| 1. |
- Berglund, Lisa, et al.
(författare)
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Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation
- 2007
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Ingår i: American Journal of Physiology: Cell Physiology. - : American Physiological Society. - 1522-1563 .- 0363-6143. ; 292:3, s. 1167-1178
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Tidskriftsartikel (refereegranskat)abstract
- The calcineurin/nuclear factor of activated T cells ( NFAT) signaling pathway has been found to play a role in regulating growth and differentiation in several cell types. However, the functional significance of NFAT in the vasculature is largely unclear. Here we show that NFATc1, NFATc3, and NFATc4 are expressed in human myometrial arteries. Confocal immunofluorescence and Western blot analysis revealed that endothelin-1 efficiently increases NFATc3 nuclear accumulation in native arteries. Endothelin-1 also stimulates NFAT-dependent transcriptional activity, as shown by a luciferase reporter assay. Both the agonist-induced NFAT nuclear accumulation and transcriptional activity were prevented by the calcineurin inhibitor CsA and by the novel NFAT blocker A-285222. Chronic inhibition of NFAT significantly reduced IL-6 production in intact myometrial arteries and inhibited cell proliferation in vascular smooth muscle cells cultured from explants from the same arteries. Furthermore, by using small interfering RNA-mediated reduction of NFATc3, we show that this isoform is involved in the regulation of cell proliferation. Protein synthesis in intact arteries was investigated using autoradiography of [S-35] methionine incorporation in serum-free culture. Inhibition of NFAT signaling did not affect overall protein synthesis or specifically the synthesis rates of major proteins associated with the contractile/cytoskeletal system. An intact contractile phenotype under these conditions was also shown by unchanged force response to depolarization or agonist stimulation. Our results demonstrate NFAT expression and activation in native human vessels and point out A-285222 as a powerful pharmacological blocker of NFAT signaling in the vasculature.
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| 2. |
- Birgegård, Gunnar, 1944-, et al.
(författare)
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Serum ferritin during infection : A longitudinal study
- 1978
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Ingår i: Scandinavian journal of haematology. - 0036-553X. ; 21:4, s. 333-340
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Tidskriftsartikel (refereegranskat)abstract
- Serum ferritin, transferrin, iron and haptoglobin have been investigated in a longitudinal study in 18 patients hospitalized for various acute infections. Within a couple of days after the onset of an infection, a rise in serum ferritin was seen, the magnitude of which was not dependent on the type of infection (bacterial or viral). The serum ferritin level remained elevated for several weeks in some patients, and 7 out of the 18 patients still had abnormally high values 5 weeks after the onset of illness. The mean curves for serum ferritin and the acute phase reactant haptoglobin were parallel. Possible mechanisms causing the elevation in serum ferritin are discussed.
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| 3. |
- Birgegård, Gunnar, 1944-, et al.
(författare)
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Serum ferritin during infection : A longitudinal study in renal transplant patients
- 1979
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Ingår i: Acta medica Scandinavica. - 0001-6101. ; 205:7, s. 641-645
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Tidskriftsartikel (refereegranskat)abstract
- In order to follow the dynamics in the reaction of iron kinetic variables to acute infection, 8 renal transplantation patients were followed with test samples every second or third day for about two months. It was found that they just as previously shown in otherwise healthy subjects, responded to acute infection with a rise in serum ferritin levels, sometimes to very high values. In most cases the ferritin elevation started within two days after the onset of fever. The peak was reached within a week, except when very high values were obtained. The fall in serum ferritin after recovery from infection was much faster than in previously investigated groups of patients: the plasma half disappearance time for ferritin in one case was but 1.5 days. Transferrin did not change in response to infection. The expected fall in serum iron during infection was often absent and sometimes obscured by unexpected, sharp peaks in serum iron, which bore a temporal relationship to episodes of transplant rejection in 7 of 12 cases.
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| 4. |
- Birgegård, Gunnar, 1944-, et al.
