| 1. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 2. |
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| 13. |
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| 14. |
- Abdallah, J., et al.
(författare)
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The Laser calibration of the ATLAS Tile Calorimeter during the LHC run 1
- 2016
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- This article describes the Laser calibration system of the ATLAS hadronic Tile Calorimeter that has been used during the run 1 of the LHC. First, the stability of the system associated readout electronics is studied. It is found to be stable with variations smaller than 0.6 %. Then, the method developed to compute the calibration constants, to correct for the variations of the gain of the calorimeter photomultipliers, is described. These constants were determined with a statistical uncertainty of 0.3 % and a systematic uncertainty of 0.2 % for the central part of the calorimeter and 0.5 % for the end-caps. Finally, the detection and correction of timing mis-configuration of the Tile Calorimeter using the Laser system are also presented.
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| 15. |
- Augustin, Ramona, et al.
(författare)
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MUSE-ALMA Haloes X : the stellar masses of gas-rich absorbing galaxies
- 2024
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Ingår i: Monthly notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 528:4, s. 6159-6166
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Tidskriftsartikel (refereegranskat)abstract
- The physical processes by which gas is accreted onto galaxies, transformed into stars, and then expelled from galaxies are of paramount importance to galaxy evolution studies. Observationally constraining each of these baryonic components in the same system, however, is challenging. Furthermore, simulations indicate that the stellar mass of galaxies is a key factor influencing CGM properties. Indeed, absorption lines detected against background quasars offer the most compelling way to study the cold gas in the circumgalactic medium (CGM). The MUSE-ALMA Haloes survey is composed of quasar fields covered with VLT/MUSE observations, comprising 32 H I absorbers at 0.2 < z < 1.4 and 79 associated galaxies, with available or upcoming molecular gas measurements from ALMA. We use a dedicated 40-orbit HST UVIS and IR WFC3 broad-band imaging campaign to characterize the stellar content of these galaxies. By fitting their spectral energy distribution, we establish they probe a wide range of stellar masses: 8.1 < log (M∗/M⊙) < 12.4. Given their star formation rates, most of these objects lie on the main sequence of galaxies. We also confirm a previously reported anticorrelation between the stellar masses and CGM hydrogen column density N (H I), indicating an evolutionary trend where higher mass galaxies are less likely to host large amounts of H I gas in their immediate vicinity up to 120 kpc. Together with other studies from the MUSE-ALMA Haloes survey, these data provide stellar masses of absorber hosts, a key component of galaxy formation and evolution, and observational constraints on the relation between galaxies and their surrounding medium.
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| 16. |
- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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| 17. |
- Karki, Arjun, et al.
(författare)
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MUSE-ALMA Haloes - IX. Morphologies and stellar properties of gas-rich galaxies
- 2023
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Ingår i: Monthly notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 524:4, s. 5524-5547
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Tidskriftsartikel (refereegranskat)abstract
- Understanding how galaxies interact with the circumgalactic medium (CGM) requires determining how galaxies’ morphological and stellar properties correlate with their CGM properties. We report an analysis of 66 well-imaged galaxies detected in Hubble Space Telescope and Very Large Telescope MUSE observations and determined to be within ±500 km s−1 of the redshifts of strong intervening quasar absorbers at 0.2 ≲ z ≲ 1.4 with H I column densities NHI>1018cm−2�HI>1018cm−2. We present the geometrical properties (Sérsic indices, effective radii, axis ratios, and position angles) of these galaxies determined using GALFIT. Using these properties along with star formation rates (SFRs, estimated using the H α or [O II] luminosity) and stellar masses (M* estimated from spectral energy distribution fits), we examine correlations among various stellar and CGM properties. Our main findings are as follows: (1) SFR correlates well with M*, and most absorption-selected galaxies are consistent with the star formation main sequence of the global population. (2) More massive absorber counterparts are more centrally concentrated and are larger in size. (3) Galaxy sizes and normalized impact parameters correlate negatively with NHI, consistent with higher NHI absorption arising in smaller galaxies, and closer to galaxy centres. (4) Absorption and emission metallicities correlate with M* and specific SFR, implying metal-poor absorbers arise in galaxies with low past star formation and faster current gas consumption rates. (5) SFR surface densities of absorption-selected galaxies are higher than predicted by the Kennicutt–Schmidt relation for local galaxies, suggesting a higher star formation efficiency in the absorption-selected galaxies.
