| 1. |
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| 2. |
- Deng, Min, et al.
(författare)
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Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
- 2013
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697-
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Tidskriftsartikel (refereegranskat)abstract
- To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
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| 3. |
- Ma, Fei, et al.
(författare)
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Association of Leukocyte Telomere Length with Mild Cognitive Impairment and Alzheimer's Disease : Role of Folate and Homocysteine
- 2019
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Ingår i: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 48:1-2, s. 56-67
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Tidskriftsartikel (refereegranskat)abstract
- Background: Leukocyte telomere length (LTL) is associated with the aging process and age-related degenerative diseases. The relation of peripheral blood LTL to mild cognitive impairment (MCI) and Alzheimer's disease (AD) and the role of folate and homocysteine (Hcy) in this relation remain unclear.Objectives: We aimed to investigate the association between LTL and the risks of MCI/AD, and to explore whether folate and Hcy may play a role in this association.Methods: This case-control study included 129 MCI subjects, 131 AD patients and 134 healthy controls. LTL was assessed using real-time polymerase chain reaction assay. Serum folate levels were tested by chemiluminescence enzyme immunoassay, and serum Hcy levels were measured using the enzymatic cycling method. Data were analyzed using multivariate logistic regression and multivariable linear regression with adjustment for potential confounders.Results: The mean LTL was 1.56 +/- 0.25 in controls, 1.44 +/- 0.23 in MCI, and 1.28 +/- 0.28 in AD patients (p< 0.01). In multivariate logistic regression, subjects in the longest LTL tertile had lower OR for MCI (OR 0.246; 95% CI 0.101-0.597) and AD (OR 0.123; 95% CI 0.044-0.345) in comparison to subjects in the shortest tertile. Shorter LTL was dose-dependently related to the ORs of MCI and AD. Further, serum folate concentration was positively associated with LTL (p < 0.01), while serum Hcy level was negatively associated with LTL (p < 0.05). In stratified analyses, LTL-MCI/AD association varied by serum folate and Hcy level. Conclusions: Shorter LTL is associated with the risks of MCI/AD. Folate and Hcy might play an important role in this association.
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| 4. |
- Su, Changqing, et al.
(författare)
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Gene-Viral Cancer Therapy Using Dual-Regulated Oncolytic Adenovirus with Antiangiogenesis Gene for Increased Efficacy.
- 2008
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Ingår i: Molecular Cancer Research. - 1557-3125. ; 6, s. 568-575
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Tidskriftsartikel (refereegranskat)abstract
- Conditionally replicative adenovirus (CRAD) represents a promising approach for cancer therapy. Several CRADs controlled by the human telomerase reverse transcriptase promoter have been developed. However, because of their replicative capacity, the importance of cancer specificity for CRADs needs to be further emphasized. In this study, we have developed a novel dual-regulated CRAD, CNHK500-mE, which has its E1a and E1b gene controlled by the human telomerase reverse transcriptase promoter and the hypoxia response element, respectively. It also carries a mouse endostatin expression cassette controlled by the cytomegalovirus promoter. These properties allow for increased cancer cell targeting specificity and decreased adverse side effects. We showed that CNHK500-mE preferentially replicated in cancer cells. Compared with a replication-defective vector carrying the same endostatin expression cassette, CNHK500-mE-mediated transgene expression level was markedly increased via viral replication within cancer cells. In the nasopharyngeal tumor xenograft model, CNHK500-mE injection resulted in antitumor efficacy at day 7 after therapy. Three weeks later, it led to significant inhibition of xenograft tumor growth due to the combined effects of viral oncolytic therapy and antiangiogenesis gene therapy. Pathologic examination showed that most cancer cells were positive for adenoviral capsid protein and for apoptotic terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling in the CNHK500-mE-treated tumor tissues, and the microvessels in these tumor tissues were diminished in quantity and abnormal in morphology. These results suggest that, as a potential cancer therapeutic agent, the CNHK500-mE is endowed with higher specificity to cancer cells and low cytotoxicity to normal cells. (Mol Cancer Res 2008;6(4):OF1-8).
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| 5. |
- Chen, Junsong, et al.
