| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Brown D., Juhlin C., Tryggvason A., Steer D., Ayarza P., Beckholmen M., Rybalka A. and Bliznetsov M.
(author)
-
The Crustal Architecture of the Southern and Middle Urals from the URSEIS, ESRU, and Alapaev Reflection Seismic Profiles, in Orogenic Processes in the Paleozoic Uralides
- 2002
-
In: Geophysical Monograph Series, AGU. ; , s. 33-48
-
Journal article (peer-reviewed)
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
- Leosson, K., et al.
(author)
-
Comparing resonant photon tunneling via cavity modes and Tamm plasmon polariton modes in metal-coated Bragg mirrors
- 2012
-
In: Optics Letters. - 0146-9592 .- 1539-4794. ; 37:19, s. 4026-4028
-
Journal article (peer-reviewed)abstract
- Resonant photon tunneling was investigated experimentally in multilayer structures containing a high-contrast (TiO2/SiO2) Bragg mirror capped with a semitransparent gold film. Transmission via a fundamental cavity resonance was compared with transmission via the Tamm plasmon polariton resonance that appears at the interface between a metal film and a one-dimensional photonic bandgap structure. The Tamm-plasmon-mediated transmission exhibits a smaller dependence on the angle and polarization of the incident light for similar values of peak transmission, resonance wavelength, and finesse. Implications for transparent electrical contacts based on resonant tunneling structures are discussed.
|
|
| 16. |
- Malehmir, A., et al.
(author)
-
Seismic imaging in the Skellefte ore district, northern Sweden
- 2005
-
In: 20th World Mining Congress, November 7-11, 2005, Tehran, Iran. - Teheran : Geological Survey of Iran. ; , s. 399-404
-
Conference paper (peer-reviewed)abstract
- In the western part of the Skellefte ore district, which is the most important metallogenic zone in Northern Sweden, several world class mines, e.g., the Kristineberg VMS mine (20.1mt, Cu-Zn-Pb-Ag-Au) are situated. In order to understand why these deposits occur where they do, it is important to understand the crustal architecture of the region. One way to understand the contact relationships between the ore bearing volcanic formations and the surrounding rocks is to develop a detailed 3-D geological model of the region. To establish the structural geologic framework at depth, new seismic reflection data were acquired along two profiles in the Kristineberg area in late August and early September 2003. Data along the two seismic profiles (Profile 1 and Profile 5), each about 25 km long and running in parallel, were collected with the purpose of obtaining high resolution images of the top 10 km of the crust. Although the structural geology is very complex, preliminary stacked sections of the data have revealed numerous reflections which can be correlated with surface geology. Results along Profile 1, which passes on top of the Kristineberg mine show the mine to be located in a major synform extending down to about 2.5-3 km depth. The structure and stratigraphy of the Kristineberg area have been debated for many years. Our seismic results suggest that the deposits occur on the northern limb of a regional syncline. The results help to identify new prospective areas, both down-plunge from known ores, and on the southern limb of the ore-bearing syncline. The results for Profile 5 show that the Revsund granite can have a thickness about 3-3.5 km but not more. Ultramafic rocks are imaged clearly. Diffraction patterns can be interpreted as orienting from either a mafic-ultramafic intrusion or a mineralization zone. A detailed study has to be done in order to determine the source of this reflectivity. In this study seismic reflection profiling has been particularly effective for imaging the major structures around the ore body, demonstrating that the seismic-reflection technique can be used for delineating complex structures that are significant in mineral exploration.
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
- Marti, J., et al.
(author)
-
Stress barriers controlling lateral migration of magma revealed by seismic tomography
- 2017
-
In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
-
Journal article (peer-reviewed)abstract
- Understanding how monogenetic volcanic systems work requires full comprehension of the local and regional stresses that govern magma migration inside them and why/how they seem to change from one eruption to another. During the 2011-2012 El Hierro eruption (Canary Islands) the characteristics of unrest, including a continuous change in the location of seismicity, made the location of the future vent unpredictable, so short term hazard assessment was highly imprecise. A 3D P-wave velocity model is obtained using arrival times of the earthquakes occurred during that pre-eruptive unrest and several latter post-eruptive seismic crises not related to further eruptions. This model reveals the rheological and structural complexity of the interior of El Hierro volcanic island. It shows a number of stress barriers corresponding to regional tectonic structures and blocked pathways from previous eruptions, which controlled ascent and lateral migration of magma and, together with the existence of N-S regional compression, reduced its options to find a suitable path to reach the surface and erupt.
|
|
| 21. |
|
|
| 22. |
- Oblander, S A, et al.
