| 1. |
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| 2. |
- Speliotes, Elizabeth K., et al.
(författare)
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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| 3. |
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| 4. |
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| 5. |
- Locke, Adam E, et al.
(författare)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 6. |
- Shungin, Dmitry, et al.
(författare)
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New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
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Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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| 7. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 10. |
- Shebanits, Oleg, 1984-, et al.
(författare)
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On Ion Drifts and Neutral Winds in Titan’s Thermosphere
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Saturn’s largest moon Titan hosts an atmosphere with complex organic chemistry initiated partly in the ionosphere. The nightside chemistry may be influenced by the ion transport from the dayside ionosphere. In turn, ion transport (ion drifts) may be affected by the neutral winds, which cannot be measured directly by Cassini. In this study we derive the ion drifts along the spacecraft trajectories based on analysis of in-situ measurements of electron and ion fluxes, mean masses of positive and negative ions and the magnetic field. Data from Titan flybys TA to T100 (Oct 2005 - Apr 2014) is included in this study, 55 flybys are below 1400 km and 48 are below 1200 km altitude. Based on the measurements, three regions of the ionosphere were defined by altitude: 1) above 1600 km, ions are ?×?-drifting (frozen into the magnetic field), 2) 1100-1600 km, dynamo-region, ions drift partly in opposite directions (perpendicular to B) and 3) below 1100 km (upper limit depends on convection electric field strength), ions are following neutrals.
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| 11. |
- Lee, Eun-Young, et al.
(författare)
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Play, Learn, and Teach Outdoors—Network (PLaTO-Net) : terminology, taxonomy, and ontology
- 2022
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Ingår i: International Journal of Behavioral Nutrition and Physical Activity. - : BioMed Central (BMC). - 1479-5868. ; 19:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: A recent dialogue in the field of play, learn, and teach outdoors (referred to as “PLaTO” hereafter) demonstrated the need for developing harmonized and consensus-based terminology, taxonomy, and ontology for PLaTO. This is important as the field evolves and diversifies in its approaches, contents, and contexts over time and in different countries, cultures, and settings. Within this paper, we report the systematic and iterative processes undertaken to achieve this objective, which has built on the creation of the global PLaTO-Network (PLaTO-Net). Methods: This project comprised of four major methodological phases. First, a systematic scoping review was conducted to identify common terms and definitions used pertaining to PLaTO. Second, based on the results of the scoping review, a draft set of key terms, taxonomy, and ontology were developed, and shared with PLaTO members, who provided feedback via four rounds of consultation. Third, PLaTO terminology, taxonomy, and ontology were then finalized based on the feedback received from 50 international PLaTO member participants who responded to ≥ 3 rounds of the consultation survey and dialogue. Finally, efforts to share and disseminate project outcomes were made through different online platforms. Results: This paper presents the final definitions and taxonomy of 31 PLaTO terms along with the PLaTO-Net ontology model. The model incorporates other relevant concepts in recognition that all the aspects of the model are interrelated and interconnected. The final terminology, taxonomy, and ontology are intended to be applicable to, and relevant for, all people encompassing various identities (e.g., age, gender, culture, ethnicity, ability). Conclusions: This project contributes to advancing PLaTO-based research and facilitating intersectoral and interdisciplinary collaboration, with the long-term goal of fostering and strengthening PLaTO’s synergistic linkages with healthy living, environmental stewardship, climate action, and planetary health agendas. Notably, PLaTO terminology, taxonomy and ontology will continue to evolve, and PLaTO-Net is committed to advancing and periodically updating harmonized knowledge and understanding in the vast and interrelated areas of PLaTO.
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| 12. |
- Mandt, Kathleen E., et al.
