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Sökning: WFRF:(Wiens Stefan)

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1.
  • Abbafati, Cristiana, et al. (författare)
  • 2020
  • Tidskriftsartikel (refereegranskat)
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3.
  • Addo, Rebecka N., et al. (författare)
  • Olfactory Functions in Adults With Autism Spectrum Disorders
  • 2017
  • Ingår i: Perception. - : SAGE Publications. - 0301-0066 .- 1468-4233. ; 46:3-4, s. 530-537
  • Tidskriftsartikel (refereegranskat)abstract
    • Autism spectrum disorders (ASD) are often characterized by atypical sensory behavior (hyperor hyporeactivity) although evidence is scarce regarding olfactory abilities in ASD; 16 adults with high-functioning ASD (mean age: 38.2, SD: 9.7) and 14 healthy control subjects (mean age: 42.0 years, SD: 12.5) were assessed in odor threshold, free and cued odor identification, and perceived pleasantness, intensity, and edibility of everyday odors. Although results showed no differences between groups, the Bayes Factors (close to 1) suggested that the evidence for no group differences on the threshold and identification tests was inconclusive. In contrast, there was some evidence for no group differences on perceived edibility (BF01 = 2.69) and perceived intensity (BF01 = 2.80). These results do not provide conclusive evidence for or against differences between ASD and healthy controls on olfactory abilities. However, they suggest that there are no apparent group differences in subjective ratings of odors.
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4.
  • Alvarsson, Jesper J. (författare)
  • Perspectives on wanted and unwanted sounds in outdoor environments : Studies of masking, stress recovery, and speech intelligibility
  • 2013
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • An acoustic environment contains sounds from various sound sources, some generally perceived as wanted, others as unwanted. This thesis examines the effects of wanted and unwanted sounds in acoustic environments, with regard to masking, stress recovery, and speech intelligibility.In urban settings, masking of unwanted sounds by sounds from water structures has been suggested as a way to improve the acoustic environment. However, Study I showed that the unwanted (road traffic) sound was better at masking the wanted (water) sound than vice versa, thus indicating that masking of unwanted sounds with sounds from water structures may prove difficult. Also, predictions by a partial loudness model of the auditory periphery overestimated the effect of masking, indicating that centrally located informational masking processes contribute to the effect. Some environments have also been shown to impair stress recovery; however studies using only auditory stimuli is lacking. Study II showed that a wanted (nature) sound improve stress recovery compared to unwanted (road traffic, ambient) sounds. This suggests that the acoustic environment influences stress recovery and that wanted sounds may facilitate stress recovery compared to unwanted sounds. An additional effect of unwanted sounds is impeded speech communication, commonly measured with speech intelligibility models. Study III showed that speech intelligibility starts to be negatively affected when the unwanted (aircraft sound) masker have equal or higher sound pressure level as the speech sound. Three models of speech intelligibility (speech intelligibility index, partial loudness and signal–to–noise ratio) predicted this effect well, with a slight disadvantage for the signal–to–noise ratio model. Together, Study I and III suggests that the partial loudness model is useful for determining effects of wanted and unwanted sounds in outdoor acoustic environments where variations in sound pressure level are large. But, in environments with large variations in other sound characteristics, models containing predictions of central processes would likely produce better results.The thesis concludes that wanted and unwanted characteristics of sounds in acoustic environments affect masking, stress recovery, and speech intelligibility, and that auditory perception models can predict these effects.
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5.
  • Alvarsson, Jesper J., et al. (författare)
  • Stress Recovery during Exposure to Nature Sound and Environmental Noise
  • 2010
  • Ingår i: International Journal of Environmental Research and Public Health. - Basel, Schweiz : MDPI Publishing. - 1660-4601 .- 1661-7827. ; 7:3, s. 1036-1046
  • Tidskriftsartikel (refereegranskat)abstract
    • Research suggests that visual impressions of natural compared with urban environments facilitate recovery after psychological stress. To test whether auditory stimulation has similar effects, 40 subjects were exposed to sounds from nature or noisy environments after a stressful mental arithmetic task. Skin conductance level (SCL) was used to index sympathetic activation, and high frequency heart rate variability (HF HRV) was used to index parasympathetic activation. Although HF HRV showed no effects, SCL recovery tended to be faster during natural sound than noisy environments. These results suggest that nature sounds facilitate recovery from sympathetic activation after a psychological stressor.
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6.
  • Anders, Silke, et al. (författare)
  • When seeing outweighs feeling : a role for prefrontal cortex in passive control of negative affect in blindsight
  • 2009
  • Ingår i: Brain. - Oxford : Oxford University Press. - 0006-8950 .- 1460-2156. ; 132:11, s. 3021-3031
  • Tidskriftsartikel (refereegranskat)abstract
    • Affective neuroscience has been strongly influenced by the viewthat a ‘feeling’ is the perception of somatic changesand has consequently often neglected the neural mechanisms thatunderlie the integration of somatic and other information inaffective experience. Here, we investigate affective processingby means of functional magnetic resonance imaging in nine corticallyblind patients. In these patients, unilateral postgeniculatelesions prevent primary cortical visual processing in part ofthe visual field which, as a result, becomes subjectively blind.Residual subcortical processing of visual information, however,is assumed to occur in the entire visual field. As we have reportedearlier, these patients show significant startle reflex potentiationwhen a threat-related visual stimulus is shown in their blindvisual field. Critically, this was associated with an increaseof brain activity in somatosensory-related areas, and an increasein experienced negative affect. Here, we investigated the patients’response when the visual stimulus was shown in the sighted visualfield, that is, when it was visible and cortically processed.Despite the fact that startle reflex potentiation was similarin the blind and sighted visual field, patients reported significantlyless negative affect during stimulation of the sighted visualfield. In other words, when the visual stimulus was visibleand received full cortical processing, the patients’ phenomenalexperience of affect did not closely reflect somatic changes.This decoupling of phenomenal affective experience and somaticchanges was associated with an increase of activity in the leftventrolateral prefrontal cortex and a decrease of affect-relatedsomatosensory activity. Moreover, patients who showed strongerleft ventrolateral prefrontal cortex activity tended to showa stronger decrease of affect-related somatosensory activity.Our findings show that similar affective somatic changes canbe associated with different phenomenal experiences of affect,depending on the depth of cortical processing. They are in linewith a model in which the left ventrolateral prefrontal cortexis a relay station that integrates information about subcorticallytriggered somatic responses and information resulting from in-depthcortical stimulus processing. Tentatively, we suggest that theobserved decoupling of somatic responses and experienced affect,and the reduction of negative phenomenal experience, can beexplained by a left ventrolateral prefrontal cortex-mediatedinhibition of affect-related somatosensory activity.
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7.
  • Cosme, Danielle, et al. (författare)
  • Self-Reported Trait Mindfulness and Affective Reactivity : A Motivational Approach Using Multiple Psychophysiological Measures
  • 2015
  • Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:3
  • Tidskriftsartikel (refereegranskat)abstract
    • As a form of attention, mindfulness is qualitatively receptive and non-reactive, and is thought to facilitate adaptive emotional responding. One suggested mechanism is that mindfulness facilitates disengagement from an affective stimulus and thereby decreases affective reactivity. However, mindfulness has been conceptualized as a state, intervention, and trait. Because evidence is mixed as to whether self-reported trait mindfulness decreases affective reactivity, we used a multi-method approach to study the relationship between individual differences in self-reported trait mindfulness and electrocortical, electrodermal, electromyographic, and self-reported responses to emotional pictures. Specifically, while participants (N = 51) passively viewed pleasant, neutral, and unpleasant IAPS pictures, we recorded high-density (128 channels) electrocortical, electrodermal, and electromyographic data to the pictures as well as to acoustic startle probes presented during the pictures. Afterwards, participants rated their subjective valence and arousal while viewing the pictures again. If trait mindfulness spontaneously reduces general emotional reactivity, then for individuals reporting high rather than low-mindfulness, response differences between emotional and neutral pictures would show relatively decreased early posterior negativity (EPN) and late positive potential (LPP) amplitudes, decreased skin conductance responses, and decreased subjective ratings for valence and arousal. High mindfulness would also be associated with decreased emotional modulation of startle eyeblink and P3 amplitudes. Although results showed clear effects of emotion on the dependent measures, in general, mindfulness did not moderate these effects. For most measures, effect sizes were small with rather narrow confidence intervals. These data do not support the hypothesis that individual differences in self-reported trait mindfulness are related to spontaneous emotional responses during picture viewing.
