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| 2. |
- Bengtsson, Mats, et al.
(författare)
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CELTIC CP5-026 WINNER+, D1.4 Initial Report on Advanced Multiple Antenna Systems
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This deliverable captures the first set of best innovative concepts identified in the field of Advanced Multiple Antenna Systems for potential inclusion into the WINNER+ system concept. The concepts consist of promising principles or ideas as well as detailed innovative techniques. For each concept, the associated benefits as well as the corresponding requirements on the system architecture and protocols, measurements and signalling, are considered. The document involves two main tracks: development of new advanced antenna schemes in the context of conventional cellular networks, and a study of coordinated multipoint transmission and reception, where multiple network nodes cooperate to enhance system performance.
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| 3. |
- Brænne, Ingrid, et al.
(författare)
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A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors
- 2017
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- Cyclooxygenase-2 inhibitors (coxibs) are characterized by multiple molecular off-target effects and increased coronary artery disease (CAD) risk. Here, we systematically explored common variants of genes representing molecular targets of coxibs for association with CAD. Given a broad spectrum of pleiotropic effects of coxibs, our intention was to narrow potential mechanisms affecting CAD risk as we hypothesized that the affected genes may also display genomic signals of coronary disease risk. A Drug Gene Interaction Database search identified 47 gene products to be affected by coxibs. We traced association signals in 200-kb regions surrounding these genes in 84,813 CAD cases and 202,543 controls. Based on a threshold of 1 × 10-5 (Bonferroni correction for 3131 haplotype blocks), four gene loci yielded significant associations. The lead SNPs were rs7270354 (MMP9), rs4888383 (BCAR1), rs6905288 (VEGFA1), and rs556321 (CACNA1E). By additional genotyping, rs7270354 at MMP9 and rs4888383 at BCAR1 also reached the established GWAS threshold for genome-wide significance. The findings demonstrate overlap of genes affected by coxibs and those mediating CAD risk and points to further mechanisms, which are potentially responsible for coxib-associated CAD risk. The novel approach furthermore suggests that genetic studies may be useful to explore the clinical relevance of off-target drug effects.
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| 4. |
- D'Amico, Valeria, et al.
(författare)
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Advanced interference management in ARTIST4G: Interference Avoidance
- 2010
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Ingår i: European Wireless Technology Conference, Paris, France, September 2010. - 9782874870187 ; , s. 21-24
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Konferensbidrag (refereegranskat)abstract
- This paper gives an overview of the objectives and current research activities on interference avoidance in the EC funded research project ARTIST4G. It is the main objective of the ARTIST4G Work Package 1 (WP1), to build forward on the 3GPP LTE Release 8 baseline, proposing a novel fair mobile broadband technological framework in which to design innovative, practical, scalable and cost-effective interference avoidance solutions. This paper provides an overview of the fundamental classes of innovations studied in ARTIST4G Work Package 1 (WP1) and presents some performance results obtained by means of numerical simulations and test-bed measurements run in the field.
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| 5. |
- Osseiran, Afif, et al.
(författare)
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A MIMO framework for 4G systems : WINNER concept and results
- 2007
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Ingår i: 2007 IEEE 8th Workshop on Signal Processing Advances in Wireless Communications. - : IEEE. - 9781424409549 ; , s. 798-802
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Konferensbidrag (refereegranskat)abstract
- In this paper, the MIMO framework within WINNER for fourth generation radio systems is further developed and assessed for various deployment scenarios. The emphasis is on radio network system aspects of multi-antenna techniques where preferred configurations for three basic deployment scenarios are given. In the wide area scenario which aims to provide ubiquitous coverage for rural, suburban and urban areas, the scheme selection depends on the user density of spatially separated users. It ranges from grid of fixed beams (GoB) (TDMA based) in case of few users to SDMA with a fixed linear precoding codebook, and finally to adaptive beams with SDMA for highly dense system. In the metropolitan area scenario which is targeting system deployments in large urban environments, multi-user (MU) MIMO precoding performs very well for slow moving users. For higher velocities, per antenna rate control (PARC) or adaptive linear dispersion codes (LDCs) are better choices. In the local area scenario which is characterized by isolated sites, the combination of SDMA and spatial multiplexing achieved by MU-MIMO precoding provides high spectral efficiency.
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| 6. |
- Pasanen, Pirjo, et al.
(författare)
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EU FP6 IST-2003-507581 WINNER, D2.6 Assessment of Multiple Access Technologies, Oct 2004.
- 2004
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The objective of this deliverable is to perform a first assessment of wireless access/multipleaccess technologies for the WINNER system concept. The study of multiple access schemes is theresponsibility of Task 4 within the WINNER workpackage 2. The work requires the collection andassessment of the numerous ideas and proposals available. The technologies and combinations oftechnologies are also assessed and compared, to identify the most promising strategies and combinations.The latter work is primarily performed by multi-link simulation and system-level simulation
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| 7. |
- Schaich, Frank, et al.
(författare)
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Antenna, PHY and MAC Design
- 2018
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Ingår i: 5G System Design: Architectural and Functional Considerations and Long Term Research. - 9781119425120 ; , s. 265-314
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Vasan, Ramachandran S, et al.
(författare)
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Genetic variants associated with cardiac structure and function : a meta-analysis and replication of genome-wide association data
- 2009
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Ingår i: Journal of the American Medical Association (JAMA). - : American Medical Association (AMA). - 0098-7484 .- 1538-3598. ; 302:2, s. 168-178
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease. OBJECTIVE: To identify common genetic variants associated with cardiac structure and function by conducting a meta-analysis of genome-wide association data in 5 population-based cohort studies (stage 1) with replication (stage 2) in 2 other community-based samples. DESIGN, SETTING, AND PARTICIPANTS: Within each of 5 community-based cohorts comprising the EchoGen consortium (stage 1; n = 12 612 individuals of European ancestry; 55% women, aged 26-95 years; examinations between 1978-2008), we estimated the association between approximately 2.5 million single-nucleotide polymorphisms (SNPs; imputed to the HapMap CEU panel) and echocardiographic traits. In stage 2, SNPs significantly associated with traits in stage 1 were tested for association in 2 other cohorts (n = 4094 people of European ancestry). Using a prespecified P value threshold of 5 x 10(-7) to indicate genome-wide significance, we performed an inverse variance-weighted fixed-effects meta-analysis of genome-wide association data from each cohort. MAIN OUTCOME MEASURES: Echocardiographic traits: LV mass, internal dimensions, wall thickness, systolic dysfunction, aortic root, and left atrial size. RESULTS: In stage 1, 16 genetic loci were associated with 5 echocardiographic traits: 1 each with LV internal dimensions and systolic dysfunction, 3 each with LV mass and wall thickness, and 8 with aortic root size. In stage 2, 5 loci replicated (6q22 locus associated with LV diastolic dimensions, explaining <1% of trait variance; 5q23, 12p12, 12q14, and 17p13 associated with aortic root size, explaining 1%-3% of trait variance). CONCLUSIONS: We identified 5 genetic loci harboring common variants that were associated with variation in LV diastolic dimensions and aortic root size, but such findings explained a very small proportion of variance. Further studies are required to replicate these findings, identify the causal variants at or near these loci, characterize their functional significance, and determine whether they are related to overt cardiovascular disease.
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