SwePub - sökning: WFRF:(Varelius R)

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1.	Lesén, Eva, 1982, et al. (författare) Dose Patterns among patients using low-dose buprenorphine patches 2013 Ingår i: Pain medicine. - : Oxford University Press (OUP). - 1526-2375 .- 1526-4637. ; 14:9, s. 1374-1380 Tidskriftsartikel (refereegranskat)abstract Objective: The objective of this study was to investigate the dose pattern of low-dose buprenorphine patches among patients in Swedish clinical practice. The clinical experts among the coauthors interpreted the results in relation to possible indications of development of tolerance and/or dependence/addiction. Design and Setting: This was a nationwide, observational study using data from the Swedish Prescribed Drug Register. Subjects: Individuals who were dispensed the low-dose buprenorphine patches continuously for more than 24 weeks during July 1, 2005 to February 28, 2011 were included. Methods: The dose pattern was analyzed as the change in dose over time for each patient: 1) the dose at baseline compared with each of the following 8-week intervals, and 2) the dose at baseline compared with the dose during the patients' last treatment period. Results: The majority of the patients were female (74%), and most were 75 years and older (69%). The median treatment duration was 260 days, and 4% and 1% of patients remained on continuous treatment for 2 and 3 years, respectively. The mean dose was 11μg/h at baseline, and 15μg/h during the patients' last treatment period. The average dose increased by 4μg/h during the patients' entire treatment course. Conclusions: The average dose increased by 4μg/h during the patients' treatment course, which lasted on an average of 260 days. From a clinical perspective, the dose increase of 4μg/h is low and does not suggest dependence/addiction, as also supported by the low proportion of patients remaining on continuous treatment. © 2013 American Academy of Pain Medicine.
2.	Murray, V, et al. (författare) Sertraline in poststroke depression - A controlled study 2002 Ingår i: Stroke. - 0039-2499 .- 1524-4628. ; 33:1, s. P292- Konferensbidrag (övrigt vetenskapligt/konstnärligt)

Lesén, Eva, 1982, et al. (författare)
Dose Patterns among patients using low-dose buprenorphine patches
2013
Ingår i: Pain medicine. - : Oxford University Press (OUP). - 1526-2375 .- 1526-4637. ; 14:9, s. 1374-1380
Tidskriftsartikel (refereegranskat)abstract
- Objective: The objective of this study was to investigate the dose pattern of low-dose buprenorphine patches among patients in Swedish clinical practice. The clinical experts among the coauthors interpreted the results in relation to possible indications of development of tolerance and/or dependence/addiction. Design and Setting: This was a nationwide, observational study using data from the Swedish Prescribed Drug Register. Subjects: Individuals who were dispensed the low-dose buprenorphine patches continuously for more than 24 weeks during July 1, 2005 to February 28, 2011 were included. Methods: The dose pattern was analyzed as the change in dose over time for each patient: 1) the dose at baseline compared with each of the following 8-week intervals, and 2) the dose at baseline compared with the dose during the patients' last treatment period. Results: The majority of the patients were female (74%), and most were 75 years and older (69%). The median treatment duration was 260 days, and 4% and 1% of patients remained on continuous treatment for 2 and 3 years, respectively. The mean dose was 11μg/h at baseline, and 15μg/h during the patients' last treatment period. The average dose increased by 4μg/h during the patients' entire treatment course. Conclusions: The average dose increased by 4μg/h during the patients' treatment course, which lasted on an average of 260 days. From a clinical perspective, the dose increase of 4μg/h is low and does not suggest dependence/addiction, as also supported by the low proportion of patients remaining on continuous treatment. © 2013 American Academy of Pain Medicine.

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