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8.
  • Critchley, Hugo D, et al. (författare)
  • Neural systems supporting interoceptive awareness.
  • 2004
  • Ingår i: Nat Neurosci. - : Springer Science and Business Media LLC. - 1097-6256 .- 1546-1726. ; 7:2, s. 189-95
  • Tidskriftsartikel (refereegranskat)abstract
    • Influential theories of human emotion argue that subjective feeling states involve representation of bodily responses elicited by emotional events. Within this framework, individual differences in intensity of emotional experience reflect variation in sensitivity to internal bodily responses. We measured regional brain activity by functional magnetic resonance imaging (fMRI) during an interoceptive task wherein subjects judged the timing of their own heartbeats. We observed enhanced activity in insula, somatomotor and cingulate cortices. In right anterior insular/opercular cortex, neural activity predicted subjects' accuracy in the heartbeat detection task. Furthermore, local gray matter volume in the same region correlated with both interoceptive accuracy and subjective ratings of visceral awareness. Indices of negative emotional experience correlated with interoceptive accuracy across subjects. These findings indicate that right anterior insula supports a representation of visceral responses accessible to awareness, providing a substrate for subjective feeling states.
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9.
  • Eklund, Rasmus, et al. (författare)
  • Auditory awareness negativity is an electrophysiological correlate of awareness in an auditory threshold task
  • 2019
  • Ingår i: Consciousness and Cognition. - : Elsevier BV. - 1053-8100 .- 1090-2376. ; 71, s. 70-78
  • Tidskriftsartikel (refereegranskat)abstract
    • One theory of visual awareness proposes that electrophysiological activity related to awareness occurs in primary visual areas approximately 200 ms after stimulus onset (visual awareness negativity: VAN) and in fronto-parietal areas about 300 ms after stimulus onset (late positivity: LP). Although similar processes might be involved in auditory awareness, only sparse evidence exists for this idea. In the present study, we recorded electrophysiological activity while subjects listened to tones that were presented at their own awareness threshold. The difference in electrophysiological activity elicited by tones that subjects reported being aware of versus unaware of showed an early negativity about 200 ms and a late positivity about 300 ms after stimulus onset. These results closely match those found in vision and provide convincing evidence for an early negativity (auditory awareness negativity: AAN), as well as an LP. These findings suggest that theories of visual awareness are also applicable to auditory awareness.
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10.
  • Eklund, Rasmus, et al. (författare)
  • Effects of a Manual Response Requirement on Early and Late Correlates of Auditory Awareness
  • 2019
  • Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • In hearing, two neural correlates of awareness are the auditory awareness negativity (AAN) and the late positivity (LP). These correlates of auditory awareness are typically observed with tasks in which subjects are required to report their awareness with manual responses. Thus, the correlates may be confounded by this manual response requirement. We manipulated the response requirement in a tone detection task (N = 52). Tones were presented at each subject’s individual awareness threshold while high-density electroencephalography (EEG) activity was recorded. In one response condition, subjects pushed a button if they were aware of the tone and withheld responding if they were unaware of the tone. In the other condition, subjects pushed a button if they were unaware of the tone and withheld responding if they were aware of the tone. To capture AAN and LP, difference waves were computed between aware and unaware trials, separately for trials in which responses were required and trials in which responses were not required. Results suggest that AAN and LP are unaffected by the response requirement. These findings imply that in hearing, early and late correlates of awareness are not confounded by a manual response requirement. Furthermore, the results suggest that AAN originates from bilateral auditory cortices, supporting the view that AAN is a neural correlate of localized recurrent processing in early sensory areas.
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11.
  • Eklund, Rasmus, 1989- (författare)
  • Electrophysiological correlates of consciousness
  • 2019
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • How does the brain enable us to experience seeing or hearing a stimulus? If a stimulus is repeatedly presented at the awareness threshold, subjects will report that they are aware of the stimulus on half of the presentations. Electroencephalography (EEG) can be used to non-invasively record neural activity as event-related potentials (ERPs). The contrastive analysis of neural activity to trials rated as aware minus neural activity to trials rated as unaware reveals the neural correlates of consciousness (NCC). Research on the NCC in vision has resulted in two ERPs: an early negative difference wave (visual awareness negativity, VAN) and a subsequent late positivity (LP). Visual awareness may be reflected by one or both of these ERPs. However, the contrastive analysis (aware minus unaware) may not isolate the NCC because it arguably compares aware processing with a combination of unaware processing and no processing. In support, previous research that tried to isolate a comparison between aware processing and unaware processing found that LP was the only NCC. However, subsequent replications suggested VAN and LP as NCC. Because of these mixed results, we followed up on these studies in Study I with a preregistered design that manipulated stimulus size. Results showed VAN and LP as NCC. The findings provide evidence for VAN as an early NCC.Another main goal of this thesis was to investigate auditory awareness. In Study II, an auditory threshold task was used, and the contrastive analysis revealed an early negative difference wave (auditory awareness negativity, AAN) and LP. These ERPs are comparable to VAN and LP in vision. Because post-perceptual processes related to responding may confound the NCC in contrastive analysis, no-response tasks can be used to isolate awareness-related activity. In vision, a previous study in which the manual response requirement was manipulated showed effects on LP but not on VAN. In Study III, we used a similar task with auditory stimuli at the awareness threshold. Results suggested that AAN and LP are unaffected by the response manipulation. However, the present no-response task may not be optimal for removing post-perceptual processing because subjects need to reflect on their experience even if they do not need to respond manually. Additional analyses that attempted source localization of the AAN suggested that it is generated in auditory cortex.From a theoretical perspective, one view of these results is that VAN and AAN reflect local recurrent processing and that this is the neural signature of awareness, whereas LP reflects global recurrent processing that enables reporting. Other views suggest that VAN and AAN merely reflect preconscious processes, whereas LP and global recurrent processing reflect consciousness. The studies described in this thesis do not support one theory over the other but provide robust evidence for early neural correlates of visual and auditory awareness.
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12.
  • Eklund, Rasmus, et al. (författare)
  • Is auditory awareness negativity confounded by performance?
  • 2020
  • Ingår i: Consciousness and Cognition. - : Elsevier BV. - 1053-8100 .- 1090-2376. ; 83
  • Tidskriftsartikel (refereegranskat)abstract
    • Research suggests that the electrophysiological correlates of consciousness are similar in hearing as in vision: the auditory awareness negativity (AAN) and the late positivity (LP). However, from a recently proposed signal-detection perspective, these correlates may be confounded by performance, as the strength of the internal responses differs between aware and unaware trials. Here, we tried to apply this signal-detection approach to correct for performance in an auditory discrimination and detection task (N = 28). A large proportion of subjects had to be excluded because even a small response bias distorted the correction. For the remaining subjects, the correction mainly increased noise in the measurement. Furthermore, the signal-detection approach is theoretically problematic because it may isolate post-perceptual processes and eliminate awareness-related activity. Therefore, we conclude that AAN and LP are not confounded by performance and that the contrastive analysis identifies both as correlates of awareness.
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13.
  • Eklund, Rasmus, et al. (författare)
  • The early but not the late neural correlate of auditory awareness reflects lateralized experiences
  • 2021
  • Ingår i: Neuropsychologia. - : Elsevier BV. - 0028-3932 .- 1873-3514. ; 158
  • Tidskriftsartikel (refereegranskat)abstract
    • Theories disagree as to whether it is the early or the late neural correlate of awareness that plays a critical role in phenomenal awareness. According to recurrent processing theory, early activity in primary sensory areas corresponds closely to phenomenal awareness. In support, research with electroencephalography found that in the visual and somatosensory modality, an early neural correlate of awareness is contralateral to the perceived side of stimulation. Thus, early activity is sensitive to the perceived side of visual and somatosensory stimulation. Critically, it is unresolved whether this is true also for hearing. In the present study (N = 26 students), Bayesian analyses showed that the early neural correlate of awareness (auditory awareness negativity, AAN) was stronger for contralateral than ipsilateral electrodes whereas the late correlate of auditory awareness (late positivity, LP) was not lateralized. These findings demonstrate that the early but not the late neural correlate of auditory awareness reflects lateralized experiences. Thus, these findings imply that AAN is a more suitable NCC than LP because it correlates more closely with lateralized experiences.
