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- Shepherd, L., et al.
(författare)
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Infection-related and -unrelated malignancies, HIV and the aging population
- 2016
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Ingår i: HIV Medicine. - : Wiley. - 1464-2662 .- 1468-1293. ; 17:8, s. 590-600
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: HIV-positive people have increased risk of infection-related malignancies (IRMs) and infection-unrelated malignancies (IURMs). The aim of the study was to determine the impact of aging on future IRM and IURM incidence. Methods: People enrolled in EuroSIDA and followed from the latest of the first visit or 1 January 2001 until the last visit or death were included in the study. Poisson regression was used to investigate the impact of aging on the incidence of IRMs and IURMs, adjusting for demographic, clinical and laboratory confounders. Linear exponential smoothing models forecasted future incidence. Results: A total of 15 648 people contributed 95 033 person-years of follow-up, of whom 610 developed 643 malignancies [IRMs: 388 (60%); IURMs: 255 (40%)]. After adjustment, a higher IRM incidence was associated with a lower CD4 count [adjusted incidence rate ratio (aIRR) CD4 count < 200 cells/μL: 3.77; 95% confidence interval (CI) 2.59, 5.51; compared with ≥ 500 cells/μL], independent of age, while a CD4 count < 200 cells/μL was associated with IURMs in people aged < 50 years only (aIRR: 2.51; 95% CI 1.40–4.54). Smoking was associated with IURMs (aIRR: 1.75; 95% CI 1.23, 2.49) compared with never smokers in people aged ≥ 50 years only, and not with IRMs. The incidences of both IURMs and IRMs increased with older age. It was projected that the incidence of IRMs would decrease by 29% over a 5-year period from 3.1 (95% CI 1.5–5.9) per 1000 person-years in 2011, whereas the IURM incidence would increase by 44% from 4.1 (95% CI 2.2–7.2) per 1000 person-years over the same period. Conclusions: Demographic and HIV-related risk factors for IURMs (aging and smoking) and IRMs (immunodeficiency and ongoing viral replication) differ markedly and the contribution from IURMs relative to IRMs will continue to increase as a result of aging of the HIV-infected population, high smoking and lung cancer prevalence and a low prevalence of untreated HIV infection. These findings suggest the need for targeted preventive measures and evaluation of the cost−benefit of screening for IURMs in HIV-infected populations.
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- Sierks, H., et al.
(författare)
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Images of Asteroid 21 Lutetia : A Remnant Planetesimal from the Early Solar System
- 2011
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 334:6055, s. 487-490
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Tidskriftsartikel (refereegranskat)abstract
- Images obtained by the Optical, Spectroscopic, and Infrared Remote Imaging System (OSIRIS) cameras onboard the Rosetta spacecraft reveal that asteroid 21 Lutetia has a complex geology and one of the highest asteroid densities measured so far, 3.4 +/- 0.3 grams per cubic centimeter. The north pole region is covered by a thick layer of regolith, which is seen to flow in major landslides associated with albedo variation. Its geologically complex surface, ancient surface age, and high density suggest that Lutetia is most likely a primordial planetesimal. This contrasts with smaller asteroids visited by previous spacecraft, which are probably shattered bodies, fragments of larger parents, or reaccumulated rubble piles.
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| 8. |
- Groussin, O., et al.
(författare)
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THERMAP : a mid-infrared spectro-imager for space missions to small bodies in the inner solar system
- 2016
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 41:1, s. 95-115
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Tidskriftsartikel (refereegranskat)abstract
- We present THERMAP, a mid-infrared spectro-imager for space missions to small bodies in the inner solar system, developed in the framework of the MarcoPolo-R asteroid sample return mission. THERMAP is very well suited to characterize the surface thermal environment of a NEO and to map its surface composition. The instrument has two channels, one for imaging and one for spectroscopy: it is both a thermal camera with full 2D imaging capabilities and a slit spectrometer. THERMAP takes advantage of the recent technological developments of uncooled microbolometer arrays, sensitive in the mid-infrared spectral range. THERMAP can acquire thermal images (8-18 mu m) of the surface and perform absolute temperature measurements with a precision better than 3.5 K above 200 K. THERMAP can acquire mid-infrared spectra (8-16 mu m) of the surface with a spectral resolution Delta lambda of 0.3 mu m. For surface temperatures above 350 K, spectra have a signal-to-noise ratio > 60 in the spectral range 9-13 mu m where most emission features occur.