(author)
-
Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation
- 2005
-
In: Developmental Biology. - : Elsevier BV. - 1095-564X .- 0012-1606. ; 277:1, s. 255-269
-
Journal article (peer-reviewed)abstract
- Membrane type 1-matrix metalloprotease (MT1-MMP or MMP-14) is a major activator of pro-MMP-2 and is essential for skeletal development. We show here that it is required for branching morphogenesis of the submandibular gland but not the lung. Instead, in the lung, it is essential for postnatal development of alveolar septae. Lung development in Mmp14-/- mice is arrested at the prealveolar stage with compensatory hyperinflation of immature saccules. Mmp2-/- mice lacked comparable defects in the lung and submandibular gland, suggesting that NIT1-MMP acts via mechanisms independent of pro-MMP-2 activation. Since the developmental defects in the lung are first manifest around the time of initial vascularization (E16.5), we investigated the behavior of pulmonary endothelial cells from Mmp14+/+ and Mmp14-/- mice. Endothelial cells from lungs of 1-week-old Mmp14-/- mice show reduced migration and formation of three-dimensional structures on Matrigel. Since pulmonary septal development requires capillary growth, the underlying mechanism of pulmonary hypoplasia in Mmp14-/- mice may be defective angiogenesis, supporting a model in which angiogenesis is a critical rate-limiting step for acquisition of pulmonary parenchymal mass.
|
|
| 23. |
- Palecanda, A, et al.
(author)
-
Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles
- 1999
-
In: The Journal of experimental medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 189:9, s. 1497-1506
-
Journal article (peer-reviewed)abstract
- Alveolar macrophages (AMs) avidly bind and ingest unopsonized environmental particles and bacteria through scavenger-type receptors (SRs). AMs from mice with a genetic deletion of the major macrophage SR (types AI and AII; SR−/−) showed no decrease in particle binding compared with SR+/+ mice, suggesting that other SRs are involved. To identify these receptors, we generated a monoclonal antibody (mAb), PAL-1, that inhibits hamster AM binding of unopsonized particles (TiO2, Fe2O3, and latex beads; 66 ± 5, 77 ± 2, and 85 ± 2% inhibition, respectively, measured by flow cytometry). This antibody identifies a protein of ∼70 kD on the AM surface (immunoprecipitation) that is expressed by AMs and other macrophages in situ. A cDNA clone encoding the mAb PAL-1–reactive protein isolated by means of COS cell expression was found to be 84 and 77% homologous to mouse and human scavenger receptor MARCO mRNA, respectively. Transfection of COS cells with MARCO cDNA conferred mAb-inhibitable TiO2 binding. Hamster MARCO also mediates AM binding of unopsonized bacteria (67 ± 5 and 47 ± 4% inhibition of Escherichia coli and Staphylococcus aureus binding by mAb PAL-1). A polyclonal antibody to human MARCO identified the expected ∼70-kD band on Western blots of lysates of normal bronchoalveolar lavage (BAL) cells (>90% AMs) and showed strong immunolabeling of human AMs in BAL cytocentrifuge preparations and within lung tissue specimens. In normal mouse AMs, the anti-MARCO mAb ED31 also showed immunoreactivity and inhibited binding of unopsonized particles (e.g., TiO2 ∼40%) and bacteria. The novel function of binding unopsonized environmental dusts and pathogens suggests an important role for MARCO in the lungs' response to inhaled particles.
|
|
| 24. |
|
|
| 25. |
|
|
| 26. |
|
|
| 27. |
|
|
| 28. |
- Sandholm, Niina, et al.
