| 1. |
- Aghanavesi, Somayeh, 1981-, et al.
(författare)
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A multiple motion sensors index for motor state quantification in Parkinson's disease
- 2020
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Ingår i: Computer Methods and Programs in Biomedicine. - : Elsevier BV. - 0169-2607 .- 1872-7565. ; 189
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To construct a Treatment Response Index from Multiple Sensors (TRIMS) for quantification of motor state in patients with Parkinson's disease (PD) during a single levodopa dose. Another aim was to compare TRIMS to sensor indexes derived from individual motor tasks. Method: Nineteen PD patients performed three motor tests including leg agility, pronation-supination movement of hands, and walking in a clinic while wearing inertial measurement unit sensors on their wrists and ankles. They performed the tests repeatedly before and after taking 150% of their individual oral levodopa-carbidopa equivalent morning dose.Three neurologists blinded to treatment status, viewed patients’ videos and rated their motor symptoms, dyskinesia, overall motor state based on selected items of Unified PD Rating Scale (UPDRS) part III, Dyskinesia scale, and Treatment Response Scale (TRS). To build TRIMS, out of initially 178 extracted features from upper- and lower-limbs data, 39 features were selected by stepwise regression method and were used as input to support vector machines to be mapped to mean reference TRS scores using 10-fold cross-validation method. Test-retest reliability, responsiveness to medication, and correlation to TRS as well as other UPDRS items were evaluated for TRIMS. Results: The correlation of TRIMS with TRS was 0.93. TRIMS had good test-retest reliability (ICC = 0.83). Responsiveness of the TRIMS to medication was good compared to TRS indicating its power in capturing the treatment effects. TRIMS was highly correlated to dyskinesia (R = 0.85), bradykinesia (R = 0.84) and gait (R = 0.79) UPDRS items. Correlation of sensor index from the upper-limb to TRS was 0.89. Conclusion: Using the fusion of upper- and lower-limbs sensor data to construct TRIMS provided accurate PD motor states estimation and responsive to treatment. In addition, quantification of upper-limb sensor data during walking test provided strong results. © 2019
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| 2. |
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| 3. |
- Andreasson, Thomas, et al.
(författare)
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Evaluation of anamnestic criteria for the identification of patients with acute community onset viral gastroenteritis in the emergency department-A prospective observational study.
- 2014
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Ingår i: Scandinavian journal of infectious diseases. - : Informa UK Limited. - 1651-1980 .- 0036-5548. ; 46:8, s. 561-565
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Tidskriftsartikel (refereegranskat)abstract
- Background: To our knowledge no clinical criteria for the identification of community onset viral gastroenteritis in individual patients have been evaluated systematically with modern PCR-based diagnostic assays as gold standard. Objective: The aim of this study was to identify factors independently associated with the detection of virus by PCR in rectal swab samples from patients with acute community onset gastroenteritis. Methods: A prospective observational study was conducted from December 2010 through March 2011 at the emergency department (ED) of a large teaching hospital. All patients who reported vomiting and/or diarrhoea up to 48 h prior to their visit to the ED were asked to participate. A rectal swab sample was obtained from each patient. Symptoms, date of onset, and epidemiological data were recorded. Samples were analysed with a multiple real-time PCR targeting 6 viral agents (astrovirus, adenovirus, rotavirus, sapovirus, and norovirus GI and GII). Results: Two hundred and five patients fulfilled the inclusion criteria, of whom 66 agreed to participate; their median (IQR) age was 65 (38-84) y and 43 (65%) were females. Thirty-one (47%) were positive by PCR for at least 1 of the agents examined (26 norovirus, 2 sapovirus, 2 rotavirus, and 1 adenovirus). Diarrhoea and a short duration of symptoms (≤ 2 days) were independently associated with a positive rectal swab sample, with odds ratios of 7.5 (95% confidence interval (CI) 2.0-28) and 10.4 (95% CI 1.9-56), respectively (p < 0.01 for both). A multivariate model including these 2 variables had a sensitivity of 81% (25/31) and a specificity of 69% (24/35). Conclusions: Diarrhoea and a short duration of symptoms were the only anamnestic criteria independently associated with acute community onset viral gastroenteritis confirmed by PCR.
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| 4. |
- Beck-Friis, Thomas, et al.
(författare)
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Burden of rotavirus infection in hospitalized elderly individuals prior to the introduction of rotavirus vaccination in Sweden
- 2019
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Ingår i: Journal of Clinical Virology. - : Elsevier BV. - 1386-6532. ; 119, s. 1-5
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Tidskriftsartikel (refereegranskat)abstract
- Background: Rotavirus gastroenteritis (GE) in the elderly has been much less studied than in children. Objectives: The aim of this study was to determine the morbidity and mortality for elderly hospitalized patients with rotavirus GE prior to the introduction of rotavirus vaccination in Sweden, and to investigate the epidemiology of rotavirus genotypes in these patients. Study design: All patients 60 years or older who were hospitalized at Sahlgrenska University Hospital, Gothenburg, Sweden, and were rotavirus positive in a clinical diagnostic test from 2009 to 2016, were included. Medical records were reviewed and rotavirus genotyping real-time PCR was performed. Results: One hundred and fifty-nine patients were included, corresponding to an annual incidence of hospitalization due to rotavirus GE of 16/100 000 inhabitants aged 60 years or older. G2P[4] was the most common genotype, followed by G1P[8] and G4P[8]. The majority of patients had community-onset of symptoms and no or few pre-existing health disorders. Four patients (2.5%) died within 30 days of sampling. Patients with hospital-onset rotavirus GE had a longer median length of stay following diagnosis compared with patients with community-onset of symptoms (19 vs. 5 days, p = 0.001) and higher 30-day mortality (8.6% (3/35) vs. < 1% (1/124), p = 0.03). Conclusions: Hospitalization due to rotavirus GE among the elderly seems to mainly affect otherwise healthy individuals and is associated with low 30-day mortality.
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| 5. |
- Beck-Friis, Thomas, et al.
(författare)
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Outdoor Absolute Humidity Predicts the Start of Norovirus GII Epidemics
- 2023
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Ingår i: Microbiology Spectrum. - : American Society for Microbiology. - 2165-0497. ; 11:2
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Tidskriftsartikel (refereegranskat)abstract
- Seasonal variation of viral gastroenteritis is related to weather conditions, but the relationship with the incidence of viral gastroenteritis (GE) is not fully understood. This study examined the impact of outdoor climate factors on seasonal variation in detection rates of gastroenteritis viruses, with emphasis on norovirus. Weekly detection rates of norovirus genogroup I (GI) and II (GII), rotavirus, adenovirus, astrovirus, and sapovirus were analyzed in relation to average weekly means of meteorological parameters. Associations between rates of PCR detection of the viral GE pathogens and climate factors were investigated with generalized linear models. Low absolute humidity was correlated with increased detection of adenovirus (P = 0.007), astrovirus (P = 0.005), rotavirus (P = 0.004), norovirus GI (P = 0.001), and sapovirus (P = 0.002). In each investigated season, a drop in absolute humidity preceded the increase in norovirus GII detections. We found a correlation between declining absolute humidity and increasing norovirus GII detection rate. Absolute humidity was a better predictor of gastrointestinal virus seasonality compared to relative humidity.IMPORTANCE Viral gastroenteritis causes considerable morbidity, especially in vulnerable groups such as the elderly and chronically ill. Predicting the beginning of seasonal epidemics is important for the health care system to withstand increasing demands. In this paper we studied the association of outdoor climate factors on the detection rates of gastrointestinal viruses and the association between these factors and the onset of annual norovirus epidemics. Declining absolute humidity preceded the increase in diagnosed norovirus GII cases by approximately 1 week. These findings contribute to the understanding of norovirus epidemiology and allow health care services to install timely preventive measures and can help the public avoid transmission. Viral gastroenteritis causes considerable morbidity, especially in vulnerable groups such as the elderly and chronically ill. Predicting the beginning of seasonal epidemics is important for the health care system to withstand increasing demands.