(författare)
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Serum ferritin during inflammation : A study on myocardial infarction
- 1979
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Ingår i: Acta medica scandinavica. - 0001-6101. ; 206:5, s. 361-366
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Tidskriftsartikel (refereegranskat)abstract
- The ferritin level in serum was investigated in 9 patients with myocardial infarction, all with a history of chest pain of less than 4 hours before admission. A significant rise in serum ferritin level was found in 8 patients. The rise was generally smaller than that seen in acute infection and not significantly correlated to the size of infarction, as estimated from changes in serum levels of myoglobin, ASAT and LDH. The rise started after a mean of 30 hours, the peak being reached within a week (M 4.3 days). Serum ferritin then fell to 120--300% (M 190) of the initial level, where it remained. An initial rise in serum iron levels was unexpectedly seen within 12 hours in 7 patients.
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| 5. |
- Hadera, Hubert, et al.
(författare)
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A Mean Value Cross Decomposition Strategy for Demand-side Management of a Pulping Process
- 2015
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Ingår i: 2th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering. - : Elsevier. - 9780444634290 ; , s. 1931-1936
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Konferensbidrag (refereegranskat)abstract
- Energy is becoming a critical resource for process industries as introduction of new policies drive changes in the energy supply systems. Energy availability and pricing is much more volatile. In this study, we propose a Mean Value Cross Decomposition approach to functionally separate production scheduling from energy-cost optimization. Such a decomposition makes it possible to exploit existing optimization solutions avoiding a need to create a new monolithic model. The proposed framework is applied to a continuous process of thermo-mechanical pulping using a discrete-time Resource-Task Network model. Example case study scenarios show that the approach gives optimal system-wide solutions while keeping the models separated.
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| 6. |
- Kjellsdotter Ivert, Linea, 1980-, et al.
(författare)
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Svenska hamnars roll i en cirkulär ekonomi
- 2023
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- För att Sverige ska kunna nå målet om att bli ett av världens första fossilfria välfärdsländer krävs en omställning till ett fossilfritt transportsystem såväl som till en cirkulär ekonomi. Sjöfart har potential att matcha de behov som en ökad cirkulär ekonomi ställer och är ett energieffektivt trafikslag. Syftet med rapporten är att förstå hur sjöfart kan nyttjas i ökad utsträckning för att transportera cirkulära produkter och material och hur hamnen kan skapa mervärde i utveckling av cirkulära logistiklösningar. Metoderna som använts är: litteraturstudier, workshops och fallstudier. Rapporten identifierar cirkulära produkter och material med potential att lyfta sig i avfallstrappan och där det är lämpligt att nyttja sjöfart för transport i det cirkulära logistiksystemet. Det handlar om muddermassor, jordmassor, mineralavfall, träavfall, plastavfall, uttjänta däck, uttjänta textilier, sorterade och återvunna textilier, planglas, spillolja och flygaska. Hamnens roll vid hantering av cirkulära material studerades mer specifikt för massor, dissolvingmassa baserad på återvunna textilier, matrester och etanol. Det blev tydligt att hamnen kan skapa värde i form av lagring, konsolidering, lossning och lastning av containrar samt vara en logistiknod som erbjuder omlastningsmöjligheter mellan olika trafikslag. Hamnen känner till de lokala förutsättningarna för effektiva logistikupplägg och är en central kugge i nya aktörsnätverk. Rapporten redovisar även en beskrivning av två cirkulära logistiklösningar med involvering av sjöfart som utvecklats och utvärderats under projektet. Det handlar dels om en demonstration av en sjötransport med kalkstabiliserad lera, dels om framtagning av beslutsunderlag för investering av en tilltänkt sorteringsmaskin av planglas i vilket logistikupplägg från ett antal olika hamnar förslogs och miljöberäkningar genomfördes.
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| 7. |
- von Wieding, Sönke, et al.
