| 1. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 2. |
- Mahajan, Anubha, et al.
(författare)
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
- 2022
-
Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 54:5, s. 560-572
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Tidskriftsartikel (refereegranskat)abstract
- We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10(-9)), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.
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| 3. |
- An, Junghwa, et al.
(författare)
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Permanent Genetic Resources added to Molecular Ecology Resources Database 1 October 2009-30 November 2009
- 2010
-
Ingår i: Molecular Ecology Resources. - : Wiley. - 1755-098X .- 1755-0998. ; 10:2, s. 404-408
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Tidskriftsartikel (refereegranskat)abstract
- This article documents the addition of 411 microsatellite marker loci and 15 pairs of Single Nucleotide Polymorphism (SNP) sequencing primers to the Molecular Ecology Resources Database. Loci were developed for the following species: Acanthopagrus schlegeli, Anopheles lesteri, Aspergillus clavatus, Aspergillus flavus, Aspergillus fumigatus, Aspergillus oryzae, Aspergillus terreus, Branchiostoma japonicum, Branchiostoma belcheri, Colias behrii, Coryphopterus personatus, Cynogolssus semilaevis, Cynoglossus semilaevis, Dendrobium officinale, Dendrobium officinale, Dysoxylum malabaricum, Metrioptera roeselii, Myrmeciza exsul, Ochotona thibetana, Neosartorya fischeri, Nothofagus pumilio, Onychodactylus fischeri, Phoenicopterus roseus, Salvia officinalis L., Scylla paramamosain, Silene latifo, Sula sula, and Vulpes vulpes. These loci were cross-tested on the following species: Aspergillus giganteus, Colias pelidne, Colias interior, Colias meadii, Colias eurytheme, Coryphopterus lipernes, Coryphopterus glaucofrenum, Coryphopterus eidolon, Gnatholepis thompsoni, Elacatinus evelynae, Dendrobium loddigesii Dendrobium devonianum, Dysoxylum binectariferum, Nothofagus antarctica, Nothofagus dombeyii, Nothofagus nervosa, Nothofagus obliqua, Sula nebouxii, and Sula variegata. This article also documents the addition of 39 sequencing primer pairs and 15 allele specific primers or probes for Paralithodes camtschaticus.
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| 4. |
- Chithra, G. K., et al.
(författare)
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Android application for ticket collector in trains
- 2017
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Ingår i: Journal of Advanced Research in Dynamical and Control Systems. - : Institute of Advanced Scientific Research, Inc.. - 1943-023X. ; 9:Special Issue 2, s. 1015-1022
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Tidskriftsartikel (refereegranskat)abstract
- The main objective of this android app is that the ticket collector checks the traveller price tag and updates the traveller list to the information whether or not the passengers are travelling in the train according to their tickets with their individual dates of a journey. This app starts with a login page. The ticket collector updates the user id and watchword manually to IRCTC and therefore the management stores his user-id and watchword within the information. So, the ticket collector 1st needs to login to the app together with his individual user-id and password. Then once logging in to the app, HOME page is displayed. during this page, the ticket collector needs to select the train range and so the date of journey and therefore the diary number and then submits this page. Then he gets the traveller list and therefore the ticket collector checks the traveller list and updates the list supported who is travelling. And at that time submits the checked traveller list and then it gets updated to the information. This app helps the ticket collector most. Some passengers take the general price tag and request ticket collector for the berth or seat within the reservation coach. So, at this time this app helps the ticket collector to look at the quantity of vacant seats. It reduces the looking out time for the ticket collector. the quantity of vacant seats is displayed once the ticket collector simply clicks the quantity of vacant seat availability option. The porter asks the traveller regarding his/her supply and destination that he needed the price tag. So, supported the traveller necessities the ticket collector chooses the supply and destination that the traveller desires the seat or berth. So, if the seats square measure vacant then the ticket collector checks the number to be paid by the traveller as fine and so asks the fine and if the traveller pays the fine to the ticket collector then he updates the traveller details who need the price tag and so he updates the traveller details to the database.
