| 1. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 2. |
- Gõmez-Elvira, Javier, et al.
(författare)
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Curiosity's rover environmental monitoring station : Overview of the first 100 sols
- 2014
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Ingår i: Journal of Geophysical Research - Planets. - 2169-9097 .- 2169-9100. ; 119:7, s. 1680-1688
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Tidskriftsartikel (refereegranskat)abstract
- In the first 100 Martian solar days (sols) of the Mars Science Laboratory mission, the Rover Environmental Monitoring Station (REMS) measured the seasonally evolving diurnal cycles of ultraviolet radiation, atmospheric pressure, air temperature, ground temperature, relative humidity, and wind within Gale Crater on Mars. As an introduction to several REMS-based articles in this issue, we provide an overview of the design and performance of the REMS sensors and discuss our approach to mitigating some of the difficulties we encountered following landing, including the loss of one of the two wind sensors. We discuss the REMS data set in the context of other Mars Science Laboratory instruments and observations and describe how an enhanced observing strategy greatly increased the amount of REMS data returned in the first 100 sols, providing complete coverage of the diurnal cycle every 4 to 6 sols. Finally, we provide a brief overview of key science results from the first 100 sols. We found Gale to be very dry, never reaching saturation relative humidities, subject to larger diurnal surface pressure variations than seen by any previous lander on Mars, air temperatures consistent with model predictions and abundant short timescale variability, and surface temperatures responsive to changes in surface properties and suggestive of subsurface layering. Key Points Introduction to the REMS results on MSL mission Overiview of the sensor information Overview of operational constraints
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| 3. |
- Cruz, Raquel, et al.
(författare)
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Novel genes and sex differences in COVID-19 severity
- 2022
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 31:22, s. 3789-3806
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Tidskriftsartikel (refereegranskat)abstract
- Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
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| 4. |
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| 5. |
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| 6. |
- Bru, Samuel, et al.
(författare)
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Polyphosphate is involved in cell cycle progression and genomic stability in Saccharomyces cerevisiae
- 2016
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Ingår i: Molecular Microbiology. - : Wiley. - 0950-382X .- 1365-2958. ; 101:3, s. 367-380
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Tidskriftsartikel (refereegranskat)abstract
- Polyphosphate (polyP) is a linear chain of up to hundreds of inorganic phosphate residues that is necessary for many physiological functions in all living organisms. In some bacteria, polyP supplies material to molecules such as DNA, thus playing an important role in biosynthetic processes in prokaryotes. In the present study, we set out to gain further insight into the role of polyP in eukaryotic cells. We observed that polyP amounts are cyclically regulated in Saccharomyces cerevisiae, and those mutants that cannot synthesise (vtc4 Delta) or hydrolyse polyP (ppn1 Delta, ppx1 Delta) present impaired cell cycle progression. Further analysis revealed that polyP mutants show delayed nucleotide production and increased genomic instability. Based on these findings, we concluded that polyP not only maintains intracellular phosphate concentrations in response to fluctuations in extracellular phosphate levels, but also muffles internal cyclic phosphate fluctuations, such as those produced by the sudden demand of phosphate to synthetize deoxynucleotides just before and during DNA duplication. We propose that the presence of polyP in eukaryotic cells is required for the timely and accurate duplication of DNA.
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| 7. |
- Ferrando, Carlos, et al.