(författare)
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Inference Method for Residual Stress Field of Titanium Alloy Parts Based on Latent Gaussian Process Introducing Theoretical Prior
- 2024
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Ingår i: Transactions of Nanjing University of Aeronautics and Astronautics. - : Nanjing University of Aeronautics an Astronautics. - 1005-1120. ; 41:2, s. 135-146
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Tidskriftsartikel (refereegranskat)abstract
- Residual stress (RS) within titanium alloy structural components is the primary factor contributing to machining deformation. It comprises initial residual stress （IRS） and machined surface residual stress (MSRS), resulting from the interplay between IRS and high-level machining-induced residual stress MIRS). Machining deformation of components poses a significant challenge in the aerospace industry，and accurately assessing RS is crucial for precise prediction and control. However, current RS prediction methods struggle to account for various uncertainties in the component manufacturing process，leading to limited prediction accuracy. Furthermore, existing measurement methods can only gauge local RS in samples，which proves inefficient and unreliable for measuring RS fields in large components. Addressing these challenges, this paper introduces a method for simultaneously estimating IRS and MSRS within titanium alloy aircraft components using a Bayesian framework. This approach treats IRS and MSRS as unobservable fields modeled by Gaussian processes. It leverages observable deformation force data to estimate IRS and MSRS while incorporating prior correlations between MSRS fields. In this context，the prior correlation between MSRS fields is represented as a latent Gaussian process with a shared covariance function. The proposed method offers an effective means of estimating the RS field using deformation force data from a probabilistic perspective. It serves as a dependable foundation for optimizing subsequent deformation control strategies.
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| 6. |
- Hua, Jiaqi, et al.
(författare)
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A zero-shot prediction method based on causal inference under non-stationary manufacturing environments for complex manufacturing systems
- 2022
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Ingår i: Robotics and Computer-Integrated Manufacturing. - : Elsevier BV. - 0736-5845 .- 1879-2537. ; 77
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Tidskriftsartikel (refereegranskat)abstract
- The state prediction of key components in manufacturing processes plays an important role in intelligent manufacturing, as it could improve the production quality, efficiency and reduce costs. Data-driven methods could learn well-performed prediction models from large volume of data. However, in complex manufacturing systems, the lack of prior knowledge limits the performance of prediction models, where the manufacturing environments changes continuously. In order to address this issue, this paper proposed a zero-shot prediction method for complex manufacturing systems based on causal inference. A deep convolutional neural network and a causal representation model are jointly optimized to extract invariant causal signal features, which can be generalized to non-stationary manufacturing environments without any new data. The experiment of tool wear prediction under non-stationary working conditions is carried out as a research example. The proposed method is verified with the open dataset on tool wear prediction, and experimental results show that the prediction accuracy could be obviously improved over existing methods.
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| 7. |
- Li, Dehua, et al.
(författare)
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An online inference method for condition identification of workpieces with complex residual stress distributions
- 2024
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Ingår i: Journal of manufacturing systems. - : Elsevier BV. - 0278-6125 .- 1878-6642. ; 73, s. 192-204
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Tidskriftsartikel (refereegranskat)abstract
- The residual stress field of structural components significantly influences their comprehensive performance and service life. Due to the lack of effective representation means and inference methods, existing methods are confined to inspecting local residual stress rather than the entire residual stress field, rendering the inference of complex residual stress fields quite difficult. In response to the challenges associated with the requirement for extensive sets of deformation force data from the current workpiece and the inherent difficulty in establishing a stable relationship between deformation forces and residual stress fields, this paper introduces a novel inference method of residual stress field is proposed based on a data-causal knowledge fusion model, where causal knowledge is introduced to eliminate the coupling effect of geometric change on residual stress, which can make up the drawback of pure data driven model. The proposed approach can accurately inference the residual stress within the workpieces, which provides an important basis for deformation control and part property improvement.
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| 8. |
- Peng, Changqing, et al.
(författare)
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LightFlow : Lightweight unsupervised defect detection based on 2D Flow
- 2024
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Ingår i: IEEE Transactions on Instrumentation and Measurement. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9456 .- 1557-9662. ; 73
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Tidskriftsartikel (refereegranskat)abstract
- In the industrial production process, unsupervised visual inspection methods have obvious advantages over supervised visual inspection methods due to the scarcity of defect samples, annotation costs and the uncertainty of defect generation. Currently, unsupervised defect detection and localization methods have demonstrated significant improvements in detection accuracy to find numerous applications in industrial inspection. Nonetheless, the complexity of these methods limits their practical application. In this paper, we integrate the FastFlow model plugin as a probability distribution by introducing a simpler and lightweight CNN pre-trained backbone. Concurrently, various training strategies are employed to optimize the 2D Flow module within the Lightweight unsupervised flow model (LightFlow). Notably, the number of model parameters in the LightFlow model is only 1/4 of the original model size of the typical Vision Transformer (ViT) model CaiT. Thereby, this offers heightened training efficiency and speed. Therefore, extensive experimental results on three challenging anomaly detection datasets (MVTec AD, VisA, and BTAD) using various CNN backbones and multiple current state-of-the-art vision algorithms demonstrate the effectiveness of our approach. Specifically, the existing method can achieve 99.1% and 95.2% image-level AUROC (area under the receiver operating characteristic) in MVTec AD and VisA, respectively. IEEE
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| 9. |
- Ruan, Changqing, et al.