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| 5. |
- Monika, K., et al.
(författare)
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Theft vehicle scheme using cloud computing techniques
- 2017
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Ingår i: Journal of Advanced Research in Dynamical and Control Systems. - : Institute of Advanced Scientific Research, Inc.. - 1943-023X. ; 9:Special Issue 2, s. 1023-1031
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Tidskriftsartikel (refereegranskat)abstract
- Due to proliferation in the metropolitan areas there existing problem of poor traffic congestion has grown at alarming event and it is not easy to find the stolen vehicles. So here we use Theft vehicle detection system for finding the theft vehicles using open source hardware of RASPBERRY PI.This system make use of RFID and embedded technology. Here each vehicle is placed with RFID tag. Whenever the RFID reader reads the RFID tag in the stolen vehicle it alert the traffic police and the signal will be automatically changed into red light until the vehicle is recovered from the stolen person. This is achieved by connecting cloud technology with server which is handle by the traffic police. When the traffic controller ensures that the particular vehicle is missed then, whenever that particular vehicle crossed by the any signal red light blinks automatically then cloud displays the message with vehicle number.By using this system, we can alert the signal and can easily find the stolen vehicle by tracking the RFID tag.
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| 6. |
- Nakatani, Yoshio, et al.
(författare)
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Role of Alanine Racemase Mutations in Mycobacterium tuberculosis D-Cycloserine Resistance
- 2017
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Ingår i: Antimicrobial Agents and Chemotherapy. - : AMER SOC MICROBIOLOGY. - 0066-4804 .- 1098-6596. ; 61:12
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Tidskriftsartikel (refereegranskat)abstract
- A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to D-cycloserine.
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| 7. |
- Osoegawa, Kazutoyo, et al.
(författare)
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Quality control project of NGS HLA genotyping for the 17th International HLA and Immunogenetics Workshop
- 2019
-
Ingår i: Human Immunology. - : ELSEVIER SCIENCE INC. - 0198-8859 .- 1879-1166. ; 80:4, s. 228-236
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Tidskriftsartikel (refereegranskat)abstract
- The 17th International HLA and Immunogenetics Workshop (IHIW) organizers conducted a Pilot Study (PS) in which 13 laboratories (15 groups) participated to assess the performance of the various sequencing library preparation protocols, NGS platforms and software in use prior to the workshop. The organizers sent 50 cell lines to each of the 15 groups, scored the 15 independently generated sets of NGS HLA genotyping data, and generated "consensus" HLA genotypes for each of the 50 cell lines. Proficiency Testing (PT) was subsequently organized using four sets of 24 cell lines, selected from 48 of 50 PS cell lines, to validate the quality of NGS HLA typing data from the 34 participating IHIW laboratories. Completion of the PT program with a minimum score of 95% concordance at the HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 loci satisfied the requirements to submit NGS HLA typing data for the 17th IHIW projects. Together, these PS and PT efforts constituted the 17th IHIW Quality Control project. Overall PT concordance rates for HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4 and HLA-DRB5 were 98.1%, 97.0% and 98.1%, 99.0%, 98.6%, 98.8%, 97.6%, 96.0%, 99.1%, 90.0% and 91.7%, respectively. Across all loci, the majority of the discordance was due to allele dropout. The high cost of NGS HLA genotyping per experiment likely prevented the retyping of initially failed HLA loci. Despite the high HLA genotype concordance rates of the software, there remains room for improvement in the assembly of more accurate consensus DNA sequences by NGS HLA genotyping software.
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| 8. |
- Sravani, K., et al.