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| 9. |
- Keller, H. U., et al.
(författare)
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E-Type Asteroid (2867) Steins as Imaged by OSIRIS on Board Rosetta
- 2010
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 327:5962, s. 190-193
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Tidskriftsartikel (refereegranskat)abstract
- The European Space Agency's Rosetta mission encountered the main-belt asteroid (2867) Steins while on its way to rendezvous with comet 67P/Churyumov-Gerasimenko. Images taken with the OSIRIS (optical, spectroscopic, and infrared remote imaging system) cameras on board Rosetta show that Steins is an oblate body with an effective spherical diameter of 5.3 kilometers. Its surface does not show color variations. The morphology of Steins is dominated by linear faults and a large 2.1-kilometer-diameter crater near its south pole. Crater counts reveal a distinct lack of small craters. Steins is not solid rock but a rubble pile and has a conical appearance that is probably the result of reshaping due to Yarkovsky-O'Keefe-Radzievskii-Paddack (YORP) spin-up. The OSIRIS images constitute direct evidence for the YORP effect on a main-belt asteroid.
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- Binzel, R.P., et al.
(författare)
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Compositional distributions and evolutionary processes for the near-Earth object population: Results from the MIT-Hawaii Near-Earth Object Spectroscopic Survey (MITHNEOS)
- 2019
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Ingår i: Icarus. - : Elsevier. - 0019-1035 .- 1090-2643. ; 324, s. 41-76
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Tidskriftsartikel (refereegranskat)abstract
- Advancing technology in near-infrared instrumentation and dedicated planetary telescope facilities have enabled nearly two decades of reconnoitering the spectral properties for near-Earth objects (NEOs). We report measured spectral properties for more than 1000 NEOs, representing >5 percent of the currently discovered population. Thermal flux detected below 2.5 microns allows us to make albedo estimates for nearly 50 objects, including two comets. Additional spectral data are reported for more than 350 Mars-crossing asteroids. Most of these measurements were achieved through a collaboration between researchers at the Massachusetts Institute of Technology and the University of Hawaii, with full cooperation of the NASA Infrared Telescope Facility (IRTF) on Mauna Kea. We call this project the MIT-Hawaii Near-Earth Object Spectroscopic Survey (MITHNEOS; myth-neos). While MITHNEOS has continuously released all spectral data for immediate use by the scientific community, our objectives for this paper are to: (1) detail the methods and limits of the survey data, (2) formally present a compilation of results including their taxonomic classification within a single internally consistent framework, (3) perform a preliminary analysis on the overall population characteristics with a concentration toward deducing key physical processes and identifying their source region for escaping the main belt. Augmenting our newly published measurements are the previously published results from the broad NEO community, including many results graciously shared by colleagues prior to formal publication. With this collective data set, we find the near-Earth population matches the diversity of the main-belt, with all main-belt taxonomic classes represented in our sample. Potentially hazardous asteroids (PHAs) as well as the subset of mission accessible asteroids (ΔV≤ 7 km/s) both appear to be a representative mix of the overall NEO population, consistent with strong dynamical mixing for the population that interacts most closely with Earth. Mars crossers, however, are less diverse and appear to more closely match the inner belt population from where they have more recently diffused. The fractional distributions of major taxonomic classes (60% S, 20% C, 20% other) appear remarkably constant over two orders of magnitude in size (10 km to 100 m), which is eight orders of magnitude in mass, though we note unaccounted bias effects enter into our statistics below about 500m. Given the range of surface ages, including possible refreshment by planetary encounters, we are able to identify a very specific space weathering vector tracing the transition from Q- to Sq- to S-types that follows the natural dispersion for asteroid spectra mapped into principal component space. We also are able to interpret a shock darkening vector that may account for some objects having featureless spectra. Space weathering effects for C-types are complex; these results are described separately by Lantz, Binzel, DeMeo. (2018, Icarus 302, 10-17). Independent correlation of dynamical models