(author)
-
New susceptibility loci associated with kidney disease in type 1 diabetes
- 2012
-
In: PLOS Genetics. - San Francisco, USA : Public Library of Science, PLOS. - 1553-7390 .- 1553-7404. ; 8:9, s. e1002921-
-
Journal article (peer-reviewed)abstract
- Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation. In addition to the decrease in the quality of life, DN accounts for a large proportion of the excess mortality associated with type 1 diabetes (T1D). Whereas the degree of glycemia plays a pivotal role in DN, a subset of individuals with poorly controlled T1D do not develop DN. Furthermore, strong familial aggregation supports genetic susceptibility to DN. However, the genes and the molecular mechanisms behind the disease remain poorly understood, and current therapeutic strategies rarely result in reversal of DN. In the GEnetics of Nephropathy: an International Effort (GENIE) consortium, we have undertaken a meta-analysis of genomewide association studies (GWAS) of T1D DN comprising similar to 2.4 million single nucleotide polymorphisms (SNPs) imputed in 6,691 individuals. After additional genotyping of 41 top ranked SNPs representing 24 independent signals in 5,873 individuals, combined meta-analysis revealed association of two SNPs with ESRD: rs7583877 in the AFF3 gene (P = 1.2 x 10(-8)) and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, rs12437854 (P = 2.0 x 10(-9)). Functional data suggest that AFF3 influences renal tubule fibrosis via the transforming growth factor-beta (TGF-beta 1) pathway. The strongest association with DN as a primary phenotype was seen for an intronic SNP in the ERBB4 gene (rs7588550, P = 2.1 x 10(-7)), a gene with type 2 diabetes DN differential expression and in the same intron as a variant with cis-eQTL expression of ERBB4. All these detected associations represent new signals in the pathogenesis of DN.
|
|
| 29. |
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
|
|
| 33. |
- Agnarsson, Björn, 1977, et al.
(author)
-
Rutile TiO 2 thin films grown by reactive high power impulse magnetron sputtering
- 2013
-
In: Thin Solid Films. - : Elsevier BV. - 0040-6090 .- 1879-2731. ; 545, s. 445-450
-
Journal article (peer-reviewed)abstract
- Thin TiO 2 films were grown on Si(001) substrates by reactive dc magnetron sputtering (dcMS) and high power impulse magnetron sputtering (HiPIMS) at temperatures ranging from 300 to 700 C.Optical and structural properties of films were compared both before and after post-annealing using scanning electron microscopy, low angle X-ray reflection (XRR), grazing inc idence X-ray diffractometry and spectroscopic ellipsometry.Both dcMS- and HiPIMS-grown films reveal polycrystalline rutile TiO 2 , even prior to post-annealing.The HiPIMS-grown films exhibit significantly larger grains compared to that of dcMC-grown films, approaching 100% of the film thickness for films grown at 700 C.In addition, the XRR surface roughness of HiPIMS-grown films was significantly lower than that of dcMS-grown films over the whole temperature range 300-700 C.Dispersion curves could only be obtained for the HiPIMS-grown films, which were shown to have a refractive index in the range of 2.7-2.85 at 500 nm.The results show that thin, rutile TiO 2 films, with high refractive index, can be obtained by HiPIMS at relatively low growth temperatures, without post-annealing.Furthermore, these films are smoother and show better optical characteristics than their dcMS-grown counterparts.© 2013 Elsevier B.V.All rights reserved.
|
|
| 34. |
- Bergman, B., et al.
(author)
-
High resolution seismic traveltime tomography incorporating static corrections applied to a till covered bedrock environment
- 2004
-
In: Geophysics. - : Society of Exploration Geophysicists. - 0016-8033 .- 1942-2156. ; 69, s. 1082-1090
-
Journal article (peer-reviewed)abstract
- A major obstacle in tomographic inversion is near-surface velocity variations. Such shallow velocity variations need to be known and correctly accounted for to obtain images of deeper structures with high resolution and quality. Bedrock cover in many areas consists of unconsolidated sediments and glacial till. To handle the problems associated with this cover, we present a tomographic method that solves for the 3D velocity structure and receiver static corrections simultaneously. We test the method on first-arrival picks from deep seismic reflection data acquired in the mid- late to 1980s in the Siljan Ring area, central Sweden. To use this data set successfully, one needs to handle a number of problems, including time-varying, near-surface velocities from data recorded in winter and summer, several sources and receivers within each inversion cell, varying thickness of the cover layer in each inversion cell, and complex 3D geology. Simultaneous inversion for static corrections and velocity produces a much better image than standard tomography without statics. The velocity model from the simultaneous inversion is superior to the velocity model produced using refraction statics obtained from standard reflection seismic processing prior to inversion. Best results using the simultaneous inversion are obtained when the initial top velocity layer is set to the near-surface bedrock velocity rather than the velocity of the cover. The resulting static calculations may, in the future, be compared to refraction static corrections in standard reflection seismic processing. The preferred final model shows a good correlation with the mapped geology and the airborne magnetic map.