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| 18. |
- Murray, Ewan J, et al.
(författare)
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Targeting Staphylococcus aureus Quorum Sensing with Nonpeptidic Small Molecule Inhibitors.
- 2014
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Ingår i: Journal of medicinal chemistry. - : American Chemical Society (ACS). - 1520-4804 .- 0022-2623. ; 57:6, s. 2813-2819
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Tidskriftsartikel (refereegranskat)abstract
- A series of 3-oxo-C12-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing inhibition in Staphylococcus aureus. Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide (AIP) activated AgrC receptor, by altering the activation efficacy of the cognate AIP-1. They appeared to act as negative allosteric modulators and are exemplified by 3-tetradecanoyltetronic acid 17, which reduced nasal cell colonization and arthritis in a murine infection model.
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| 19. |
- Subramanian, Elaiyaraja, et al.
(författare)
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A small noncoding RNA links ribosome recovery and translation control to dedifferentiation during salamander limb regeneration
- 2023
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Ingår i: Developmental Cell. - : Elsevier. - 1534-5807 .- 1878-1551. ; 58:6, s. 450-460
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Tidskriftsartikel (refereegranskat)abstract
- Building a blastema from the stump is a key step of salamander limb regeneration. Stump-derived cells temporarily suspend their identity as they contribute to the blastema by a process generally referred to as dedifferentiation. Here, we provide evidence for a mechanism that involves an active inhibition of protein syn-thesis during blastema formation and growth. Relieving this inhibition results in a higher number of cycling cells and enhances the pace of limb regeneration. By small RNA profiling and fate mapping of skeletal muscle progeny as a cellular model for dedifferentiation, we find that the downregulation of miR-10b-5p is critical for rebooting the translation machinery. miR-10b-5p targets ribosomal mRNAs, and its artificial upregulation causes decreased blastema cell proliferation, reduction in transcripts that encode ribosomal subunits, dimin-ished nascent protein synthesis, and retardation of limb regeneration. Taken together, our data identify a link between miRNA regulation, ribosome biogenesis, and protein synthesis during newt limb regeneration.
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| 20. |
- Weiskopf, Sarah R., et al.
(författare)
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A Conceptual Framework to Integrate Biodiversity, Ecosystem Function, and Ecosystem Service Models
- 2022
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Ingår i: BioScience. - : Oxford University Press (OUP). - 0006-3568 .- 1525-3244. ; 72:11, s. 1062-1073
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Tidskriftsartikel (refereegranskat)abstract
- Global biodiversity and ecosystem service models typically operate independently. Ecosystem service projections may therefore be overly optimistic because they do not always account for the role of biodiversity in maintaining ecological functions. We review models used in recent global model intercomparison projects and develop a novel model integration framework to more fully account for the role of biodiversity in ecosystem function, a key gap for linking biodiversity changes to ecosystem services. We propose two integration pathways. The first uses empirical data on biodiversity–ecosystem function relationships to bridge biodiversity and ecosystem function models and could currently be implemented globally for systems and taxa with sufficient data. We also propose a trait-based approach involving greater incorporation of biodiversity into ecosystem function models. Pursuing both approaches will provide greater insight into biodiversity and ecosystem services projections. Integrating biodiversity, ecosystem function, and ecosystem service modeling will enhance policy development to meet global sustainability goals.
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| 21. |
- Weiskopf, Sarah R., et al.