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| 6. |
- Bjordal, Kristin, et al.
(författare)
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A prospective study of quality of life in head and neck cancer patients. Part II: Longitudinal data
- 2001
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Ingår i: Laryngoscope. - 1531-4995. ; 111:8, s. 1440-1452
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To evaluate the health-related quality of life (HRQL) of patients with head and neck cancer during and after treatment with radiotherapy, surgery, and chemotherapy. STUDY DESIGN: Prospective, descriptive study. METHODS: All new patients in four institutions in Norway and Sweden were asked to participate. Health-related quality of life was assessed at baseline and at 1, 2, 3, 6, and 12 months after start of treatment by means of the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire and the EORTC head and neck cancer-specific questionnaire. Baseline results are described elsewhere; longitudinal results are presented in the current article. Three hundred fifty-seven patients with cancer in the oral cavity, pharynx, larynx, nose, sinuses, and salivary glands and neck node metastases from unknown primaries filled in the questionnaires at baseline. RESULTS: Seventy-eight percent of the patients who were alive after 12 months filled in all questionnaires (218/280). The general trend was that HRQL deteriorated significantly during treatment, followed by a slow recovery until the 12-month follow-up with few exceptions (senses, dry mouth, and sexuality). Patients who later died reported worse HRQL at each assessment point compared with patients who filled in all six questionnaires, whereas those who dropped out of the study for other reasons were quite similar to patients who filled in all questionnaires. The patients with pharyngeal cancer in general reported worse HRQL compared with the other groups and did not reach pretreatment values in several domains. Stage was also an important factor for HRQL in patients with head and neck cancer. CONCLUSION: Detailed knowledge about the differences between groups and changes over time may aid us in the communication with patients and in the design of intervention studies focusing on improvement of the support and rehabilitation of patients with head and neck cancer.
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| 7. |
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| 8. |
- Broman, Lars Mikael, et al.
(författare)
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Pressure and flow properties of cannulae for extracorporeal membrane oxygenation II : drainage (venous) cannulae
- 2019
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Ingår i: Perfusion. - : SAGE PUBLICATIONS LTD. - 0267-6591 .- 1477-111X. ; 34, s. 65-73
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Tidskriftsartikel (refereegranskat)abstract
- The use of extracorporeal life support devices such as extracorporeal membrane oxygenation in adults requires cannulation of the patient's vessels with comparatively large diameter cannulae to allow circulation of large volumes of blood (>5 L/min). The cannula diameter and length are the major determinants for extracorporeal membrane oxygenation flow. Manufacturing companies present pressure-flow charts for the cannulae; however, these tests are performed with water. Aims of this study were 1. to investigate the specified pressure-flow charts obtained when using human blood as the circulating medium and 2. to support extracorporeal membrane oxygenation providers with pressure-flow data for correct choice of the cannula to reach an optimal flow with optimal hydrodynamic performance. Eighteen extracorporeal membrane oxygenation drainage cannulae, donated by the manufacturers (n = 6), were studied in a centrifugal pump driven mock loop. Pressure-flow properties and cannula features were described. The results showed that when blood with a hematocrit of 27% was used, the drainage pressure was consistently higher for a given flow (range 10%-350%) than when water was used (data from each respective manufacturer's product information). It is concluded that the information provided by manufacturers in line with regulatory guidelines does not correspond to clinical performance and therefore may not provide the best guidance for clinicians.
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| 9. |
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| 10. |
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| 11. |
- Chakwizira, Arthur, et al.
(författare)
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Diffusion MRI with free gradient waveforms on a high-performance gradient system : Probing restriction and exchange in the human brain
- 2023
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Ingår i: NeuroImage. - 1053-8119. ; 283
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Tidskriftsartikel (refereegranskat)abstract
- The dependence of the diffusion MRI signal on the diffusion time carries signatures of restricted diffusion and exchange. Here we seek to highlight these signatures in the human brain by performing experiments using free gradient waveforms designed to be selectively sensitive to the two effects. We examine six healthy volunteers using both strong and ultra-strong gradients (80, 200 and 300 mT/m). In an experiment featuring a large set of 150 gradient waveforms with different sensitivities to restricted diffusion and exchange, our results reveal unique and different time-dependence signatures in grey and white matter. Grey matter was characterised by both restricted diffusion and exchange and white matter predominantly by restricted diffusion. Exchange in grey matter was at least twice as fast as in white matter, across all subjects and all gradient strengths. The cerebellar cortex featured relatively short exchange times (115 ms). Furthermore, we show that gradient waveforms with tailored designs can be used to map exchange in the human brain. We also assessed the feasibility of clinical applications of the method used in this work and found that the exchange-related contrast obtained with a 25-minute protocol at 300 mT/m was preserved in a 4-minute protocol at 300 mT/m and a 10-minute protocol at 80 mT/m. Our work underlines the utility of free waveforms for detecting time dependence signatures due to restricted diffusion and exchange in vivo, which may potentially serve as a tool for studying diseased tissue.
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| 12. |
- Collin, Jonas, et al.
(författare)
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How to Design Virtual Video Production for Augmented Student Presentations
- 2022
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Ingår i: Proceedings of the 21st European Conference on e-Learning - ECEL 2022. - : Academic Conferences International (ACI). - 9781914587559 ; , s. 71-78
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Konferensbidrag (refereegranskat)abstract
- E-learning environments have been developed and used by teachers and learners for decades. However, it is well known that sending, recording or meeting online can have a lack of presence and immersion. Furthermore, the configuration of a studio environment typically depends on physical props and technologies, which can be time consuming and hard to use for teaching purposes where each session may need a different configuration. Virtual Video Production (VVP) is a relatively new technology that builds on advances in extended reality (XR), supported by game engines and computer-controlled camera equipment. Camera data (pan, tilt, zoom, position) can be sent to a virtual camera in the game engine. The scene can be rendered via a green screen or with large LED displays. This provides an immersive presence with virtual 3D objects positioned in the room. Light settings can be mixed into the scene with remote control of LED lights to be in sync with virtual lights. Thus, VVP opens many opportunities for more immersive e-learning experiences. The challenge is how to apply these opportunities that involve syncing of several technical components and layers, designed to be useful within limited course resources. The question in this paper is how VVP can be designed and set up in an easy way for teachers and students to use it for presentations in courses? This paper presents results from a course in Immersive Environments where students first developed mobile Augmented Reality app prototypes and then used VVP to present their final work together with the authors. The authors documented preparation, wrote instructions for students and observed with notes taken during recording sessions. The results show how VVP can be designed and set up for course presentations that goes beyond a plain video recording in a lecture room or at home, but also beyond what was previously possible in a video studio at the university. This includes e.g., technical setup, direction of students, synopsis, concepts and virtual 3D props. Finally, the authors draw conclusions of what challenges remain for future research and suggestions of how to overcome them.
