| 1. |
- Kattge, Jens, et al.
(författare)
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TRY plant trait database - enhanced coverage and open access
- 2020
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Ingår i: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
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Tidskriftsartikel (refereegranskat)abstract
- Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
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| 2. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 3. |
- Battaglia, Marco, et al.
(författare)
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R&D paths of pixel detectors for vertex tracking and radiation imaging
- 2013
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 716, s. 29-45
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Forskningsöversikt (refereegranskat)abstract
- This report reviews current trends in the R&D of semiconductor pixellated sensors for vertex tracking and radiation imaging. It identifies requirements of future HEP experiments at colliders, needed technological breakthroughs and highlights the relation to radiation detection and imaging applications in other fields of science.
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| 4. |
- Bilenky, Samoil M., et al.
(författare)
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Tests of CPT invariance at neutrino factories
- 2002
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Ingår i: Physical Review D. Particles and fields. - : The American Physical Society. - 0556-2821 .- 1089-4918. ; 65:7, s. 073024-1-073024-6
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Tidskriftsartikel (refereegranskat)abstract
- We investigate possible tests of CPT invariance on the level of event rates at neutrino factories. We do not assume any specific model but phenomenological differences in the neutrino-antineutrino masses and mixing angles in a Lorentz invariance preserving context, such as could be induced by physics beyond the standard model. We especially focus on the muon neutrino and antineutrino disappearance channels in order to obtain constraints on the neutrino-antineutrino mass and mixing angle differences; we found, for example, that the sensitivity \m(3)-(m) over bar (3)\less than or similar to1.9x10(-4) eV could be achieved.
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| 5. |
- Blennow, Mattias, et al.
(författare)
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Damping signatures in future neutrino oscillation experiments
- 2005
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Ingår i: Journal of High Energy Physics (JHEP). - : IOP Publishing. - 1126-6708 .- 1029-8479. ; 2005:06, s. 049-
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Tidskriftsartikel (refereegranskat)abstract
- We discuss the phenomenology of damping signatures in the neutrino oscillation probabilities, where either the oscillating terms or the probabilities can be damped. This approach is a possibility for tests of damping effects in future neutrino oscillation experiments, where we mainly focus on reactor and long-baseline experiments. We extensively motivate different damping signatures due to small corrections by neutrino decoherence, neutrino decay, oscillations into sterile neutrinos, or other mechanisms, and classify these signatures according to their energy ( spectral) dependencies. We demonstrate, at the example of short baseline reactor experiments, that damping can severely alter the interpretation of results, e. g., it could fake a value of sin(2)(2 theta(13)) smaller than the one provided by Nature. In addition, we demonstrate how a neutrino factory could constrain different damping models with emphasis on how these different models could be distinguished, i.e., how easily the actual type of effect could be identified. We find that the damping models cluster in different categories, which can be much better distinguished from each other than models within the same cluster.
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| 6. |
- Blennow, Mattias, et al.
(författare)
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Non-standard Hamiltonian effects on neutrino oscillations
- 2007
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Ingår i: The European Physical Journal C. - : Springer-Verlag / Società Italiana di Fisica. - 1434-6044 .- 1434-6052. ; 49:4, s. 1023-1039
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Tidskriftsartikel (refereegranskat)abstract
- We investigate non-standard Hamiltonian effects on neutrino oscillations, which are effective additional contributions to the vacuum or matter Hamiltonian. Since these effects can enter in either the flavor or mass basis, we develop an understanding of the difference between these bases representing the underlying theoretical model. In particular, the simplest of these effects are classified as "pure" flavor or mass effects, where the appearance of such a "pure" effect can be quite plausible as a leading non-standard contribution from theoretical models. Compared to earlier studies investigating particular effects, we aim for a top-down classification of a possible "new physics" signature at future long-baseline neutrino oscillation precision experiments. We develop a general framework for such effects with two neutrino flavors and discuss the extension to three neutrino flavors, and we demonstrate the challenges for a neutrino factory to distinguish the theoretical origin of these effects with a numerical example as well. We find how the precision measurements of neutrino oscillation parameters can be altered by non-standard effects alone (not including non-standard interactions in the creation and detection processes) and that the non-standard effects on Hamiltonian level can be distinguished from other non-standard effects (such as neutrino decoherence and decay) if we consider the specific imprint of the effects on the energy spectra of several different oscillation channels at a neutrino factory.
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| 7. |
- Duong, Janna K., et al.
