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Träfflista för sökning "WFRF:(Visentini Marcella) "

Sökning: WFRF:(Visentini Marcella)

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1.
  • Camponeschi, Alessandro, et al. (författare)
  • Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells.
  • 2022
  • Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 219:9
  • Tidskriftsartikel (refereegranskat)abstract
    • CD38 is a multifunctional protein expressed on the surface of B cells in healthy individuals but also in B cell malignancies. Previous studies have suggested a connection between CD38 and components of the IgM class B cell antigen receptor (IgM-BCR) and its coreceptor complex. Here, we provide evidence that CD38 is closely associated with CD19 in resting B cells and with the IgM-BCR upon engagement. We show that targeting CD38 with an antibody, or removing this molecule with CRISPR/Cas9, inhibits the association of CD19 with the IgM-BCR, impairing BCR signaling in normal and malignant B cells. Together, our data suggest that CD38 is a new member of the BCR coreceptor complex, where it exerts a modulatory effect on B cell activation upon antigen recognition by regulating CD19. Our study also reveals a new mechanism where α-CD38 antibodies could be a valuable option in therapeutic approaches to B cell malignancies driven by aberrant BCR signaling.
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2.
  • Lundqvist, Christina, 1988, et al. (författare)
  • Switched CD21-/low B cells with an antigen-presenting phenotype in the infant thymus.
  • 2019
  • Ingår i: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 143:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Half of all B cells in the human thymus are mature CD21-/low AIRE-expressing cells with a professional antigen presenting cell phenotype, implying a role in T-cell selection and therefore critical in preventing autoimmunity.
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