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| 13. |
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| 14. |
- Eusébio Garcia, Franco, et al.
(författare)
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Workshop: Towards Inclusive Co-creation of Inclusive Games
- 2019
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Ingår i: Entertainment Computing and Serious Games. - Cham : Springer. - 9783030346430 - 9783030346447 ; , s. 485-488
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Konferensbidrag (refereegranskat)abstract
- Game creation precedes game play. In this workshop, we describe our efforts towards enabling people with different (dis)abilities to co-create and play digital games. We focus on abilities, skills and knowledge to enable collaborative and inclusive co-creation of inclusive games.
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| 15. |
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| 16. |
- Gusev, Dmitri A, et al.
(författare)
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Motion sickness-related aspects of inclusion of color deficient observers in virtual reality
- 2018
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Ingår i: International Journal of Child Health and Human Development. - 1939-5965. ; 11:2, s. 177-181
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Tidskriftsartikel (refereegranskat)abstract
- Color blindness is one of the most common forms of disability. Virtual reality (VR) development has increased recently, and it is important not to exclude people with impairments or other limitations. Visually induced motion sickness (VIMS) can be worse due to color versus black, white and gray environments. Can non-color factors in dynamic environments be excluded by performing color deficiency impacted tasks and comparing them to the equivalent static and dynamic tasks performed by a color sighted person? Would a color based experiment causing VIMS produce different results for a color deficient observer (CDO)? This paper advocates a novel approach to color blindness and motion sickness in VR based on psychophysical experiments. The aim is to find solutions and develop recommendations that will improve accessibility of VR for the color blind.
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| 17. |
- Gusev, Dmitri, et al.
(författare)
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Motion sickness related aspects of inclusion of color deficient observers in virtual reality
- 2016
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Ingår i: The 11th International Conference on Disability, Virtual Reality and Associated Technologies. - : ICDVRAT and the University of Reading. - 9780704915473 ; , s. 303-306
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Konferensbidrag (refereegranskat)abstract
- Color blindness is one of the most common forms of disability. Virtual reality (VR) developmenthas increased recently, and it is important not to exclude people with impairments or otherlimitations. Visually induced motion sickness (VIMS) can be worse due to color versus black, whiteand gray environments. Can non-color factors in dynamic environments be excluded by performingcolor deficiency impacted tasks and comparing them to the equivalent static and dynamic tasksperformed by a color-sighted person? Would a color-based experiment causing VIMS producedifferent results for a color deficient observer (CDO)? This paper advocates a novel approach tocolor blindness and motion sickness in VR based on psychophysical experiments. The aim is tofind solutions and develop recommendations that will improve accessibility of VR for the colorblind.
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| 18. |
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| 19. |
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| 20. |
- Haettner Aurelius, Eva, et al.
(författare)
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"Agnes von Krusenstjerna läser Kriser och kransar"
- 2011
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Ingår i: Vandring genom tiden. Till Anders Cullhed 18/3 2011. - 9789171398666 ; , s. 85-100
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Agnes von Krusenstjerna skrev ett brev till Birger Sjöberg (trol. 1926), där hon tackade för Kriser och kransar (1926. Det finns stora likheter mellan de båda författarskapen,främst i det att båda tematiserar det omedvetnas, ssk driftens roll i konst och samhälle, men också i det att båda gestaltar sinnesjukdom, själsliga sammanbrott. Båda drömmer om en försoning av drift och ande, och båda visar en kärlek till idyllen, och de umgås då och nu obekymrat med litterära klichéer.
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| 21. |
- Hammerlid, Eva, 1957, et al.
(författare)
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A prospective study of quality of life in head and neck cancer patients. Part I: At diagnosis
- 2001
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Ingår i: Laryngoscope. - : Wiley. - 0023-852X. ; 111:4 Pt 1, s. 669-680
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: A Swedish and Norwegian study was designed to examine health-related quality of life (HQL) in patients with head and neck cancer (head and neck) at diagnosis and during treatment and rehabilitation. The overall aim was to examine the impact on HQL at diagnosis depending on tumor location, stage, sex, and age (part I) and to describe HQL longitudinally and determine for which patients and during which period HQL deteriorated most (part II), This article presents the results at diagnosis. Method Patients with head and neck cancer at five hospitals in Sweden and Norway were consecutively requested to participate, They were asked to answer the EORTC QLQ-C30 and QLQ-H&N35 (the European Organization for Research and Treatment of Cancer, Core 30 questionnaire and head and neck cancer module) repeatedly during I year. A total of 357 patients (mean age, 63 y; 72% males) were included, Results: Patients with different tumor locations all had their special problems at diagnosis, for example, those with tumors in the larynx with communication, those with oral tumors with pain, and those with pharyngeal tumors with nutrition and pain. The patients with hypopharyngeal cancer reported the worst HQL. Stage appeared to have the strongest impact on HQL. Patients with a more advanced tumor stage reported significantly worse HQL scores for 24 of 32 variables reflecting functioning or problems. The females scored worse than the males for some areas, in particular, emotional functioning. The older patients scored significantly better for emotional and social functioning than patients <65 years but worse for physical functioning and various symptoms. The traditional way of grouping the tumor locations into oral, pharyngeal, laryngeal, and "other" tumors (salivary gland, sinus and nose, and unknown primary) was tested from a HQL point of view and found to be consistent. Conclusions: The chosen questionnaires differentiated between different sites of head and neck cancer at diagnosis. Tumor stage had the most powerful impact on HQL score.
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| 22. |
- Hammerlid, Eva, 1957, et al.
(författare)
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Malnutrition and food intake in relation to quality of life in head and neck cancer patients
- 1998
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Ingår i: Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. - 1043-3074. ; 20:6, s. 540-548
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Tidskriftsartikel (refereegranskat)abstract
- Background. The quality of life (QL)of cancer patients has attracted an increasing interest in recent years. Patients with head and neck cancer often have troublesome symptoms due to the disease and to treatment side effects, which will have an impact on the patient's QL. The aim of this study was to evaluate the possibility of studying QL in relation to well-known clinical parameters. Methods. Patient's QL was evaluated according to the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30) combined with a diagnosis-specific questionnaire. Quality of life was measured in a cross section of head and neck cancer patients (n = 48) and related to nutritional status, energy intake, severity of disease, and 2-year survival. Results. Fifty-one percent of the patients (mean age, 67 years) fulfilled the criteria proposed for malnutrition, and 55% had a negative energy balance. We did not find any correlation between the severity of the cancer disease and the patient's self-rated QL. However, we found significantly better QL ratings among the 2-year survivors (mean, 63; range 52-76 versus mean, 42; range, 31-54; p < .05). There were few correlations between the QL items and malnutrition. Conclusions. Quality of life measurements offer objective information on well-being, sometimes quite opposite that of other clinical parameters, such as tumor stage. Furthermore, QL measurements may be of prognostic value concerning the survival of head and neck cancer patients. (C) 1998 John Wiley & Sons, Inc.