(författare)
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Individualised perioperative open-lung approach versus standard protective ventilation in abdominal surgery (iPROVE) : a randomised controlled trial
- 2018
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Ingår i: The Lancet Respiratory Medicine. - : ELSEVIER SCI LTD. - 2213-2600 .- 2213-2619. ; 6:3, s. 193-203
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Tidskriftsartikel (refereegranskat)abstract
- Background The effects of individualised perioperative lung-protective ventilation (based on the open-lung approach [OLA]) on postoperative complications is unknown. We aimed to investigate the effects of intraoperative and postoperative ventilatory management in patients scheduled for abdominal surgery, compared with standard protective ventilation. Methods We did this prospective, multicentre, randomised controlled trial in 21 teaching hospitals in Spain. We enrolled patients who were aged 18 years or older, were scheduled to have abdominal surgery with an expected time of longer than 2 h, had intermediate-to-high-risk of developing postoperative pulmonary complications, and who had a body-mass index less than 35 kg/m(2). Patients were randomly assigned (1: 1: 1: 1) online to receive one of four lung-protective ventilation strategies using low tidal volume plus positive end-expiratory pressure (PEEP): open-lung approach (OLA)-iCPAP (individualised intraoperative ventilation [individualised PEEP after a lung recruitment manoeuvre] plus individualised postoperative continuous positive airway pressure [CPAP]), OLA-CPAP (intraoperative individualised ventilation plus postoperative CPAP), STD-CPAP (standard intraoperative ventilation plus postoperative CPAP), or STD-O-2 (standard intraoperative ventilation plus standard postoperative oxygen therapy). Patients were masked to treatment allocation. Investigators were not masked in the operating and postoperative rooms; after 24 h, data were given to a second investigator who was masked to allocations. The primary outcome was a composite of pulmonary and systemic complications during the first 7 postoperative days. We did the primary analysis using the modified intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT02158923. Findings Between Jan 2, 2015, and May 18, 2016, we enrolled 1012 eligible patients. Data were available for 967 patients, whom we included in the final analysis. Risk of pulmonary and systemic complications did not differ for patients in OLA-iCPAP (110 [46%] of 241, relative risk 0.89 [95% CI 0.74-1.07; p=0.25]), OLA-CPAP (111 [47%] of 238, 0.91 [0.76-1.09; p=0.35]), or STD-CPAP groups (118 [48%] of 244, 0.95 [0.80-1.14; p=0.65]) when compared with patients in the STD-O-2 group (125 [51%] of 244). Intraoperatively, PEEP was increased in 69 (14%) of patients in the standard perioperative ventilation groups because of hypoxaemia, and no patients from either of the OLA groups required rescue manoeuvres. Interpretation In patients who have major abdominal surgery, the different perioperative open lung approaches tested in this study did not reduce the risk of postoperative complications when compared with standard lung-protective mechanical ventilation.
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| 8. |
- Hamilton, Victoria E., et al.
(författare)
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Observations and preliminary science results from the first 100 sols of MSL Rover Environmental Monitoring Station ground temperature sensor measurements at Gale Crater
- 2014
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Ingår i: Journal of Geophysical Research - Planets. - : John Wiley & Sons. - 2169-9097 .- 2169-9100. ; 119:4, s. 745-770
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Tidskriftsartikel (refereegranskat)abstract
- We describe preliminary results from the first 100 sols of ground temperature measurements along the Mars Science Laboratory's traverse from Bradbury Landing to Rocknest in Gale. The ground temperature data show long-term increases in mean temperature that are consistent with seasonal evolution. Deviations from expected temperature trends within the diurnal cycle are observed and may be attributed to rover and environmental effects. Fits to measured diurnal temperature amplitudes using a thermal model suggest that the observed surfaces have thermal inertias in the range of 265-375?J m-2 K-1 s-1/2, which are within the range of values determined from orbital measurements and are consistent with the inertias predicted from the observed particle sizes on the uppermost surface near the rover. Ground temperatures at Gale Crater appear to warm earlier and cool later than predicted by the model, suggesting that there are multiple unaccounted for physical conditions or processes in our models. Where the Mars Science Laboratory (MSL) descent engines removed a mobile layer of dust and fine sediments from over rockier material, the diurnal temperature profile is closer to that expected for a homogeneous surface, suggesting that the mobile materials on the uppermost surface may be partially responsible for the mismatch between observed temperatures and those predicted for materials having a single thermal inertia. Models of local stratigraphy also implicate thermophysical heterogeneity at the uppermost surface as a potential contributor to the observed diurnal temperature cycle. Key Points Diurnal ground temperatures vary with location Diurnal temperature curves are not well matched by a homogeneous thermal model GTS data are consistent with a varied stratigraphy and thermophysical properties.
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| 9. |
- Hassler, Donald M., et al.
(författare)
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Mars’ surface radiation environment measured with the Mars Science Laboratory’s Curiosity Rover
- 2014
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 343:6169
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Tidskriftsartikel (refereegranskat)abstract
- The Radiation Assessment Detector (RAD) on the Mars Science Laboratory’s Curiosity rover began making detailed measurements of the cosmic ray and energetic particle radiation environment on the surface of Mars on 7 August 2012. We report and discuss measurements of the absorbed dose and dose equivalent from galactic cosmic rays and solar energetic particles on the martian surface for ~300 days of observations during the current solar maximum. These measurements provide insight into the radiation hazards associated with a human mission to the surface of Mars and provide an anchor point with which to model the subsurface radiation environment, with implications for microbial survival times of any possible extant or past life, as well as for the preservation of potential organic biosignatures of the ancient martian environment.
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| 10. |
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| 11. |
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| 12. |
- Kim, Myung-Hee Y., et al.