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14.
  • Eklund, Rasmus, et al. (författare)
  • Visual awareness negativity is an early neural correlate of awareness : A preregistered study with two Gabor sizes
  • 2018
  • Ingår i: Cognitive, Affective, & Behavioral Neuroscience. - : Springer Science and Business Media LLC. - 1530-7026 .- 1531-135X. ; 18:1, s. 176-188
  • Tidskriftsartikel (refereegranskat)abstract
    • Electrophysiological recordings are commonly used to study the neural correlates of consciousness in humans. Previous research is inconsistent as to whether awareness can be indexed with visual awareness negativity (VAN) at about 200 ms or if it occurs later. The present study was preregistered with two main aims: First, to provide independent evidence for or against the presence of VAN, and second, to study whether stimulus size may account for the inconsistent findings. Subjects were shown low-contrast Gaussian filtered gratings (Gabor patches) in the four visual quadrants. Gabor size (large and small) was varied in different sessions and calibrated to each subject’s threshold of visual awareness. Event-related potentials were derived from trials in which subjects localized the Gabors correctly to capture the difference between trials in which they reported awareness versus no awareness. Bayesian analyses revealed very strong evidence for the presence of VAN for both Gabor sizes. However, there was no evidence for or against an effect of stimulus size. The present findings provide evidence for VAN as an early neural correlate of awareness.
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17.
  • Gavazzeni, Joachim, et al. (författare)
  • Age, Gender, and Arousal in Recognition of Negative and Neutral Pictures 1 Year Later
  • 2012
  • Ingår i: Psychology and Aging. - : American Psychological Association (APA). - 0882-7974 .- 1939-1498. ; 27:4, s. 1039-1052
  • Tidskriftsartikel (refereegranskat)abstract
    • Compared with nonarousing stimuli, arousing stimuli enhance memory performance. The most robust effects have been reported for negative stimuli, "the negativity effect," although a number of mediating factors prevent definitive conclusions, for example, age, gender, memory task, retention period, and alternative arousal measures. To clarify whether the negativity effect is robust across age, gender, and time, we studied incidental recognition of neutral and negative pictures from the International Affective Picture System (Lang, Bradley, & Cuthbert, 1999) in healthy younger and older adults-women and men-after a 1-year retention interval. Memory performance was related to 2 arousal measures at encoding, skin conductance response (SCR), and intensity rating of unpleasantness. The results showed weaker overall memory performance for older adults compared with younger adults. The negativity effect on accuracy (d') was gender dependent and age independent. In contrast, the negativity effect on response bias (c) interacted with age, but not gender, being weaker for older adults. Despite significant differences in arousal (SCR and arousal rating) between negative and neutral pictures, the correlations between arousal measures and memory performance were weak. Controlling for age and gender, a small negative partial correlation was found between arousal ratings and accuracy. The results extend previous studies by relating long-term recognition to both age and gender as well as to arousal at encoding.
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18.
  • Gray, Marcus A, et al. (författare)
  • Modulation of emotional appraisal by false physiological feedback during fMRI.
  • 2007
  • Ingår i: PLoS ONE. - 1932-6203. ; 2:6, s. e546-
  • Tidskriftsartikel (refereegranskat)abstract
    • James and Lange proposed that emotions are the perception of physiological reactions. Two-level theories ofemotion extend this model to suggest that cognitive interpretations of physiological changes shape self-reported emotions.Correspondingly false physiological feedback of evoked or tonic bodily responses can alter emotional attributions. Moreover,anxiety states are proposed to arise from detection of mismatch between actual and anticipated states of physiologicalarousal. However, the neural underpinnings of these phenomena previously have not been examined. Methodology/Principal Findings. We undertook a functional brain imaging (fMRI) experiment to investigate how both primary and secondorderlevels of physiological (viscerosensory) representation impact on the processing of external emotional cues. 12participants were scanned while judging face stimuli during both exercise and non-exercise conditions in the context of trueand false auditory feedback of tonic heart rate. We observed that the perceived emotional intensity/salience of neutral faceswas enhanced by false feedback of increased heart rate. Regional changes in neural activity corresponding to this behaviouralinteraction were observed within included right anterior insula, bilateral mid insula, and amygdala. In addition, right anteriorinsula activity was enhanced during by asynchronous relative to synchronous cardiac feedback even with no change inperceived or actual heart rate suggesting this region serves as a comparator to detect physiological mismatches. Finally, BOLDactivity within right anterior insula and amygdala predicted the corresponding changes in perceived intensity ratings at botha group and an individual level. Conclusions/Significance. Our findings identify the neural substrates supportingbehavioural effects of false physiological feedback, and highlight mechanisms that underlie subjective anxiety states,including the importance of the right anterior insula in guiding second-order ‘‘cognitive’’ representations of bodily arousalstate.
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19.
  • Hadynska-Klek, K., et al. (författare)
  • Quadrupole collectivity in Ca-42 from low-energy Coulomb excitation with AGATA
  • 2018
  • Ingår i: Physical Review C. - : AMER PHYSICAL SOC. - 2469-9985 .- 2469-9993. ; 97:2
  • Tidskriftsartikel (refereegranskat)abstract
    • ACoulomb-excitation experiment to study electromagnetic properties of Ca-42 was performed using a 170-MeV calcium beam from the TANDEM XPU facility at INFN Laboratori Nazionali di Legnaro. gamma rays from excited states in Ca-42 were measured with the AGATA spectrometer. The magnitudes and relative signs of ten E2 matrix elements coupling six low-lying states in Ca-42, including the diagonal E2 matrix elements of 2(1)(+) and 2(2)(+) states, were determined using the least-squares code GOSIA. The obtained set of reduced E2 matrix elements was analyzed using the quadrupole sum rule method and yielded overall quadrupole deformation for 0(1),(+)(2) and 2(1,2)(+) states, as well as triaxiality for 0(1,2)(+) states, establishing the coexistence of a weakly deformed ground-state band and highly deformed slightly triaxial sideband in Ca-42. The experimental results were compared with the state-of-the-art large-scale shell-model and beyond-mean-field calculations, which reproduce well the general picture of shape coexistence in Ca-42.
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20.
  • Hadynska-Klek, K., et al. (författare)
  • Superdeformed and Triaxial States in Ca-42
  • 2016
  • Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 117:6
  • Tidskriftsartikel (refereegranskat)abstract
    • Shape parameters of a weakly deformed ground-state band and highly deformed slightly triaxial sideband in Ca-42 were determined from E2 matrix elements measured in the first low-energy Coulomb excitation experiment performed with AGATA. The picture of two coexisting structures is well reproduced by new state-of-the-art large-scale shell model and beyond-mean-field calculations. Experimental evidence for superdeformation of the band built on 0(2)(+) has been obtained and the role of triaxiality in the A similar to 40 mass region is discussed. Furthermore, the potential of Coulomb excitation as a tool to study superdeformation has been demonstrated for the first time.
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21.
  • Hadynska-Klek, K., et al. (författare)
  • Towards The Determination Of Superdeformation In Ca-42
  • 2013
  • Ingår i: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 44:3, s. 617-625
  • Tidskriftsartikel (refereegranskat)abstract
    • The Coulomb excitation experiment to study electromagnetic structure of low-lying states in Ca-42 with a focus on a possible superdeformation in this nucleus was performed at the Laboratori Nazionali di Legnaro in Italy. Preliminary values of the determined quadrupole deformation parameters for both the ground state band and the presumed superdeformed band are presented.
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22.
