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- Skorpil, M., et al.
(author)
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Soft-tissue fat tumours : differentiating malignant from benign using proton density fat fraction quantification MRI
- 2019
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In: Clinical Radiology. - : Saunders Elsevier. - 0009-9260 .- 1365-229X. ; 74:7, s. 534-538
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Journal article (peer-reviewed)abstract
- Aim: To evaluate if quantifying proton density fat fraction (PDFF) would be useful in separating lipoma, atypical lipomatous tumour (ALT) and liposarcoma in the extremities and trunk. In addition, differentiating ALT versus non-classical lipomas using magnetic resonance imaging (MRI)-based fatty acidcomposition (FAC) and three-dimensional (3D) texture analysis was tested.Material and methods: This prospective study (undertaken between 2014–2017; comprising 20 women, 21 men) was approved by the Regional Ethical Review Board and informed consent was obtained from all participants. For PDFF and FAC 3D spoiled gradient multi-echo images were acquired. PDFF was analysed in 16 lipomas (25–76 years), 14 ALTs (42–78 years) and 11 myxoid liposarcomas (31–68 years). The difference of mean PDFF was tested with one-way analysis of variance. A support vector machine algorithm was used to find the separating mean PDFF values.Results: Mean PDFF for lipomas was 90% (range 76–98%), for ALT 83% (range 62–91%), and for liposarcoma 4% (range 0–21%). The difference of mean PDFF for liposarcomas versus ALT and lipoma was significant (p=0.0001, for both), and for ALT versus lipoma (p=0.021). The optimal threshold for separating liposarcoma from ALT and lipoma was 41.5%, and for ALT and lipoma 85%. Texture analysis could not separate ALT and non-classical lipomas, while the difference for FAC unsaturation degree was significant (p=0.013).Conclusion: Measuring PDFF is a promising complement to standard MRI, to separate liposarcomas from ALT and lipomas. Lipomas that are not solely composed of fat cannot confidently be separated from ALT using PDFF, FAC, or texture analysis.
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| 2. |
- Braumann, L, et al.
(author)
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Femoral Metastasis from Penile Carcinoma: Report of 2 Cases
- 2015
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In: Case reports in urology. - : Hindawi Limited. - 2090-696X .- 2090-6978. ; 2015, s. 583851-
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Journal article (peer-reviewed)abstract
- Purpose. Penile cancer rarely gives symptomatic skeletal metastases.Methods. We present 2 patients with squamous carcinoma of the penis who were surgically treated for metastases in the femur.Results. Both patients had pathological fractures and were operated on. In one case, the skeletal metastasis preceded any lymphatic spread of the disease, suggesting early haematogenous dissemination.Conclusions. Endoprosthetic reconstruction resulted in pain relief and restored the ambulatory capacity. Clinicians should be aware of the possibility for symptomatic bone metastases with a risk for pathological fracture in patients with penile cancer.
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