(författare)
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Carbonized cellulose beads for efficient capacitive energy storage
- 2018
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Ingår i: Cellulose. - : Springer Science and Business Media LLC. - 0969-0239 .- 1572-882X. ; 25:6, s. 3545-3556
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Tidskriftsartikel (refereegranskat)abstract
- Natural biomaterials, including polysaccharides and amino acids, provide a sustainable source of functional carbon materials for electric energy storage applications. We present a one-pot reductive amination process to functionalize 2,3-dialdehyde cellulose (DAC) beads with chitosan and l-cysteine to provide single (N)- and dual (N/S)-doped materials. The functionalization enables the physicochemical properties of the materials to be tailored and can provide carbon precursors with heteroatom doping suitable for energy storage applications. Scanning electron microscopy, Fourier transform infrared spectroscopy and thermogravimetric analysis were used to characterize the changes to the beads after functionalization and carbonization. The results of X-ray photoelectron spectroscopy and energy-dispersive X-ray spectroscopy verified that the doping was effective, while the nitrogen sorption isotherms and pore-size distributions of the carbonized beads showed the effects of doping with different hierarchical porosities. In the electrochemical experiments, three kinds of carbon beads [pyrolyzed from DAC, chitosan-crosslinked DAC (CS-DAC) and l-cysteine-functionalized DAC] were used as electrode materials. Electrodes of carbonized CS-DAC beads had a specific capacitance of up to 242 F g(-1) at a current density of 1 A g(-1). These electrodes maintained a capacitance retention of 91.5% after 1000 charge/discharge cycles, suggesting excellent cycling stability. The results indicate that reductive amination of DAC is an effective route for heteroatom doping of carbon materials to be used as electrode active materials for energy storage.
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| 10. |
- Song, Yang, et al.
(författare)
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Unveiling the Enigma of Matter under Extreme Conditions : From Planetary Cores to Functional Materials
- 2023
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 13
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Pressure, as one of the fundamental thermodynamic parameters, can profoundly change the interatomic distances, electronic interactions, chemical bonding and crystal structures, leading to exotic structures and properties of materials. High-pressure techniques have significantly impacted disciplines like physics, chemistry, geology, and life science, creating new materials, advancing knowledge of Earth's interior, and influencing pharmaceutical development. This editorial reviews the latest research published in this Collection, highlighting the potential of high-pressure studies to further our understanding of materials' behavior under extreme conditions.
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| 11. |
- Wang, Zhaohui, et al.
(författare)
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Conducting Polymer Paper-Derived Mesoporous 3D N-doped Carbon Current Collectors for Na and Li Metal Anodes : A Combined Experimental and Theoretical Study
- 2018
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Ingår i: The Journal of Physical Chemistry C. - : AMER CHEMICAL SOC. - 1932-7447 .- 1932-7455. ; 122:41, s. 23352-23363
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Tidskriftsartikel (refereegranskat)abstract
- Herein, the manufacturing of a free-standing N-doped mesoporous carbon (CPPY) paper by straightforward carbonization of polypyrrole-coated nanocellulose paper is described. The deposition of Na and Li on these CPPY electrodes, which also serve as current collectors, is studied using a combination of experiments and theoretical calculations. The porous CPPY electrodes gave rise to decreased current densities, which helped to prolong the life-time of the Na electrodes. While the density functional theory calculations suggest that both Na and Li should be deposited uniformly on the CPPY electrodes, the experimental results clearly show that the sodium deposition was more well-defined on the surface of the CPPY electrodes. In contrast to Li, dendrite-free Na depositions could be carried out using deposition capacities up to 12 mAh cm(-2 )and a stable Na electrode cycling performance was found during 1000 h at 1 mA cm(-2). The results suggest that it was difficult to predict the Na or Li deposition behavior merely based on calculations of the metal adsorption energies, as kinetic effects should also be taken into account. Nevertheless, the experimental results clearly show that the use of the present type of porous electrodes provides new possibilities for the development of durable Na electrodes for high-performance sodium metal batteries.
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| 12. |
- Wang, Zhaohui, et al.