(författare)
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Framtidens moderna intermodala logistiknoder - kunskaps- och utvecklingsbehov
- 2023
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Modern intermodal nodes of the future – Requirements on knowledge and developmentThe purpose of the project was to compile existing knowledge to analyze the function, design, and organization of intermodal nodes, as well as identify gaps for future research within Trafikverket’s research program and serve as a basis for Trafikverket's strategic work. The project uses both literature reviews and empirical studies through workshops with experts. The project has five main results:1. Criteria are proposed to define sustainable intermodal nodes aimed at promoting economic, social, and environmental goals for authorities, cargo owners, and carriers. The aim is to identify challenges and areas where nodes can improve their sustainability to avoid sub-optimization.2. A two-dimensional matrix is proposed to categorize intermodal nodes according to their role in society's goods supply, as well as the local economy and environment.3. Various organizational forms for nodes are described, including terminals and associated logistics areas that can be owned and managed by public, private, or combined entities.4. A discussion on how technological innovations such as electrification, digitization, and automation can affect intermodal nodes in the future.5. Opportunities and needs for further work and research in the field are presented
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| 8. |
- Wide, Ann, 1962-, et al.
(författare)
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Sätt vid kloratframställning : [Method of preparing chlorate]
- 1990
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Patent (populärvet., debatt m.m.)abstract
- The invention discloses a method in the electrolytic production of alkali metal chlorate which is recovered by crystallization and separation of the crystals from a solution recycled to the electrolysis process. A given proportion of the crystals formed are separated and removed from the mother liquor after they have been in contact with the mother liquor for a shorter period of time than the remaining crystals, whereby they obtain a sulphate content which is higher than in the crystals that have been in contact with the mother liquor for a longer period of time.
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| 9. |
- Wide, Per, et al.
(författare)
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Efficiency effects of information on operational disruption management in port hinterland freight transport : simulation of a Swedish dry port case
- 2023
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Ingår i: International Journal of Logistics. - : Taylor and Francis Ltd.. - 1367-5567 .- 1469-848X. ; 26:5, s. 524-547
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Tidskriftsartikel (refereegranskat)abstract
- Management of operational disruptions with support of information is essential to facilitate the shift from road to rail and to ensure efficient hinterland intermodal transport chains. Therefore, the purpose of this paper is to investigate the operational efficiency effects of information on operational disruption management in hinterland transport with a dry port to facilitate efficient intermodal hinterland transport. For that purpose, a simulation model with five scenarios was developed and applied using empirical data from a real-world case of a hinterland transport chain with a dry port. The results show that the resource utilisation of the trucks that deliver containers from the dry port to the receivers can be increased using the information that supports management of the disruption. Nevertheless, in attempts to increase resource utilisation when managing the disruption, issues arose from efficiency measures that are important for other actors, e.g. the receivers.
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| 10. |
- Wide, Per, 1990
(författare)
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Improving decisions support for operational disruption management in freight transport
- 2020
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Ingår i: Research in Transportation Business and Management. - : Elsevier BV. - 2210-5395 .- 2210-5409. ; 37
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Tidskriftsartikel (refereegranskat)abstract
- In this study, the operational management of disruptions is investigated in transport chains with a focus on phases after disruptions have occurred. Instead of focusing on strategies mitigating risk before disruption occurs this paper considers the recovery phase of a disruption at operational level. The purpose of this paper is to provide insights for operational disruption management to achieve improved decision support for the recovery phase. A qualitative method of a case study is used in this paper for the transport around a distribution centre at a FMCG company in Sweden with data collected from semi-structured interviews and observations. The analysis of the findings proposes different types of detection in the recovery phase, which give insights for how to perform early recovery actions. The study contributes to disruption management in transport chains through insights on how to achieve early recovery actions by combining the different detection types with the phases of prediction and action. Instead of focusing on strategies mitigating risk before disruption occurs this paper considers the recovery phase of a disruption at operational level. This is shown to be important to understand reactive or proactive actions in the recovery phase. Transport managers can use the proposed detection types in this paper to detect disruptions in order to respond to disruptions earlier instead of developing competences of fire-fighting for occurred impacts.
