| 1. |
- Fenstermacher, M.E., et al.
(författare)
-
DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
- 2022
-
Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:4
-
Tidskriftsartikel (refereegranskat)abstract
- DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limits and regulate β N in the ITER baseline scenario, based on plasma response to probing 3D fields, was demonstrated. Finally, innovative tokamak operation using a negative triangularity shape showed many attractive features for future pilot plant operation.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Clement, R. Carter, et al.
(författare)
-
A proposed set of metrics for standardized outcome reporting in the management of low back pain
- 2015
-
Ingår i: Acta Orthopaedica. - : Medical Journals Sweden AB. - 1745-3682 .- 1745-3674. ; 86:5, s. 523-533
-
Tidskriftsartikel (refereegranskat)abstract
- Background and purpose - Outcome measurement has been shown to improve performance in several fields of healthcare. This understanding has driven a growing interest in value-based healthcare, where value is defined as outcomes achieved per money spent. While low back pain (LBP) constitutes an enormous burden of disease, no universal set of metrics has yet been accepted to measure and compare outcomes. Here, we aim to define such a set. Patients and methods - An international group of 22 specialists in several disciplines of spine care was assembled to review literature and select LBP outcome metrics through a 6-round modified Delphi process. The scope of the outcome set was degenerative lumbar conditions. Results - Patient-reported metrics include numerical pain scales, lumbar-related function using the Oswestry disability index, health-related quality of life using the EQ-5D-3L questionnaire, and questions assessing work status and analgesic use. Specific common and serious complications are included. Recommended follow-up intervals include 6, 12, and 24 months after initiating treatment, with optional follow-up at 3 months and 5 years. Metrics for risk stratification are selected based on preexisting tools. Interpretation - The outcome measures recommended here are structured around specific etiologies of LBP, span a patient's entire cycle of care, and allow for risk adjustment. Thus, when implemented, this set can be expected to facilitate meaningful comparisons and ultimately provide a continuous feedback loop, enabling ongoing improvements in quality of care. Much work lies ahead in implementation, revision, and validation of this set, but it is an essential first step toward establishing a community of LBP providers focused on maximizing the value of the care we deliver.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Bausch, Birke, et al.
(författare)
-
Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed Prevention
- 2017
-
Ingår i: JAMA Oncology. - : AMER MEDICAL ASSOC. - 2374-2437 .- 2374-2445. ; 3:9, s. 1204-1212
-
Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE Effective cancer prevention is based on accurate molecular diagnosis and results of genetic family screening, genotype-informed risk assessment, and tailored strategies for early diagnosis. The expanding etiology for hereditary pheochromocytomas and paragangliomas has recently included SDHA, TMEM127, MAX, and SDHAF2 as susceptibility genes. Clinical management guidelines for patients with germline mutations in these 4 newly included genes are lacking. OBJECTIVE To study the clinical spectra and age-related penetrance of individuals with mutations in the SDHA, TMEM127, MAX, and SDHAF2 genes. DESIGN, SETTING, AND PATIENTS This study analyzed the prospective, longitudinally followed up European-American-Asian Pheochromocytoma-Paraganglioma Registry for prevalence of SDHA, TMEM127, MAX, and SDHAF2 germline mutation carriers from 1993 to 2016. Genetic predictive testing and clinical investigation by imaging from neck to pelvis was offered to mutation-positive registrants and their relatives to clinically characterize the pheochromocytoma/paraganglioma diseases associated with mutations of the 4 new genes. MAIN OUTCOMES AND MEASURES Prevalence and spectra of germline mutations in the SDHA, TMEM127, MAX, and SDHAF2 genes were assessed. The clinical features of SDHA, TMEM127, MAX, and SDHAF2 disease were characterized. RESULTS Of 972 unrelated registrants without mutations in the classic pheochromocytoma- and paraganglioma-associated genes (632 female [65.0%] and 340 male [35.0%]; age range, 8-80; mean [SD] age, 41.0 [13.3] years), 58 (6.0%) carried germline mutations of interest, including 29 SDHA, 20 TMEM127, 8 MAX, and 1 SDHAF2. Fifty-three of 58 patients (91%) had familial, multiple, extra-adrenal, and/or malignant tumors and/or were younger than 40 years. Newly uncovered are 7 of 63 (11%) malignant pheochromocytomas and paragangliomas in SDHA and TMEM127 disease. SDHA disease occurred as early as 8 years of age. Extra-adrenal tumors occurred in 28 mutation carriers (48%) and in 23 of 29 SDHA mutation carriers (79%), particularly with head and neck paraganglioma. MAX disease occurred almost exclusively in the adrenal glands with frequently bilateral tumors. Penetrance in the largest subset, SDHA carriers, was 39% at 40 years of age and is statistically different in index patients (45%) vs mutation-carrying relatives (13%; P amp;lt; .001). CONCLUSIONS AND RELEVANCE The SDHA, TMEM127, MAX, and SDHAF2 genes may contribute to hereditary pheochromocytoma and paraganglioma. Genetic testing is recommended in patients at clinically high risk if the classic genes are mutation negative. Gene-specific prevention and/or early detection requires regular, systematic whole-body investigation.
|
|
| 9. |
- Ekenberg, Martin, et al.