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| 23. |
- Hammerlid, Eva, et al.
(författare)
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Prospective, longitudinal quality-of-life study of patients with head and neck cancer: a feasibility study including the EORTC QLQ-C30
- 1997
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Ingår i: Otolaryngology: Head and Neck Surgery. - 0194-5998. ; 116:6, s. 666-673
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Tidskriftsartikel (refereegranskat)abstract
- Despite modern advances in the treatment of head and neck cancer, the survival rate fails to improve. Considering the different treatment modalities involved, quality of life has been thought of as an additional end point criterion for use in clinical trials. A Nordic protocol to measure the quality of life of head and neck cancer patients before, during, and after treatment was established. Before the study, a pilot study was done with this protocol. The main purpose of this pilot study was to find out whether this cancer population would answer quality-of-life questionnaires repeatedly (six times) over a 1-year period and whether the chosen questionnaires-a core questionnaire (European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30)), a tumor-specific questionnaire, and a psychological distress measure (Hospital Anxiety and Depression scale (HAD))-were sensitive for changes to functions and symptoms during the study year. The results presented in this article all refer to the pilot study. Forty-eight consecutive patients agreed to participate in the study. The most common tumor locations were the oral cavity (17) and the larynx (12). Almost all patients received combined treatment: 45 of 48 radiation therapy, 18 of 48 chemotherapy, and 17 of 48 surgery. After the primary treatment, 40 patients had complete tumor remission. Four of the 48 patients did not answer any questionnaires and were therefore excluded from the study. Of the remaining 44 patients, 3 died during the study year, and another 6 withdrew for various reasons. Thirty-five (85%) of the 41 patients alive at the 1-year follow-up answered all six questionnaires and thus completed the study. Mailed questionnaires were used throughout the study. All questionnaires were well accepted and found to be sensitive to changes during the study year. The greatest variability was found for symptoms and functions related specifically to head and neck cancer. The symptoms were swallowing difficulties, hoarse voice, sore mouth, dry mouth, and problems with taste. They all showed the same pattern, with an increase of symptoms during and just after finishing the treatment. The HAD scale revealed a high level of psychological distress, with 21% probable cases of psychiatric morbidity at diagnosis. In conclusion, it was shown that the study design and questionnaires were feasible for the forthcoming prospective quality-of-life assessment of Swedish and Norwegian head and neck cancer patients.
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| 24. |
- Huang, Lida, et al.
(författare)
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A Study of the Challenges of Eye Tracking Systems and Gaze Interaction for Individuals with Motor Disabilities
- 2022
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Ingår i: HCI International 2022 – Late Breaking Papers: HCI for Health, Well-being, Universal Access and Healthy Aging: 24th International Conference on Human-Computer Interaction, HCII 2022, Virtual Event, June 26 – July 1, 2022, Proceedings. - Cham : Springer Nature Switzerland. - 9783031179013 ; , s. 396-411
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Konferensbidrag (refereegranskat)abstract
- Eye tracking systems are crucial methods by which motor disabled people can interact with computers. Previous research in this field has identified various accessibility affecting eye tracking technologies and applications. However, there is limited research into first-hand user experiences among individuals with motor disabilities. This study aims to examine the actual challenges with eye tracking systems and the gaze interaction faced by motor disabled people. A survey was conducted among people with motor disabilities who used eye trackers for computer interactions. It reveals the current issues from their first-hand experiences in three areas: eye tracking program, gaze interaction, and accessible applications. A knowledge graph arising from the survey delineates the connections among the eye tracking usability issues. The survey’s results also indicate practical strategies for future improvements in eye trackers.
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| 25. |
- Huang, Lida, et al.
(författare)
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A Study on Gaze Control : Game Accessibility Among Novice Players and Motor Disabled People
- 2020
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Ingår i: Computers Helping People with Special Needs. - Cham : Springer. - 9783030587956 - 9783030587963 ; , s. 205-216
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Konferensbidrag (refereegranskat)abstract
- Gaze control is a substitution for disabled people to play computer games. However, many disabled people may be inexperienced in games and/or novices using gaze-control. This study presents a game accessibility approach using gaze control modality for novice players and disabled people. A workshop was conducted involving a playtest on three games with gaze-control. The game experiences were observed, recorded, and evaluated with mixed methods. The study estimated the gaze control game accessibility by System Usability Scale (SUS), Game Experience Questionnaire (GEQ), and an open-ended questionnaire. The gaze control modality demonstrated possible game accessibility to people with motor disabilities. The results also indicate that the challenge of game mechanics and the accuracy of the gaze-control system are two significant impact factors. Further research will be conducted on gaze-control games including more disabled people, and also develop the data analysis methods for evaluating gaze-control modality for game accessibility.
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| 26. |
- Huang, Lida, et al.
(författare)
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Eyes can draw : A high-fidelity free-eye drawing method with unimodal gaze control
- 2023
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Ingår i: International journal of human-computer studies. - : Elsevier BV. - 1071-5819 .- 1095-9300. ; 170
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Tidskriftsartikel (refereegranskat)abstract
- EyeCompass is a novel free-eye drawing system enabling high-fidelity and efficient free-eye drawing through unimodal gaze control, addressing the bottlenecks of gaze-control drawing. EyeCompass helps people to draw using only their eyes, which is of value to people with motor disabilities. Currently, there is no effective gaze-control drawing application due to multiple challenges including involuntary eye movements, conflicts between visuomotor transformation and ocular observation, gaze trajectory control, and inherent eye-tracking errors. EyeCompass addresses this using two initial gaze-control drawing mechanisms: brush damping dynamics and the gaze-oriented method. The user experiments compare the existing gaze-control drawing method and EyeCompass, showing significant improvements in the drawing performance of the mechanisms concerned. The field study conducted with motor-disabled people produced various creative graphics and indicates good usability of the system. Our studies indicate that EyeCompass is a high-fidelity, accurate, feasible free-eye drawing method for creating artistic works via unimodal gaze control.
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| 27. |
- Huang, Lida, et al.
(författare)
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Interactive Painting Volumetric Cloud Scenes with Simple Sketches Based on Deep Learning
- 2022
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Ingår i: 15th International Conference on Human System Interaction (HSI) 2022. - : IEEE. - 9781665468220
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Konferensbidrag (refereegranskat)abstract
- Synthesizing realistic clouds is a complex and demanding task, as clouds are characterized by random shapes, complex scattering and turbulent appearances. Existing approaches either employ two-dimensional image matting or three-dimensional physical simulations. This paper proposes a novel sketch-to-image deep learning system using fast sketches to paint and edit volumetric clouds. We composed a dataset of 2000 real cloud images and translated simple strokes into authentic clouds based on a conditional generative adversarial network (cGAN). Compared to previous cloud simulation methods, our system demonstrates more efficient and straightforward processes to generate authentic clouds for computer graphics, providing a widely accessible sky scene design approach for use by novices, amateurs, and expert artists.