(författare)
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Ion densities and composition of Titan's upper atmosphere derived from the Cassini Ion Neutral Mass Spectrometer : Analysis methods and comparison of measured ion densities to photochemical model simulations
- 2012
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 117, s. E10006-
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Tidskriftsartikel (refereegranskat)abstract
- The Cassini Ion Neutral Mass Spectrometer (INMS) has measured both neutral and ion species in Titan's upper atmosphere and ionosphere and the Enceladus plumes. Ion densities derived from INMS measurements are essential data for constraining photochemical models of Titan's ionosphere. The objective of this paper is to present an optimized method for converting raw data measured by INMS to ion densities. To do this, we conduct a detailed analysis of ground and in-flight calibration to constrain the instrument response to ion energy, the critical parameter on which the calibration is based. Data taken by the Cassini Radio Plasma Wave Science Langmuir Probe and the Cassini Plasma Spectrometer Ion Beam Spectrometer are used as independent measurement constraints in this analysis. Total ion densities derived with this method show good agreement with these data sets in the altitude region (similar to 1100-1400 km) where ion drift velocities are low and the mass of the ions is within the measurement range of the INMS (1-99 Daltons). Although ion densities calculated by the method presented here differ slightly from those presented in previous INMS publications, we find that the implications for the science presented in previous publications is mostly negligible. We demonstrate the role of the INMS ion densities in constraining photochemical models and find that (1) cross sections having high resolution as a function of wavelength are necessary for calculating the initial photoionization products and (2) there are disagreements between the measured ion densities representative of the initial steps in Titan photochemistry that require further investigation.
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| 13. |
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| 14. |
- Dreyer, Joshua, et al.
(författare)
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Utilizing Helium Ion Chemistry to Derive Mixing Ratios of Heavier Neutral Species in Saturn's Equatorial Ionosphere
- 2023
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Ingår i: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 128:6
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Tidskriftsartikel (refereegranskat)abstract
- A surprisingly strong influx of organic-rich material into Saturn's upper atmosphere from its rings was observed during the proximal obits of the Grand Finale of the Cassini mission. Measurements by the Ion and Neutral Mass Spectrometer (INMS) gave insights into the composition of the material, but it remains to be resolved what fraction of the inferred heavy volatiles should be attributed as originating from the fragmentation of dust particles in the instrument versus natural ablation of grains in the atmosphere. In the present study, we utilize measured light ion and neutral densities to further constrain the abundances of heavy volatiles in Saturn's ionosphere through a steady-state model focusing on helium ion chemistry. We first show that the principal loss mechanism of He+ in Saturn's equatorial ionosphere is through reactions with species other than H-2. Based on the assumption of photochemical equilibrium at altitudes below 2,500 km, we then proceed by estimating the mixing ratio of heavier volatiles down to the closest approaches for Cassini's proximal orbits 288 and 292. Our derived mixing ratios for the inbound part of both orbits fall below those reported from direct measurements by the INMS, with values of similar to 2 x 10(-4) at closest approaches and order-of-magnitude variations in either direction over the orbits. This aligns with previous suggestions that a large fraction of the neutrals measured by the INMS stems from the fragmentation of infalling dust particles that do not significantly ablate in the considered part of Saturn's atmosphere and are thus unavailable for reactions. Plain Language Summary During the final orbits of the Cassini mission, the spacecraft flew between Saturn's rings and the planets upper atmosphere. The onboard plasma instruments detected a large amount of ring particles falling toward the planet, but direct measurements of the composition of these grains are complicated due to the high spacecraft speed and instrumental effects. In this study, we present an independent method to estimate the abundance of heavier neutral species entering the atmosphere from infalling ring material. This method relies on helium ion chemistry and the measured light ion and neutral densities. Our results generally fall below those inferred from direct measurements. Together with comparisons to other studies, this potentially suggests that a large fraction of the infalling neutral species do not significantly ablate in the considered part of Saturn's atmosphere (and remain bound to the dust grains instead) and are thus unavailable for reactions.
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| 15. |
- Kobayashi, Kensei, et al.
(författare)
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Laboratory Studies of Methane and Its Relationship to Prebiotic Chemistry
- 2017
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Ingår i: Astrobiology. - : Mary Ann Liebert Inc. - 1531-1074 .- 1557-8070. ; 17:8, s. 786-812
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Forskningsöversikt (refereegranskat)abstract
- To examine how prebiotic chemical evolution took place on Earth prior to the emergence of life, laboratory experiments have been conducted since the 1950s. Methane has been one of the key molecules in these investigations. In earlier studies, strongly reducing gas mixtures containing methane and ammonia were used to simulate possible reactions in the primitive atmosphere of Earth, producing amino acids and other organic compounds. Since Earth's early atmosphere is now considered to be less reducing, the contribution of extraterrestrial organics to chemical evolution has taken on an important role. Such organic molecules may have come from molecular clouds and regions of star formation that created protoplanetary disks, planets, asteroids, and comets. The interstellar origin of organics has been examined both experimentally and theoretically, including laboratory investigations that simulate interstellar molecular reactions. Endogenous and exogenous organics could also have been supplied to the primitive ocean, making submarine hydrothermal systems plausible sites of the generation of life. Experiments that simulate such hydrothermal systems where methane played an important role have consequently been conducted. Processes that occur in other Solar System bodies offer clues to the prebiotic chemistry of Earth. Titan and other icy bodies, where methane plays significant roles, are especially good targets. In the case of Titan, methane is both in the atmosphere and in liquidospheres that are composed of methane and other hydrocarbons, and these have been studied in simulation experiments. Here, we review the wide range of experimental work in which these various terrestrial and extraterrestrial environments have been modeled, and we examine the possible role of methane in chemical evolution.
