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1.	Georgiadis, Marios, et al. (author) Nanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue 2021 In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 12:1 Journal article (peer-reviewed)abstract Myelin insulates neuronal axons and enables fast signal transmission, constituting a key component of brain development, aging and disease. Yet, myelin-specific imaging of macroscopic samples remains a challenge. Here, we exploit myelin’s nanostructural periodicity, and use small-angle X-ray scattering tensor tomography (SAXS-TT) to simultaneously quantify myelin levels, nanostructural integrity and axon orientations in nervous tissue. Proof-of-principle is demonstrated in whole mouse brain, mouse spinal cord and human white and gray matter samples. Outcomes are validated by 2D/3D histology and compared to MRI measurements sensitive to myelin and axon orientations. Specificity to nanostructure is exemplified by concomitantly imaging different myelin types with distinct periodicities. Finally, we illustrate the method’s sensitivity towards myelin-related diseases by quantifying myelin alterations in dysmyelinated mouse brain. This non-destructive, stain-free molecular imaging approach enables quantitative studies of myelination within and across samples during development, aging, disease and treatment, and is applicable to other ordered biomolecules or nanostructures.

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Type of publication: journal article (1)

Type of content: peer-reviewed (1)

Author/Editor: Yang, Lin (1); Liebi, Marianne, 198 ... (1); Sommer, Stefan (1); Guizar-Sicairos, Man ... (1); Rudin, Markus (1); Bunk, Oliver (1); show more...; Gao, Zirui (1); Georgiadis, Marios (1); Weiss, Thomas (1); David, Gergely (1); Schroeter, Aileen (1); Leuze, Christoph (1); McNab, Jennifer A. (1); Balolia, Aleezah (1); Veraart, Jelle (1); Ades-Aron, Benjamin (1); Kim, Sunglyoung (1); Shepherd, Timothy (1); Lee, Choong H. (1); Walczak, Piotr (1); Chodankar, Shirish (1); DiGiacomo, Phillip (1); Augath, Mark (1); Zerbi, Valerio (1); Rajkovic, Ivan (1); Zhang, Jiangyang (1); Novikov, Dmitry S. (1); Zeineh, Michael (1); Fieremans, Els (1); show less...

University: Chalmers University of Technology (1)

Language: English (1)

Research subject (UKÄ/SCB): Engineering and Technology (1); Medical and Health Sciences (1)

Year: 2021 (1)

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