  • Heinisch, C., et al. (författare)
  • Self-face recognition in schizophrenia is related to insight
  • 2013
  • Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - : Springer. - 0940-1334 .- 1433-8491. ; 263:8, s. 655-662
  • Tidskriftsartikel (refereegranskat)abstract
    • A core feature of schizophrenia is the breakdown of the sense of self. A widespread clinical consequence of impaired self-awareness is a lack of insight. Self-face recognition is regarded as one aspect of self-awareness; how this relates to other self-referential processes such as insight into the disorder is as yet unknown. Nineteen patients with schizophrenia performed a facial recognition task using video morphings during which an average face gradually transformed into one’s own, a famous or an unfamiliar face (and vice versa). Reaction times to detect faces during the transitions were compared between patients and a matched control group. In the patient group, we also examined correlations between face recognition and insight, psychopathology, and self-evaluation. Both patients with schizophrenia and controls recognised their own faces faster than unfamiliar faces. Whereas healthy subjects recognised a famous face at an intermediate speed that did not differ significantly from the recognition of one’s own and unfamiliar faces, schizophrenia patients recognised the famous face, similar to their own face, significantly faster than an unfamiliar face. Moreover, in the patient group, higher insight correlated with faster reaction times in distinguishing one’s own from famous faces. Patients with schizophrenia seem to distinguish less than controls between their own and a famous face relative to an unfamiliar face. Patients with good insight into the disorder, however, were better able to differentiate between their own and a famous face. This study supports the view that self-face recognition is an indicator for higher-order self-awareness.
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23.
  • Iannilli, Emilia, et al. (författare)
  • A spatiotemporal comparison between olfactory and trigeminal event-related potentials
  • 2013
  • Ingår i: NeuroImage. - : Elsevier BV. - 1053-8119 .- 1095-9572. ; 77, s. 254-261
  • Tidskriftsartikel (refereegranskat)abstract
    • The present study compared the temporal and spatial aspects of human olfactory and trigeminal processing. A relatively selective trigeminal stimulus, CO2, and a relatively selective olfactory stimulus, H2S, were delivered with an olfactometer to young, healthy volunteers. The analysis was performed in a classical (5-electrode, main ERPs peaks) and modern approach (high topographical resolution, inverse solution, source localization). Results of microstate segmentation highlighted 5 maps that generally described the two processes at cerebral level. The trigeminal response differed from the olfactory response up to 300 ms after stimulus onset. In this time range, source analysis pointed out that the olfactory stimulation involved olfactory related areas, while trigeminal stimulation involved noxious/somatosensoiy specific brain areas. Moreover, from 300 ms on our data showed a similarity between the two processes. Statistical parametrical mapping of the differences between conditions suggested greater activation in a specific motor/sniffing network for the CO2 stimulation (probably related to a regulation of the potential noxious stimulus) and a greater activation of the ipsilateral primary olfactory cortex for H2S.
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24.
  • Ingre, Michael, 1965- (författare)
  • P-hacking in academic research : a critical review of the job strain model and of the association between night work and breast cancer in women
  • 2017
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • P-hacking can be described as a more or less deliberate, explorative approach to data analysis with a flexible/opportunistic search space and the reporting of primarily statistically significant findings. This leads to inflated type-1 error rates and to bias in reported estimates in the scientific literature.This thesis aims to describe how p-hacking can be manifested in academic research and to illustrate how bias due to p-hacking is expected to affect the veracity of published findings using two specific examples from the literature. This thesis also argues that when evaluating published findings in the current academic environment, we should assume a priori that biases due to p-hacking and publication bias are present.The thesis used Monte Carlo simulations and systematic reviews of the literature in two specific fields: the proposed associations between exposure to night work and breast cancer in women, and between job strain and coronary heart disease.A general model and mathematical framework to predict expected bias from p-hacking was developed, and can be used for  a priori defined protected inferences of any published finding, under explicit assumptions of various levels of p-hacking. The model indicated a close to 100% chance of demonstrating a false positive association in larger studies, but also showed that even minimal p-hacking results in substantial bias in estimates.The literature review identified large flexibility in the analytical process, allowing for the final model to be picked from a large pool of available models, with an implied search space of thousands of estimates. Some of the specific observations made here could be used to argue evidence for high risk of p-hacking and publication bias in the reviewed literature:None of the 17 reviewed studies on job strain and coronary heart disease reported the proper estimate of the job strain interaction (chapter 6) and our analysis showed that the proper estimate would not have been statistically significant in any of the studies (chapter 7).One study described a data driven approach with an implied search space of at least 502 models, where adjusting for confounding did not reduce the strength of the association, as would be expected, but instead increased its strength so it fell above the threshold for statistical significance (chapter 5).One study was based on a speculative and marginally significant estimate after arbitrarily restricting the analysis to a subgroup, when estimates on the full group were available and indicated a non-significant association (chapter 5).Statistical power analyses on research into night work and breast cancer indicated that statistically significant findings were over-represented in the literature (p≈.001) suggesting the presence of bias from p-hacking or selective publishing of significant findings (chapter 5).The findings also suggest that previously reported estimates in meta-analyses was likely to represent prevailing bias in the two fields reviewed here. A bias-adjusted meta-analysis on the job strain model and coronary heart disease with a total of 462,220 subjects and 6,836 CHD events indicated no support for the job strain interaction (RR=1.00; 95% CI: 0.88--1.14). In addition, it did not show an increased risk due to high job demand (RR=1.03; 95% CI: 0.97--1.11) but it did confirm previously reported risks due to low job control (RR=1.11; 95% CI: 1.03--1.20).
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25.
  • Keus van de Poll, Marijke, 1984- (författare)
  • Disruption of writing in noisy office environments
  • 2018
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The overall aim of the four experimental studies included in this dissertation was to investigate the influence of background speech on writing performance. In Paper I, a manipulation of speech intelligibility of background speech, by using the Speech Transmission Index (STI), revealed disruptive effects at lower STI values (i.e. with relative low speech intelligibility) than expected, based on an earlier developed model. This showed that writing is more sensitive to disruption from background speech than previously thought.Experiment 1 in Paper II addressed the question whether the sound of babble, sound of water waves, or pink noise is the most effective and appreciated way of masking background speech to reduce its intelligibility and thereby its disruptiveness. Masking with babble was best. Experiment 2 in Paper II followed this finding up by showing that the disruption of writing by background speech is a function of the number of voices talking in the background—less voices, more disruption.Paper III investigated the combined impact of background speech and task interruptions on writing performance. Background speech (which was played during the whole condition) after an interruption was expected to prolong the time it took to resume the same writing speed as before the interruption. This hypothesis was not confirmed, but participants’ self-reports showed that the combination of task interruptions and background speech convey a particularly high workload.Paper IV explored what role sound source location and individual differences (inattention, noise sensitivity and working memory capacity) play in the disruption of writing by background speech. Self-reports showed that speech in front of the individual was perceived as more distracting compared to speech from behind. Other results in the same study showed that high inattentive individuals profit more from less intelligible speech located behind them than attentive individuals and high noise-sensitive individuals were more distracted by highly intelligible background speech than by less intelligible background speech.The most important and replicable finding in this dissertation is that writing fluency is very sensitive to disruption from background speech; a finding relevant for the design of open work environments. In work areas where writing is a common task, the aim should be to create quiet work areas.
  •  
26.
  • Larsson, Maria, et al. (författare)
  • A Meta-Analysis of Odor Thresholds and Odor Identification in Autism Spectrum Disorders
  • 2017
  • Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 8
  • Forskningsöversikt (refereegranskat)abstract
    • Autism Spectrum Disorders (ASD) are often accompanied by atypical visual, auditory, and tactile sensory behavior. Evidence also suggests alterations of the olfactory system, but the pattern of findings appears mixed. To quantify this pattern systematically, we conducted a meta-analysis. Studies were included if they examined olfactory function (i.e., odor threshold, or odor identification) in ASD compared with healthy age-matched control groups. We also coded for the potential moderators gender, age, and IQ. Articles were identified through computerized literature search using Web of Science, PubMed, and Scopus databases. A total of 11 articles compared odor threshold and/or odor identification between cases and controls (for threshold, n = 143 ASD and 148 controls; and for identification, n = 132 ASD and 139 controls). Effects sizes showed a substantial heterogeneity. As a result, the 95% prediction intervals were wide and ranged between a large negative and a large positive effect size for odor threshold, [-1.86, 2.05], and for odor identification, [-1.51, 2.52]. Exploratory analyses suggested that age and IQ may be potential moderators. To conclude, the large heterogeneity is consistent with the notion of both hyposensitivity and hypersensitivity in individuals with ASD. However, future research needs to predict and test the specific direction of the effect to provide convincing evidence for atypical olfactory functions in ASD.