(författare)
-
Biological reduction of hexavalent chromium - A field study
- 2005
-
Ingår i: Water Environment Research. - 1061-4303. ; 77:4, s. 425-428
-
Tidskriftsartikel (refereegranskat)abstract
- When ferrochromium is produced at Vargon Alloys AB (Vargon, Sweden), an offgas dust is generated as a byproduct. A leachate that contains hexavalent chromium (Cr6+) is formed when rainwater percolates through the dust deposit. In this study, Cr6+ in the leachate was reduced to trivalent chromium (Cr3+) by biological treatment in a biofilm process operated under anaerobic conditions. The reactor volume was 26 m(3) and it was filled with 16 m(3) plastic packing. Acetic acid was added as an electron donor. The Cr6+ Was reduced from 10 to 20 mg/L to below 0.03 mg/L when the reactor was operated at a hydraulic retention time of 11 hours. The reduction activity in the process gradually decreased as the water temperature dropped below 10 degrees C.
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
- Fröjdh, Christer, 1952-, et al.
(författare)
-
New sensors for dental X-ray imaging
- 1999
-
Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 434:1, s. 24-29
-
Tidskriftsartikel (refereegranskat)
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
- Kugelberg, Johan, et al.
(författare)
-
Role of SDHAF2 and SDHD in von Hippel-Lindau Associated Pheochromocytomas
- 2014
-
Ingår i: World Journal of Surgery. - : Springer Verlag (Germany). - 0364-2313 .- 1432-2323. ; 38:3, s. 724-732
-
Tidskriftsartikel (refereegranskat)abstract
- Background Pheochromocytomas (PCCs) develop from the adrenal medulla and are often part of a hereditary syndrome such as von Hippel-Lindau (VHL) syndrome. In VHL, only about 30 % of patients with a VHL missense mutation develop PCCs. Thus, additional genetic events leading to formation of such tumors in patients with VHL syndrome are sought. SDHAF2 (previously termed SDH5) and SDHD are both located on chromosome 11q and are required for the function of mitochondrial complex II. While SDHAF2 has been shown to be mutated in patients with paragangliomas (PGLs), SDHD mutations have been found both in patients with PCCs and in patients with PGLs. Materials and methods Because loss of 11q is a common event in VHL-associated PCCs, we aimed to investigate whether SDHAF2 and SDHD are targets. In the present study, 41 VHL-associated PCCs were screened for mutations and loss of heterozygosity (LOH) in SDHAF2 or SDHD. Promoter methylation, as well as mRNA expression of SDHAF2 and SDHD, was studied. In addition, immunohistochemistry (IHC) of SDHB, known to be a universal marker for loss of any part the SDH complex, was conducted. Results and conclusions LOH was found in more than 50 % of the VHL-associated PCCs, and was correlated with a significant decrease (p less than 0.05) in both SDHAF2 and SDHD mRNA expression, which may be suggestive of a pathogenic role. However, while SDHB protein expression as determined by IHC in a small cohort of tumors was lower in PCCs than in the surrounding adrenal cortex, there was no obvious correlation with LOH or the level of SDHAF2/SDHD mRNA expression. In addition, the lack of mutations and promoter methylation in the investigated samples indicates that other events on chromosome 11 might be involved in the development of PCCs in association with VHL syndrome.