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| 11. |
- Wide, Per, 1990, et al.
(författare)
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Information on Resource Utilisation for Operational Planning in Port Hinterland Transport
- 2021
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Ingår i: Transactions on Maritime Science. - : University of Split, Faculty of Maritime Studies. - 1848-3313 .- 1848-3305. ; 10:2, s. 477-487
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Tidskriftsartikel (refereegranskat)abstract
- To meet increased freight flows through maritime ports, a high level of resource utilisation in hinterland transport is of crucial importance. However, various perspectives on resource utilisation create issues with use of information for operational decisions in port hinterland. The purpose of this paper is to explore the use of information related to resource utilisation for operational planning in port hinterland freight transport to facilitate its improvement. The study is case-based, and the data is collected through semi-structured interviews, visual observations, and company documents. The findings are analysed with a framework built from literature emphasising different resource utilisation perspectives and the use of information in road freight transport chain decisions. The findings show that the use of information on resource utilisation in operational freight transport decisions in the port hinterland transport system is limited and lacks a complete system overview. Instead of the information on measured parameters, different types of estimates of efficiency parameters (including resource utilisation) are commonly used for operational planning decisions. The information about the measured indicators has to be combined with other information to obtain an efficient level of resource utilisation; otherwise, it could generate incorrect assumptions regarding utilisation. The paper contributes to the topic of operational freight transport planning by describing the use of information on resource utilisation.
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| 12. |
- Wide, Per, 1990, et al.
(författare)
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Operational Coordination in Intermodal Hinterland Transport as Support for Managing Operational Disruptions – An Information Processing Perspective
- 2021
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Ingår i: Operations and Supply Chain Management. - : OSCM Forum. - 1979-3561 .- 2579-9363. ; 14:4, s. 507-519
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Tidskriftsartikel (refereegranskat)abstract
- Intermodal solutions, compared to the use of only road, in port hinterland transport involve numerous actors and activities that increase operational uncertainty. The purpose of this paper is to investigate the role of information, through an information processing perspective, for operational coordination in supporting operational disruption management in intermodal hinterland transport. A qualitative case study approach is adopted to obtain an in-depth understanding of operational coordination in a hinterland transport system. The results provide insights into how the actors use information processing for coordination to influence the mitigation of the impact from operational disruptions. The paper supports managers in improving disruption management by understand the processing of real-time information in the coordination for intermodal hinterland transport solutions. This paper provides input for operational disruptions using information for coordination on a day-to-day basis via an information processing perspective in contrast to the predominant coordination at a strategic level in the literature.
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| 13. |
- Wide, Per
(författare)
-
Real-time information for disruption management in intermodal freight transport
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis focuses on the recovery phase after operational disruptions in intermodal freight transport, which is a vital aspect of mitigating impacts such as late deliveries and thus achieving high operational efficiency. Intermodal freight transport is influenced by the ongoing development of information and communication technologies. Real-time information from these technologies has been shown useful for managing disruptions at the operational level. Previous research on intermodal freight transport has focused on the effects of actions enabled by real-time information, which has generated a lack of understanding the importance of real-time information concerning the process that result in these actions, such as using real-time information to manage operational disruptions. In this thesis, the process of managing disruptions in the recovery phase by using real-time information to detect a disruption, predict its impacts and take suitable action is termed disruption management. The purpose of this thesis is to contribute to the understanding of the importance of real-time information for disruption management in intermodal freight transport. This thesis draws from a compilation of five studies conducted to examine various aspects of real-time information used during the recovery phase in different intermodal freight transport settings. The studies involved applying various methods used in qualitative case studies, such as interviews, observations, and a focus group, as well as a quantitative study involving discrete event simulation. The main results are as follows. First, the results identified how real-time information supports the phases of disruption management (i.e., detection, prediction and action) depending on different factors of real-time information. Second, connections between operational coordination regarding information and buffers are discussed in terms of how they influence the real-time information used for disruption management. Last, an investigation of the efficiency effects was made with different scenarios for real-time information regarding prediction of impact. Through these results, the thesis provides insights into the importance of real-time information for disruption management and theoretical contributions to intermodal freight transport by conceptualising the role of real-time information for disruption management at the operational level and its effects. The detailed descriptions of real-time information for recovery provides practical contributions for transport managers to understand and evaluate their processes at the recovery phase.