  •  
27.
  • Lovén, Johanna, et al. (författare)
  • Who are you looking at? : The influence of face gender on visual attention and memory for own- and other-race faces
  • 2012
  • Ingår i: Memory. - : Informa UK Limited. - 0965-8211 .- 1464-0686. ; 20:4, s. 321-331
  • Tidskriftsartikel (refereegranskat)abstract
    • Previous research suggests that the own-race bias (ORB) in memory for faces is a result of other-race faces receiving less visual attention at encoding. As women typically display an own-gender bias in memory for faces and men do not, we investigated whether face gender and sex of viewer influenced visual attention and memory for own- and other-race faces, and if preferential viewing of own-race faces contributed to the ORB in memory. Participants viewed pairs of female or male own- and other-race faces while their viewing time was recorded. Afterwards, they completed a surprise memory test. We found that (1) other-race males received the initial focus of attention, (2) own-race faces were viewed longer than other-race faces over time, although the difference was larger for female faces, and (3) even though longer viewing time increased the probability of remembering a face, it did not explain the magnified ORB in memory for female faces. Importantly, these findings highlight that face gender moderates attentional responses to and memory for own- and other-race faces.
  •  
28.
  • Maurex, Liselotte, et al. (författare)
  • Emotionally controlled decision-making and a gene variant related to serotonin synthesis in women with borderline personality disorder
  • 2009
  • Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564 .- 1467-9450. ; 50:1, s. 5-10
  • Tidskriftsartikel (refereegranskat)abstract
    • The Iowa Gambling Task (IGT) was used to examine (i) social decision-making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision-making and the tryptophan hydroxylase-1 (TPH-1) gene, involved in serotonin synthesis. Forty-two women with BPD and a history of suicide attempts were genotyped, and the frequency of a TPH-1 haplotype previously uniquely associated with BPD was calculated. The BPD group scored significantly lower than a control group in the IGT. Furthermore, the TPH-1 haplotype displayed a significantly higher frequency in BPD participants with impaired decision making, compared to BPD participants with normal scores. These findings suggest that impaired decision-making as determined by the IGT is a feature of BPD and may be (i) associated with serotonin dysfunction, and (ii) possibly relevant for suicidal behavior.
  •  
29.
  • Norberg, Joakim, 1976- (författare)
  • Fearful attention : Investigating event-related potentials in spider phobia
  • 2012
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Previous studies showed that emotional pictures capture attention. Further, this effect was decreased by manipulating spatial attention. In contrast, studies produced mixed findings for effects of perceptual load on attention to emotional pictures. Emotional pictures can be phobic or nonphobic. Because phobia might be an evolutionary adaption, it is possible that effects of phobic pictures on attention differ from effects of nonphobic emotional pictures. The present thesis aimed at investigating attention in spider phobia. Attention to emotional pictures was operationalized as event-related potentials (ERPs) (P1, early posterior negativity [EPN,] and late positive potential [LPP]). Two research questions were formulated. First, do phobic pictures evoke larger ERPs than what can be expected from arousal and valence? Second, are effects of spatial attention and perceptual load on ERPs the same for phobic and nonphobic emotional pictures? To investigate this, phobic and nonphobic negative pictures were presented to spider phobic and nonphobic participants. To determine effects of spatial attention on ERPs, participants were instructed to divert attention to a single letter that was presented in the periphery. To determine effects of perceptual load on ERPs, participants were instructed to perform a letter discrimination task on one, two, or three letters that were presented in the periphery. Study 1 showed enhanced LPP amplitudes to phobic pictures independent of arousal and valence. Further, this effect was present in both phobic and nonphobic participants. Study 2 showed that there was no effect of perceptual load on LPP to phobic pictures. Study 3 showed that spatial attention reduced LPP amplitudes, and to a similar extent for both phobic and nonphobic pictures. Further, perceptual load did not reduce EPN or LPP amplitudes to either phobic or nonphobic pictures. To conclude, the results suggest that phobic pictures evoke larger ERP amplitudes than nonphobic pictures. Still, ERPs to phobic and nonphobic pictures are moderated similarly by spatial attention and perceptual load.
  •  
30.
  • Norberg, Joakim, et al. (författare)
  • Never mind the spider : Late positive potentials to phobic threat at fixation are unaffected by perceptual load
  • 2010
  • Ingår i: Psychophysiology. - : Wiley. - 0048-5772 .- 1469-8986. ; 47:6, s. 1151-1158
  • Tidskriftsartikel (refereegranskat)abstract
    • Research suggests that processing of emotional stimuli may be eliminated if a concurrent task places sufficient demands on attentional resources. To test whether this holds for stimuli with strong emotional significance, pictures of spiders as well as mushrooms were presented at fixation to spider-fearful and non-fearful participants. Concurrently, perceptual load was manipulated in two levels with a peripheral letter discrimination task. Results of event-related potentials showed that, compared with non-fearful participants, spider-fearful participants showed greater late positive potentials (LPP) to spiders than mushrooms, which provides a manipulation check that spiders were emotionally meaningful to spider-fearful participants. Critically, this effect was not affected by level of perceptual load. These findings suggest that strong emotional stimuli at fixation may resist manipulations of perceptual load.
  •  
31.
  • Norberg, Joakim, 1976-, et al. (författare)
  • Similar effects of manipulations of attention on processing of phobic and nonphobic pictures
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Previous studies showed reduced amplitudes of the early posterior negativity (EPN) and late positive potential (LPP) to emotional pictures when their location was task irrelevant. Perceptual load showed mixed effects on ERPs to emotional pictures. The present study investigated whether effects of spatial attention and perceptual load on emotional ERPs differed between phobic and other highly negative but nonphobic stimuli. Results confirmed that participants with phobia showed greater EPN and LPP to phobic and nonphobic, negative pictures than to neutral pictures. Critically, when the location of emotional pictures was task-irrelevant, LPP was reduced similarly to both phobic and nonphobic negative pictures (EPN was unaffected). Perceptual load had no effects on emotional ERPs to either phobic or nonphobic negative pictures. Our findings suggest that effects of spatial attention and perceptual load on emotional ERPs are comparable for phobic and other highly negative but nonphobic stimuli.
  •  
32.
  • Norberg, Joakim, 1976-, et al. (författare)
  • Spiders leave no one untouched : Spider pictures increase emotional ERPs beyond arousal and valence
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • People with phobias show enhanced amplitudes on emotional event-related potentials (ERPs) to phobic stimuli. Yet, it is unresolved whether there are independent contributions on the emotional ERPs that cannot be explained by ratings of high arousal and negative valence. We recorded ERPs as participants with and without spider phobia viewed spider pictures, highly negative pictures, and neutral pictures. Participants with phobia showed larger amplitudes in the early posterior negativity (EPN) and the early interval of the late positive potential (LPP) to spider than negative pictures. Importantly, participants without phobia also showed larger amplitudes to spider than neutral pictures even though they rated spiders and neutral pictures as equally neutral in valence and equally low in arousal. These findings suggest two effects of spider pictures on attention: One effect of emotion (valence and arousal) that influences only participants with phobia. The other effect influences both participants with and without phobia. We suggest that this is an effect of evolutionary threat. But, because this effect was present in participants with and without phobia, it is unlikely to play a role in the etiology of phobia.
  •  
33.