(författare)
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Comparison of Martian surface ionizing radiation measurements from MSL-RAD with Badhwar-O'Neill 2011/HZETRN model calculations
- 2014
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Ingår i: Journal of Geophysical Research - Planets. - 2169-9097 .- 2169-9100. ; 119:6, s. 1311-1321
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Tidskriftsartikel (refereegranskat)abstract
- Dose rate measurements from Mars Science Laboratory-radiation assessment detector (MSL-RAD) for 300 sols on Mars are compared to simulation results using the Badhwar-O'Neill 2011 galactic cosmic ray (GCR) environment model and the high-charge and energy transport (HZETRN) code. For the nuclear interactions of primary GCR through Mars atmosphere and Curiosity rover, the quantum multiple scattering theory of nuclear fragmentation is used. Daily atmospheric pressure is measured at Gale Crater by the MSL Rover Environmental Monitoring Station. Particles impinging on top of the Martian atmosphere reach RAD after traversing varying depths of atmosphere that depend on the slant angles, and the model accounts for shielding of the RAD “E” detector (used for dosimetry) by the rest of the instrument. Simulation of average dose rate is in good agreement with RAD measurements for the first 200 sols and reproduces the observed variation of surface dose rate with changing heliospheric conditions and atmospheric pressure. Model results agree less well between sols 200 and 300 due to subtleties in the changing heliospheric conditions. It also suggests that the average contributions of albedo particles (charge number Z < 3) from Martian regolith comprise about 10% and 42% of the average daily point dose and dose equivalent, respectively. Neutron contributions to tissue-averaged effective doses will be reduced compared to point dose equivalent estimates because a large portion of the neutron point dose is due to low-energy neutrons with energies.
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| 13. |
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| 16. |
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| 19. |
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| 20. |
- Mueller, Stefanie H., et al.
(författare)
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Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry
- 2023
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Ingår i: Genome Medicine. - : BioMed Central (BMC). - 1756-994X. ; 15
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Tidskriftsartikel (refereegranskat)abstract
- Background: Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.Methods: We evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Gene-based associations were also combined in meta-analysis across individuals with European, Asian, African, and Latin American and Hispanic ancestry.Results: In European ancestry samples, 14 genes were significantly associated (q < 0.05) with BC. Of those, two genes, FMNL3 (P = 6.11 x 10(-6)) and AC058822.1 (P = 1.47 x 10(-4)), represent new associations. High FMNL3 expression has previously been linked to poor prognosis in several other cancers. Meta-analysis of samples with diverse ancestry discovered further associations including established candidate genes ESR1 and CBLB. Furthermore, literature review and database query found further support for a biologically plausible link with cancer for genes CBLB, FMNL3, FGFR2, LSP1, MAP3K1, and SRGAP2C.Conclusions: Using extended gene-based aggregation tests including coding and regulatory variation, we report identification of plausible target genes for previously identified single-marker associations with BC as well as the discovery of novel genes implicated in BC development. Including multi ancestral cohorts in this study enabled the identification of otherwise missed disease associations as ESR1 (P = 1.31 x 10(-5)), demonstrating the importance of diversifying study cohorts.
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| 21. |
- Pérez, Juana, et al.
(författare)
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The antibiotic crisis : How bacterial predators can help
- 2020
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Ingår i: Computational and Structural Biotechnology Journal. - : Elsevier BV. - 2001-0370. ; 18, s. 2547-2555
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Forskningsöversikt (refereegranskat)abstract
- Discovery of antimicrobials in the past century represented one of the most important advances in public health. Unfortunately, the massive use of these compounds in medicine and other human activities has promoted the selection of pathogens that are resistant to one or several antibiotics. The current antibiotic crisis is creating an urgent need for research into new biological weapons with the ability to kill these superbugs. Although a proper solution requires this problem to be addressed in a variety of ways, the use of bacterial predators is emerging as an excellent strategy, especially when used as whole cell therapeutic agents, as a source of new antimicrobial agents by awakening silent metabolic pathways in axenic cultures, or as biocontrol agents. Moreover, studies on their prey are uncovering mechanisms of resistance that can be shared by pathogens, representing new targets for novel antimicrobial agents. In this review we discuss potential of the studies on predator-prey interaction to provide alternative solutions to the problem of antibiotic resistance.
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| 22. |
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| 23. |
- Rafkin, Scot C.R., et al.
(författare)
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Diurnal variations of energetic particle radiation at the surface of Mars as observed by the Mars Science Laboratory Radiation Assessment Detector
- 2014
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Ingår i: Journal of Geophysical Research - Planets. - 2169-9097 .- 2169-9100. ; 119:6, s. 1345-1358
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Tidskriftsartikel (refereegranskat)abstract
- The Radiation Assessment Detector onboard the Mars Science Laboratory rover Curiosity is detecting the energetic particle radiation at the surface of Mars. Data collected over the first 350 Martian days of the nominal surface mission show a pronounced diurnal cycle in both the total dose rate and the neutral particle count rate. The diurnal variations detected by the Radiation Assessment Detector were neither anticipated nor previously considered in the literature. These cyclic variations in dose rate and count rate are shown to be the result of changes in atmospheric column mass driven by the atmospheric thermal tide that is characterized through pressure measurements obtained by the Rover Environmental Monitoring Station, also onboard the rover. In addition to bulk changes in the radiation environment, changes in atmospheric shielding forced by the thermal tide are shown to disproportionately affect heavy ions compared to H and He nuclei.
