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Sökning: WFRF:(Uhles S)

  • Resultat 1-14 av 14
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  • Finan, B, et al. (författare)
  • Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans
  • 2013
  • Ingår i: Science translational medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6242 .- 1946-6234. ; 5:209, s. 209ra151-
  • Tidskriftsartikel (refereegranskat)abstract
    • Compared to best-in-class GLP-1 mono-agonists, unimolecular co-agonists of GLP-1 and GIP with optimized pharmacokinetics enhance glycemic and metabolic benefits in mammals.
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  • Leibiger, B, et al. (författare)
  • Short-term regulation of insulin gene transcription
  • 2002
  • Ingår i: Biochemical Society transactions. - : Portland Press Ltd.. - 0300-5127 .- 1470-8752. ; 30:2, s. 312-317
  • Tidskriftsartikel (refereegranskat)abstract
    • Short-term regulation of insulin gene transcription is still a matter of debate. However, an increasing body of evidence shows that insulin gene transcription is affected by signals, such as incretins, glucose metabolites, intracellular Ca2+, and by insulin secreted from pancreatic β-cells, all supporting the concept of an immediate response resulting in insulin gene transcription following food-uptake. The present review aims to summarize the current view on the mechanisms underlying the up-regulation of insulin gene transcription in response to glucose, the major nutrient factor in insulin secretion and biosynthesis.
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  • Uhles, S, et al. (författare)
  • Isoform-specific insulin receptor signaling involves different plasma membrane domains
  • 2003
  • Ingår i: The Journal of cell biology. - : Rockefeller University Press. - 0021-9525 .- 1540-8140. ; 163:6, s. 1327-1337
  • Tidskriftsartikel (refereegranskat)abstract
    • In pancreatic β-cells, insulin selectively up-regulates the transcription of its own gene and that of the glucokinase gene by signaling through the two isoforms of the insulin receptor, i.e., A-type (Ex11−) and B-type (Ex11+), using different signaling pathways. However, the molecular mechanism(s) that allows the discrete activation of signaling cascades via the two receptor isoforms remains unclear. Here we show that activation of the insulin promoter via A-type and of the glucokinase promoter via B-type insulin receptor is not dependent on receptor isoform–specific differences in internalization but on the different localization of the receptor types in the plasma membrane. Our data demonstrate that localization and function of the two receptor types depend on the 12–amino acid string encoded by exon 11, which acts as a sorting signal rather than as a physical spacer. Moreover, our data suggest that selective activation of the insulin and glucokinase promoters occurs by signaling from noncaveolae lipid rafts that are differently sensitive toward cholesterol depletion.
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  • Resultat 1-14 av 14

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