  • Nordström, Henrik, et al. (författare)
  • Emotional event-related potentials are larger to figures than scenes but are similarly reduced by inattention
  • 2012
  • Ingår i: BMC Neuroscience. - : Springer Science and Business Media LLC. - 1471-2202. ; 13, s. 49-
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: In research on event-related potentials (ERP) to emotional pictures, greater attention to emotional than neutral stimuli (i.e., motivated attention) is commonly indexed by two difference waves between emotional and neutral stimuli: the early posterior negativity (EPN) and the late positive potential (LPP). Evidence suggests that if attention is directed away from the pictures, then the emotional effects on EPN and LPP are eliminated. However, a few studies have found residual, emotional effects on EPN and LPP. In these studies, pictures were shown at fixation, and picture composition was that of simple figures rather than that of complex scenes. Because figures elicit larger LPP than do scenes, figures might capture and hold attention more strongly than do scenes. Here, we showed negative and neutral pictures of figures and scenes and tested first, whether emotional effects are larger to figures than scenes for both EPN and LPP, and second, whether emotional effects on EPN and LPP are reduced less for unattended figures than scenes.Results: Emotional effects on EPN and LPP were larger for figures than scenes. When pictures were unattended, emotional effects on EPN increased for scenes but tended to decrease for figures, whereas emotional effects on LPP decreased similarly for figures and scenes.Conclusions: Emotional effects on EPN and LPP were larger for figures than scenes, but these effects did not resist manipulations of attention more strongly for figures than scenes. These findings imply that the emotional content captures attention more strongly for figures than scenes, but that the emotional content does not hold attention more strongly for figures than scenes.
  •  
34.
  • Olofsson, Jonas K., et al. (författare)
  • Effects of oxazepam on affective perception, recognition, and event-related potentials
  • 2011
  • Ingår i: Psychopharmacology. - : Springer Science and Business Media LLC. - 0033-3158 .- 1432-2072. ; 215:2, s. 301-309
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Little is known about how rapid electrocortical responses (event-related potentials; ERPs) to affective pictures are modulated by benzodiazepine agonists. The present study investigated effects of oxazepam (20 mg p.o.) on behavioral measures and ERPs associated with affective picture processing during perception and recognition memory retrieval. Methods Forty-three healthy young adults were given oxazepam or placebo treatment under a double-blind experimental procedure. Affective pictures (negatively arousing or neutral) elicited ERP responses and participants rated pictures for emotionality (during incidental encoding) and recognition. Results Oxazepam did not affect perceptual (P1, P2) or emotional (early posterior negativity and late parietal positivity) ERPs or ratings during perception. However, oxazepam impaired recognition performance and decreased positive mid-frontal ERP component at 420-450 ms for old vs. new pictures. The memory impairment was retained at the delayed memory test. Conclusions Oxazepam does not selectively influence electrocortical or perceptual indexes of emotional perception or emotional memory. Rather, it blocks memory consolidation independent of valence category. These findings indicate that ERPs can be of use in assessing effects of benzodiazepines on memory-related processes.
  •  
35.
  • Olofsson, Jonas K., et al. (författare)
  • Fast Versus Slow Word Integration of Visual and Olfactory Objects : EEG Biomarkers of Decision Speed Variability
  • 2018
  • Ingår i: Behavioral Neuroscience. - : American Psychological Association (APA). - 0735-7044 .- 1939-0084. ; 132:6, s. 587-594
  • Tidskriftsartikel (refereegranskat)abstract
    • In psychological experiments, behavioral speed varies across trials, and this variation is often associated with corresponding fluctuations in cortical activity. Little is known about such cortical variations in semantic priming tasks where target words are matched with preceding sensory object cues. Here, two visually presented target words (pear and lilac) were repeatedly cued by corresponding odors or pictures, and the participants were to indicate matching or nonmatching combinations. Data were split in behaviorally fast versus slow trials. We hypothesized that slow trials would be associated with higher prestimulus alpha activity and reduced ERP amplitudes, and that response-time differences between odor-cued and picture-cued trials would be especially large in slow behavioral trials. Results confirmed that slow trials showed increased alpha-band activity prior to word target onset, as well as amplitude decreases in the sensory P1 and semantic N400 components. However, no interactions between cue-modality and processing speed were observed. Instead, odor-cue integration responses were uniquely delayed on incongruent trials, a novel behavioral effect that was not observed in EEG measures. The results show that semantic integration speed is reflected in cortical activity before and during stimulus processing. Behavioral interactions with cue modality did not correspond to observed cortical activity changes, perhaps because olfactory circuits are not readily observed in scalp-recorded EEG. We conclude that combining behavioral speed variability and cortical EEG measures is useful in understanding the fluctuating nature of cognitive processing sequences.
  •  
36.
  • Olofsson, Jonas K, 1965-, et al. (författare)
  • Odor identification impairment in carriers of ApoE-ε4 is independent of clinical dementia
  • 2010
  • Ingår i: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 31:4, s. 567-577
  • Tidskriftsartikel (refereegranskat)abstract
    • The ApoE gene is expressed in olfactory brain structures and is believed to play a role in neuronal regenerative processes as well as in development of Alzheimer's disease (AD), the most common form of dementia. The ε4 allele has been reported to be associated with compromised odor identification ability in the elderly, and this deficit has been interpreted as a sign of pre-diagnostic AD. However, because it has not been demonstrated that the relationship between the ε4 allele and odor identification is mediated by dementia, it is possible that the ε4 allele may have an effect on odor identification over and above any effects of dementia. The present study investigated effects of ApoE-status on odor identification in a large, population-based sample (n = 1236) of adults (45–80 years), who were assessed for dementia at time of testing and 5 years later. The results showed that the ε4 allele was associated with an odor identification deficit among elderly participants (75–80). Critically, this effect remained after current and pre-diagnostic dementia, vocabulary, global cognitive status and health variables were partialled out. The present results suggest that the ApoE gene plays a role in olfactory functioning that is independent of dementia conversion within 5 years.
  •  
37.
  • Peira, Nathalie, et al. (författare)
  • Emotional responses in spider fear are closely related to picture awareness :
  • 2012
  • Ingår i: Cognition & Emotion. - : Informa UK Limited. - 0269-9931 .- 1464-0600. ; 26:2, s. 252-260
  • Tidskriftsartikel (refereegranskat)abstract
    • Theories of emotion propose that responses to emotional pictures can occur independently of whether or not people are aware of the picture content. Because evidence from dissociation paradigms is inconclusive, we manipulated picture awareness gradually and studied whether emotional responses varied with degree of awareness. Spider fearful and non-fearful participants viewed pictures of spiders and flowers at four levels of backward masking while electrodermal activity and heart rate were measured continuously. Recognition ratings confirmed that participants’ picture awareness decreased with masking. Critically, effects of spider fear on emotion ratings and heart rate also decreased with masking. These findings suggest that effects of spider fear on emotion ratings and heart rate are closely related to picture awareness.
  •  
38.
  • Peira, Nathalie, 1981- (författare)
  • Guided by Fear : Effects on attention and awareness
  • 2010
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Because the visual system has limited capacity, emotions such as fear may play an important role in guiding the selection of relevant input (LeDoux, 2000; Öhman & Mineka, 2001). The aim of the current thesis was to investigate how fear can guide the organism by influencing:  (I) attentional processes, (II) awareness of the visual input, and (III) affective processing independent of awareness. The aim of Study I was to investigate whether attention may be directed to threatening rather than neutral input in a task that resembles real-life viewing behavior but with stimuli controlled for low-level visual attributes unrelated to object identity. Results showed that spider fear was associated with faster detection of schematic spiders but not of flowers. These findings suggest that fear guides attention by processing object features rather than simple low-level features. The aim of Study II was to investigate with visual masking whether perceptual thresholds in spider and snake fear may be lower for threatening stimuli than for neutral stimuli. Results suggest that spider and snake fear are not associated with threat recognition in center view but with the tendency to misinterpret nonthreatening cues as threatening (response bias). In contrast, disgust sensitivity was associated with recognition of threat (spiders and snakes). The aim of Study III was to investigate if affective processing (subjective ratings and psychophysiological responses) occurs independently of awareness. Results showed that both emotion ratings and heart rate differed as a function of threat recognition. These results do not support the notion that emotional responses are independent from awareness. Instead, results suggest that emotional reactions to threatening stimuli are sensitive to variations in awareness.
  •  
39.
