in mussels (81%) compared to oysters (64%). Calculations of depuration rates for all individual esters of each parent compound showed that the esters of DTX1 depurated significantly slower from both mussels and oysters compared to esters of OA, DTX2 and PTX2 SA, but overall the deputation rates of esters of both toxin group were highly similar for both species. This indicated that differences in depuration rates are not causing the large species-specific differences in levels and profiles of these toxins. Instead, the results for the CA-group toxins suggested that a higher rate of esterification in oysters is the main factor causing the observed differences in the proportion of esters to free toxin. For FM SA, large differences in ester profiles and a higher proportion of esters of PTX2 SA in mussels compared to oysters suggested differential assimilation and metabolic rate processes for the PTXs compared to OA-group toxins between these species. Hence, although produced by the same Dinophysis species, conclusions about the dynamics of one toxin group based on results from the other group should be avoided in future studies. (C) 2008 Elsevier Ltd. All rights reserved.
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| 30. |
- Watson, HJ, et al.
(författare)
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Eating Disorders, Pregnancy, and the Postpartum Period: Findings from the Norwegian Mother and Child Cohort Study (MoBa)
- 2014
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Ingår i: Norsk epidemiologi = Norwegian journal of epidemiology. - : Norwegian University of Science and Technology (NTNU) Library. - 0803-2491. ; 24:1-2, s. 51-62
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Tidskriftsartikel (refereegranskat)abstract
- This review summarizes studies on eating disorders in pregnancy and the postpartum period that have been conducted as part of the broader Norwegian Mother and Child Cohort Study (MoBa). Prior to the 2000s, empirical literature on eating disorders in pregnancy was sparse and consisted mostly of studies in small clinical samples. MoBa has contributed to a new era of research by making population-based and largesample research possible. To date, MoBa has led to 19 eating disorder studies on diverse questions including the prevalence, course, and risk correlates of eating disorders during pregnancy and the postpartum. The associations between eating disorder exposure and pregnancy, birth and obstetric outcomes, and maternal and offspring health and well-being, have also been areas of focus. The findings indicate that eating disorders in pregnancy are relatively common and appear to confer health risks to mother and her child related to sleep, birth outcomes, maternal nutrition, and child feeding and eating.
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