(författare)
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Conducting polymer paper-derived separators for lithium metal batteries
- 2018
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Ingår i: Energy Storage Materials. - : Elsevier BV. - 2405-8289 .- 2405-8297. ; 13, s. 283-292
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Tidskriftsartikel (refereegranskat)abstract
- Overoxidised polypyrrole (PPy) paper has been employed as a mesoporous separator for lithium metal batteries (LMBs) based on its narrow pore size distribution, good thermal stability, high ionic conductivity (1.1 mS cm−1 with a LP40 electrolyte) and high electrolyte wettability. The overoxidised PPy paper was produced from a PPy/cellulose composite using a combined base and heat-treatment process, yielding a highly interrupted pyrrole molecular structure including N-containing polar groups maintaining the readily adaptable mesoporous structure of the pristine PPy paper. This well-defined pore structure gave rise to a homogeneous current distribution which significantly increased the performance of a LiFePO4|Li cell. With the overoxidised PPy separator, a symmetric Li|Li cell could be cycled reversibly for more than 600 h without any short-circuits in a LP40 electrolyte. This approach facilitates the manufacturing of well-defined separators for fundamental investigations of the influence of the separator structure on the performance of LMBs.
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| 13. |
- Wang, Zhaohui, et al.
(författare)
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Redox-active Separators for High-capacity Lithium-ion Batteries
- 2017
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Ingår i: Advanced Sience.
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Tidskriftsartikel (refereegranskat)abstract
- High capacity lithium-ion batteries (LIBs) with good charge/discharge rate capabilities are profoundly needed to be able to meet next decade´s energy demand. Various new cathode materials and electrode engineering technologies that enhance battery performance have been developed, but less effort has been dedicated to improving capacity beyond optimizing the electrodes. We present an electrochemically active separator designed to enhance the capacity and charge/discharge rate capability of LIBs. The thin, mesoporous separator consists of an insulating nanocellulose layer in contact with an electrochemically active polypyrrole-nanocellulose supporting layer. Introducing polypyrrole into the separator i) minimizes the commonly observed “dead weight/volume”, ii) transforms the separator into a redox-active component with a conducting upper current-collecting layer, and iii) increases the pore size and porosity of the separator. In comparison with commercial batteries, our LIB with a LiFePO4 cathode and a redox-active separator shows an enhanced charge/discharge rate capability and a much greater capacity (320 mAh g-1) with respect to the weight of the cathode. Rendering the mesoporous separator redox-active could potentially also boost the capacity and rate performance of other types of lithium-ion batteries as well as electric energy storage devices in general.
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| 14. |
- Wang, Zhaohui, et al.
(författare)
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Redox-Active Separators for Lithium-Ion Batteries
- 2018
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Ingår i: Advanced Science. - : WILEY. - 2198-3844. ; 5:3
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Tidskriftsartikel (refereegranskat)abstract
- A bilayered cellulose-based separator design is presented that can enhance the electrochemical performance of lithium-ion batteries (LIBs) via the inclusion of a porous redox-active layer. The proposed flexible redox-active separator consists of a mesoporous, insulating nanocellulose fiber layer that provides the necessary insulation between the electrodes and a porous, conductive, and redox-active polypyrrole-nanocellulose layer. The latter layer provides mechanical support to the nanocellulose layer and adds extra capacity to the LIBs. The redox-active separator is mechanically flexible, and no internal short circuits are observed during the operation of the LIBs, even when the redox-active layer is in direct contact with both electrodes in a symmetric lithium-lithium cell. By replacing a conventional polyethylene separator with a redox-active separator, the capacity of the proof-of-concept LIB battery containing a LiFePO4 cathode and a Li metal anode can be increased from 0.16 to 0.276 mA h due to the capacity contribution from the redox-active separator. As the presented redox-active separator concept can be used to increase the capacities of electrochemical energy storage systems, this approach may pave the way for new types of functional separators.
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| 15. |
- Xu, Bo, et al.
(författare)
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Tailor-Making Low-Cost Spiro[fluorene-9,9′-xanthene]-Based 3D Oligomers for Perovskite Solar Cells
- 2017
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Ingår i: Chem. - : Elsevier. - 2451-9308 .- 2451-9294. ; 2:5, s. 676-687
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Tidskriftsartikel (refereegranskat)abstract
- The power-conversion efficiencies (PCEs) of perovskite solar cells (PSCs) have increased rapidly from about 4% to 22% during the past few years. One of the major challenges for further improvement of the efficiency of PSCs is the lack of sufficiently good hole transport materials (HTMs) to efficiently scavenge the photogenerated holes and aid the transport of the holes to the counter-electrode in the PSCs. In this study, we tailor-made two low-cost spiro[fluorene-9,9′-xanthene] (SFX)-based 3D oligomers, termed X54 and X55, by using a one-pot synthesis approach for PSCs. One of the HTMs, X55, gives a much deeper HOMO level and a higher hole mobility and conductivity than the state-of-the-art HTM, Spiro-OMeTAD. PSC devices based on X55 as the HTM show a very impressive PCE of 20.8% under 100 mW·cm−2 AM1.5G solar illumination, which is much higher than the PCE of the reference devices based on Spiro-OMeTAD (18.8%) and X54 (13.6%) under the same conditions.
