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- Bernal, Ximena E., et al.
(författare)
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Empowering Latina scientists
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 363:6429, s. 825-826
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Faux, Pierre, et al.
(författare)
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Neanderthal introgression in SCN9A impacts mechanical pain sensitivity
- 2023
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Ingår i: Communications Biology. - 2399-3642. ; 6:1
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Tidskriftsartikel (refereegranskat)abstract
- The Nav1.7 voltage-gated sodium channel plays a key role in nociception. Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate with pain symptomatology in UK BioBank data. In 1000 genomes data, these variants are absent in Europeans but common in Latin Americans. Analysing high-density genotype data from 7594 Latin Americans, we characterized Neanderthal introgression in SCN9A. We find that tracts of introgression occur on a Native American genomic background, have an average length of similar to 123kb and overlap the M932L, V991L, and D1908G coding positions. Furthermore, we measured experimentally six pain thresholds in 1623 healthy Colombians. We found that Neanderthal ancestry in SCN9A is significantly associated with a lower mechanical pain threshold after sensitization with mustard oil and evidence of additivity of effects across Nav1.7 variants. Our findings support the reported association of Neanderthal Nav1.7 variants with clinical pain, define a specific sensory modality affected by archaic introgression in SCN9A and are consistent with independent effects of the Neanderthal variants on Nav1.7 function. Neanderthal-derived variants in the SCN9A gene (encoding the voltage gated sodium channel, Nav1.7) are associated with enhanced experimental mechanical pain sensitivity in modern humans.
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| 3. |
- Flynn, Susan, et al.
(författare)
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Cam. Alice’s Looking Glass in the 21st Century
- 2021
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Ingår i: The Body Onscreen in the Digital Age. Essays on Voyeurism, Violence and Power. - Jefferson : McFarland. - 9781476680996
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Bokkapitel (refereegranskat)
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| 4. |
- Mendoza-Revilla, Javier, et al.
(författare)
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Disentangling Signatures of Selection Before and After European Colonization in Latin Americans
- 2022
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Ingår i: Molecular biology and evolution. - : Oxford University Press (OUP). - 0737-4038 .- 1537-1719. ; 39:4
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Tidskriftsartikel (refereegranskat)abstract
- Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated human groups. Although classical and recent work have shown that studying admixture can yield novel historical insights, the extent to which this process contributed to adaptation remains underexplored. Here, we introduce a novel statistical model, specific to admixed populations, that identifies loci under selection while determining whether the selection likely occurred post-admixture or prior to admixture in one of the ancestral source populations. Through extensive simulations, we show that this method is able to detect selection, even in recently formed admixed populations, and to accurately differentiate between selection occurring in the ancestral or admixed population. We apply this method to genome-wide SNP data of ∼4,000 individuals in five admixed Latin American cohorts from Brazil, Chile, Colombia, Mexico, and Peru. Our approach replicates previous reports of selection in the human leukocyte antigen region that are consistent with selection post-admixture. We also report novel signals of selection in genomic regions spanning 47 genes, reinforcing many of these signals with an alternative, commonly used local-ancestry-inference approach. These signals include several genes involved in immunity, which may reflect responses to endemic pathogens of the Americas and to the challenge of infectious disease brought by European contact. In addition, some of the strongest signals inferred to be under selection in the Native American ancestral groups of modern Latin Americans overlap with genes implicated in energy metabolism phenotypes, plausibly reflecting adaptations to novel dietary sources available in the Americas.
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| 12. |
- Villegas Lindvall, Valeria Alejandra, 1987
(författare)
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Wicked women and witches. Subversive readings of the female monster in Mexican and Argentinian horror film
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis accrues to the growing field of Latin American horror scholarship in relation to gender and sexuality, discussing the implications of the representation of the feminized, racialized and/or impoverished monster in relation to Mexican and Argentinian national identity discourses. The thesis looks at two distinct iterations of gendered monstrosity in Mexican and Argentinian visual culture: La Llorona and the bruja (witch), respectively. Through six case studies, the thesis examines the ways in which these monsters shore up and negotiate the roles allotted to their bodies in the larger process of national identity writing. This study ascertains the usefulness of these monstrous entities in perpetual categorical inbetweenness, a position from which they enable critique on the colonial optic that has informed their depiction. These distributions of power, it is argued, are worked through foundational conflicts that embroil La Llorona and the bruja, namely: Mexico’s reckoning with a colonial past turned colonial present and Argentina’s foundational opposition between the redeeming potentialities of “civilization” over “barbarism.” In order to tackle the transmogrification and hierarchization of sexual difference as vital to the writing of national identity discourses, this thesis draws from feminist philosophy and decolonial thought. From the former, it recuperates Luce Irigaray’s writing on fluidity and her critique of the constraints of patriarchal languages in the articulation of gender and sexuality and the hierarchization of difference. I envision fluidity as a faculty that allows us to better understand the ways in which patriarchal organizations of knowledge, time and sexuality reveal cracks in their configuration. These organizations, I posit, can be readily ascertained as the foundation of national projects written from colonial, patriarchal predominance. However, this thesis also acknowledges the limitations of psychoanalytical frameworks to account for racial difference and its relation to gender. Therefore, I turn to decolonial thought, reflecting on race and gender as co-constitutive, colonial fictions that inform representations of La Llorona and the bruja. In addition, this thesis relies on contextual readings that account for the importance of the political, cultural and historical circumstances in which each case study is embedded. Chapter One offers and overview of the ways in which Mexico and Argentina have followed similar tracks in terms of horror filmmaking, arguing for the parallel evaluation of their industrial, cultural and historical contexts, to present a novel way of reading the fashioning of their national identities by looking at their genre films. Chapter Two focuses on the figure of La Llorona (The Weeping Woman) as a presence that evinces the painful colonial wound over which mestizo nationalism has encroached, voicing the trauma of oppression and exploitation of racialized and feminized bodies in service of colonial patriarchy. The chapter tracks the origins of the myth to La Llorona (dir. Ramón Peón, 1933), its subversion to La Maldición de La Llorona (dir. Rafael Baledón, 1961) and its updating as a figure of resistance in the era of feminicidio and gore capitalism in Vuelven (dir. Issa López, 2017). Lastly, Chapter Three explores the possibilities of the Argentinian bruja as the embodiment of all that stands outside of “civilization,” resisting the violence of its project in the advancement of colonial modernity by denouncing the regulation of the body and its knowledges. The chapter offers the hypersexual witch of Embrujada (dir. Armando Bó, 1969) as an affront to the policing of the body, its pleasures and knowledges and as a way to negotiate normative models of femininity and family in accordance to nationalist values. It then approaches the policing and governance of the body, birth and reproduction in two contemporary pieces: Habitaciones para turistas (dir. Adrián García Bogliano, 2004) and Luciferina (dir. Gonzalo Calzada, 2018). These case studies, I argue, find in the bruja a figure that either challenges or enacts the oppressions of extreme coloniality embodied in dictatorial necropolitical projects, always functioning as an enabler of critical thought.
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