  • Peira, Nathalie, 1981-, et al. (författare)
  • What you fear will appear : Detection of schematic spiders in spider fear
  • 2010
  • Ingår i: Experimental psychology (Göttingen). - : Hogrefe Publishing Group. - 1618-3169 .- 2190-5142. ; 57:6, s. 470-475
  • Tidskriftsartikel (refereegranskat)abstract
    • Various experimental tasks suggest that fear guides attention. However, because these tasks often lack ecological validity, it is unclear to what extent results from these tasks can be generalized to real-life situations. In change detection tasks, a brief interruption of the visual input (i.e., a blank interval or a scene cut) often results in undetected changes in the scene. This setup resembles real-life viewing behavior and is used here to increase ecological validity of the attentional task without compromising control over the stimuli presented. Spider-fearful and nonfearful women detected schematic spiders and flowers that were added to one of two identical background pictures that alternated with a brief blank in between them (i.e., flicker paradigm). Results showed that spider-fearful women detected spiders (but not flowers) faster than did nonfearful women. Because spiders and flowers had similar low-level features, these findings suggest that fear guides attention on the basis of object features rather than simple low-level features.
  •  
40.
  • Qin, Nan, et al. (författare)
  • Effects of selective attention on the C1 ERP component : A systematic review and meta-analysis
  • 2022
  • Ingår i: Psychophysiology. - : Wiley. - 0048-5772 .- 1469-8986. ; 59:12
  • Forskningsöversikt (refereegranskat)abstract
    • The C1 event-related potential (ERP) captures the earliest stage of feedforward processing in the primary visual cortex (V1). An ongoing debate is whether top-down selective attention can modulate the C1. One side of the debate pointed out that null findings appear to outnumber positive findings; thus, selective attention does not seem to influence the C1. However, this suggestion is not based on a valid approach to summarizing evidence across studies. Therefore, we conducted a systematic review and meta-analysis investigating the effects of selective attention on the C1, involving 47 experiments and 794 subjects in total. Despite heterogeneity across studies, results suggested that attention has a moderate effect on the C1 (Cohen's $$ dz= 0.33, p < .0001); that is, C1 amplitude is larger for visual stimuli that are attended than unattended. These results suggest that C1 is affected by top-down selective attention.
  •  
41.
  • Sand, Anders, et al. (författare)
  • Processing of unattended, simple negative pictures resists perceptual load
  • 2011
  • Ingår i: NeuroReport. - 0959-4965 .- 1473-558X. ; 22:7, s. 348-352
  • Tidskriftsartikel (refereegranskat)abstract
    • As researchers debate whether emotional pictures can be processed irrespective of spatial attention and perceptual load, negative and neutral pictures of simple figure-ground composition were shown at fixation and were surrounded by one, two, or three letters. When participants performed a picture discrimination task, there was evidence for motivated attention; that is, an early posterior negativity (EPN) and late positive potential (LPP) to negative versus neutral pictures. When participants performed a letter discrimination task, the EPN was unaffected whereas the LPP was reduced. Although performance decreased substantially with the number of letters (one to three), the LPP did not decrease further. Therefore, attention to simple, negative pictures at fixation seems to resist manipulations of perceptual load.
  •  
42.
  • Sbarra, AN, et al. (författare)
  • Mapping routine measles vaccination in low- and middle-income countries
  • 2021
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 589:7842, s. 415-
  • Tidskriftsartikel (refereegranskat)abstract
    • The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhood MCV1 coverage at 5 × 5-km2pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children.
  •  
43.
  • Ströberg, Kim, et al. (författare)
  • Electrocortical N400 Effects of Semantic Satiation
  • 2017
  • Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Semantic satiation is characterised by the subjective and temporary loss of meaning after high repetition of a prime word. To study the nature of this effect, previous electroencephalography (EEG) research recorded the N400, an ERP component that is sensitive to violations of semantic context. The N400 is characterised by a relative negativity to words that are unrelated vs. related to the semantic context. The semantic satiation hypothesis predicts that the N400 should decrease with high repetition. However, previous findings have been inconsistent. Because of these inconsistent findings and the shortcomings of previous research, we used a modified design that minimises confounding effects from non-semantic processes. We recorded 64-channel EEG and analysed the N400 in a semantic priming task in which the primes were repeated 3 or 30 times. Critically, we separated low and high repetition trials and excluded response trials. Further, we varied the physical features (letter case and format) of consecutive primes to minimise confounding effects from perceptual habituation. For centrofrontal electrodes, the N400 was reduced after 30 repetitions (vs. 3 repetitions). Explorative source reconstructions suggested that activity decreased after 30 repetitions in bilateral inferior temporal gyrus, the right posterior section of the superior and middle temporal gyrus, right supramarginal gyrus, bilateral lateral occipital cortex, and bilateral lateral orbitofrontal cortex. These areas overlap broadly with those typically involved in the N400, namely middle temporal gyrus and inferior frontal gyrus. The results support the semantic rather than the perceptual nature of the satiation effect.
  •  
44.
  • Svärd, Joakim, et al. (författare)
  • Superior recognition performance for happy masked and unmasked faces in both younger and older adults
  • 2012
  • Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 3:11
  • Tidskriftsartikel (refereegranskat)abstract
    • In the aging literature it has been shown that even though emotion recognition performance decreases with age, the decrease is less for happiness than other facial expressions. Studies in younger adults have also revealed that happy faces are more strongly attended to and better recognized than other emotional facial expressions. Thus, there might be a more age independent happy face advantage in facial expression recognition. By using a backward masking paradigm and varying stimulus onset asynchronies (17–267 ms) the temporal development of a happy face advantage, on a continuum from low to high levels of visibility, was examined in younger and older adults. Results showed that across age groups, recognition performance for happy faces was better than for neutral and fearful faces at durations longer than 50 ms. Importantly, the results showed a happy face advantage already during early processing of emotional faces in both younger and older adults. This advantage is discussed in terms of processing of salient perceptual features and elaborative processing of the happy face. We also investigate the combined effect of age and neuroticism on emotional face processing. The rationale was previous findings of age-related differences in physiological arousal to emotional pictures and a relation between arousal and neuroticism. Across all durations, there was an interaction between age and neuroticism, showing that being high in neuroticism might be disadvantageous for younger, but not older adults’ emotion recognition performance during arousal enhancing tasks. These results indicate that there is a relation between aging, neuroticism, and performance, potentially related to physiological arousal.
  •  
45.
  • Syrjänen, Elmeri, et al. (författare)
  • Background Odors Modulate N170 ERP Component and Perception of Emotional Facial Stimuli
  • 2018
  • Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 9
  • Tidskriftsartikel (refereegranskat)abstract
    • Successful social interaction relies on the accurate decoding of other peoples' emotional signals, and their contextual integration. However, little is known about how contextual odors may lead to modulation of cortical processing in response to facial expressions. We investigated how unpleasant and pleasant contextual background odors affected emotion perception and cortical event-related potential (ERP) responses to pictures of faces expressing happy, neutral and disgusted facial expressions. Faces were, regardless of expression, rated more positively in the pleasant odor condition and more negatively in the unpleasant odor condition. Faces were overall rated as more emotionally arousing in the presence of an odor, irrespective of its valence. Contextual odors also interacted with facial expressions, such that happy faces were rated as especially non-arousing in the unpleasant odor condition. The early, face-sensitive N170 ERP component also displayed an interaction effect. Here, disgusted faces were affected by the odor context such that the N170 revealed a relatively larger negativity in the context of a pleasant odor compared with an unpleasant odor. There were no odor effects on the responses to faces in other measured ERP components (P1, VPP, P2, and LPP). These results suggest that odors bias socioemotional perception early stages of the visual processing stream. However, effects may vary across emotional expressions and measurements.
  •  
46.
  • Syrjänen, Elmeri, et al. (författare)
  • Gender moderates valence effects on the late positive potential to emotional distracters
  • 2013
  • Ingår i: Neuroscience Letters. - : Elsevier BV. - 0304-3940 .- 1872-7972. ; 551, s. 89-93
  • Tidskriftsartikel (refereegranskat)abstract
    • Attention is captured more strongly by emotional pictures than by neutral pictures. This allocation of attention to emotional pictures is commonly indexed by the late positive potential (LPP). This event-related potential (ERP) is larger for negative and positive pictures than for neutral pictures. However, findings are mixed in regards to valence effects, that is, whether the LPP is larger for negative pictures than for positive pictures (negativity bias) or vice versa (positivity bias). Additionally, previous ERP studies have not explicitly considered a moderating effect of gender. In the present study, positive, negative, and neutral pictures were shown at fixation but were always task-irrelevant. Results showed that LPP amplitudes for the positive and negative distracters were moderated by gender. Men showed a positivity bias on the LPP (i.e., larger amplitudes for positive pictures than for negative pictures). Women did not show a clear valence bias on the LPP, but they showed a negativity bias on picture ratings. These gender differences for the LPP did not habituate, as they were obtained even for pictures that were repeated 20 times. Because previous studies with other measures suggest a positivity bias for men and a negativity bias for women, the present findings extend these studies suggesting that attention allocation for emotional pictures of different valence is similarly moderated by gender.