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| 16. |
- Zhang, Jinbao, et al.
(författare)
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Incorporation of Counter Ions in Organic Molecules : New Strategy in Developing Dopant-Free Hole Transport Materials for Efficient Mixed-Ion Perovskite Solar Cells
- 2017
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Ingår i: Advanced Energy Materials. - : WILEY-V C H VERLAG GMBH. - 1614-6832 .- 1614-6840. ; 7:14
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Tidskriftsartikel (refereegranskat)abstract
- Hole transport matertial (HTM) as charge selective layer in perovskite solar cells (PSCs) plays an important role in achieving high power conversion efficiency (PCE). It is known that the dopants and additives are necessary in the HTM in order to improve the hole conductivity of the HTM as well as to obtain high efficiency in PSCs, but the additives can potentially induce device instability and poor device reproducibility. In this work a new strategy to design dopant-free HTMs has been presented by modifying the HTM to include charged moieties which are accompanied with counter ions. The device based on this ionic HTM X44 dos not need any additional doping and the device shows an impressive PCE of 16.2%. Detailed characterization suggests that the incorporated counter ions in X44 can significantly affect the hole conductivity and the homogeneity of the formed HTM thin film. The superior photovoltaic performance for X44 is attributed to both efficient hole transport and effective interfacial hole transfer in the solar cell device. This work provides important insights as regards the future design of new and efficient dopant free HTMs for photovotaics or other optoelectronic applications.
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| 17. |
- Zhang, Jinbao, et al.
(författare)
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The Importance of Pendant Groups on Triphenylamine-Based Hole Transport Materials for Obtaining Perovskite Solar Cells with over 20% Efficiency
- 2018
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Ingår i: Advanced Energy Materials. - : Wiley. - 1614-6832 .- 1614-6840. ; 18:2
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Tidskriftsartikel (refereegranskat)abstract
- Tremendous progress has recently been achieved in the field of perovskite solar cells (PSCs) as evidenced by impressive power conversion efficiencies (PCEs); but the high PCEs of >20% in PSCs has so far been mostly achieved by using the hole transport material (HTM) spiro-OMeTAD; however, the relatively low conductivity and high cost of spiro-OMeTAD significantly limit its potential use in large-scale applications. In this work, two new organic molecules with spiro[fluorene-9,9-xanthene] (SFX)-based pendant groups, X26 and X36, have been developed as HTMs. Both X26 and X36 present facile syntheses with high yields. It is found that the introduced SFX pendant groups in triphenylamine-based molecules show significant influence on the conductivity, energy levels, and thin-film surface morphology. The use of X26 as HTM in PSCs yields a remarkable PCE of 20.2%. In addition, the X26-based devices show impressive stability maintaining a high PCE of 18.8% after 5 months of aging in controlled (20%) humidity in the dark. We believe that X26 with high device PCEs of >20% and simple synthesis show a great promise for future application in PSCs, and that it represents a useful design platform for designing new charge transport materials for optoelectronic applications.
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| 18. |
- Zhao, Zhiwei, et al.
(författare)
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A subsequent-machining-deformation prediction method based on the latent field estimation using deformation force
- 2022
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Ingår i: Journal of manufacturing systems. - : Elsevier BV. - 0278-6125 .- 1878-6642. ; 63, s. 224-237
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Tidskriftsartikel (refereegranskat)abstract
- Machining deformation control for large structural parts is an intractable problem, which is highly important for the dimensional accuracy and fatigue life of parts, and deformation prediction is the basis for deformation control. Existing prediction methods rely on the measurement of residual stress, which is limited by the measurement accuracy of residual stress distributed within thick blanks, and it is still a worldwide challenge. To address the above issue, this paper proposes a machining deformation prediction method based on estimation of latent filed for residual stress field using deformation force. The residual stress field is represented by latent field, which is estimated by deformation force monitoring data during the machining process based on the proposed physical-field estimation neural network. The estimated latent field is used to predict the subsequent deformation force and deformation via an inference network by combining the machining process information. The proposed method is verified by both simulation and actual environment, and it can provide a helpful reference for other machining related difficult-to-measure field.
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