(författare)
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Increasing the uptake of ecological model results in policy decisions to improve biodiversity outcomes
- 2022
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Ingår i: Environmental Modelling & Software. - : Elsevier BV. - 1364-8152 .- 1873-6726. ; 149
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Tidskriftsartikel (refereegranskat)abstract
- Models help decision-makers anticipate the consequences of policies for ecosystems and people; for instance, improving our ability to represent interactions between human activities and ecological systems is essential to identify pathways to meet the 2030 Sustainable Development Goals. However, use of modeling outputs in decision-making remains uncommon. We share insights from a multidisciplinary National Socio-Environmental Synthesis Center working group on technical, communication, and process-related factors that facilitate or hamper uptake of model results. We emphasize that it is not simply technical model improvements, but active and iterative stakeholder involvement that can lead to more impactful outcomes. In particular, trust-and relationship-building with decision-makers are key for knowledge-based decision making. In this respect, nurturing knowledge exchange on the interpersonal (e.g., through participatory processes) and institutional level (e.g., through science-policy interfaces across scales) represents a promising approach. To this end, we offer a generalized approach for linking modeling and decision-making.
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| 22. |
- Weng, Simon, et al.
(författare)
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MUSE-ALMA Haloes XI : gas flows in the circumgalactic medium
- 2023
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Ingår i: Monthly notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 523:1, s. 676-700
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Tidskriftsartikel (refereegranskat)abstract
- The flow of gas into and out of galaxies leaves traces in the circumgalactic medium which can then be studied using absorption lines towards background quasars. We analyse 27 log[N(H I) /cm(-2)] > 18. 0 H I absorbers at z = 0.2 to 1.4 from the MUSEALMA Haloes survey with at least one galaxy counterpart within a line of sight velocity of +/- 500 km s(-1). We perform 3D kinematic forward modelling of these associated galaxies to examine the flow of dense, neutral gas in the circumgalactic medium. From the VLT/MUSE, HST broad-band imaging, and VLT/UVES and Keck/HIRES high-resolution UV quasar spectroscopy observations, we compare the impact parameters, star-formation rates, and stellar masses of the associated galaxies with the absorber properties. We find marginal evidence for a bimodal distribution in azimuthal angles for strong H I absorbers, similar to previous studies of the Mg II and O VI absorption lines. There is no clear metallicity dependence on azimuthal angle, and we suggest a larger sample of absorbers is required to fully test the relationship predicted by cosmological hydrodynamical simulations. A case-by-case study of the absorbers reveals that ten per cent of absorbers are consistent with gas accretion, up to 30 per cent trace outflows, and the remainder trace gas in the galaxy disc, the intragroup medium, and low-mass galaxies below the MUSE detection limit. Our results highlight that the baryon cycle directly affects the dense neutral gas required for star-formation and plays a critical role in galaxy evolution.
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| 23. |
- Aad, G., et al.
(författare)
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- 2015
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Tidskriftsartikel (refereegranskat)
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| 24. |
- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t
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| 25. |
- Aad, G., et al.
(författare)
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- 2015
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Tidskriftsartikel (refereegranskat)
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| 26. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :1
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Tidskriftsartikel (refereegranskat)
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| 27. |
- Aad, G., et al.
(författare)
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- 2014
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Tidskriftsartikel (refereegranskat)
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| 28. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Journal of High Energy Physics. - : Springer. - 1029-8479 .- 1126-6708. ; :8
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Tidskriftsartikel (refereegranskat)
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| 29. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :4
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Tidskriftsartikel (refereegranskat)
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| 30. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :1
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Tidskriftsartikel (refereegranskat)
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| 31. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Journal of High Energy Physics. - : Springer-Verlag New York. - 1029-8479 .- 1126-6708. ; :5
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Tidskriftsartikel (refereegranskat)
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| 32. |
- Aad, G., et al.
(författare)
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- 2015
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Tidskriftsartikel (refereegranskat)
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| 33. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Journal of High Energy Physics. - : Springer-Verlag New York. - 1029-8479 .- 1126-6708. ; :6
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Tidskriftsartikel (refereegranskat)
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| 34. |
- Aad, G, et al.
(författare)
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- 2014
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 113:17
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Tidskriftsartikel (refereegranskat)
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| 35. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 91:3
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Tidskriftsartikel (refereegranskat)
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| 36. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :3
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Tidskriftsartikel (refereegranskat)
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