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Sökning: WFRF:(Uhrig Sascha)

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  • Demichev, Vadim, et al. (författare)
  • A time-resolved proteomic and prognostic map of COVID-19
  • 2021
  • Ingår i: Cell Systems. - : Elsevier BV. - 2405-4712 .- 2405-4720. ; 12:8, s. 780-794.e7
  • Tidskriftsartikel (refereegranskat)abstract
    • COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts and enzyme activities, as well as untargeted plasma proteomes at 687 sampling points. We report an initial spike in a systemic inflammatory response, which is gradually alleviated and followed by a protein signature indicative of tissue repair, metabolic reconstitution, and immunomodulation. We identify prognostic marker signatures for devising risk-adapted treatment strategies and use machine learning to classify therapeutic needs. We show that the machine learning models based on the proteome are transferable to an independent cohort. Our study presents a map linking routinely used clinical diagnostic parameters to plasma proteomes and their dynamics in an infectious disease.
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2.
  • Weber, Werner, et al. (författare)
  • The EMC2 Project on Embedded Microcontrollers: Technical Progress after two years
  • 2016
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Since April 2014 the Artemis/ECSEL project EMC2 is running and provides significant results. EMC2 stands for “Embedded Multi-Core Systems for Mixed Criticality Applications in Dynamic and Changeable Real-Time Environments”. In this paper we report recent progress on technical work in the different workpackages and use cases. We highlight progress in the research on system architecture, design methodology, platform and operating systems, and in qualification and certification. Application cases in the fields of automotive, avionics, health care, and industry are presented exploiting the technical results achieved. 
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