|
|
| 16. |
- Larsson, Madeleine
(författare)
-
Anaerobic Digestion of Wastewaters from Pulp and Paper Mills : A Substantial Source for Biomethane Production in Sweden
- 2015
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Swedish pulp and paper industry is the third largest exporter of pulp and paper products worldwide. It is a highly energy-demanding and water-utilising industry, which generates large volumes of wastewater rich in organic material. These organic materials are to different extents suitable for anaerobic digestion (AD) and production of energy-rich biomethane. The implementation of an AD process within the wastewater treatment plant of a mill would increase the treatment capacity and decrease the overall energy consumption due to less aeration and lower sludge production and in addition produce biomethane. Despite the many benefits of AD it is only applied at two mills in Sweden today. The reason for the low implementation over the years may be due to problems encountered linked to the complexity and varying composition of the wastewaters. Due to changes in market demands many mills have broadened their product portfolios and turned towards more refined products. This has increased both the complexity and the variations of the wastewaters´ composition even further, as the above changes can imply an increased pulp bleaching and utilisation of more diverse raw materials within the mills.The main aim of this thesis was therefore to generate knowledge needed for an expansion of the biomethane production within the pulp and paper industry. As a first step to achieve this an evaluation of the biomethane potential and the suitability for AD of wastewaters within a range of Swedish pulp and paper mills was performed. Thus, around 70 wastewater streams from 11 different processes at eight mills were screened for their biomethane potential. In a second step, the impact of shifts in wood raw material and bleaching on the AD process and the biomethane production was investigated and further evaluated in upflow anaerobic sludge bed (UASB) reactors.The screening showed that the biomethane potential within the Swedish pulp and paper industry could be estimated to 700 GWh, which corresponds to 40% of the Swedish biomethane production during 2014. However, depending on the conditions at each specific mill the strategy for the establishment of AD needs to differ. For mills producing kraft pulp the potential is mainly found in wastewaters rich in fibres, alkaline kraft bleaching wastewaters and methanol-rich condensates. The biomethane potential within thermo-mechanical pulp- (TMP) and chemical thermo-mechanical pulp (CTMP) mills is mainly present in the total effluents after pre-sedimentation and in the bleaching effluents as these holds high concentrations of dissolved organic material. The screening further showed that the raw material used for pulp production is an important factor for the biomethane potential of a specific wastewater stream, i.e. hardwood (HW) wastewaters have higher potentials than those from softwood (SW) pulp production. This was confirmed in the lab-scale UASB reactor experiments, in which an alkaline kraft bleaching wastewater and a composite pulping and bleaching CTMP wastewater were used as substrates. AD processes were developed and maintained stable throughout shifts in wastewater composition related to changes in the wood raw materials between SW and HW for the kraft wastewater and spruce, aspen and birch for the CTMP wastewater. The lower biomethane production from SW- compared to HW wastewaters was due to a lower degradability together with a higher ratio of sulphuric compounds per TOC for the SW case. The impact of shifts between bleached and unbleached CTMP production could not be fully evaluated in the continuous process mainly due to technical problems. However, due to the large increase in dissolved organic material when bleaching is applied, the potential biomethane production will increase during the production of bleached pulp compared to unbleached pulp. Based on the biomethane potentials obtained for one of the included CTMP mills, their yearly production of biomethane was estimated to 5-27 GWh with the lowest and the highest value corresponding to the production of unbleached spruce pulp vs. bleached birch pulp.Thus, the results of the investigations presented in this thesis show that the UASBreactor is suitable for AD of wastewaters within the pulp and paper industry. The results also show that challenges related to variations in the organic material composition of the wastewaters due to variations in wood raw materials could be managed. The outcome of the thesis work also imply that the production of more refined products, which may include the introduction of an increased number of raw materials and extended bleaching protocols, could increase the potential biomethane production, especially if the pulp production will make use of more HW.
|
|
| 17. |
- Liss, Anna, 1979, et al.
(författare)
-
Patient-reported experiences and outcomes following two different approaches for non-surgical periodontal treatment: a randomized field study
- 2021
-
Ingår i: BMC Oral Health. - : Springer Science and Business Media LLC. - 1472-6831. ; 21
-
Tidskriftsartikel (refereegranskat)abstract
- Context: The current report is part of a prospective, multi-center, two-arm, quasi-randomized field study focusing on the effectiveness in general praxis of evidence-based procedures in the non-surgical treatment of patients with periodontitis. Objective: The specific aims were to (i) evaluate patient-reported experience and outcome measures of treatment following a guided approach to periodontal infection control (GPIC) compared to conventional non-surgical therapy (CNST) and to (ii) identify potential predictors of subjective treatment outcomes and patient’s adherence to self-performed infection control, i.e. adequate oral hygiene. Methods: The study sample consisted of 494 patients treated per protocol with questionnaire- and clinical data at baseline and 6-months. The GPIC approach (test) comprised patient education for adequate oral hygiene prior to a single session of full-mouth ultra-sonic instrumentation, while the CNST approach (control) comprised education and instrumentation (scaling and root planing) integrated at required number of consecutive appointments. Clinical examinations and treatment were performed by Dental Hygienists, i.e. not blinded. Data were processed with bivariate statistics for comparison between treatment groups and with multiple regression models to identify potential predictors of subjective and clinical outcomes. The primary clinical outcome was gingival bleeding scores. Results: No substantial differences were found between the two treatment approaches regarding patient-reported experiences or outcomes of therapy. Patients’ experiences of definitely being involved in therapy decisions was a significant predictor for a desirable subjective and clinical outcome in terms of; (i) that oral health was considered as much improved after therapy compared to how it was before, (ii) that the treatment definitively had been worth the cost and efforts, and (iii) adherence to self-performed periodontal infection control. In addition, to be a current smoker counteracted patients’ satisfaction with oral health outcome, while gingival bleeding scores at baseline predicted clinical outcome in terms of bleeding scores at 6-months. Conclusions: The results suggest that there are no differences with regard to patient-reported experiences and outcomes of therapy following a GPIC approach to periodontal infection control versus CNST. Patients’ experiences of being involved in therapy decisions seem to be an important factor for satisfaction with care and for adherence to self-performed periodontal infection control. Registered at: ClinicalTrials.gov (NCT02168621).