(författare)
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The variability in beta-cell function in placebo-treated subjects with type 2 diabetes : application of the weight-HbA1c-insulin-glucose (WHIG) model
- 2017
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Ingår i: British Journal of Clinical Pharmacology. - : WILEY-BLACKWELL. - 0306-5251 .- 1365-2125. ; 83:3, s. 487-497
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Tidskriftsartikel (refereegranskat)abstract
- AIM The weight-glycosylated haemoglobin (HbA1C)-insulin-glucose (WHIG) model describes the effects of changes in weight on insulin sensitivity (IS) in newly diagnosed, obese subjects receiving placebo treatment. Thismodel was applied to a wider population of placebo-treated subjects, to investigate factors influencing the variability in IS and beta-cell function. METHODS The WHIG model was applied to the WHIG dataset (Study 1) and two other placebo datasets (Studies 2 and 3). Studies 2 and 3 consisted of nonobese subjects and subjects with advanced type 2 diabetes mellitus (T2DM). Body weight, fasting serum insulin (FSI), fasting plasma glucose (FPG) and HbA1c were used for nonlinear mixed-effects modelling (using NONMEM v7.2 software). Sources of interstudy variability (ISV) and potential covariates (age, gender, diabetes duration, ethnicity, compliance) were investigated. RESULTS An ISV for baseline parameters (body weight and beta-cell function) was required. The baseline beta-cell function was significantly lower in subjects with advanced T2DM (median difference: Study 2: 15.6%, P < 0.001; Study 3: 22.7%, P < 0.001) than in subjects with newly diagnosed T2DM (Study 1). A reduction in the estimated insulin secretory response in subjects with advanced T2DM was observed but diabetes duration was not a significant covariate. CONCLUSION The WHIG model can be used to describe the changes in weight, IS and beta-cell function in the diabetic population. IS remained relatively stable between subjects but a large ISV in beta-cell function was observed. There was a trend towards decreasing beta-cell responsiveness with diabetes duration, and further studies, incorporating subjects with a longer history of diabetes, are required.
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| 8. |
- Jacobsson, Björn, et al.
(författare)
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Effects of random matter density fluctuations on the neutrino oscillation transition probabilities in the Earth
- 2002
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Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 532:04-mar, s. 259-266
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Tidskriftsartikel (refereegranskat)abstract
- In this Letter, we investigate the effects of random fluctuations of the Earth matter density for long baselines on the neutrino oscillation transition probabilities. We especially identify relevant parameters characterizing the matter density noise and calculate their effects by averaging over statistical ensembles of a large number of matter density profiles. For energies and baselines appropriate to neutrino factories, absolute errors on the relevant appearance probabilities are at the level of \DeltaP(alphabeta)\ similar to 10(-4) (with perhaps \P-mue similar to 1% for neutrinos), whereby a modest improvement in understanding of the geophysical data should render such effects unimportant.
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| 9. |
- Jacobsson, Björn, et al.
(författare)
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The effects of matter density uncertainties on neutrino oscillations in the Earth
- 2003
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Ingår i: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 29:8, s. 1873-1875
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Tidskriftsartikel (refereegranskat)abstract
- We compare three different methods of evaluating uncertainties in the Earth's matter density profile, which are relevant to long baseline experiments, such as neutrino factories.
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| 10. |
- Krege, Susanne, et al.
(författare)
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European consensus conference on diagnosis and treatment of germ cell cancer: A report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): Part I
- 2008
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Ingår i: European Urology. - : Elsevier BV. - 1873-7560 .- 0302-2838. ; 53:3, s. 478-496
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Forskningsöversikt (refereegranskat)abstract
- Objectives: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. Methods: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. Results: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. Conclusions: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged. (C) 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved.
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| 11. |
- Krege, Susanne, et al.
(författare)
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European consensus conference on diagnosis and treatment of germ cell cancer: A report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): Part II
- 2008
-
Ingår i: European Urology. - : Elsevier BV. - 1873-7560 .- 0302-2838. ; 53:3, s. 497-513
-
Forskningsöversikt (refereegranskat)abstract
- Objectives: The first consensus report that had been presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, The Netherlands. Methods: Medical oncologists, urologic surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference and incorporated the new data into updated and revised guidelines. As for the first meeting the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. Results: The second part of the consensus paper includes the treatment of metastasised disease, residual tumour resection, salvage therapy, follow-up, and late toxicities. Conclusions: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early-stage as well as of advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. in addition, the particular needs of testicular cancer survivors have been acknowledged. (C) 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved.
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| 12. |
- Landén, Mikael, 1966, et al.
(författare)
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Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
- 2021
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 26, s. 5124-5139
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Tidskriftsartikel (refereegranskat)abstract
- Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted “brain age” and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen’s d = 0.14, 95% CI: 0.08–0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates. © 2020, The Author(s).