(författare)
-
Prescription viewer medcare application using android programming
- 2017
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Ingår i: Journal of Advanced Research in Dynamical and Control Systems. - : Institute of Advanced Scientific Research, Inc.. - 1943-023X. ; 9:Special Issue 2, s. 1360-1370
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Tidskriftsartikel (refereegranskat)abstract
- Living healthy is valuable to everyone. The expert assumes an essential part in sparing one's life by giving the therapeutic solution. The issues faced by patients in their busy lives can't keep the records of prescription safely, inappropriate and overdosed admission of meds furthermore neglecting to get meeting with specialist by going to doctor's facility. This can be explained by Medcare application using android programming. Android is the Operating System that has huge development as of late. The fundamental plan of this paper is to make patients sensible about the application, through which they can see the medicine given by specialist, set suggestion to planned drug, find adjacent drug stores and can alter next meeting with particular branch of specialist without going to healing facility.
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| 9. |
- Suhasini, K., et al.
(författare)
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Comparison analysis of brain tumor segmentation techniques
- 2017
-
Ingår i: Journal of Advanced Research in Dynamical and Control Systems. - : Institute of Advanced Scientific Research, Inc.. - 1943-023X. ; 9:Special Issue 2, s. 1068-1077
-
Tidskriftsartikel (refereegranskat)abstract
- Computer aided diagnosis/detection (CAD) frameworks can upgrade the indicative abilities of doctors also, decrease the time required for precise determination. The target of this paper is to survey the later distributed segmentation and order strategies and their cutting edge for the human brain magnetic resonance pictures (MRI). The survey uncovers the CAD frameworks of human brain MRI pictures are still an open issue. Depiction of dynamic tumor area and perifocal edema from Magnetic Resonance (MR) pictures of Glioblastoma Multiforme (GBM) is troublesome as GBM is exceedingly penetrating and no enhancing on symbolism. The segmentation gets to be testing when the tissue classes in the perifocal region, for example, White Matter (WM) and edema, also, putrefaction and Gray Matter (GM) are homogenous in force and surface. Exact depiction of GBM-center and perifocal edema is compulsory for surgical and Radio Therapy (RT) planning and for the assessment of tumor advancement furthermore, productivity of treatment. This article is an exhaustive survey on procedures utilized for the segmentation of GBM from MR pictures.
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| 10. |
- Uma, K., et al.
(författare)
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Scanned compound images using different compression techniques
- 2017
-
Ingår i: Journal of Advanced Research in Dynamical and Control Systems. - : Institute of Advanced Scientific Research, Inc.. - 1943-023X. ; 9:Special Issue 2, s. 994-1000
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Tidskriftsartikel (refereegranskat)abstract
- This Paper involves a detailed study of different compression techniques of scanned compound images. A compound image is a different kind of image that contains text, natural image and graphic image. Some of the Image compression techniques which include DCT,JPEG, H.264,MMP AND APM-MMP have been reviewed and presented in this paper. Discrete cosine transform (DCT) is a method which compresses the compound image without any loss of data. To compress image DCT is computed using two dimensional functions (2D).Join Picture Expert Group(JPEG) is mostly used as standard format for compressed images. Due to loss of data the compressed image differs from the original image.H.264 is a video compression standard which is also capable of compressing a compound image.MMP is specifically calculated to encode separately the macro blocks information of text and image. Since complexity is high in these above techniques the proposed technique Adaptive Probability Model-MMP solves the limitations like redundant data removal and enhances the image quality. It also improves the encoding efficiency thus modifying the MMP’s character.
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| 11. |
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| 12. |
- Ghosal, Suman, et al.