  •  
47.
  • Szychowska, Malina, et al. (författare)
  • Effects of sound pressure level and visual perceptual load on the auditory mismatch negativity
  • 2017
  • Ingår i: Neuroscience Letters. - : Elsevier BV. - 0304-3940 .- 1872-7972. ; 640, s. 37-41
  • Tidskriftsartikel (refereegranskat)abstract
    • Auditory change detection has been studied extensively with mismatch negativity (MMN), an event-related potential. Because it is unresolved if the duration MMN depends on sound pressure level (SPL), we studied effects of different SPLs (56, 66, and 76 dB) on the duration MMN. Further, previous research suggests that the MMN is reduced by a concurrent visual task. Because a recent behavioral study found that high visual perceptual load strongly reduced detection sensitivity to irrelevant sounds, we studied if the duration MMN is reduced by load, and if this reduction is stronger at low SPLs. Although a duration MMN was observed for all SPLs, the MMN was apparently not moderated strongly by SPL, perceptual load, or their interaction, because all 95% CIs overlapped zero. In a contrast analysis of the MMN (across loads) between the 56-dB and 76-dB groups, evidence (BF = 0.31) favored the null hypothesis that duration MMN is unaffected by a 20-dB increase in SPL. Similarly, evidence (BF = 0.19) favored the null hypothesis that effects of perceptual load on the duration MMN do not change with a 20-dB increase in SPL. However, evidence (BF = 3.12) favored the alternative hypothesis that the effect of perceptual load in the present study resembled the overall effect in a recent meta-analysis. When the present findings were combined with the meta-analysis, the effect of load (low minus high) was −0.43 μV, 95% CI [−0.64, −0.22] suggesting that the duration MMN decreases with load. These findings provide support for a sensitive monitoring system of the auditory environment.
  •  
48.
  • Szychowska, Malina, 1991- (författare)
  • Effects of visual load on auditory processing
  • 2020
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • In daily life, people need to be able to focus on a task while ignoring any task-irrelevant background noise. For example, people who work in an open-space office may have to work on a report while ignoring the background talk among co-workers. Theories of attention argue that processing of task-irrelevant auditory information should become attenuated when attentional capacity is exhausted by task-relevant stimuli, for example a visual task. According to early-filter theory, top-down attenuation of auditory responses is possible at various stages of the auditory pathway through multiple recurrent loops. Furthermore, the adaptive filtering model of selective attention suggests that filtering occurs early when concurrent visual tasks are demanding (e.g., high load) and late when tasks are easy (e.g., low load).The main aim of this thesis was to investigate whether auditory processing is attenuated during concurrent visual load manipulation, and if so, at which stage of the auditory pathway. Recurrent loops that are present throughout the entire auditory pathway should allow top-down modulation of even earliest responses, especially when accompanied by a highly demanding task. Recording these auditory responses during concurrent visual tasks with different levels of load could potentially show at which stages of auditory processing the filtering happens when the task demands are high or low, or there is no task at all.This thesis tested the effects of visual load manipulation on the responses originating from different stages of the auditory pathway: mismatch negativity (MMN) to duration in Study I, MMN to frequency in Study III, auditory steady-state responses (ASSRs) to a 40-Hz modulation frequency in Study IV, and ASSRs to 20-, 40-, and 80-Hz modulation frequencies in Study V. Additionally, Study II compared different control conditions (cascade vs. no-repetition control) for evoking MMN to find a design that reduces confounds in the MMN. Results of Study II showed that cascade and no-repetition control are comparable control conditions for evoking MMN.For the effects of visual load manipulation on auditory MMN (low vs. high load), results showed moderate evidence for the effect of load on duration MMN and moderate evidence for no effect of load on frequency MMN. However, results for the duration MMN might be confounded by physical differences between the low load and high load conditions in the visual task, and by a biased oddball paradigm used to evoke the MMN. Thus, it is most likely that auditory MMN is not affected by visual load (low vs. high).For the effects of visual load on ASSRs (no, low, and high load), results showed moderate to strong evidence for no effects of load manipulation on ASSRs, but some comparisons were inconclusive. The convincing evidence obtained in Studies IV and V points to the robustness of ASSRs against visual load manipulation.Because it is most likely that neither MMN nor ASSRs are affected by visual load manipulation, results presented in this thesis support the idea that attentional resources are modality specific. Because it is possible that filtering occurs at one stage of auditory processing and does not change with the concurrent task demands, the present results do not rule out the early-filter theory. However, results are inconsistent with the adaptive filtering model because filtering of task-irrelevant responses does not vary with the demands of the concurrent task.
  •  
49.
  • Szychowska, Malina, 1991-, et al. (författare)
  • Visual load does not decrease the auditory steady‐state response to 40‐Hz amplitude‐modulated tones
  • 2020
  • Ingår i: Psychophysiology. - : Wiley. - 0048-5772 .- 1469-8986. ; 57:12
  • Tidskriftsartikel (refereegranskat)abstract
    • The auditory pathway consists of multiple recurrent loops of afferent and efferent connections that extend from the cochlea up to the prefrontal cortex. The early-filter theory proposes that these loops allow topdown filtering of early and middle latency auditory responses. Furthermore, the adaptive filtering model suggests that filtering of irrelevant auditory stimuli should start lower in the pathway during more demanding tasks. If so, the 40-Hz auditory steady state responses (ASSRs) to irrelevant sounds should be affected by top-down crossmodal attention to a visual task, and effects should vary with the load of the visual task. Because few studies have examined this possibility, we conducted two preregistered studies that manipulated visual load (Study 1: N = 43, Study 2: N = 45). Study 1 used two levels (low and high), and Study 2 used four levels (no, low, high, and very high). Subjects were asked to ignore a 500-Hz taskirrelevant tone that was amplitude-modulated to evoke 40-Hz ASSRs. Results from Bayesian analyses provided moderate to extreme support for no effect of load (or of task) on ASSRs. Results also supported no interaction with time (i.e., over blocks, over minutes, or with changes in ASSRs that were synchronized with the onset of the visual stimuli). Further, results provided moderate support for no correlation between effects of load and working memory capacity. Because the present findings support the robustness of ASSRs against manipulations of crossmodal attention, they are not consistent with the adaptive filtering model.
  •  
50.
  • Szychowska, Malina, 1991-, et al. (författare)
  • Visual load effects on the auditory steady state responses to 20-, 40-, and 80-Hz amplitude-modulated tones
  • 2021
  • Ingår i: Physiology & Behavior. - : Elsevier BV. - 0031-9384. ; 228
  • Tidskriftsartikel (refereegranskat)abstract
    • Ignoring background sounds while focusing on a visual task is a necessary ability in everyday life. If attentional resources are shared between modalities, processing of task-irrelevant auditory information should become attenuated when attentional capacity is exhausted by visual demands. According to earlyfilter theory, top-down attenuation of auditory responses is possible at various stages of the auditory pathway through multiple recurrent loops. Furthermore, the adaptive filtering model of selective attention suggests that filtering occurs early when concurrent visual tasks are demanding (e.g., high load) and late when tasks are easy (e.g., low load). This study examined effects of visual load on auditory steady state responses (ASSRs) to determine where in the auditory pathway the filtering occurs. Subjects performed a visual task with three levels of load (no, low, and high) while ignoring task-irrelevant sounds. The auditory stimuli were 500-Hz tones amplitude-modulated at 20 Hz, 40 Hz, or 80 Hz to target different processing stages of the auditory pathway. Results from bayesian analyses suggest that ASSRs are unaffected by visual load. These findings also suggest that attentional resources are modality specific and that the attentional filter of auditory processing does not vary with visual task demands.
  •  
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