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- Hamon, Camille
(författare)
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Probabilistic security management for power system operations with large amounts of wind power
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Power systems are critical infrastructures for the society. They are therefore planned and operated to provide a reliable eletricity delivery. The set of tools and methods to do so are gathered under security management and are designed to ensure that all operating constraints are fulfilled at all times.During the past decade, raising awareness about issues such as climate change, depletion of fossil fuels and energy security has triggered large investments in wind power. The limited predictability of wind power, in the form of forecast errors, pose a number of challenges for integrating wind power in power systems. This limited predictability increases the uncertainty already existing in power systems in the form of random occurrences of contingencies and load forecast errors. It is widely acknowledged that this added uncertainty due to wind power and other variable renewable energy sources will require new tools for security management as the penetration levels of these energy sources become significant.In this thesis, a set of tools for security management under uncertainty is developed. The key novelty in the proposed tools is that they build upon probabilistic descriptions, in terms of distribution functions, of the uncertainty. By considering the distribution functions of the uncertainty, the proposed tools can consider all possible future operating conditions captured in the probabilistic forecasts, as well as the likeliness of these operating conditions. By contrast, today's tools are based on the deterministic N-1 criterion that only considers one future operating condition and disregards its likelihood.Given a list of contingencies selected by the system operator and probabilitistic forecasts for the load and wind power, an operating risk is defined in this thesis as the sum of the probabilities of the pre- and post-contingency violations of the operating constraints, weighted by the probability of occurrence of the contingencies.For security assessment, this thesis proposes efficient Monte-Carlo methods to estimate the operating risk. Importance sampling is used to substantially reduce the computational time. In addition, sample-free analytical approximations are developed to quickly estimate the operating risk. For security enhancement, the analytical approximations are further embedded in an optimization problem that aims at obtaining the cheapest generation re-dispatch that ensures that the operating risk remains below a certain threshold. The proposed tools build upon approximations, developed in this thesis, of the stable feasible domain where all operating constraints are fulfilled.
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| 2. |
- Levels, Johannes HM, et al.
(författare)
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High-density Lipoprotein proteome dynamics in human endotoxemia
- 2011
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Ingår i: Proteome Science. - : BiOMed Central. - 1477-5956. ; 9:34
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Tidskriftsartikel (refereegranskat)abstract
- Background: A large variety of proteins involved in inflammation, coagulation, lipid-oxidation and lipid metabolism have been associated with high-density lipoprotein (HDL) and it is anticipated that changes in the HDL proteome have implications for the multiple functions of HDL. Here, SELDI-TOF mass spectrometry (MS) was used to study the dynamic changes of HDL protein composition in a human experimental low-dose endotoxemia model. Ten healthy men with low HDL cholesterol (0.7+/-0.1 mmol/L) and 10 men with high HDL cholesterol levels (1.9+/-0.4mmol/L) were challenged with endotoxin (LPS) intravenously (1ng/kg bodyweight). We previously showed that subjects with low HDL cholesterol are more susceptible to an inflammatory challenge. The current study tested the hypothesis that this discrepancy may be related to differences in the HDL proteome.Results: Plasma drawn at 7 time-points over a 24 hour time period after LPS challenge was used for direct capture of HDL using antibodies against apolipoprotein A-I followed by subsequent SELDI-TOF MS profiling. Upon LPS administration, profound changes in 21 markers (adjusted p-value<0.05) were observed in the proteome in both study groups. These changes were observed 1 hour after LPS infusion and sustained up to 24 hours, but unexpectedly were not different between the 2 study groups. Hierarchical clustering of the protein spectra at all time points of all individuals revealed 3 distinct clusters, which were largely independent of baseline HDL cholesterol levels but correlated with paraoxonase 1 activity. The acute phase protein serum amyloid A-1/2 (SAA-1/2) was clearly upregulated after LPS infusion in both groups and comprised both native and N-terminal truncated variants that were identified by two-dimensional gel electrophoresis and mass spectrometry. Individuals of one of the clusters were distinguished by a lower SAA-1/2 response after LPS challenge and a delayed time-response of the truncated variants.Conclusions: This study shows that the semi-quantitative differences in the HDL proteome as assessed by SELDI-TOF MS cannot explain why subjects with low HDL cholesterol are more susceptible to a challenge with LPS than those with high HDL cholesterol. Instead the results indicate that hierarchical clustering could be useful to predict HDL functionality in acute phase responses towards LPS.
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