|
|
| 35. |
|
|
| 36. |
|
|
| 37. |
|
|
| 38. |
|
|
| 39. |
- Brown, D., et al.
(author)
-
Mountain building processes during continent-continent collision in the Uralides
- 2008
-
In: Earth-Science Reviews. - : Elsevier BV. - 0012-8252 .- 1872-6828. ; 89:3-4, s. 177-195
-
Journal article (peer-reviewed)abstract
- Since the early 1990's the Paleozoic Uralide Orogen of Russia has been the target of a significant research initiative as part of EUROPROBE and GEODE, both European Science Foundation programmes. One of the main objectives of these research programmes was the determination of the tectonic processes that went into the formation of the orogen. In this review paper we focus on the Late Paleozoic continent-continent collision that took place between Laurussia and Kazakhstania. Research in the Uralides was concentrated around two deep seismic profiles crossing the orogen. These were accompanied by geological, geophysical, geochronological, geochemical, and low-temperature thermochronological studies. The seismic profiles demonstrate that the Uralides has an overall bivergent structural architecture, but with significantly different reflectivity characteristics from one tectonic zone to another. The integration of other types of data sets with the seismic data allows us to interpret what tectonic processes where responsible for the formation of the structural architecture, and when they were active. On the basis of these data, we suggest that the changes in the crustal-scale structural architecture indicate that there was significant partitioning of tectonothermal conditions and deformation from zone to zone across major fault systems, and between the lower and upper crust. Also, a number of the structural features revealed in the bivergent architecture of the orogen formed either in the Neoproterozoic or in the Paleozoic, prior to continent-continent collision. From the end of continent-continent collision to the present, low-temperature thermochronology suggests that the evolution of the Uralides has been dominated by erosion and slow exhumation. Despite some evidence for more recent topographic uplift, it has so far proven difficult to quantify it.
|
|
| 40. |
|
|
| 41. |
|
|
| 42. |
- Domogatskaya, A, et al.
(author)
-
Functional diversity of laminins
- 2012
-
In: Annual review of cell and developmental biology. - : Annual Reviews. - 1530-8995 .- 1081-0706. ; 28, s. 523-553
-
Journal article (peer-reviewed)abstract
- Laminins are a large family of conserved, multidomain trimeric basement membrane proteins that contribute to the structure of extracellular matrix and influence the behavior of associated cells, such as adhesion, differentiation, migration, phenotype stability, and resistance to anoikis. In lower organisms such as Hydra there is only one isoform of laminin, but higher organisms have at least 16 trimeric isoforms with varying degrees of cell/tissue specificity. In vitro protein and cell culture studies, gene manipulation in animals, and laminin gene mutations in human diseases have provided insight into the specific functions of some laminins, but the biological roles of many isoforms are still largely unexplored, mainly owing to difficulties in isolating them in pure form from tissues or cells. In this review, we elucidate the evolution of laminins, describe their molecular complexity, and explore the current knowledge of their diversity and functional aspects, including laminin-mediated signaling via membrane receptors, in vitro cell biology, and involvement in various tissues gained from animal model and human disease studies. The potential use of laminins in cell biology research and biotechnology is discussed.
|
|
| 43. |
|
|
| 44. |
|
|
| 45. |
|
|
| 46. |
|
|
| 47. |
|
|
| 48. |
|
|
| 49. |
|
|
| 50. |
|
|
