SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Vincent CT) "

Search: WFRF:(Vincent CT)

  • Result 1-11 of 11
Sort/group result
   
EnumerationReferenceCoverFind
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  • Losa, M, et al. (author)
  • Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion
  • 2018
  • In: Development (Cambridge, England). - : The Company of Biologists. - 1477-9129 .- 0950-1991. ; 145:5
  • Journal article (peer-reviewed)abstract
    • Human cleft lip with or without cleft palate (CL/P) is a common craniofacial abnormality caused by impaired fusion of the facial prominences. We have previously reported that in the mouse embryo epithelial apoptosis mediates fusion at the seam where the prominences coalesce. Here, we show that apoptosis alone is not sufficient to remove the epithelial layers. We observed morphological changes in the seam epithelia, intermingling of cells of epithelial descent into the mesenchyme, and molecular signatures of Epithelial-Mesenchymal-Transition (EMT). Utilizing mouse lines with cephalic epithelium-specific Pbx loss exhibiting CL/P, we demonstrate that these cellular behaviors are Pbx-dependent, as is the transcriptional regulation of the EMT driver Snail1. Furthermore, in the embryo the majority of epithelial cells expressing high levels of Snail1 do not undergo apoptosis. Pbx1 loss- and gain-of-function in a tractable epithelial culture system revealed that Pbx1 is both necessary and sufficient for EMT induction. This study establishes that Pbx-dependent EMT programs mediate murine upper lip/primary palate morphogenesis and fusion via regulation of Snail1. Of note, the EMT signatures observed in the embryo are mirrored in the epithelial culture system.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
11.
  • Vincent, CT, et al. (author)
  • EMT, inflammation and metastasis
  • 2017
  • In: Seminars in cancer biology. - : Elsevier BV. - 1096-3650 .- 1044-579X. ; 47, s. 168-169
  • Journal article (other academic/artistic)
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-11 of 11

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view