| 1. |
- Bösl, Korbinian, et al.
(författare)
-
Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis
- 2019
-
Ingår i: Frontiers in Immunology. - : FRONTIERS MEDIA SA. - 1664-3224. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways and evade innate immune response by modulating key host factors and signaling pathways. A collective view of these multiple studies could advance our understanding of virus-host interactions and provide new therapeutic perspectives for the treatment of viral diseases. Here, we performed an integrative meta-analysis to elucidate the 17 different host-virus interactomes. Network and bioinformatics analyses showed how viruses with small genomes efficiently achieve the maximal effect by targeting multifunctional and highly connected host proteins with a high occurrence of disordered regions. We also identified the core cellular process subnetworks that are targeted by all the viruses. Integration with functional RNA interference (RNAi) datasets showed that a large proportion of the targets are required for viral replication. Furthermore, we performed an interactome-informed drug re-purposing screen and identified novel activities for broad-spectrum antiviral agents against hepatitis C virus and human metapneumovirus. Altogether, these orthogonal datasets could serve as a platform for hypothesis generation and follow-up studies to broaden our understanding of the viral evasion landscape.
|
|
| 2. |
- Ianevski, Aleksandr, et al.
(författare)
-
Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010-2018
- 2019
-
Ingår i: Viruses. - : MDPI AG. - 1999-4915. ; 11:3
-
Tidskriftsartikel (refereegranskat)abstract
- With the increasing pace of global warming, it is important to understand the role of meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of temperature, UV index, humidity, wind speed, atmospheric pressure, and precipitation on IV activity in Norway, Sweden, Finland, Estonia, Latvia and Lithuania during 2010-2018. Both correlation and machine learning analyses revealed that low temperature and UV indexes were the most predictive meteorological factors for IV epidemics in Northern Europe. Our in vitro experiments confirmed that low temperature and UV radiation preserved IV infectivity. Associations between these meteorological factors and IV activity could improve surveillance and promote development of accurate predictive models for future influenza outbreaks in the region.
|
|
| 3. |
- Ianevski, Aleksandr, et al.
(författare)
-
Novel activities of safe-in-human broad-spectrum antiviral agents
- 2018
-
Ingår i: Antiviral Research. - : Elsevier. - 0166-3542 .- 1872-9096. ; 154, s. 174-182
-
Tidskriftsartikel (refereegranskat)abstract
- According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-inhuman antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we reviewed all approved, investigational and experimental antiviral agents, which are safe in man, and identified 59 compounds that target at least three viral diseases. We tested 55 of these compounds against eight different RNA and DNA viruses. We found novel activities for dalbavancin against echovirus 1, ezetimibe against human immunodeficiency virus 1 and Zika virus, as well as azacitidine, cyclosporine, minocycline, oritavancin and ritonavir against Rift valley fever virus. Thus, the spectrum of antiviral activities of existing antiviral agents could be expanded towards other viral diseases.
|
|
| 4. |
- Skrodeniene, Erika, et al.
(författare)
-
Associations between HLA class II haplotypes, environmental factors and type 1 diabetes mellitus in Lithuanian children with type 1 diabetes and controls
- 2010
-
Ingår i: Polish Annals of Medicine. - Warsaw, Poland : Elsevier Urban & Partner Sp. z o.o.. - 1230-8013. ; 17:1, s. 7-15
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction. The onset of type 1 diabetes (T1D) is determined by genetic predisposition and environmental factors. Aim. The aim of our work was to identify associations between human leukocytes antigen (HLA) class II alleles, environmental factors and T1D in Lithuania. Materials and methods. Our case-control study included 124 diabetic children (mean age 9.19±3.94 years) and 78 controls (mean age 10.77±3.36 years). The age ranged from 0 to 15 years. HLA-DRB1, DQA1 and DQB1 alleles were genotyped using polymerase chain reaction. Information concerning the environmental factors was collected via questionnaires. Results. Logistic regression model indicated that three haplotypes: (DR3)-DQA1*0501-DQB1*0201, (DR4)-DQA1*0301-DQB1*0302 and (DR1)-DQA1 *010-04-DQB1*0501, increased the T1D risk statistically significantly 18.1, 12.3 and 3.4 times, respectively, while (DR11/12/13)-DQA1*05-DQB1*0301 haplotype decreased the risk of T1D 9.1 times. Several different regression models included environmental factors and different sets of risk and protective haplotypes. The results suggest that living in a remote area with lower population density during pregnancy increased the risk of T1D, as well as short breastfeeding, introduction of eggs before 5th month of age and infections during the last 6 months before diagnosis. Smoking during pregnancy as well as rubella and varicella virus infections seemed to decrease the risk of T1D. These associations were revealed while evaluating only environmental factors and when different HLA haplotypes together with environmental factors were included in the regression model. Discussion. The HLA typing shows that the differences in the incidence of T1D between Lithuania and neighboring countries cannot be explained only by genetics, but lifestyle and/or environmental factors should be considered. A number of studies presented here, have shown conflicting results regarding environmental factors and their associations with T1D. Conclusions. Both genetic and environmental factors play a major role in diabetes development and protection. However, even quite rapidly ongoing changes of environmental factors and lifestyle in Lithuania have not helped us to reveal any clear picture.
|
|