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| 24. |
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| 25. |
- Ullán, Aurora, et al.
(författare)
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Analysis of wind-induced dynamic pressure fluctuations during one and a half Martian years at Gale Crater
- 2017
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Ingår i: Icarus. - : Elsevier. - 0019-1035 .- 1090-2643. ; 288, s. 78-87
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Tidskriftsartikel (refereegranskat)abstract
- The Rover Environmental Monitoring Station (REMS) instrument on-board the Mars Science Laboratory (MSL) has acquired unprecedented measurements of key environmental variables at the base of Gale Crater. The pressure measured by REMS shows modulations with a very structured pattern of short-time scale (of the order of seconds to several minutes) mild fluctuations (typically up to 0.2 Pa at daytime and 1 Pa at night-time). These dynamic pressure oscillations are consistent with wind, air and ground temperature modulations measured simultaneously by REMS. We detect the signals of a repetitive pattern of upslope/downslope winds, with maximal speeds of about 21 m/s, associated with thermal changes in the air and surface temperatures, that are initiated after sunset and finish with sunrise proving that Gale, a 4.5 km deep impact crater, is an active Aeolian environment. At nighttime topographic slope winds are intense with maximal activity from 17:00 through 23:00 Local Mean Solar Time, and simultaneous changes of surface temperature are detected. During the day, the wind modulations are related to convection of the planetary boundary layer, winds are softer with maximum wind speed of about 14 m/s. The ground temperature is modulated by the forced convection of winds, with amplitudes between 0.2 K and 0.5 K, and the air temperatures fluctuate with amplitudes of about 2 K. The analysis of more than one and a half Martian years indicates the year-to-year repeatability of these environmental phenomena. The wind pattern minimizes at the beginning of the south hemisphere winter (Ls 90) season and maximizes during late spring and early summer (Ls 270). The procedure that we present here is a useful tool to investigate in a semi-quantitative way the winds by: i) filling both seasonal and diurnal gaps where wind measurements do not exist, ii) providing an alternative way for comparisons through different measuring principia and, iii) filling the gap of observation of short time-wind variability, where the REMS wind-sensor is blind
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| 26. |
- Webster, Christopher R., et al.
(författare)
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Background levels of methane in Mars' atmosphere show strong seasonal variations
- 2018
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Ingår i: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 360:6393, s. 1093-1096
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Tidskriftsartikel (refereegranskat)abstract
- Variable levels of methane in the martian atmosphere have eluded explanation partly because the measurements are not repeatable in time or location. We report in situ measurements at Gale crater made over a 5-year period by the Tunable Laser Spectrometer on the Curiosity rover. The background levels of methane have a mean value 0.41 ± 0.16 parts per billion by volume (ppbv) (95% confidence interval) and exhibit a strong, repeatable seasonal variation (0.24 to 0.65 ppbv). This variation is greater than that predicted from either ultraviolet degradation of impact-delivered organics on the surface or from the annual surface pressure cycle. The large seasonal variation in the background and occurrences of higher temporary spikes (~7 ppbv) are consistent with small localized sources of methane released from martian surface or subsurface reservoirs.
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| 27. |
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| 29. |
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| 30. |
- Abdullahi, Idris Nasir, et al.
(författare)
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Nasotracheal Microbiota of Nestlings of Parent White storks with Different Foraging Habits in Spain
- 2023
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Ingår i: EcoHealth. - 1612-9202. ; 20, s. 105-121
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Tidskriftsartikel (refereegranskat)abstract
- Migratory storks could be vectors of transmission of bacteria of public health concern mediated by the colonization, persistence and excretion of such bacteria. This study aims to determine genera/species diversity, prevalence, and co-colonization indices of bacteria obtained from tracheal (T) and nasal (N) samples from storks in relation to exposure to point sources through foraging. One-hundred and thirty-six samples from 87 nestlings of colonies of parent white storks with different foraging habits (natural habitat and landfills) were obtained (84 T-samples and 52 N-samples) and processed. Morphologically distinct colonies (up to 12/sample) were randomly selected and identified by MALDI-TOF-MS. About 87.2% of the total 806 isolates recovered were identified: 398 from T-samples (56.6%) and 305 from N-samples (43.4%). Among identified isolates, 17 genera and 46 species of Gram-positive and Gram-negative bacteria were detected, Staphylococcus (58.0%) and Enterococcus (20.5%) being the most prevalent genera. S. sciuri was the most prevalent species from T (36.7%) and N (34.4%) cavities of total isolates, followed by E. faecalis (11.1% each from T and N), and S. aureus [T (6.5%), N (13.4%)]. Of N-samples, E. faecium was significantly associated with nestlings of parent storks foraging in landfills (p = 0.018). S. sciuri (p = 0.0034) and M. caseolyticus (p = 0.032) from T-samples were significantly higher among nestlings of parent storks foraging in natural habitats. More than 80% of bacterial species in the T and N cavities showed 1–10% co-colonization indices with one another, but few had ≥ 40% indices. S. sciuri and E. faecalis were the most frequent species identified in the stork nestlings. Moreover, they were highly colonized by other diverse and potentially pathogenic bacteria. Thus, storks could be sentinels of point sources and vehicles of bacterial transmission across the “One Health” ecosystems.