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| 16. |
- Shebanits, Oleg, et al.
(författare)
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Photoionization modeling of Titan’s dayside ionosphere
- 2017
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8205 .- 2041-8213. ; 850:2
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Tidskriftsartikel (refereegranskat)abstract
- Previous modeling studies of Titan’s dayside ionosphere predicts electron numberdensities roughly a factor of 2 higher than observed by the RPWS/Langmuir probe. The issuecan equivalently be described as that the ratio between the calculated electron productionrates and the square of the observed electron number densities result in roughly a factor of4 higher effective recombination coefficient than expected from the ion composition and theelectron temperature. Here we make an extended reassessment of Titan’s dayside ionizationbalance focusing on 34 flybys between TA and T120. Using a re-calibrated dataset and bytaking the presence of negative ions into account we arrive at lower effective recombinationcoefficients compared with earlier studies. The values are still higher than expected from theion composition and the electron temperature, but by a factor of ~2 − 3 instead of a factorof ~4. We have also investigated whether the derived effective recombination coefficientsdisplay dependencies on parameters such as the solar zenith angle, the integrated solar EUVintensity (< 80 nm) and the corotational plasma ram direction and found statisticallysignificant trends which may be explained by a declining photoionization against thebackground ionization by magnetospheric particles (SZA, RAM) and altered photochemistry(EUV). We find that a series of flybys that occurred during solar minimum (2008) and withsimilar flyby geometries are associated with enhanced values of the effective recombinationcoefficient compared with the remaining dataset, which also suggests a chemistry dependenton the sunlight conditions.
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| 17. |
- Shebanits, Oleg, et al.
(författare)
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Titan’s ionosphere : A survey of solar EUV influences
- 2017
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Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 122:7, s. 7491-7503
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Tidskriftsartikel (refereegranskat)abstract
- Effects of solar EUV on positive ions and heavy negative charge carriers (molecular ions, aerosol, and/or dust) in Titan’s ionosphere are studied over the course of almost 12 years, including 78 flybys below 1400 km altitude between TA (October 2004) and T120 (June 2016). The Radio and Plasma Wave Science/Langmuir Probe-measured ion charge densities (normalized by the solar zenith angle) show statistically significant variations with respect to the solar EUV flux. Dayside charge densities increase by a factor of ≈2 from solar minimum to maximum, while nightside charge densities are found to anticorrelate with the EUV flux and decrease by a factor of ≈3–4. The overall EUV dependence of the ion charge densities suggest inapplicability of the idealized Chapman theory below 1200 km in Titan’s ionosphere. Nightside charge densities are also found to vary along Titan’s orbit, with higher values in the sunward magnetosphere of Saturn compared to the magnetotail.
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| 18. |
- Sulaiman, Ali H., et al.
(författare)
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Enceladus and Titan : emerging worlds of the Solar System
- 2022
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Ingår i: Experimental astronomy. - : Springer Nature. - 0922-6435 .- 1572-9508. ; 54:2-3, s. 849-876
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Tidskriftsartikel (refereegranskat)abstract
- Some of the major discoveries of the recent Cassini-Huygens mission have put Titan and Enceladus firmly on the Solar System map. The mission has revolutionised our view of Solar System satellites, arguably matching their scientific importance with that of their host planet. While Cassini-Huygens has made big surprises in revealing Titan's organically rich environment and Enceladus' cryovolcanism, the mission's success naturally leads us to further probe these findings. We advocate the acknowledgement of Titan and Enceladus science as highly relevant to ESA's long-term roadmap, as logical follow-on to Cassini-Huygens. In this White Paper, we will outline important science questions regarding these satellites and identify the science themes we recommend ESA cover during the Voyage 2050 planning cycle. Addressing these science themes would make major advancements to the present knowledge we have about the Solar System, its formation, evolution, and likelihood that other habitable environments exist outside the Earth's biosphere.
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