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| 14. |
- Wide, Per, 1990
(författare)
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Real-time information for operational disruption management in hinterland road transport
- 2020
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Ingår i: World Review of Intermodal Transportation Research. - : Inderscience Publishers. - 1749-4729 .- 1749-4737. ; 9:4, s. 358-375
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Tidskriftsartikel (refereegranskat)abstract
- Port hinterland transport literature has previously taken mainly a port perspective of operational disruption, for example delays or congestion, and as such lacks understanding of how real-time information can contribute to management of operational disruption outside the port. Therefore, the purpose of the paper is to explore real-time information for operational disruption management in road hinterland transport. A qualitative single case study approach is adopted at a logistics service provider responsible for road hinterland transport. The findings show improvement potential in disruption management by applying real-time information. Mainly issues related to the detection of disruption are highlighted to generate insufficiencies for the operational disruption management. Furthermore, the focus of real-time information for the impact on goods flow, rather than disruptions in the surrounding environment of transport operations, was found to limit disruption management. The paper intends to contribute to the hinterland transport literature by broadening the understanding for management of operational disruption through use of real-time information.
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| 15. |
- Wide, Per, 1990
(författare)
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Recovery actions in freight transport through real-time disruption management
- 2019
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis focuses on the management of disruption in freight transport. The management of disruption is of importance to achieve planned efficiency in the transport system by mitigating or avoiding the impacts of disruptions, such as late arrivals of deliveries. The transport system is influenced by the ongoing development of information and communication technologies, which makes real-time information related to the transport operations available. This information has been shown to be useful for disruption management and has created possibilities for a shift towards more autonomous transport systems. This thesis investigates the real-time disruption management, as the recovery phase of disruption at the operational level, using relevant information after a disruption has occurred. The studied literature has mainly considered this phase to be reactive and focused on recovery strategies as proactive actions before disruptions occur. This thesis considers proactive recovery actions as made after a disruption but before it impacts the transport chain. These kinds of recovery actions provide less impact from disruptions on the freight transport system than reactive recovery actions made after the impact has occurred do. The purpose of this research is to investigate real-time disruption management in freight transport, in order to generate possibilities for proactive recovery actions. Two cases of real-time disruption management have been investigated in this thesis, in three different studies. Each study examined different aspects regarding detection of disruptions, of what is detected, how it is detected and where in the transport system it is detected, influence on the initiation of real-time disruption management. The results from the performed studies point towards the importance of that detecting different objects of a disruption, which is further influenced by how and where in the system the detection is made. Furthermore, these insights into the detection phase are connected to the other phases for real-time disruption management, prediction and action, in order to state the possibilities of generating proactive recovery actions. In contrast to the developed literature of strategic recovery strategies, this thesis establishes a detailed description of the viewpoint of real-time management of disruptions. As the identified objects for detection in this research are shown to be represented by different information, it is valuable for the development of disruption management to match future autonomous parts of the transport system and develop decision support systems accordingly. Furthermore, the research contributes with two dimensions in which recovery actions can be viewed as proactive. This is generated either with real-time disruption management performed after impact but before impact on the transport system or after the impact on transport system but before impact on upcoming operations. The practical contribution includes concepts revolving around real-time disruption management, which can be used for an outline for needed information in order to generate possibilities for proactive recovery actions.
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