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| 31. |
- Abelev, Betty, et al.
(författare)
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Long-range angular correlations on the near and away side in p-Pb collisions at root S-NN=5.02 TeV
- 2013
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 719:1-3, s. 29-41
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Tidskriftsartikel (refereegranskat)abstract
- Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p(T) bins, and the widths show no significant evolution with event multiplicity or p(T). These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge. (c) 2013 CERN. Published by Elsevier B.V. All rights reserved.
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| 32. |
- Abelev, Betty, et al.
(författare)
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Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :11
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Tidskriftsartikel (refereegranskat)abstract
- The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.
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| 33. |
- Abelev, Betty, et al.
(författare)
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Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :7
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.
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| 34. |
- Adamina, Michel, et al.
(författare)
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ECCO Guidelines on Therapeutics in Crohns Disease: Surgical Treatment
- 2020
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Ingår i: Journal of Crohn's & Colitis. - : OXFORD UNIV PRESS. - 1873-9946 .- 1876-4479. ; 14:2, s. 155-168
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Tidskriftsartikel (refereegranskat)abstract
- This article is the second in a series of two publications relating to the European Crohns and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohns disease. The first article covers medical management; the present article addresses surgical management, including preoperative aspects and drug management before surgery. It also provides technical advice for a variety of common clinical situations. Both articles together represent the evidence-based recommendations of the ECCO for Crohns disease and an update of previous guidelines.
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| 35. |
- Ahearn, Thomas U., et al.
(författare)
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Common variants in breast cancer risk loci predispose to distinct tumor subtypes
- 2022
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Ingår i: Breast Cancer Research. - : Springer Nature. - 1465-5411 .- 1465-542X. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundGenome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear.MethodsAmong 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes.ResultsEighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions.ConclusionThis report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction.
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| 36. |
- Arridge, Christopher S., et al.
(författare)
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Uranus Pathfinder : exploring the origins and evolution of Ice Giant planets
- 2012
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 33:2-3, s. 753-791
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Tidskriftsartikel (refereegranskat)abstract
- The "Ice Giants" Uranus and Neptune are a different class of planet compared to Jupiter and Saturn. Studying these objects is important for furthering our understanding of the formation and evolution of the planets, and unravelling the fundamental physical and chemical processes in the Solar System. The importance of filling these gaps in our knowledge of the Solar System is particularly acute when trying to apply our understanding to the numerous planetary systems that have been discovered around other stars. The Uranus Pathfinder (UP) mission thus represents the quintessential aspects of the objectives of the European planetary community as expressed in ESA's Cosmic Vision 2015-2025. UP was proposed to the European Space Agency's M3 call for medium-class missions in 2010 and proposed to be the first orbiter of an Ice Giant planet. As the most accessible Ice Giant within the M-class mission envelope Uranus was identified as the mission target. Although not selected for this call the UP mission concept provides a baseline framework for the exploration of Uranus with existing low-cost platforms and underlines the need to develop power sources suitable for the outer Solar System. The UP science case is based around exploring the origins, evolution, and processes at work in Ice Giant planetary systems. Three broad themes were identified: (1) Uranus as an Ice Giant, (2) An Ice Giant planetary system, and (3) An asymmetric magnetosphere. Due to the long interplanetary transfer from Earth to Uranus a significant cruise-phase science theme was also developed. The UP mission concept calls for the use of a Mars Express/Rosetta-type platform to launch on a Soyuz-Fregat in 2021 and entering into an eccentric polar orbit around Uranus in the 2036-2037 timeframe. The science payload has a strong heritage in Europe and beyond and requires no significant technology developments.
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| 37. |
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| 38. |
- Azua-Bustos, Armando, et al.