(författare)
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Long intergenic noncoding RNA profiles of pheochromocytoma and paraganglioma : A novel prognostic biomarker
- 2020
-
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 146:8, s. 2326-2335
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Tidskriftsartikel (refereegranskat)abstract
- Many long intergenic noncoding RNAs (lincRNAs) serve as cancer biomarkers for diagnosis or prognostication. To understand the role of lincRNAs in the rare neuroendocrine tumors pheochromocytoma and paraganglioma (PCPG), we performed first time in-depth characterization of lincRNA expression profiles and correlated findings to clinical outcomes of the disease. RNA-Seq data from patients with PCPGs and 17 other tumor types from The Cancer Genome Atlas and other published sources were obtained. Differential expression analysis and a machine-learning model were used to identify transcripts specific to PCPGs, as well as established PCPG molecular subtypes. Similarly, lincRNAs specific to aggressive PCPGs were identified, and univariate and multivariate analysis was performed for metastasis-free survival. The results were validated in independent samples using RT-PCR. From a pan-cancer context, PCPGs had a specific and unique lincRNA profile. Among PCPGs, five different molecular subtypes were identified corresponding to the established molecular classification. Upregulation of 13 lincRNAs was found to be associated with aggressive/metastatic PCPGs. RT-PCR validation confirmed the overexpression of four lincRNAs in metastatic compared to non-metastatic PCPGs. Kaplan-Meier analysis identified five lincRNAs as prognostic markers for metastasis-free survival of patients in three subtypes of PCPGs. Stratification of PCPG patients with a risk-score formulated using multivariate analysis of lincRNA expression profiles, presence of key driver mutations, tumor location, and hormone secretion profiles showed significant differences in metastasis-free survival. PCPGs thus exhibit a specific lincRNA expression profile that also corresponds to the established molecular subgroups and can be potential marker for the aggressive/metastatic PCPGs.
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| 13. |
- Hemmilä, Sofia, 1984-, et al.
(författare)
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Development of eleven microsatellite markers in the red-listed tree species Myristica malabarica
- 2010
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Ingår i: Conservation Genetics Resources. - : Springer Science and Business Media LLC. - 1877-7252 .- 1877-7260. ; 2:Suppl. 1, s. 305-307
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Tidskriftsartikel (refereegranskat)abstract
- The Myristicaceae family is a primitive angiosperm family and is characterized by species that are highly endemic to the Western Ghats area of India. Myristica malabarica is confined to the evergreen forests of Western Ghats and Sri Lanka. In this paper we describe for the first time the development of eleven polymorhpic microsatellite markers for Myristica malabarica, which had 2–14 alleles per locus. These microsatellite markers could be used to study the population genetic structure of the species.
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| 14. |
- Hemmilä, Sofia, 1984-, et al.
(författare)
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Development of polymorphic microsatellite loci in the endangered tree species Dysoxylum malabaricum
- 2010
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Dysoxylum malabaricum Bedd. (Meliaceae) is an economically important tree species occurring in the Western Ghats, a mega-diversity hotspot in southern India. In this paper, we report the development of fifteen microsatellite markers for D. malabaricum. The microsatellite primers development of fifteen microsatellite markers for D. malabaricum. The microsatellite primers screened had 2-9 alleles per locus and the observed and expected heterozygosity ranged from 0.07 to 1.00 and 0.07 to 0.9 respectively. Seven microsatellites cross amplified in the related species Dysoxylum binectariferum and showed good polymorphism. These are the first microsatellites described for D. malabaricum and they will be used to study population structure and genetic diversity.
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| 15. |
- Hoban, Sean, et al.
(författare)
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Global Commitments to Conserving and Monitoring Genetic Diversity Are Now Necessary and Feasible
- 2021
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Ingår i: BioScience. - : Oxford University Press (OUP). - 0006-3568 .- 1525-3244. ; 71:9, s. 964-976
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Tidskriftsartikel (refereegranskat)abstract
- Global conservation policy and action have largely neglected protecting and monitoring genetic diversity-one of the three main pillars of biodiversity. Genetic diversity (diversity within species) underlies species' adaptation and survival, ecosystem resilience, and societal innovation. The low priority given to genetic diversity has largely been due to knowledge gaps in key areas, including the importance of genetic diversity and the trends in genetic diversity change; the perceived high expense and low availability and the scattered nature of genetic data; and complicated concepts and information that are inaccessible to policymakers. However, numerous recent advances in knowledge, technology, databases, practice, and capacity have now set the stage for better integration of genetic diversity in policy instruments and conservation efforts. We review these developments and explore how they can support improved consideration of genetic diversity in global conservation policy commitments and enable countries to monitor, report on, and take action to maintain or restore genetic diversity.
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| 16. |
- Myers-Smith, Isla H., et al.