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| 13. |
- Laraia, Luca, et al.
(författare)
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The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis
- 2019
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Ingår i: Nature Chemical Biology. - : Nature Publishing Group. - 1552-4450 .- 1552-4469. ; 15:7, s. 710-720
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Tidskriftsartikel (refereegranskat)abstract
- Autophagy mediates the degradation of damaged proteins, organelles and pathogens, and plays a key role in health and disease. Thus, the identification of new mechanisms involved in the regulation of autophagy is of major interest. In particular, little is known about the role of lipids and lipid-binding proteins in the early steps of autophagosome biogenesis. Using target-agnostic, high-content, image-based identification of indicative phenotypic changes induced by small molecules, we have identified autogramins as a new class of autophagy inhibitor. Autogramins selectively target the recently discovered cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A, which had not previously been implicated in autophagy), and directly compete with cholesterol binding to the GRAMD1A StART domain. GRAMD1A accumulates at sites of autophagosome initiation, affects cholesterol distribution in response to starvation and is required for autophagosome biogenesis. These findings identify a new biological function of GRAMD1A and a new role for cholesterol in autophagy.
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| 14. |
- Lindner, Manfred, et al.
(författare)
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A combined treatment of neutrino decay and neutrino oscillations
- 2001
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Ingår i: Nuclear Physics B. - : Elsevier Science B.V.. - 0550-3213 .- 1873-1562. ; 607:02-jan, s. 326-354
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Tidskriftsartikel (refereegranskat)abstract
- Neutrino decay in vacuum has often been considered as an alternative to neutrino oscillations. Because nonzero neutrino masses imply the possibility of both neutrino decay and neutrino oscillations, we present a model-independent formal treatment of these combined scenarios. For that, we show for the example of Majoron decay that in many cases decay products are observable and may even oscillate. Furthermore, we construct a minimal scenario in which we study the physical implications of neutrino oscillations with intermediate decays.
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| 15. |
- Lindner, Manfred, et al.
(författare)
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Decays of supernova neutrinos
- 2002
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Ingår i: Nuclear Physics B. - : Elsevier Science B.V.. - 0550-3213 .- 1873-1562. ; 622:02-jan, s. 429-456
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Tidskriftsartikel (refereegranskat)abstract
- Supernova neutrinos could be well-suited for probing neutrino decay, since decay may be observed even for very small decay rates or coupling constants. We will introduce an effective operator framework for the combined description of neutrino decay and neutrino oscillations for supernova neutrinos, which can especially take into account two properties: one is the radially symmetric neutrino flux, allowing a decay product to be re-directed towards the observer even if the parent neutrino had a different original direction of propagation. The other is decoherence because of the long baselines for coherently produced neutrinos. We will demonstrate how to use this effective theory to calculate the time-dependent fluxes at the detector. In addition, we will show the implications of a Majoron-like decay model. As a result, we will demonstrate that for certain parameter values one may observe some effects which could also mimic signals similar to the ones expected from supernova models, making it in general harder to separate neutrino and supernova properties.
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| 16. |
- Lindner, Manfred, et al.
(författare)
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Tomography of the Earth's core using supernova neutrinos
- 2003
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Ingår i: Astroparticle physics. - : Elsevier B.V.. - 0927-6505 .- 1873-2852. ; 19:6, s. 755-770
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the possibility to use the neutrinos coming from a future galactic supernova explosion to perform neutrino oscillation tomography of the Earth's core. We propose to use existing or planned detectors, resulting in an additional payoff. Provided that all of the discussed uncertainties can be reduced as expected, we find that the average matter densities of the Earth's inner and outer cores could be measured with a precision competitive with geophysics. However, since seismic waves are more sensitive to matter density jumps than average matter densities, neutrino physics would give partly complementary information.
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| 17. |
- Meloni, Davide, et al.
(författare)
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Non-standard interactions versus non-unitary lepton flavor mixing at a neutrino factory
- 2010
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer-Verlag. - 1126-6708 .- 1029-8479. ; 2010:04, s. 041-
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Tidskriftsartikel (refereegranskat)abstract
- The impact of heavy mediators on neutrino oscillations is typically described by non-standard four-fermion interactions (NSIs) or non-unitarity (NU). We focus on leptonic dimension-six effective operators which do not produce charged lepton flavor violation. These operators lead to particular correlations among neutrino production, propagation, and detection non-standard effects. We point out that these NSIs and NU phenomenologically lead, in fact, to very similar effects for a neutrino factory, for completely different fundamental reasons. We discuss how the parameters and probabilities are related in this case, and compare the sensitivities. We demonstrate that the NSIs and NU can, in principle, be distinguished for large enough effects at the example of non-standard effects in the mu-tau-sector, which basically corresponds to differentiating between scalars and fermions as heavy mediators as leading order effect. However, we find that a near detector at superbeams could provide very synergistic information, since the correlation between source and matter NSIs is broken for hadronic neutrino production, while NU is a fundamental effect present at any experiment.