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| 28. |
- Johansson, Dongni, 1988, et al.
(författare)
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Evaluation of a sensor algorithm for motor state rating in Parkinson's disease
- 2019
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Ingår i: Parkinsonism & Related Disorders. - : Elsevier BV. - 1353-8020 .- 1873-5126. ; 64:July, s. 112-117
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: A treatment response objective index (TRIS) was previously developed based on sensor data from pronation-supination tests. This study aimed to examine the performance of TRIS for medication effects in a new population sample with Parkinson's disease (PD) and its usefulness for constructing individual dose-response models. Methods: Twenty-five patients with PD performed a series of tasks throughout a levodopa challenge while wearing sensors. TRIS was used to determine motor changes in pronation-supination tests following a single levodopa dose, and was compared to clinical ratings including the Treatment Response Scale (TRS) and six sub-items of the UPDRS part III. Results: As expected, correlations between TRIS and clinical ratings were lower in the new population than in the initial study. TRIS was still significantly correlated to TRS (r(s) = 0.23, P < 0.001) with a root mean square error (RMSE) of 1.33. For the patients (n = 17) with a good levodopa response and clear motor fluctuations, a stronger correlation was found (r(s) = 0.38, RMSE = 1.29, P < 0.001). The mean TRIS increased significantly when patients went from the practically defined off to their best on state (P = 0.024). Individual dose-response models could be fitted for more participants when TRIS was used for modelling than when TRS ratings were used. Conclusion: The objective sensor index shows promise for constructing individual dose-response models, but further evaluations and retraining of the TRIS algorithm are desirable to improve its performance and to ensure its clinical effectiveness.
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| 29. |
- Johansson, Dongni, 1988, et al.
(författare)
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Individualization of levodopa treatment using a microtablet dispenser and ambulatory accelerometry
- 2018
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Ingår i: CNS Neuroscience & Therapeutics. - : Wiley. - 1755-5930 .- 1755-5949. ; 24:5, s. 439-447
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Tidskriftsartikel (refereegranskat)abstract
- Aim: This 4-week open-label observational study describes the effect of introducing a microtablet dose dispenser and adjusting doses based on objective free-living motor symptom monitoring in individuals with Parkinson's disease (PD). Methods: Twenty-eight outpatients with PD on stable levodopa treatment with dose intervals of ≤4 hour had their daytime doses of levodopa replaced with levodopa/carbidopa microtablets, 5/1.25 mg (LC-5) delivered from a dose dispenser device with programmable reminders. After 2 weeks, doses were adjusted based on ambulatory accelerometry and clinical monitoring. Results: Twenty-four participants completed the study per protocol. The daily levodopa dose was increased by 15% (112 mg, P < 0.001) from period 1 to 2, and the dose interval was reduced by 12% (22 minutes, P = 0.003). The treatment adherence to LC-5 was high in both periods. The MDS-UPDRS parts II and III, disease-specific quality of life (PDQ-8), wearing-off symptoms (WOQ-19), and nonmotor symptoms (NMS Quest) improved after dose titration, but the generic quality-of-life measure EQ-5D-5L did not. Blinded expert evaluation of accelerometry results demonstrated improvement in 60% of subjects and worsening in 25%. Conclusions: The introduction of a levodopa microtablet dispenser and accelerometry aided dose adjustments improve PD symptoms and quality of life in the short term.
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| 30. |
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| 31. |
- Kullvén, Håkan, 1959-, et al.
(författare)
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Clickers in Education : Do students perceptions of clickers differ with the purpose?
- 2012
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- How can we encourage student participation in large classes? More specifically, how can participation best be encouraged with clickers; if they are used with anonymity for the student, or if the teacher can track each student and her/his performance? In this study, we evaluated student’s experiences of clickers in two settings; one where students used clickers anonymously, and one where clickers were used both for controlling attendance and as a part of setting the grade for the student in the course. We found pros and cons of both approaches. It seems that students are more satisfied and learn more from clickers’ activities as such when used without control, but that students that have experienced control are more positive to this and that the control as such can force them to participate more in the lectures and, by that, learn more. For both settings, we noted positive attitudes towards clickers, indicating that the use of clickers makes students more positive to the course and its content, irrespective of if clickers are used for control or not.
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| 32. |
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| 33. |
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| 34. |
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| 35. |
- Liebmann, Thomas, et al.
(författare)
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Regulation of Neuronal Na,K-ATPase by Extracellular Scaffolding Proteins
- 2018
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 19:8
-
Tidskriftsartikel (refereegranskat)abstract
- Neuronal activity leads to an influx of Na+ that needs to be rapidly cleared. The sodium-potassium ATPase (Na,K-ATPase) exports three Na+ ions and imports two K+ ions at the expense of one ATP molecule. Na,K-ATPase turnover accounts for the majority of energy used by the brain. To prevent an energy crisis, the energy expense for Na+ clearance must provide an optimal effect. Here we report that in rat primary hippocampal neurons, the clearance of Na+ ions is more efficient if Na,K-ATPase is laterally mobile in the membrane than if it is clustered. Using fluorescence recovery after photobleaching and single particle tracking analysis, we show that the ubiquitous alpha 1 and the neuron-specific alpha 3 catalytic subunits as well as the supportive beta 1 subunit of Na,K-ATPase are highly mobile in the plasma membrane. We show that cross-linking of the beta 1 subunit with polyclonal antibodies or exposure to Modulator of Na,K-ATPase (MONaKA), a secreted protein which binds to the extracellular domain of the beta subunit, clusters the alpha 3 subunit in the membrane and restricts its mobility. We demonstrate that clustering, caused by cross-linking or by exposure to MONaKA, reduces the efficiency in restoring intracellular Na+. These results demonstrate that extracellular interactions with Na,K-ATPase regulate the Na+ extrusion efficiency with consequences for neuronal energy balance.
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| 36. |
- Lindh, Magnus, 1960, et al.
(författare)
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Response prediction and treatment tailoring for chronic hepatitis C virus genotype 1 infection
- 2007
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Ingår i: J Clin Microbiol. - 0095-1137. ; 45:8, s. 2439-45
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Tidskriftsartikel (refereegranskat)abstract
- We monitored early viral response during the treatment of hepatitis C virus (HCV) infection with the aim of identifying predictors of treatment outcome. We studied 53 patients with genotype 1 infection who received 180 microg/week pegylated interferon alfa-2a and 1,000 or 1,200 mg/day ribavirin depending on body weight and serially assessed HCV RNA in serum, using the Cobas TaqMan assay. Thirty-one patients (58%) achieved sustained viral response (SVR). SVR was obtained in 100% (10/10) of patients with pretreatment viremia concentrations below 400,000 IU/ml, in 100% (14/14) of patients with more than 1.5 log reduction of HCV RNA after 4 days of treatment, and in 95% (22/23) of patients with a rate of decline in viremia higher than 0.70 log units/week during the second phase. Non-SVR was seen in all patients with a second-phase decline rate lower than 0.35 log units/week. Patients with slopes between 0.50 and 0.80 log units/week achieved SVR (4/4) unless the treatment dose was modified (3/3). We conclude that the second-phase slope appears to be an accurate and useful predictor of treatment response. On the basis of these findings, we propose a model of tailored treatment which takes into account the second-phase slope and the amount of HCV RNA after 21 days of treatment.