(författare)
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Aeolian transport of viable microbial life across the Atacama Desert, Chile : Implications for Mars
- 2019
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Ingår i: Scientific Reports. - : Springer. - 2045-2322. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Here we inspect whether microbial life may disperse using dust transported by wind in the Atacama Desert in northern Chile, a well-known Mars analog model. By setting a simple experiment across the hyperarid core of the Atacama we found that a number of viable bacteria and fungi are in fact able to traverse the driest and most UV irradiated desert on Earth unscathed using wind-transported dust, particularly in the later afternoon hours. This finding suggests that microbial life on Mars, extant or past, may have similarly benefited from aeolian transport to move across the planet and find suitable habitats to thrive and evolve.
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| 39. |
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| 40. |
- Bhardwaj, Anshuman, et al.
(författare)
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A review on remotely sensed land surface temperature anomaly as an earthquake precursor
- 2017
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Ingår i: International Journal of Applied Earth Observation and Geoinformation. - : Elsevier. - 1569-8432 .- 1872-826X. ; 63, s. 158-166
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Tidskriftsartikel (refereegranskat)abstract
- The low predictability of earthquakes and the high uncertainty associated with their forecasts make earthquakes one of the worst natural calamities, capable of causing instant loss of life and property. Here, we discuss the studies reporting the observed anomalies in the satellite-derived Land Surface Temperature (LST) before an earthquake. We compile the conclusions of these studies and evaluate the use of remotely sensed LST anomalies as precursors of earthquakes. The arrival times and the amplitudes of the anomalies vary widely, thus making it difficult to consider them as universal markers to issue earthquake warnings. Based on the randomness in the observations of these precursors, we support employing a global-scale monitoring system to detect statistically robust anomalous geophysical signals prior to earthquakes before considering them as definite precursors.
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| 41. |
- Bhardwaj, Anshuman, et al.
(författare)
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Are Slope Streaks Indicative of Global‐Scale Aqueous Processes on Contemporary Mars?
- 2019
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Ingår i: Reviews of geophysics. - : American Geophysical Union (AGU). - 8755-1209 .- 1944-9208. ; 57:1, s. 48-77
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Tidskriftsartikel (refereegranskat)abstract
- Slope streaks are prevalent and intriguing dark albedo surface features on contemporary Mars. Slope streaks are readily observed in the equatorial and subequatorial dusty regolith regions with low thermal inertia. They gradually fade over decadal timescales. The proposed mechanisms for their formation vary widely based on several physicochemical and geomorphological explanations. The scientific community is divided in proposing both dry and wet mechanisms for the formation of slope streaks. Here we perform a systematic evaluation of the literature for these wet and dry mechanisms. We discuss the probable constraints on the various proposed mechanisms and provide perspectives on the plausible process driving global‐scale slope streak formation on contemporary Mars. Although per our understanding, a thorough consideration of the global distribution of slope streaks, their morphology and topography, flow characteristics, physicochemical and atmospheric coincidences, and terrestrial analogies weighs more in favor of several wet mechanisms, we acknowledge that such wet mechanisms cannot explain all the reported morphological and terrain variations of slope streaks. Thus, we suggest that explanations considering both dry and wet processes can more holistically describe all the observed morphological variations among slope streaks. We further acknowledge the constraints on the resolutions of remote sensing data and on our understanding of the Martian mineralogy, climate, and atmosphere and recommend continuous investigations in this direction using future remote sensing acquisitions and simulations. In this regard, finding more wet and dry terrestrial analogs for Martian slope streaks and studying them at high spatiotemporal resolutions can greatly improve our understanding.
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| 42. |
- Bhardwaj, Anshuman, et al.
(författare)
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Discovery of recurring slope lineae candidates in Mawrth Vallis, Mars
- 2019
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Several interpretations of recurring slope lineae (RSL) have related RSL to the potential presence of transient liquid water on Mars. Such probable signs of liquid water have implications for Mars exploration in terms of rover safety, planetary protection during rover operations, and the current habitability of the planet. Mawrth Vallis has always been a prime target to be considered for Mars rover missions due to its rich mineralogy. Most recently, Mawrth Vallis was one of the two final candidates selected by the European Space Agency as a landing site for the ExoMars 2020 mission. Therefore, all surface features and landforms in Mawrth Vallis that may be of special interest in terms of scientific goals, rover safety, and operations must be scrutinised to better assess it for future Mars missions. Here, we report on the initial detection of RSL candidates in two craters of Mawrth Vallis. The new sightings were made outside of established RSL regions and further prompt the inclusion of a new geographical region within the RSL candidate group. Our inferences on the RSL candidates are based on several morphological and geophysical evidences and analogies: (i) the dimensions of the RSL candidates are consistent with confirmed mid-latitude RSL; (ii) albedo and thermal inertia values are comparable to those of other mid-latitude RSL sites; and (iii) features are found in a summer season image and on the steep and warmest slopes. These results denote the plausible presence of transient liquid brines close to the previously proposed landing ellipse of the ExoMars rover, rendering this site particularly relevant to the search of life. Further investigations of Mawrth Vallis carried out at higher spatial and temporal resolutions are needed to identify more of such features at local scales to maximize the scientific return from the future Mars rovers, to prevent probable biological contamination during rover operations, to evade damage to rover components as brines can be highly corrosive, and to quantify the ability of the regolith at mid-latitudes to capture atmospheric water which is relevant for in-situ-resource utilization.
