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1.	Groenen, M. A., et al. (author) Analyses of pig genomes provide insight into porcine demography and evolution 2012 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 491:7424, s. 393-398 Journal article (peer-reviewed)abstract For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars approximately 1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.
2.	Bergman, I. M., et al. (author) Wild boars from Sweden, Austria, the Czech Republic and Japan possess intact mannose-binding lectin 2 (MBL2) genes 2015 In: International Journal of Immunogenetics. - : Wiley. - 1744-3121 .- 1744-313X. ; 42:3, s. 204-207 Journal article (peer-reviewed)abstract The two-nucleotide deletion recently detected in the mannose-binding lectin 2 gene in purebred and crossbred domestic pigs was not found among 68 wild boars representing 4 populations from Europe and Asia. This suggests that the deletion is a result of breeding and/or genetic drift/bottle necks.
3.	Makino, Y, et al. (author) Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells 2007 In: The Journal of biological chemistry. - 0021-9258. ; 282:19, s. 14073-14082 Journal article (peer-reviewed)

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Uenishi, H. (2); Chen, C. (1); Kim, H. (1); Li, S. (1); Li, Y. (1); Wang, J. (1); show more...; White, S. (1); Zhang, J. (1); Zhang, G (1); Jones, M. (1); Takeuchi, Y. (1); Kim, J. (1); Kim, J. H. (1); Schwartz, J. (1); Makino, Y. (1); Ahn, H (1); Blomberg, Jonas (1); Lu, Y (1); Okamoto, K. (1); Tanaka, H. (1); Liu, W. (1); Ma, J (1); Zhao, S (1); Lee, K (1); Poellinger, L (1); Matthews, L (1); Bolund, L. (1); Park, C (1); Jeon, J T (1); Xu, X. (1); Sperber, Göran (1); Thomsen, B. (1); Bendixen, C. (1); Nguyen, D. T. (1); Kim, T. H. (1); Kim, K. W. (1); Jern, Patric (1); Rogers, J. (1); Lee, K T (1); Mann, K (1); Fadista, J. (1); Larson, G (1); Bergman, I. M. (1); Edfors, Inger (1); Okumura, N. (1); Hammer, S. E. (1); Knoll, A. (1); Juul-Madsen, H. R. (1); McLaren, S. (1); Wali, R (1); show less...

University: Uppsala University (1); Linnaeus University (1); Karolinska Institutet (1)

Language: English (3)

Research subject (UKÄ/SCB): Natural sciences (2); Agricultural Sciences (1)

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