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| 37. |
- Lindner, Philip, et al.
(författare)
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Cognitive flexibility does not predict symptom reduction in Internet interventions
- 2015
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- PURPOSE: Little is known about whether individual differences in executive functions predict outcomes after Internet-delivered psychological treatments. We hypothesized that learning and utilizing skills taught in treatment is reliant on cognitive flexibility, as measurable by perseverative errors (PE) on the 64-card Wisconsin Card Sorting Test (WCST). We tested this by correlating PE scores with symptom reduction following treatment for social anxiety disorder (n=116), depression (n=42) and tinnitus discomfort (n=28). METHOD: In all groups, the WCST was administered online prior to treatment and partial correlation (controlling for age) were calculated between PE and percentage symptom reduction on the respective primary outcome measure. RESULTS: Number of PE did not correlate with pre-treatment symptom scores in any group. There was no generic association between symptom reduction and PE, and, after outlier removal, no group-specific associations either. CONCLUSIONS: Lower cognitive flexibility does not appear to impede symptom reduction in Internet-delivered psychological treatments.
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| 38. |
- Lindner, Philip, et al.
(författare)
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Does cognitive flexibility predict treatment gains in Internet-delivered psychological treatment of social anxiety disorder, depression, or tinnitus?
- 2016
-
Ingår i: PeerJ. - : PeerJ. - 2167-8359. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- Little is known about the individual factors that predict outcomes in Internet-administered psychological treatments. We hypothesized that greater cognitive flexibility (i.e. the ability to simultaneously consider several concepts and tasks and switch effortlessly between them in response to changes in environmental contingencies) would provide a better foundation for learning and employing the cognitive restructuring techniques taught and exercised in therapy, leading to greater treatment gains. Participants in three trials featuring Internet-administered psychological treatments for depression (n = 36), social anxiety disorder (n = 115) and tinnitus (n = 53) completed the 64-card Wisconsin Card Sorting Test (WCST) prior to treatment. We found no significant associations between perseverative errors on the WCST and treatment gains in any group. We also found low accuracy in the classification of treatment responders. We conclude that lower cognitive flexibility, as captured by perseverative errors on the WCST, should not impede successful outcomes in Internet-delivered psychological treatments.
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| 39. |
- Lindvall, Linus, et al.
(författare)
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How not to run into a wall : A comparative experiment of Movement in Virtual Reality
- 2017
-
Ingår i: NES 2017: Conference Proceedings. - : Nordic Ergonomics and Human Factors Society (NES). - 9789177531524 ; , s. 354-362
-
Konferensbidrag (refereegranskat)abstract
- Recent technical developments have resulted in the increased use of Virtual Reality and Head Mounted Displays (HMDs) for entertainment and industrial purposes (Bengtson, Borsos, & Krupenia, 2017). A persistent problem associated with the use of HMDs for VR is that when moving within a virtual environment, the user can experience motion sickness and disorientation resulting in reduced ease of use or efficiency. The purpose of the current research was to establish which movement-based design principle(s) is/are best suited for a virtual environment. Three movement techniques were implemented and tested; a fading teleport, a drag/floating movement, and a hybrid concept. Of interest were motion sickness, disorientation, ease of use, and efficiency. Results indicated that the fading teleport technique best supported ease of use and also reduced disorientation. Further investigation into the teleportation technique and how it can be further improved is suggested.
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| 40. |
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| 41. |
- Memedi, Mevludin, 1983-, et al.
(författare)
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Construction of levodopa-response index from wearable sensors for quantifying Parkinson's disease motor functions
- 2016
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The goal of this study was to investigate the feasibility of wrist worn motion sensors to objectively measure motor functions in Parkinson’s disease (PD). More specifically, the aim was to construct a sensor-based levodopa-response index (SBLRI) and evaluate its clinimetric properties (convergent validity and internal consistency). Nineteen advanced PD patients and 22 healthy controls were recruited in a single center, open label, single dose clinical trial in Sweden. The subjects performed standardized motor tasks while wearing one sensor on each wrist and one on each ankle. Each sensor unit consisted of three-dimensional accelerometer and gyroscope. The patients were video recorded and the videos were blindly rated by three independent movement disorder specialists. The clinical scores were given using the Treatment Response Scale (TRS) on a scale from -3 = ‘Very Off’ to 0 = ‘On’ to +3 = ‘Very dyskinetic’. The clinical assessments were based on the overall motor function of the patients. A mean TRS was defined as the mean of the three specialists’ assessments per time point. The measurements were repeated over several time points following a single levodopa/carbidopa morning dose (50% over normal to induce dyskinesias). Sensor measurements during rapid alternating movements of hands were processed with time series analysis methods to calculate spatiotemporal parameters designed to measure bradykinesia and dyskinesia. For each hand, 96 spatiotemporal parameters were calculated and their average scores were then used in a principal component analysis to reduce the dimensionality by retaining 6 principal components. These components were then used as predictors to support vector machines and to be mapped to the mean TRS ratings of the three specialists and to calculate the SBLRI. For this analysis, a 10-fold stratified cross-validation was performed. The SBLRI was strongly correlated to mean TRS with a Pearson correlation coefficient of 0.79 (CI: 0.74-0.83, p<0.001). The 95% confidence interval for the mean squared error of SBLRI on patients data was ± 1.62 with a mean value of 0.57 whereas on healthy controls data was ± 1 with a mean value of 0.27. The sensor-based spatiotemporal parameters had good internal consistency with a Cronbach’s Alpha coefficient of 0.87 and significantly differed between patients and healthy controls. The results demonstrated that the SBLRI had good clinimetric properties for measuring motor functions (Off and dyskinesia) in PD patients. The method could also distinguish hand rotation movements exhibited by patients from those exhibited by healthy controls. The SBLRI provides effect-time profiles, which could be useful during therapy individualization of advanced PD patients.
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| 42. |
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| 43. |
- Memedi, Mevludin, et al.
(författare)
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Self-assessments and motor tests via telemetry in a 36-month levodopa-carbidopa intestinal gel infusion trial
- 2014
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Objective: The aim of this study was to investigate if a telemetry test battery can be used to measure effects of Parkinson’s disease (PD) treatment intervention and disease progression.Methods: Sixty-five patients diagnosed with advanced PD were recruited in an open longitudinal 36-month study; 35 treated with levodopa-carbidopa intestinal gel (LCIG) and 30 were candidates for switching from oral PD treatment to LCIG. They utilized a test battery, consisting of self-assessments of symptoms and fine motor tests (tapping and spiral drawings), four times per day in their homes during week-long test periods. The repeated measurements were summarized into an overall test score (OTS) to represent the global condition of the patient during a test period. Clinical assessments included ratings on Unified PD Rating Scale (UPDRS) and 39-item PD Questionnaire (PDQ-39) scales.Results: In LCIG-naïve patients, mean OTS compared to baseline was significantly improved from the first test period on LCIG treatment until month 24. In LCIG-non-naïve patients, there were no significant changes in mean OTS, except at month 36 (P<0.01). The OTS correlated adequately with total UPDRS (rho = 0.59) and total PDQ-39 (0.59).Conclusions: PD symptoms can be remotely monitored over time with this test battery. The trends of the test scores were similar to the trends of clinical rating scores. Correlations between OTS and clinical rating scales were adequate indicating that the test battery contains important elements of the information of the well-established scales.