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| 43. |
- Bhardwaj, Anshuman, et al.
(författare)
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Distribution and Morphologies of Transverse Aeolian Ridges in ExoMars 2020 Rover Landing Site
- 2019
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Ingår i: Remote Sensing. - : MDPI. - 2072-4292. ; 11:8
-
Tidskriftsartikel (refereegranskat)abstract
- Aeolian processes are believed to play a major role in the landscape evolution of Mars. Investigations on Martian aeolian landforms such as ripples, transverse aeolian ridges (TARs), and dunes, and aeolian sediment flux measurements are important to enhance our understanding of past and present wind regimes, the ongoing dust cycle, landscape evolution, and geochemistry. These aeolian bedforms are often comprised of loose sand and sharply undulating topography and thus pose a threat to mobility and maneuvers of Mars rovers. Here we present a first-hand account of the distribution, morphologies, and morphometrics of TARs in Oxia Planum, the recently selected ExoMars 2020 Rover landing site. The gridded mapping was performed for contiguous stretches of TARs within all the landing ellipses using 57 sub-meter high resolution imaging science experiment (HiRISE) scenes. We also provide the morphological descriptions for all types of TARs present within the landing ellipses. We use HiRISE digital terrain models (DTMs) along with the images to derive morphometric information for TARs in Oxia Planum. In general, the average areal TAR coverage was found to be 5.4% (±4.9% standard deviation), increasing from west to east within the landing ellipses. We report the average TAR morphometrics in the form of crest–ridge width (131.1 ± 106.2 m), down-wind TAR length (17.6 ± 10.1 m), wavelength (37.3 ± 11.6 m), plan view aspect ratio (7.1 ± 2.3), inter-bedform spacing (2.1 ± 1.1), slope (10.6° ± 6.1°), predominant orientations (NE-SW and E-W), and height (1.2 ± 0.8 m). While simple TARs are predominant, we report other TAR morphologies such as forked TAR, wavy TAR with associated smaller secondary ripples, barchan-like TAR, networked TAR, and mini-TARs from the region. Our results can help in planning the rover traverses in terms of both safe passage and scientific returns favoring aeolian research, particularly improving our understanding of TARs.
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| 44. |
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| 45. |
- Bhardwaj, Anshuman, et al.
(författare)
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LiDAR remote sensing of the cryosphere : Present applications and future prospects
- 2016
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Ingår i: Remote Sensing of Environment. - : Elsevier BV. - 0034-4257 .- 1879-0704. ; 177, s. 125-143
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Tidskriftsartikel (refereegranskat)abstract
- The cryosphere consists of frozen water and includes lakes/rivers/sea ice, glaciers, ice caps/sheets, snow cover, and permafrost. Because highly reflective snow and ice are the main components of the cryosphere, it plays an important role in the global energy balance. Thus, any qualitative or quantitative change in the physical properties and extents of the cryosphere affects global air circulation, ocean and air temperatures, sea level, and ocean current patterns. Due to the hardships involved in collecting ground control points and field data for high alpine glaciers or vast polar ice sheets, several researchers are currently using remote sensing. Satellites provide an effective space-borne platform for remotely sensing frozen areas at the global and regional scales. However, satellite remote sensing has several constraints, such as limited spatial and temporal resolutions and expensive data acquisition. Therefore, aerial and terrestrial remote sensing platforms and sensors are needed to cover temporal and spatial gaps for comprehensive cryospheric research. Light Detection and Ranging (LiDAR) antennas form a group of active remote sensors that can easily be deployed on all three platforms, i.e., satellite, aerial, and terrestrial. The generation of elevation data for glacial and snow-covered terrain from photogrammetry requires high contrast amongst various reflective surfaces (ice, snow, firn, and slush). Conventional passive optical remote sensors do not provide the necessary accuracy, especially due to the unavailability of reliable ground control points. However, active LiDAR sensors can fill this research gap and provide high-resolution and accurate Digital Elevation Models (DEMs). Due to the obvious advantages of LiDAR over conventional passive remote sensors, the number of LiDAR-based cryospheric studies has increased in recent years. In this review, we highlight studies that have utilised LiDAR sensors for the cryospheric research of various features, such as snow cover, polar ice sheets and their atmospheres, alpine glaciers, and permafrost. Because this technology shows immense promise for applications in future cryospheric research, we also emphasise the prospects of utilising LiDAR sensors. In this paper, a large compilation of relevant references is presented to allow readers to explore particular topics of interest.
