| 1. |
- Affatato, S., et al.
(författare)
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Microstructural effects on the wear resistance of CO-CR implant alloys
- 2006
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Ingår i: Proceedings of the 8th Biennial Conference on Engineering Systems Design and Analysis. - : ASMEDC. - 0791837793 - 9780791837795 ; , s. -951
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Konferensbidrag (refereegranskat)abstract
- Modem metal-on-metal articulation have been proposed to reduce the incidence of osteolysis due to polyethylene particles debris, as a late complication. The tribology of large metal-on-metal articulations allows theoretical advantages with respect to other configurations, especially for the lubrication regime. This study was aimed to compare the wear performances of different diameters of clinically available acetabular metallic components manufactured in a cast cobalt-chrome alloy. To evaluate the influence of the material properties of wear and microstructure, metal-on-metal components were tested in a hip joint simulator for five million cycles with bovine calf serum as lubricant. In particular, three different configurations of metal-on-metal components (28-mm, 36-mm, 54-mm) were tested. After the test all specimens were examined with optical and electronic scanning microscope. A statistical difference were observed among the three groups tested in the run-in and steady-state wear rates, favoring the larger femoral heads. The results of this study indicate that the 54-mm diameter femoral heads prove a better wear behavior than the smaller configurations.
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| 2. |
- Hunter, P, et al.
(författare)
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A vision and strategy for the virtual physiological human in 2010 and beyond
- 2010
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Ingår i: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences. - : The Royal Society. - 1364-503X. ; 368:1920, s. 2595-2614
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Tidskriftsartikel (refereegranskat)abstract
- European funding under framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for nearly 2 years. The VPH network of excellence (NoE) is helping in the development of common standards, open-source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also helping to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by framework 6 strategy for a European physiome (STEP) project in 2006. It is now time to assess the accomplishments of the last 2 years and update the STEP vision for the VPH. We consider the biomedical science, healthcare and information and communications technology challenges facing the project and we propose the VPH Institute as a means of sustaining the vision of VPH beyond the time frame of the NoE.
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| 3. |
- Imboden, S., et al.
(författare)
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A Haptic Enabled Multimodal Pre-Operative Planner for Hip Arthroplasty
- 2005
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Ingår i: World Haptics Conference: First Joint Eurohaptics Conference and Symposium on Haptic Interfaces for Virutual Environment and Teleoperator Systems, Proceedings. - 0769523102 ; , s. 503-504
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Konferensbidrag (refereegranskat)abstract
- This paper introduces the multisense idea, with a special reference to the use of haptics in the medical field and, in particular, in the planning of total hip replacement surgery. We emphasise the integration of different modalities and the capability of the multimodal system to gather and register data coming from different sources.
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| 4. |
- Testi, D., et al.
(författare)
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A multimodal and multisensorial pre-operative planning environment for total hip replacement
- 2005
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Ingår i: Proceedings - Third International Conference on Medical Information Visualisation - BioMedical Visualisation, MediVis 2005. - 0769523935 - 9780769523934 ; , s. 25-29
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Konferensbidrag (refereegranskat)abstract
- This paper describes a new environment for the pre-operative planning of total hip replacement. The system is based on a multimodal/multisensorial interface, which includes advanced software visualisation and evaluation modules for the planning and state-of-the-art technologies for immersive interface (stereoscopic display, different six degrees of freedom tracking technologies, speech recognition, and haptic feedbacks). This paper is focused on the final clinical application description. More specific visualisation-related modules are described in other related papers.
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| 5. |
- Coveney, PV, et al.
(författare)
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Integrative approaches to computational biomedicine
- 2013
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Ingår i: INTERFACE FOCUS. - : The Royal Society. - 2042-8898 .- 2042-8901. ; 3:2
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The new discipline of computational biomedicine is concerned with the application of computer-based techniques and particularly modelling and simulation to human health. Since 2007, this discipline has been synonymous, in Europe, with the name given to the European Union's ambitious investment in integrating these techniques with the eventual aim of modelling the human body as a whole: the virtual physiological human. This programme and its successors are expected, over the next decades, to transform the study and practice of healthcare, moving it towards the priorities known as ‘4P's’: predictive, preventative, personalized and participatory medicine.
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| 6. |
- Jedenmalm, Anneli, et al.
(författare)
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Effect of head surface roughness and sterilization on wear of UHMWPE acetabular cups
- 2009
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Ingår i: Journal of Biomedical Materials Research. - : Wiley. - 0021-9304 .- 1097-4636 .- 1549-3296 .- 1552-4965. ; 90:4, s. 1032-1042
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Tidskriftsartikel (refereegranskat)abstract
- The impact of femoral head surface roughness on wear of gamma-irradiation sterilized (3 MRad in nitrogen, crosslinked) and nonsterilized (not crosshnked) UHMWPE acetabular cups has been evaluated. Gravimetric wear testing was performed in a hip joint simulator for 2 x 10(6) cycles. CoCrMo heads were used with different surface roughness (R-a = 15 nm and R-a = 400 rim). The surface roughness after wear test was unchanged for the roughened heads, whereas the initially smooth heads showed a few scratches. The roughened heads increased the wear of the acetabular cups 2-fold. The gamma-irradiated cups tested against rough heads underwent the highest wear. The absorption of water was highest for the gamma-irradiated cups (0.0204% compared to 0.0031% after 85 days). Raman spectroscopy showed small but significant crystallinity changes in the wear zone, where the gamma-irradiated cups with the most extensive abrasion increased in crystallinity, whereas the nonsterilized cups underwent a crystallinity decrease.
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| 7. |
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