(författare)
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Complexity revealed in the greening of the Arctic
- 2020
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Ingår i: Nature Climate Change. - : Springer Science and Business Media LLC. - 1758-678X .- 1758-6798. ; 10:2, s. 106-117
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Tidskriftsartikel (refereegranskat)abstract
- As the Arctic warms, vegetation is responding, and satellite measures indicate widespread greening at high latitudes. This ‘greening of the Arctic’ is among the world’s most important large-scale ecological responses to global climate change. However, a consensus is emerging that the underlying causes and future dynamics of so-called Arctic greening and browning trends are more complex, variable and inherently scale-dependent than previously thought. Here we summarize the complexities of observing and interpreting high-latitude greening to identify priorities for future research. Incorporating satellite and proximal remote sensing with in-situ data, while accounting for uncertainties and scale issues, will advance the study of past, present and future Arctic vegetation change.
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| 17. |
- Razia Sulthana, A., et al.
(författare)
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Improvement on software testing techniques and tools
- 2017
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Ingår i: Journal of Advanced Research in Dynamical and Control Systems. - : Institute of Advanced Scientific Research, Inc.. - 1943-023X. ; 9:2 Special Issue, s. 1049-1058
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Tidskriftsartikel (refereegranskat)abstract
- Programming Testing is a procedure of discovering mistakes while executing a program with the goal that we get a zero deformity programming. It is gone for assessing the ability or ease of use of a program. Programming testing is an essential methods for getting to nature of programming. Despite the fact that a great deal of progressions have been done in formal strategies and check procedures, still we require programming to be completely tried before it could be dealt with to the client side. Subsequently there are various trying systems and instruments made to finish the undertaking. Programming testing is a vital zone of research and a great deal of advancement has been made in this field. In this paper, testing systems and apparatuses have been depicted. Some run of the mill most recent inquiries about have been outlined. Programming testing is increasing increasingly significance later on.
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| 18. |
- Siddiqui, Moneeza K., et al.
(författare)
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A common missense variant of LILRB5 is associated with statin intolerance and myalgia
- 2017
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 38:48, s. 3569-U31
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Tidskriftsartikel (refereegranskat)abstract
- Aims: A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. We examined the association of this variant with statin intolerance ascertained from electronic medical records in the GoDARTS study.Methods and results: In the GoDARTS cohort, the LILRB5 Asp247 variant was associated with statin intolerance (SI) phenotypes; one defined as having raised CK and being non-adherent to therapy [odds ratio (OR) 1.81; 95% confidence interval (CI): 1.34–2.45] and the other as being intolerant to the lowest approved dose of a statin before being switched to two or more other statins (OR 1.36; 95% CI: 1.07–1.73). Those homozygous for Asp247 had increased odds of developing both definitions of intolerance. Importantly the second definition did not rely on CK elevations. These results were replicated in adjudicated cases of statin-induced myopathy in the PREDICTION-ADR consortium (OR1.48; 95% CI: 1.05–2.10) and for the development of myalgia in the JUPITER randomized clinical trial of rosuvastatin (OR1.35, 95% CI: 1.10–1.68). A meta-analysis across the studies showed a consistent association between Asp247Gly and outcomes associated with SI (OR1.34; 95% CI: 1.16–1.54).Conclusion: This study presents a novel immunogenetic factor associated with statin intolerance, an important risk factor for cardiovascular outcomes. The results suggest that true statin-induced myalgia and non-specific myalgia are distinct, with a potential role for the immune system in their development. We identify a genetic group that is more likely to be intolerant to their statins.
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| 19. |
- Tamil Priya, D., et al.