|
|
| 18. |
- Mathioudaki, Argyri, Ph.D student, 1986-, et al.
(författare)
-
The sex-stratified genetic architecture of ankylosing spondylitis
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Sexual dimorphism is an emerging feature of ankylosing spondylitis (AS), a chronic rheumatic condition affecting upto three times more men than women. Using 691 individuals from a Swedish case-control cohort, we revealed thatsex biases are also a hallmark of AS genetic predisposition, and that this multifactorial disease is in part driven byboth rare and common variants. We identified SNPs via the targeted re-sequencing of 7 270 coding and non-codingloci, and assessed novel patterns of association with both single marker and aggregate loci SKAT tests. The malespecific RUNX3 locus (including rs7414934, OR=2.58, p=1.7x10-5) and female specific MICB SKAT locus (27variants, p=1.2x10-6; rs3828903, OR=4.62, p=6.2x10-13) exceeded discovery thresholds. Multiple risk variants fromeach locus were shown to be functionally active in immune (Jurkat), skin (HaCat) and bone (SaOS-2) cell lines.Differential patterns of genetic predisposition may point to alternative disease mechanisms in male and femalepatients. Genetic and functional analyses demonstrated that risk alleles should not be considered in isolation and thatassociated variants would likely affect gene regulation across multiple tissues. This work illustrates the need toconsider the contribution of sex to the genetics of AS and the duality that individual loci may play in the key clinical outcomes of disease.
|
|
| 19. |
- Nyström, Birgitta, et al.
(författare)
-
Bemanningsanställd och rättslös - eller?
- 2014
-
Ingår i: Festskrift till Catharina Calleman : i rättens utkanter - i rättens utkanter. - 9789176788899
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 20. |
- Pettersson, Hanna, et al.
(författare)
-
Arbetsdomstolen och behovsanställningarna
- 2014
-
Ingår i: Festskrift till Catharina Calleman: i rättens utkanter. - 9789176788899 ; , s. 317-331
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 21. |
|
|
| 22. |
- Schömer, Eva, 1960-, et al.
(författare)
-
Etnisk diskriminering, en rättslig paradox
- 2014. - 1
-
Ingår i: Festskrift till Catharina Calleman. - Uppsala : Iustus förlag. - 9789176788899 ; , s. 351-369, s. 251-269
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 23. |
|
|
| 24. |
|
|
| 25. |
|
|
| 26. |
- Tomasi, Cristiano, 1964, et al.
(författare)
-
A randomized multi-centre study on the effectiveness of non-surgical periodontal therapy in general practice
- 2022
-
Ingår i: Journal of Clinical Periodontology. - : Wiley. - 0303-6979 .- 1600-051X. ; 49:11, s. 1092-1105
-
Tidskriftsartikel (refereegranskat)abstract
- Aim To evaluate the effectiveness of two non-surgical treatment protocols for periodontitis patients in general dental practice. Materials and Methods Ninety-five dental hygienists (59 dental clinics) were randomly assigned to one of two treatment protocols: (i) establishment of adequate self-performed oral hygiene prior to a single session of ultrasonic instrumentation (guided periodontal infection control [GPIC]) or (ii) conventional non-surgical therapy (CNST) including patient education and scaling and root planing integrated in multiple sessions. Residual pockets at 3 months were retreated in both groups. The primary outcome was pocket closure (probing pocket depth <= 4 mm) at 6 months. Multilevel models were utilized. Results Based on data from 615 patients, no significant differences with regard to clinical outcomes were observed between treatment protocols. Treatment-related costs (i.e., chair time, number of sessions) were significantly lower for GPIC than CNST. Smoking and age significantly affected treatment outcomes. Conclusions No significant differences between the two approaches were observed in regard to clinical outcomes. GPIC was more time-effective. Patient education should include information on the detrimental effects of smoking. ClinicalTrials.gov (NCT02168621).
|
|
| 27. |
|
|
| 28. |
|
|
| 29. |
|
|
