| 1. |
- Dao, Trong Tuan, et al.
(författare)
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Resveratrol suppressed lps-induced cox-2 VIA miR-146a-5p inhibition in raw246.7 cells
- 2017
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Ingår i: Farmacia. - 0014-8237. ; 65:2, s. 214-218
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Tidskriftsartikel (refereegranskat)abstract
- Trans-resveratrol (Res) is a well-known natural stilbene frequently found in grapes which have been reported to possess antioxidant, anti-cancer activities and inhibited COX-2 expression. MicroRNAs (miRNAs) are short endogenous non-coding RNAs involved in the regulation of mRNA stability and protein synthesis. In our research, resveratrol isolated from Vitis heyneana Roem. & Schult Vitis heyneana was observed to suppress lipopolysaccharides (LPS)-induced COX-2 expression in Raw264.7 cells in a dose dependent manner. Using qPCR it was revealed that LPS induced the expression of miR-25, miR- 125a, miR-125b, miR-146a-5p, miR-146a-3p and miR-455. However, we only observed miR-146a-5p expression significantly decreased in resveratrol compared to untreated-control group. In addition, resveratrol abrogated the effect of miR-146a-5p mimic induced-COX-2 expression in Raw264.7 cells. Taken together, this study demonstrated for the first time the involvement of miR-146a-5p in resveratrol inhibited LPS-induced COX-2 expression in Raw264.7 cells.
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| 2. |
- Ha, Do Thi, et al.
(författare)
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Anti-inflammatory effect of oligostilbenoids from Vitis heyneana in LPS-stimulated RAW 264.7 macrophages via suppressing the NF-ΚB activation
- 2018
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Ingår i: Chemistry Central Journal. - : Springer Science and Business Media LLC. - 1752-153X. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property. Results: Bioassay-guided fractionation of the EtOAc soluble fraction from the aerial part of Vitis heyneana resulted in the isolation of a series of oligostilbenoids as piceid (1), 2-r-viniferin (2), betulifol A (3), vitisinol C (4), (-)-trans-ε-viniferin (5), α-viniferin (6), shoreaketon (7), amurensin B (8), vitisinol B (9), and cis-vitisin B (10). Compound 5 showed the most potent inhibitory activities by suppressing LPS-induced COX-2 expression and PGE2 production. This compound exhibited significantly reduced LPS-induced nitric oxide (NO) release in a dose-dependent manner. These effects are accompanied with the inhibition of transcription factor NF-ΚB activation. Conclusion: The results suggested that trans-ε-viniferin exerts anti-inflammatory effects via suppression the NF-ΚB activation in RAW 264.7 cells. [Figure not available: see fulltext.]
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| 3. |
- Nguyen, Viet-Tien, et al.
(författare)
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GIS Based Novel Hybrid Computational Intelligence Models for Mapping Landslide Susceptibility : A Case Study at Da Lat City, Vietnam
- 2019
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Ingår i: Sustainability. - Switzerland : MDPI. - 2071-1050. ; 11:24
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Tidskriftsartikel (refereegranskat)abstract
- Landslides affect properties and the lives of a large number of people in many hilly parts of Vietnam and in the world. Damages caused by landslides can be reduced by understanding distribution, nature, mechanisms and causes of landslides with the help of model studies for better planning and risk management of the area. Development of landslide susceptibility maps is one of the main steps in landslide management. In this study, the main objective is to develop GIS based hybrid computational intelligence models to generate landslide susceptibility maps of the Da Lat province, which is one of the landslide prone regions of Vietnam. Novel hybrid models of alternating decision trees (ADT) with various ensemble methods, namely bagging, dagging, MultiBoostAB, and RealAdaBoost, were developed namely B-ADT, D-ADT, MBAB-ADT, RAB-ADT, respectively. Data of 72 past landslide events was used in conjunction with 11 landslide conditioning factors (curvature, distance from geological boundaries, elevation, land use, Normalized Difference Vegetation Index (NDVI), relief amplitude, stream density, slope, lithology, weathering crust and soil) in the development and validation of the models. Area under the receiver operating characteristic (ROC) curve (AUC), and several statistical measures were applied to validate these models. Results indicated that performance of all the models was good (AUC value greater than 0.8) but B-ADT model performed the best (AUC= 0.856). Landslide susceptibility maps generated using the proposed models would be helpful to decision makers in the risk management for land use planning and infrastructure development.
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| 4. |
- Hien Tran, Thi, et al.
(författare)
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Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway
- 2016
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Ingår i: Biomedical and Pharmacology Journal. - : Oriental Scientific Publishing Company. - 0974-6242. ; 9:2, s. 519-524
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Tidskriftsartikel (refereegranskat)abstract
- p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells.
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