(författare)
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Similarity based face identification using metrics analysis
- 2017
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Ingår i: Journal of Advanced Research in Dynamical and Control Systems. - : Institute of Advanced Scientific Research, Inc.. - 1943-023X. ; 9:Special Issue 2, s. 1371-1378
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Tidskriftsartikel (refereegranskat)abstract
- Confront acknowledgment framework is one of the biometrics strategies that are utilized as a part of assortment of uses utilizing the picture handling systems. Confront acknowledgment framework is produced utilizing the Mat lab condition with the systems took after by main segment investigation and the straight discriminant examination. The execution is measured utilizing the time rate, remove rate, pixel values and the element separated determination rate. The ideal acknowledgment is executed when the time traverse around half and the separation rate around the 90 %. What’s more, on account of pixel and determination, when the pixel qualities are expanding then the determination calculate ought to likewise be an expanding request. On the off chance that the removed element contains more pixels then the determination element is progressively that identifies with the quality in separating the element. The execution is measured utilizing the two distinctive programming metric techniques to be specific spearmen and Pearson metric. At that point the general measure is characterized by picking up with the two metric strategies. The execution is plotted utilizing the diagram to foresee the rate of time and extricated include.
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| 20. |
- Tattikota, Sudhir G, et al.
(författare)
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MiR-184 regulates pancreatic β-cell function according to glucose metabolism.
- 2015
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Ingår i: Journal of Biological Chemistry. - 1083-351X. ; 290:33, s. 20284-20294
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Tidskriftsartikel (refereegranskat)abstract
- In response to fasting or hyperglycemia, the pancreatic β-cell alters its output of secreted insulin; however the pathways governing this adaptive response are not entirely established. While the precise role of microRNAs (miRNAs) is also unclear, a recurring theme emphasizes their function in cellular stress responses. We recently showed that miR-184, an abundant miRNA in the β-cell, regulates compensatory proliferation and secretion during insulin resistance. Consistent with previous studies showing miR-184 suppresses insulin release, expression of this miRNA was increased in islets after fasting, demonstrating an active role in the β-cell as glucose levels lower and the insulin demand ceases. Additionally, miR-184 was negatively regulated upon administration of a sucrose-rich diet in Drosophila demonstrating strong conservation of this pathway through evolution. Furthermore, miR-184 and its target Argonaute2 (Ago2) remained inversely correlated as concentrations of extracellular glucose increased, underlining a functional relationship between this miRNA and its targets. Lastly, restoration of Ago2 in the presence of miR-184 rescued suppression of miR-375-targeted genes suggesting these genes act in a coordinated manner during changes in the metabolic context. Together, these results highlight the adaptive role of miR-184 according to glucose metabolism and suggest the regulatory role of this miRNA in energy homeostasis is highly conserved.
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| 21. |
- Uma, K., et al.
(författare)
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A novel method for smart vehicle safety
- 2017
-
Ingår i: Journal of Advanced Research in Dynamical and Control Systems. - : Institute of Advanced Scientific Research, Inc.. - 1943-023X. ; 2017:Special Issue 2, s. 1259-1269
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Tidskriftsartikel (refereegranskat)abstract
- This to a great extent reduces the manpower, saves time and operates efficiently without human intervention. With the advent in technology, the existing systems are developed to have in built intelligence. The proposed work to monitor the pressure of the vehicle tire using the Arduino, this will be very much helpful to avoid the burst of tire and to understand about the tire pressure under various load situation of a vehicle. fuel level and the location can be updated during abnormal condition using wireless technology. The accident can be monitored using the high level vibration sensor and if the accident has occurred in any location it can immediately inform to the nearby hospital or ambulance service, the location of the accident. It is tire pressure monitoring. Pressure sensor acts as a main role to monitor the pressure of the vehicle, and it reports to the owner of the vehicle when the pressure gets low with the help of GSM work. This GSM work and the pressure sensor is connected to the Arduino board with the help of connecting wires. It is fuel level monitoring. Fuel level sensor is used to monitor the fuel of the vehicle and when the fuel gets low a message is automatically sent to the owner of the vehicle with the help of GSM work. This GSM work and the fuel sensor is connected to the arduino board with the help of connecting wires. It is accident tracking and intimating to nearby hospital. If the accident happens to the vehicle, with the help of vibration sensor the accident is recorded. The vibration is transmitted to GPS, GPS tracks the location of the vehicle and sent to GSM. It sends message to the nearby hospital and the hospital management has to take the responsibility in taking patient to the hospital for treatment.
