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Träfflista för sökning "WFRF:(Turina M.) "

Search: WFRF:(Turina M.)

  • Result 1-16 of 16
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  • 2021
  • swepub:Mat__t
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  • Tabiri, S, et al. (author)
  • 2021
  • swepub:Mat__t
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  • Bravo, L, et al. (author)
  • 2021
  • swepub:Mat__t
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  • Zaborowski, AM, et al. (author)
  • Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response
  • 2022
  • In: The British journal of surgery. - : Oxford University Press (OUP). - 1365-2168 .- 0007-1323. ; 109:3, s. 251-255
  • Journal article (peer-reviewed)abstract
    • In this study of 400 patients with early-onset rectal cancer, 12.5 per cent demonstrated microsatellite instability (MSI). MSI was associated with a reduced likelihood of nodal positivity, an increased rate of pathological complete response, and improved disease-specific survival.
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  • Abudurexiti, A, et al. (author)
  • Taxonomy of the order Bunyavirales: update 2019
  • 2019
  • In: Archives of virology. - : Springer Science and Business Media LLC. - 1432-8798 .- 0304-8608. ; 164:7, s. 1949-1965
  • Journal article (peer-reviewed)
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  • Nielsen, J. S., et al. (author)
  • Rough-Form Lipopolysaccharide Increases Apoptosis in Human CD4+and CD8+T Lymphocytes
  • 2012
  • In: Scandinavian Journal of Immunology. - : Wiley. - 0300-9475 .- 1365-3083. ; 75:2, s. 193-202
  • Journal article (peer-reviewed)abstract
    • Immunosuppression induced by lymphocyte apoptosis is considered an important factor in the pathogenesis of sepsis and has been demonstrated in both animal models of lipopolysaccharide (LPS)-induced endotoxemia and septic patients. As rough-form LPS (R-LPS) has recently been shown to elicit a stronger immunological response than regular smooth-form LPS (S-LPS), we aimed to assess the apoptosis-inducing capabilities of R-LPS in different subsets of lymphocytes (CD4+ T cells, CD8+ T cell, B cells and NK cells). Using multicolour flow cytometry on human peripheral blood mononuclear cells, we found that R-LPS increased apoptosis in CD4+ and CD8+ T cells assessed by annexin V and propidium iodide (AV+PI-), compared with both S-LPS-stimulated and unstimulated cells. 7-Amino-actinomycin D and staining for intracellular active caspase-3, which are considered later signs of apoptosis, did not reveal the same results. Both forms appeared to inhibit apoptosis in B cells, but no LPS-form-specific effect was seen on B or NK cells. Our results indicate that R-LPS induces a stronger AV+PI--assessed apoptotic response in T cells than S-LPS. Our findings emphasize the importance of T cell apoptosis in endotoxemia and advocates for control of LPS form in both endotoxemia research and clinical trials with Gram-negative infections.
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  • Result 1-16 of 16

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