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| 44. |
- Memedi, Mevludin, et al.
(författare)
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Self-reported symptoms and motor tests via telemetry in a 36-month levodopa-carbidopa intestinal gel infusion trial
- 2013
-
Ingår i: Movement Disorders : Supplement. - : Wiley-Blackwell. - 0885-3185. ; , s. S168-S168
-
Konferensbidrag (refereegranskat)abstract
- ObjectiveTo investigate if a home environment test battery can be used to measure effects of Parkinson’s disease (PD) treatment intervention and disease progression.BackgroundSeventy-seven patients diagnosed with advanced PD were recruited in an open longitudinal 36-month study at 10 clinics in Sweden and Norway; 40 of them were treated with levodopa-carbidopa intestinal gel (LCIG) and 37 patients were candidates for switching from oral PD treatment to LCIG. They utilized a mobile device test battery, consisting of self-assessments of symptoms and objective measures of motor function through a set of fine motor tests (tapping and spiral drawings), in their homes. Both the LCIG-naïve and LCIG-non-naïve patients used the test battery four times per day during week-long test periods.MethodsAssessmentsThe LCIG-naïve patients used the test battery at baseline (before LCIG), month 0 (first visit; at least 3 months after intraduodenal LCIG), and thereafter quarterly for the first year and biannually for the second and third years. The LCIG-non-naïve patients used the test battery from the first visit, i.e. month 0. Out of the 77 patients, only 65 utilized the test battery; 35 were LCIG-non-naïve and 30 LCIG-naïve. In 20 of the LCIG-naïve patients, assessments with the test battery were available during oral treatment and at least one test period after having started infusion treatment. Three LCIG-naïve patients did not use the test battery at baseline but had at least one test period of assessments thereafter. Hence, n=23 in the LCIG-naïve group. In total, symptom assessments in the full sample (including both patient groups) were collected during 379 test periods and 10079 test occasions. For 369 of these test periods, clinical assessments including UPDRS and PDQ-39 were performed in afternoons at the start of the test periods. The repeated measurements of the test battery were processed and summarized into scores representing patients’ symptom severities over a test period, using statistical methods. Six conceptual dimensions were defined; four subjectively-reported: ‘walking’, ‘satisfied’, ‘dyskinesia’, and ‘off’ and two objectively-measured: ‘tapping’ and ‘spiral’. In addition, an ‘overall test score’ (OTS) was defined to represent the global health condition of the patient during a test period.Statistical methodsChange in the test battery scores over time, that is at baseline and follow-up test periods, was assessed with linear mixed-effects models with patient ID as a random effect and test period as a fixed effect of interest. The within-patient variability of OTS was assessed using intra-class correlation coefficient (ICC), for the two patient groups. Correlations between clinical rating scores and test battery scores were assessed using Spearman’s rank correlations (rho).ResultsIn LCIG-naïve patients, mean OTS compared to baseline was significantly improved from the first test period on LCIG treatment until month 24. However, there were no significant changes in mean OTS scores of LCIG-non-naïve patients, except for worse mean OTS at month 36 (p<0.01, n=16). The mean scores of all subjectively-reported dimensions improved significantly throughout the course of the study, except ‘walking’ at month 36 (p=0.41, n=4). However, there were no significant differences in mean scores of objectively-measured dimensions between baseline and other test periods, except improved ‘tapping’ at month 6 and month 36, and ‘spiral’ at month 3 (p<0.05). The LCIG-naïve patients had a higher within-subject variability in their OTS scores (ICC=0.67) compared to LCIG-non-naïve patients (ICC=0.71). The OTS correlated adequately with total UPDRS (rho=0.59) and total PDQ-39 (rho=0.59).ConclusionsIn this 3-year follow-up study of advanced PD patients treated with LCIG we found that it is possible to monitor PD progression over time using a home environment test battery. The significant improvements in the mean OTS scores indicate that the test battery is able to measure functional improvement with LCIG sustained over at least 24 months.
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| 45. |
- Memedi, Mevludin, 1983-, et al.
(författare)
-
Self-reported symptoms and motor tests via telemetry in a 36-month levodopa-carbidopa intestinal gel infusion trial
- 2013
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Objective: To determine if a home environment test battery can be used to measure effects of Parkinson’s disease (PD) treatment intervention and disease progression.Background: Sixty-five patients diagnosed with advanced PD were recruited in an open longitudinal 36-month study. On inclusion, 35 of them were treated with continuous intraduodenal administration of a levodopa-carbidopa intestinal gel (LCIG) and 30 patients were candidates for switching from conventional oral PD treatment to LCIG. They utilized a test battery, consisting of self-assessments and fine motor tests (tapping and spiral drawings), in their homes. Assessments were performed four times per day during week-long test periods. For the majority of these test periods, UPDRS and PDQ-39 ratings were performed at the start of the period.Methods: The test battery time series were summarized into scores for representing symptom severities over test periods. Six conceptual dimensions were defined; four subjectively-reported: ‘Walking’, ‘Satisfied’, ‘Dyskinesia’ and ‘Off’, and two objectively-measured: ‘Tapping’ and ‘Spiral’. In addition, an overall test score (OTS) was defined to represent the overall condition of a patient during a test period.Results: In LCIG-naïve patients, mean OTS improved startingf rom the first test period on LCIG treatment and this improvement remained statistically significant until month 24 (figure). In contrast to objectively-measured dimensions, mean scores of subjectively-reported dimensions improved significantly throughout the study. In LCIG-non-na€ıve patients, there were no significant changes in mean OTS, except at month 36 (p < 0.01). The OTS correlated adequately with total UPDRS (rho 5 0.59) and total PDQ-39 (0.59).Conclusions: Using the test battery it is possible to monitor PD symptoms over time. The trends of the test scores were strikingly similar to the trends of the clinical rating scores. Correlations between OTS and the rating scales were adequate indicating that the test battery contains important elements of the information of these well-established scales.
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| 46. |
- Memedi, Mevludin, et al.