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| 22. |
- Uma, K., et al.
(författare)
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Smart cart system using IoT
- 2017
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Ingår i: Journal of Advanced Research in Dynamical and Control Systems. - : Institute of Advanced Scientific Research, Inc.. - 1943-023X. ; 9:Special Issue 2, s. 1086-1096
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Tidskriftsartikel (refereegranskat)abstract
- Shopping in this present reality is developing and is giving intelligent experience since many stores are coordinating different innovations to bolster customers in shopping process. There has likewise been an expansion sought after for brisk and simple techniques for getting to and shopping the things and furthermore instalment of bills in numerous stores. In this process we can save a lot of time in searching for the products and at billing counters. This venture depicts how to manufacture an efficient and computerized framework in the retail world that makes the shopping client well disposed, secure and gives fast understanding to the client. Our venture, Smart Cart is proposed such that the client can examine things with the standardized tag scanner appended to the truck itself. Each Cart is furnished with the tablet PC settled to it. Each thing that is looked over the on-board standardized identification scanner won't be affirmed by the framework unless it is put inside the truck. He will be advised all the time inside the store with his closest item accessible in like manner to his readied list of things to get before he/she enters the store by utilizing the sensors settled with the racks and items. With the assistance of the weight sensors accessible with truck affirms the item as per the list of things to get. He can include any item right away likewise which will likewise be included into his truck for charging. When he/she completes their shopping they will be told with the last payable sum in the wake of deducting the rebates (assuming any) where he can pay on the web or card or he/she can pay in real money moreover.
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| 23. |
- Uma, K., et al.
(författare)
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The challenges and issues on big data analytics
- 2017
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Ingår i: Journal of Advanced Research in Dynamical and Control Systems. - : Institute of Advanced Scientific Research, Inc.. - 1943-023X. ; 2017:Special Issue 2, s. 1242-1258
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Tidskriftsartikel (refereegranskat)abstract
- A tremendous store of terabytes of information is created every day from present day data frameworks and advanced innovations, for example, Internet of Things and cloud computing. Analysing of these terabytes of information requires a ton of activities at various levels to extract data from knowledge base. In this manner, big data examination is a momentum region of innovative work. The fundamental goal of this paper is to analyse the potential effect of big data challenges, open research issues, and different tools related with it. Accordingly, this article gives a stage to investigate big data information at various stages. It finally provides the researchers to develop the solution based upon their challenges and also provides research issues.
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| 24. |
- Vijayakumar, M., et al.
(författare)
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Security issues in cloud computing
- 2017
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Ingår i: Journal of Advanced Research in Dynamical and Control Systems. - : Institute of Advanced Scientific Research, Inc.. - 1943-023X. ; 2017:Special Issue 2, s. 1001-1014
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Tidskriftsartikel (refereegranskat)abstract
- Recently, cloud computing has become an important part of Information Technology. Cloud computing is a network based environment which provides platform for sharing and processing data and services over internet. Cloud computing is one of the greatest trendy vocabulary in the PC world nowadays. It permits asset sharing that incorporates programming, stage and framework by means of virtualization. Virtualization is the center innovation behind cloud asset sharing. This condition endeavors to be alterable, dependable, and adjustable with an ensured nature of administration. It gives the capacity to use versatile, circulated processing conditions through the Internet. Throughout the years, cloud computing has developed from being a capable business idea to a quickly developing part in IT associations. It has developed as a capable facilitating stage that permits a wise utilization of a gathering of uses, data and framework included pools of PC, system and capacity assets. In any case, undertaking clients are as yet cautious to send their business in the cloud. Security is one of the key component which hamper development of cloud computing. It is as quite a bit of an issue in the cloud as it is anyplace else. Distinctive individuals share diverse point of view on distributed computing. Some trust it is dangerous to utilize cloud. Cloud merchants make a special effort to guarantee security.Cloud computing has ability to solve various problems but it cannot address certain issues like reliability, performance and security, among which security is the most common issue seen in cloud computing. This paper proposes some solutions to some security issues.