with taxonomic classes map the escape zones for NEOs to main-belt regions consistent with well established heliocentric compositional gradients. We push beyond taxonomy to interpret our visible plus near-infrared spectra in terms of the olivine and pyroxene mineralogy consistent with the H, L, and LL classes of ordinary chondrites meteorites. Correlating meteorite interpretations with dynamical escape region models shows a preference for LL chondrites to arrive from the ν6 resonance and H chondrites to have a preferential signature from the mid-belt region (3:1 resonance). L chondrites show some preference toward the outer belt, but not at a significant level. We define a Space Weathering Parameter as a continuous variable and find evidence for step-wise changes in space weathering properties across different planet crossing zones in the inner solar system. Overall we hypothesize the relative roles of planetary encounters, YORP spin-up, and thermal cycling across the inner solar system.
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| 13. |
- Le Coroller, H., et al.
(författare)
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K-Stacker : an algorithm to hack the orbital parameters of planets hidden in high-contrast imaging
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 639
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Tidskriftsartikel (refereegranskat)abstract
- Context. Recent high-contrast imaging surveys, using the Spectro-Polarimetic High contrast imager for Exoplanets REsearch (SPHERE) or the Gemini Planet Imager in search of planets in young, nearby systems, have shown evidence of a small number ofgiant planets at relatively large separation beyond 10–30 au, where those surveys are the most sensitive. Access to smaller physical separations between 5 and 30 au is the next step for future planet imagers on 10 m telescopes and the next generation of extremely large telescopes in order to bridge the gap with indirect techniques such as radial velocity, transit, and soon astrometry with Gaia. In addition to new technologies and instruments, the development of innovative observing strategies combined with optimized data processing tools is participating in the improvement of detection capabilities at very close angular separation. In that context, we recently proposed a new algorithm, Keplerian-Stacker, which combines multiple observations acquired at different epochs and takes into account the orbital motion of a potential planet present in the images to boost the ultimate detection limit. We showed that this algorithm is able to find planets in time series of simulated images of the SPHERE InfraRed Dual-band Imager and Spectrograph (IRDIS) even when a planet remains undetected at one epoch.Aims. Our goal is to test and validate the K-Stacker algorithm performances on real SPHERE datasets to demonstrate the resilience of this algorithm to instrumental speckles and the gain offered in terms of true detection. This will motivate future dedicated multi-epoch observation campaigns of well-chosen, young, nearby systems and very nearby stars carefully selected to search for planets in emitted and reflected light, respectively, to open a new path concerning the observing strategy used with current and future planet imagers.Methods. To test K-Stacker, we injected fake planets and scanned the low signal-to-noise ratio (S/N) regime in a series of raw observations obtained by the SPHERE/IRDIS instrument in the course of the SPHERE High-contrast ImagiNg survey for Exoplanets. We also considered the cases of two specific targets intensively monitored during this campaign: β Pictoris and HD 95086. For each target and epoch, the data were reduced using standard angular differential imaging processing techniques and then recombined with K-Stackerto recover the fake planetary signals. In addition, the known exoplanets β Pictoris b and HD 95086 b previously identified at lower S/N in single epochs have also been recovered by K-Stacker.Results. We show that K-Stacker achieves a high success rate of ≈100% when the S/N of the planet in the stacked image reaches≈9. The improvement of the S/N is given as the square root of the total exposure time contained in the data being combined. At S/N<6−7, the number of false positives is high near the coronagraphic mask, but a chromatic study or astrophysical criteria can help to disentangle between a bright speckle and a true detection. During the blind test and the redetection of HD 95086 b, and β Pic b, we highlight the ability of K-Stacker to find orbital solutions consistent with those derived by the current Markov chain Monte Carlo orbital fitting techniques. This confirms that in addition to the detection gain, K-Stacker offers the opportunity to characterize the most probable orbital solutions of the exoplanets recovered at low S/N.
