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- Varedian, M, et al.
(författare)
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Interplaying Factors for the Formation of Photoswitchable beta-Hairpins: the Advantage of a Flexible Switch.
- 2009
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Ingår i: J. Pept. Sci.. ; 15, s. 107-113
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Tidskriftsartikel (refereegranskat)abstract
- A series of peptidomimetics intended to promote the β-hairpin motif have been studied. Structural variations include a turn region with and without a photoswitchable chromophore, and strands with amino acid side chains supporting various degrees of interstrand interactions for hairpin stabilisation. The propensity of the compounds to form β-hairpinswas evaluated experimentally by NMR spectroscopy, translational self-diffusion studies and CD spectroscopy. In the presence of hairpin stabilising interstrand interactions, the structurally flexible stilbene chromophore appeared to be well compatible with the imposed secondary structure.
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