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| 46. |
- Bhardwaj, Anshuman, et al.
(författare)
-
Martian slope streaks as plausible indicators of transient water activity
- 2017
-
Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 7:1
-
Tidskriftsartikel (refereegranskat)abstract
- Slope streaks have been frequently observed in the equatorial, low thermal inertia and dusty regions of Mars. The reason behind their formation remains unclear with proposed hypotheses for both dry and wet mechanisms. Here, we report an up-to-date distribution and morphometric investigation of Martian slope streaks. We find: (i) a remarkable coexistence of the slope streak distribution with the regions on Mars with high abundances of water-equivalent hydrogen, chlorine, and iron; (ii) favourable thermodynamic conditions for transient deliquescence and brine development in the slope streak regions; (iii) a significant concurrence of slope streak distribution with the regions of enhanced atmospheric water vapour concentration, thus suggestive of a present-day regolith-atmosphere water cycle; and (iv) terrain preferences and flow patterns supporting a wet mechanism for slope streaks. These results suggest a strong local regolith-atmosphere water coupling in the slope streak regions that leads to the formation of these fluidised features. Our conclusions can have profound astrobiological, habitability, environmental, and planetary protection implications
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| 47. |
- Bhardwaj, Anshuman, et al.
(författare)
-
MODIS-based estimates of strong snow surface temperature anomaly related to high altitude earthquakes of 2015
- 2017
-
Ingår i: Remote Sensing of Environment. - : Elsevier. - 0034-4257 .- 1879-0704. ; 188, s. 1-8
-
Tidskriftsartikel (refereegranskat)abstract
- The high levels of uncertainty associated with earthquake prediction render earthquakes some of the worst natural calamities. Here, we present our observations of MODerate resolution Imaging Spectroradiometer (MODIS)-derived Land Surface Temperature (LST) anomaly for earthquakes in the largest tectonically active Himalayan and Andean mountain belts. We report the appearance of fairly detectable pre-earthquake Snow Surface Temperature (SST) anomalies. We use 16 years (2000–2015) of MODIS LST time-series data to robustly conclude our findings for three of the most destructive earthquakes that occurred in 2015 in the high mountains of Nepal, Chile, and Afghanistan. We propose the physical basis behind higher sensitivity of snow towards geothermal emissions. Although the preliminary appearance of SST anomalies and their amplitudes vary, we propose employing a global-scale monitoring system for detecting and studying such spatio-temporal geophysical signals. With the advent of improved remote sensors, we anticipate that such efforts can be another step towards improved earthquake predictions.
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| 48. |
- Bhardwaj, Anshuman, et al.
(författare)
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Revisiting enigmatic Martian slope streaks
- 2019
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Ingår i: Earth Space and Science News - Editors Vox. - : American Geophysical Union (AGU). ; 100
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 49. |
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| 50. |
- Bhardwaj, Anshuman, et al.
(författare)
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The challenges and possibilities of earthquake predictions using non-seismic precursors
- 2021
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Ingår i: The European Physical Journal Special Topics. - : Springer. - 1951-6355 .- 1951-6401. ; 230:1, s. 367-380
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Forskningsöversikt (refereegranskat)abstract
- The catastrophic magnitude of life and monetary losses associated with earthquakes deserve serious attention and mitigation measures. However, in addition to the pre-earthquake and post-earthquake alleviation actions, the scientific community indeed needs to reconsider the possibilities of earthquake predictions using non-seismic precursors. A significant number of studies in the recent decades have reported several possible earthquake precursors such as anomalies in electric field, magnetic field, gas/aerosol emissions, ionospheric signals, ground water level, land surface temperature, surface deformations, animal behaviour, thermal infrared signals, atmospheric gravity waves, and lightning. Such substantial number of scientific articles and reported anomalous signals cannot be overlooked without a thoughtful appraisal. Here, we provide an opinion on the way forward for earthquake prediction in terms of challenges and possibilities while using non-seismic precursors. A general point of concern is the widely varying arrival times and the amplitudes of the anomalies, putting a question mark on their universal applicability as earthquake markers. However, a unifying concept which does not only define the physical basis of either all or most of these anomalies but which also streamlines their characterisation procedure must be the focus of future earthquake precursory research. Advancements in developing the adaptable instrumentation for in-situ observations of the claimed non-seismic precursors must be the next step and the satellite observations should not be taken as a replacement for field-based research. We support the need to standardise the precursor detection techniques and to employ a global-scale monitoring system for making any possible earthquake predictions reliable.
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