| 1. |
- Bahraini, Masoud, 1991, et al.
(författare)
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Sliding mode control revisited
- 2020
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Ingår i: Transactions of the Institute of Measurement and Control. - : SAGE Publications. - 1477-0369 .- 0142-3312. ; 42:14, s. 2698-2707
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Tidskriftsartikel (refereegranskat)abstract
- Controller design for nonlinear systems in its general form is complicated and an open problem. Finding a solution to this problem becomes more complicated when unwanted terms, such as disturbance, are taken into account. To provide a robust design for a subclass of nonlinear systems, sliding mode controllers (SMCs) are used. These controllers have a systematic design procedure and can reject bounded disturbances and at the same time guarantee stability. The guaranteed stability is achieved by separating system states into two parts and assuming that the input to state stability (ISS) condition holds for internal dynamics. This condition restricts the applicability of the SMC and limits the system performance when the controller is designed based on that. In order to remove this restriction and improve the performance, the ISS condition has been relaxed in this study. The relaxation is performed by redesigning SMCs based on suggested Lyapunov functions. The proposed idea insures global asymptotic stability of the closed loop system and is used to revise different well-known SMCs such as conventional SMC, terminal SMC, non-singular terminal SMC, integral SMC, super-twisting SMC, and super-twisting integral SMC. Comparisons between conventional and revised versions are made using simulation to demonstrate excellence of the revisited controllers.
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| 2. |
- Aleksich, Mariya, et al.
(författare)
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XFEL Microcrystallography of Self-Assembling Silver n-Alkanethiolates
- 2023
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Ingår i: Journal of the American Chemical Society. - 0002-7863. ; 145:31, s. 17042-17055
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Tidskriftsartikel (refereegranskat)abstract
- New synthetic hybrid materials and their increasing complexity have placed growing demands on crystal growth for single-crystal X-ray diffraction analysis. Unfortunately, not all chemical systems are conducive to the isolation of single crystals for traditional characterization. Here, small-molecule serial femtosecond crystallography (smSFX) at atomic resolution (0.833 Å) is employed to characterize microcrystalline silver n-alkanethiolates with various alkyl chain lengths at X-ray free electron laser facilities, resolving long-standing controversies regarding the atomic connectivity and odd-even effects of layer stacking. smSFX provides high-quality crystal structures directly from the powder of the true unknowns, a capability that is particularly useful for systems having notoriously small or defective crystals. We present crystal structures of silver n-butanethiolate (C4), silver n-hexanethiolate (C6), and silver n-nonanethiolate (C9). We show that an odd-even effect originates from the orientation of the terminal methyl group and its role in packing efficiency. We also propose a secondary odd-even effect involving multiple mosaic blocks in the crystals containing even-numbered chains, identified by selected-area electron diffraction measurements. We conclude with a discussion of the merits of the synthetic preparation for the preparation of microdiffraction specimens and compare the long-range order in these crystals to that of self-assembled monolayers.
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| 3. |
- Tanhaian, Abbas, et al.
(författare)
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In Silico and In Vitro Investigation of a Likely Pathway for Anti-Cancerous Effect of Thrombocidin-1 as a Novel Anticancer Peptide
- 2020
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Ingår i: Protein peptide letters. - : Bentham Science Publishers Ltd. - 0929-8665 .- 1875-5305. ; 27:8, s. 751-762
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Tidskriftsartikel (refereegranskat)abstract
- Background: Antimicrobial and antifungal activities of Thrombocidin-1 (TC-1) is shown previously, however, the anti-cancerous feature of this peptide is still uncovered. Objective: The objective is to evaluate anti-cancerous feature of recombinant TC-1. Methods: In this study, based on the significant similarity of rTC-1 and IL-8 in case of coding sequence, tertiary structure, and also docking and molecular dynamic simulation (MD) results with CXCR1, a receptor which has positive correlation with different cancers, a likely pathway for anti-cancerous effect of rTC-1 was proposed. In addition, the coding sequence of TC-1+6 x histidine (rTC-1) was inserted into the pET22b(+) vector and cloned and expressed by E. coli BL21 and finally purified through nickel affinity column. Afterward, the retrieved rTC-1 was used in MTT assay against mouse colon adenocarcinoma, hepatocellular carcinoma, chondrosarcoma, mouse melanoma, and breast adenocarcinoma cell lines to investigate its probable anticancer application. Results: Docking and MD simulation results showed that rTC-1 and IL-8 share almost the same residues in the interaction with CXCR1 receptor. Besides, the stability of the rTC-l_CXCR1(1-)(38) complex was shown during 100ns MD simulation. In addition, the successful expression and purification of rTC-1 depict an 8kD peptide. The IC50 results of MTT assay revealed that rTC-1 has cytotoxic effect on C26-A and SW1353 cancerous cell lines. Conclusion: Therefore, apart from probable anti-cancerous effect of rTC-1 on C26-A and SW1353 cell lines, this peptide may be able to mimic the anti-cancerous pathway of IL-8.
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