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| 14. |
- Rousselot, P., et al.
(författare)
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Search for water outgassing of (1) Ceres near perihelion
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 628
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Tidskriftsartikel (refereegranskat)abstract
- Context. (1) Ceres is the largest body in the main asteroid belt and one of the most intriguing objects in the solar system, in part because of the discovery of water outgassing by the Herschel Space Observatory (HSO) and its still-debated origin. Ceres was the target of NASA's Dawn spacecraft for 3.5 yr, which achieved a detailed characterization of the dwarf planet. The possible influence of the local flux of solar energetic particles (SEP) on the production of a Cerean exosphere and water vapor has been suggested, in addition to the sublimation of water ice that depends on the temperature, meaning the heliocentric distance. Aims. We used the opportunity of both the perihelion passage of (1) Ceres in April 2018, and the presence of Dawn in its vicinity (for measuring the SEP flux in real time) to check the influence of heliocentric distance and SEP flux on water outgassing. Methods. We searched for OH emission lines near the limb of Ceres in the near-UV with the UVES spectrograph mounted on the 8-m ESO Very Large Telescope. Two spectra were recorded when Ceres was close to its perihelion, in February 2018, and with Dawn spacecraft orbiting Ceres. It was possible to simultaneously measure energetic particles around Ceres at the time of our observations. Results. Our observations did not permit detection of OH emission lines to a very high sensitivity level. This level is estimated to correspond to a global water production rate of QH2O ∼ 2 × 1026 molecules s-1, similar to the water production rate derived from HSO observations. The solar energetic particles flux measured around Ceres was negligible at the time of these observations. Conclusions. Our observations support the idea that heliocentric distance (i.e., the sublimation of water ice) does not play a major role in the water emission from Ceres. This production rate could be either related to SEP events or to other mechanisms, possibly of endogenic origin.
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| 16. |
- Marsset, Michaël, et al.
(författare)
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The Debiased Compositional Distribution of MITHNEOS: Global Match between the Near-Earth and Main-belt Asteroid Populations, and Excess of D-type Near-Earth Objects
- 2022
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Ingår i: Astronomical Journal. - : Institute of Physics (IOP). - 0004-6256 .- 1538-3881. ; 163:4
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Tidskriftsartikel (refereegranskat)abstract
- We report 491 new near-infrared spectroscopic measurements of 420 near-Earth objects (NEOs) collected on the NASA InfraRed Telescope Facility as part of the MIT-Hawaii NEO Spectroscopic Survey. These measurements were combined with previously published data from Binzel et al. and bias-corrected to derive the intrinsic compositional distribution of the overall NEO population, as well as of subpopulations coming from various escape routes (ERs) in the asteroid belt and beyond. The resulting distributions reflect well the overall compositional gradient of the asteroid belt, with decreasing fractions of silicate-rich (S- and Q-type) bodies and increasing fractions of carbonaceous (B-, C-, D- and P-type) bodies as a function of increasing ER distance from the Sun. The close compositional match between NEOs and their predicted source populations validates dynamical models used to identify ERs and argues against any strong composition change with size in the asteroid belt between ∼5 km and ∼100 m. A notable exception comes from the overabundance of D-type NEOs from the 5:2J and, to a lesser extend, the 3:1J and ν6 ERs, hinting at the presence of a large population of small D-type asteroids in the main belt. Alternatively, this excess may indicate preferential spectral evolution from D-type surfaces to C and P types as a consequence of space weathering, or point to the fact that D-type objects fragment more often than other spectral types in the NEO space. No further evidence for the existence of collisional families in the main belt, below the detection limit of current main-belt surveys, was found in this work.
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