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| 25. |
- Walker, Donald A., et al.
(författare)
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Cumulative Effects of Rapid Land-Cover and Land-Use Changes on the Yamal Peninsula, Russia
- 2011
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Ingår i: Eurasian Arctic Land Cover and Land Use in a Changing Climate. - New York : Springer Netherlands. - 9789048191178 - 9789048191185 ; , s. 207-236
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The Yamal Peninsula in northwest Siberia is undergoing some of the most rapid land-cover and land-use changes in the Arctic due to a combination of gas development, reindeer herding, and climate change. Unusual geological conditions (nutrient-poor sands, massive ground ice and extensive landslides) exacerbate the impacts. These changes will likely increase markedly as transportation corridors are built to transport the gas to market. Understanding the nature, extent, causes and consequences (i.e., the cumulative effects) of the past and ongoing rapid changes on the Yamal is important for effective, long-term decision-making and planning. The cumulative effects to vegetation are the focus of this chapter because the plants are a critical component of the Yamal landscape that support the indigenous Nenets people and their reindeer and also protect the underlying ice-rich permafrost from melting. We are using a combination of ground-based studies (a transect of live locations across the Yamal), remote-sensing studies, and analyses of Nenets land-use activities to develop vegetation-change models that can be used to help anticipate future states of the tundra and how those changes might affect traditional reindeer herding practices and the thermal state of the permafrost. This chapter provides an overview of the approach, some early results, and recommendations for expanding the concept of cumulative-effects analysis to include examining the simultaneous and interactive effects of multiple drivers of change.
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| 26. |
- Walker, Donald A., et al.
(författare)
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Vegetation on mesic loamy and sandy soils along a 1700-km maritime Eurasia Arctic Transect
- 2019
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Ingår i: Applied Vegetation Science. - : John Wiley & Sons. - 1402-2001 .- 1654-109X. ; 22:1, s. 150-167
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Tidskriftsartikel (refereegranskat)abstract
- Questions: How do plant communities on zonal loamy vs. sandy soils vary across the full maritime Arctic bioclimate gradient? How are plant communities of these areas related to existing vegetation units of the European Vegetation Classification? What are the main environmental factors controlling transitions of vegetation along the bioclimate gradient?Location: 1700-km Eurasia Arctic Transect (EAT), Yamal Peninsula and Franz Josef Land (FJL), Russia.Methods: The Braun-Blanquet approach was used to sample mesic loamy and sandy plots on 14 total study sites at six locations, one in each of the five Arctic bioclimate subzones and the forest-tundra transition. Trends in soil factors, cover of plant growth forms (PGFs) and species diversity were examined along the summer warmth index (SWI) gradient and on loamy and sandy soils. Classification and ordination were used to group the plots and to test relationships between vegetation and environmental factors.Results: Clear, mostly non-linear, trends occurred for soil factors, vegetation structure and species diversity along the climate gradient. Cluster analysis revealed seven groups with clear relationships to subzone and soil texture. Clusters at the ends of the bioclimate gradient (forest-tundra and polar desert) had many highly diagnostic taxa, whereas clusters from the Yamal Peninsula had only a few. Axis 1 of a DCA was strongly correlated with latitude and summer warmth; Axis 2 was strongly correlated with soil moisture, percentage sand and landscape age.Conclusions: Summer temperature and soil texture have clear effects on tundra canopy structure and species composition, with consequences for ecosystem properties. Each layer of the plant canopy has a distinct region of peak abundance along the bioclimate gradient. The major vegetation types are weakly aligned with described classes of the European Vegetation Checklist, indicating a continuous floristic gradient rather than distinct subzone regions. The study provides ground-based vegetation data for satellite-based interpretations of the western maritime Eurasian Arctic, and the first vegetation data from Hayes Island, Franz Josef Land, which is strongly separated geographically and floristically from the rest of the gradient and most susceptible to on-going climate change.
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