| 1. |
- McNabb, B, et al.
(författare)
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Using surface velocities to infer ice thickness and bed topography : A case study a Columbia Glacier, Alaska, USA
- 2012
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Ingår i: Journal of Glaciology. - 0022-1430 .- 1727-5652. ; 58:212, s. 1151-1164
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Tidskriftsartikel (refereegranskat)abstract
- Information about glacier volume and ice thickness distribution is essential for manyglaciological applications, but direct measurements of ice thickness can be diffcult and costly. Wepresent a new method that calculates ice thickness via an estimate of ice fux. We solve the familiarcontinuity equation between adjacent fowlines, which decreases the computational time requiredcompared to a solution on the whole grid. We test the method on Columbia Glacier, a large tidewaterglacier in Alaska, USA, and compare calculated and measured ice thicknesses, with favorable results.This shows the potential of this method for estimating ice thickness distribution of glaciers for whichonly surface data are available. We fnd that both the mean thickness and volume of Columbia Glacierwere approximately halved over the period 1957–2007, from 281m to 143m, and from 294km3to134km3, respectively. Using bedrock slope and considering how waves of thickness change propagatethrough the glacier, we conduct a brief analysis of the instability of Columbia Glacier, which leads usto conclude that the rapid portion of the retreat may be nearing an end.
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| 2. |
- Bergek, Anna, 1973, et al.
(författare)
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Technological innovation systems in contexts: Conceptualizing contextual structures and interaction dynamics
- 2015
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Ingår i: Environmental Innovation and Societal Transitions. - : Elsevier BV. - 2210-4224 .- 2210-4232. ; 16, s. 51-64
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Tidskriftsartikel (refereegranskat)abstract
- This paper addresses interactions between technological innovation systems (TIS) and wider "context structures". While TIS studies have always considered various kinds of contextual influences, we suggest that the TIS framework can be further strengthened by a more elaborated conceptualization of TIS context structures and TIS-context interactions. For that purpose, we identify and discuss four especially important types of context structures: technological, sectorial, geographical and political. For each of these, we provide examples of different ways in which context structures can interact with a focal TIS and how our understanding of TIS dynamics is enhanced by considering them explicitly. Lessons for analysts are given and a research agenda is outlined.
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| 3. |
- Cherunya, Pauline C., et al.
(författare)
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Anchoring innovations in oscillating domestic spaces: Why sanitation service offerings fail in informal settlements
- 2020
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Ingår i: Research Policy. - : Elsevier BV. - 0048-7333. ; 49:1
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Tidskriftsartikel (refereegranskat)abstract
- A persistent conundrum for practitioners and researchers in the development context is that, often, newly provided and improved basic services are not maintained by users despite seemingly superior functionality and user convenience. We argue that one major reason for this is an insufficient understanding of the context in which users have to manage their daily lives. We therefore propose an approach to analysing the embedding of basic services that focuses on the users’ daily practices. We do so by borrowing insights from ‘socio-technical transitions’ and ‘practice theory’ in developing our concept of oscillating domestic spaces. The concept reflects the need for people to constantly respond to quickly changing and precarious circumstances by rearranging their daily practices in time and space and developing a multiplicity of alternative options and partial solutions. We illustrate the analytical approach in a case study of sanitation access in informal settlements of Nairobi, Kenya. The analysis shows how the introduction of a container-based toilet resulted in partial embedding. The innovation anchored to only a part of the oscillating domestic spaces and was in disarray with the needs of users most of the time. The conceptual approach contributes to the understanding about how users take part in sustainability transitions as well as the added value of the time-space dimension in analysing practices in highly complex contexts. We conclude by reflecting on the potential applicability of the analytical approach to transition cases in the Global North.
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| 4. |
- Ye, Zilu, et al.
(författare)
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One-Tip enables comprehensive proteome coverage in minimal cells and single zygotes
- 2024
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- Mass spectrometry (MS)-based proteomics workflows typically involve complex, multi-step processes, presenting challenges with sample losses, reproducibility, requiring substantial time and financial investments, and specialized skills. Here we introduce One-Tip, a proteomics methodology that seamlessly integrates efficient, one-pot sample preparation with precise, narrow-window data-independent acquisition (nDIA) analysis. One-Tip substantially simplifies sample processing, enabling the reproducible identification of >9000 proteins from ~1000 HeLa cells. The versatility of One-Tip is highlighted by nDIA identification of ~6000 proteins in single cells from early mouse embryos. Additionally, the study incorporates the Uno Single Cell Dispenser™, demonstrating the capability of One-Tip in single-cell proteomics with >3000 proteins identified per HeLa cell. We also extend One-Tip workflow to analysis of extracellular vesicles (EVs) extracted from blood plasma, demonstrating its high sensitivity by identifying >3000 proteins from 16 ng EV preparation. One-Tip expands capabilities of proteomics, offering greater depth and throughput across a range of sample types.
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