(författare)
-
Validity and responsiveness of at-home touch-screen assessments in advanced Parkinson's disease
- 2015
-
Ingår i: IEEE journal of biomedical and health informatics. - : Institute of Electrical and Electronics Engineers (IEEE). - 2168-2194 .- 2168-2208. ; 19:6, s. 1829-1834
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate if a telemetry test battery can be used to measure effects of Parkinson’s disease (PD) treatment intervention and disease progression in patients with fluctuations. Sixty-five patients diagnosed with advanced PD were recruited in an open longitudinal 36-month study; 35 treated with levodopa-carbidopa intestinal gel (LCIG) and 30 were candidates for switching from oral PD treatment to LCIG. They utilized a test battery, consisting of self-assessments of symptoms and fine motor tests (tapping and spiral drawings), four times per day in their homes during week-long test periods. The repeated measurements were summarized into an overall test score (OTS) to represent the global condition of the patient during a test period. Clinical assessments included ratings on Unified PD Rating Scale (UPDRS) and 39-item PD Questionnaire (PDQ-39) scales. In LCIG-naïve patients, mean OTS compared to baseline was significantly improved from the first test period on LCIG treatment until month 24. In LCIG-non-naïve patients, there were no significant changes in mean OTS until month 36. The OTS correlated adequately with total UPDRS (rho = 0.59) and total PDQ-39 (0.59). Responsiveness measured as effect size was 0.696 and 0.536 for OTS and UPDRS respectively. The trends of the test scores were similar to the trends of clinical rating scores but dropout rate was high. Correlations between OTS and clinical rating scales were adequate indicating that the test battery contains important elements of the information of well-established scales. The responsiveness and reproducibility were better for OTS than for total UPDRS.
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| 47. |
- Mishra, Shubhra, et al.
(författare)
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Personalized Assistive Technologies for Motor-Impaired Students : A Case of Learning Process Mining
- 2023
-
Ingår i: Assistive Technology. - : IOS Press. - 9781643684222 ; , s. 564-571
-
Konferensbidrag (refereegranskat)abstract
- Motor disability includes the lack of sensation, movement, or coordination, and Assistive Technologies (AT) can help overcome these challenges. Motor-disabled students need different ATs and configurations depending on courses and individual needs, and some solutions can be expensive. Some affordable AT has roots in gaming but can also be used for other purposes. However, there is little research on how they can be combined to define a personalized setting. Therefore, we performed a literature review to identify challenges and solutions to support students with motor disabilities in using information systems. The result defines a framework for identifying personalized settings. The usability of the result was demonstrated by performing a self-experimentation study of the first author, who has a motor disability. The results show its utility while learning process mining using the Graphical User Interface (GUI) and code-based tools. We identified challenges in using different User Interface (UI) elements, which can be used as a guideline for designers of process mining tools as well as other information systems to support diversity.
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| 48. |
- Mozelius, Peter, et al.
(författare)
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Gaming habits, study habits and compulsive gaming among digital gaming natives
- 2016
-
Ingår i: Proceedings of the 10th European Conference on Game Based Learning. - : Academic Conferences Publishing. - 9781911218098 ; , s. 486-491
-
Konferensbidrag (refereegranskat)abstract
- The so called "N-generation" or the "Digital natives" extensive use of computers and Internet resources have been widely discussed in research, but there are different opinions on how good their general computer skills are seen from a Computer science perspective. Considering digital gaming there seem to be stronger indications supporting the concept of a new generation with new habits. Most students in the group from where data has been collected for this study have gaming experiences from early pre-school childhood and will therefore in this paper be called "Digital gaming natives". Gaming has also been a considerable part of their later childhood and they are all enrolled for studies on computer game construction. The aim of this paper is to analyse and discuss digital native gamers’ gaming habits and how excessive gaming might have disturbed school studies or other social activities. Data has been collected from a course batch of 30 students following a university programme for Game construction at a department of Computer science. Out of the 28 students that wrote essays about their gaming habits 6 are female and 22 are male. A content analysis was conducted based on the student essays that were submitted and discussed online in a course on Games-based learning. Students’ experiences from gaming habits and study habits were also discussed at course seminars and have later been discussed with other teachers. Findings show that the Digital gaming natives’ gaming habits definitely are strong and that they in many situations have clashed with the informants’ study habits. In several cases parents have created gaming restrictions and there are examples of students’ self-restrictions, but there exist also examples of when excessive nightly gaming have interfered with the daily school work. Almost all students’ defend their gaming and claim that it has given them a richer life with nice experiences even if there are risks of addiction and displacement. One student wrote in his essay that: "Generally, gaming is a fantastic possibility to escape daily routines for a while to be immersed, to discover and to learn. At the same time this can lead to less pleasant states like compulsive gaming or addiction."
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| 49. |
- Mozelius, Peter, et al.
(författare)
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Transfer of knowledge and skills from computer gaming to non-digital real world contexts
- 2015
-
Ingår i: Proceedings of the 10th International Conference on e-Learning. - : Academic Conferences Publishing. - 9781910810255 - 9781910810262
-
Konferensbidrag (refereegranskat)abstract
- The "N-generation" or the "digital natives" have now entered university programmes and their extensive use of computers and digital games is a fact (Spires 2008). Digital games and gamification are also proliferating in private, professional as well as in educational domains (Reinhardt & Sykes 2014). Phenomena as play, narration and gamification are classified as transmedial, i.e. they exist in digital as well as non-digital contexts (Dymek, 2010), but there is no consensus on learning transfer from digital gaming to real world contexts. While some researchers claim a strong learning potential (Gee, 2003; Reinhardt & Sykes, 2014), others have more sceptical standpoints (Hays 2005; Linderoth 2012). Would the opinions on learning transfer be different if the question is asked to the digital natives themselves? The aim of this paper is to analyse and discuss what students in the digital natives’ generation might have learnt in gaming and if acquired skills and knowledge can be transferred to other contexts. A content analysis has been carried out on student essays submitted and discussed in a course on Games-based learning. Students’ experiences from gaming and learning transfer have also been discussed in course examination seminars. Findings show that the digital natives definitely have strong gaming habits, and a majority of the students perceived that they had learnt meaningful things from gaming. Regarding knowledge and skill transfer, variations were noted among the various types of games. Furthermore, there are several examples from both educational games and commercial-off-the-shelf games where acquired skills and knowledge can be seen as transmedial and of use in non-digital contexts.
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| 50. |
- Männikkö-Barbutiu, Sirkku, et al.
(författare)
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Supporting Sustainability Through Collaborative Awareness Raising – A Case of Sri Lankan Telecentres
- 2017
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Ingår i: Information and Communication Technologies for Development. - Cham : Springer. - 9783319591100 - 9783319591117 ; , s. 410-421
-
Konferensbidrag (refereegranskat)abstract
- For the development of sustainable ICT services, participation of the local communities is crucial. A meaningful involvement requires awareness and understanding of the various possibilities of the ICTs. In this paper, the processes of awareness raising among underprivileged population in the Sri Lankan tea estate district of Nuwara Eliya are examined, drawing on the findings from an empirical study conducted at two telecentres. A specific participatory methodology, where co-inspirational sessions and brainstorming constituted main activities of co-creation of knowledge was applied. Our empirical data confirms that the participatory methods can trigger curiosity and engagement among participants. Ideas and suggestions that emerged during brainstorming demonstrate relevance, realism as well as they are a proof of real needs and requirements of a population that lives under difficult conditions in remote locations. Participatory methods can initiate community engagement for a longstanding, sustainable transformation of the TCs, in collaboration with ICT developers, and TC staff.
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