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| 18. |
- Ohlsson, Tommy, 1973-, et al.
(författare)
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Could one find petroleum using neutrino oscillations in matter?
- 2002
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Ingår i: Europhysics letters. - : EDP Sciences / IOP Publishing. - 0295-5075 .- 1286-4854. ; 60:1, s. 34-39
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Tidskriftsartikel (refereegranskat)abstract
- In neutrino physics, it is now widely believed that neutrino oscillations are influenced by the presence of matter, modifying the energy spectrum produced by a neutrino beam traversing the Earth. Here, we will discuss the reverse problem, i.e. what could be learned about the Earth's interior from a single neutrino baseline energy spectrum, especially about the Earth's mantle. We will use a statistical analysis with a low-energy neutrino beam under very optimistic assumptions. At the end, we will note that it is hard to find petroleum with such a method, though it is not too far away from technical feasibility.
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| 19. |
- Ohlsson, Tommy, 1973-, et al.
(författare)
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Reconstruction of the Earth's matter density profile using a single neutrino baseline
- 2001
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Ingår i: Physics Letters B. - : Elsevier Science B.V.. - 0370-2693 .- 1873-2445. ; 512:04-mar, s. 357-364
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Tidskriftsartikel (refereegranskat)abstract
- In this Letter, we show numerically that a symmetric Earth matter density profile can, in principle, be reconstructed from a single baseline energy spectrum up to a certain precision. For the numerical evaluations in the high-dimensional parameter space we use a genetic algorithm.
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| 20. |
- Ohlsson, Tommy, 1973-, et al.
(författare)
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The Role of matter density uncertainties in the analysis of future neutrino factory experiments
- 2003
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Ingår i: Physical Review D. Particles and fields. - : The American Physical Society. - 0556-2821 .- 1089-4918. ; 68:7, s. 073007-1-073007-11
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Tidskriftsartikel (refereegranskat)abstract
- Matter density uncertainties can affect the measurements of the neutrino oscillation parameters at future neutrino factory experiments, such as the measurements of the mixing parameters theta(13) and delta(CP). We compare different matter density uncertainty models and discuss the possibility to include the matter density uncertainties in a complete statistical analysis. Furthermore, we systematically study in which measurements and where in the parameter space matter density uncertainties are most relevant. We illustrate this discussion with examples that show the effects as functions of different magnitudes of the matter density uncertainties. We find that matter density uncertainties are especially relevant for large sin(2)2theta(13)greater than or similar to10(-3). Within the KamLAND-allowed range, they are most relevant for the precision measurements of sin(2)2theta(13) and delta(CP), but less relevant for binary measurements, such as for the sign of Deltam(31)(2), the sensitivity to sin(2)2theta(13), or the sensitivity to maximal CP violation. In addition, we demonstrate that knowing the matter density along a specific baseline better than to about 1% precision means that all measurements will become almost independent of the matter density uncertainties.
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| 21. |
- Purschke, Oliver, et al.
(författare)
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Contrasting changes in taxonomic, phylogenetic and functional diversity during a long-term succession: insights into assembly processes
- 2013
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Ingår i: Journal of Ecology. - : Wiley. - 1365-2745 .- 0022-0477. ; 101:4, s. 857-866
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Tidskriftsartikel (refereegranskat)abstract
- 1. Theory predicts that the processes generating biodiversity after disturbance will change during succession. Comparisons of phylogenetic and functional (alpha and beta) diversity with taxonomic diversity can provide insights into the extent to which community assembly is driven by deterministic or stochastic processes, but comparative approaches have yet to be applied to successional systems. 2. We characterized taxonomic, phylogenetic and functional plant (alpha and beta) diversity within and between four successional stages in a > 270-year-long arable-to-grassland chronosequence. Null models were used to test whether functional and phylogenetic turnover differed from random expectations, given the levels of species diversity. 3. The three facets of diversity showed different patterns of change during succession. Between early and early-mid succession, species richness increased but there was no increase in functional or phylogenetic diversity. Higher than predicted levels of functional similarity between species within the early and early-mid successional stages, indicate that abiotic filters have selected for sets of functionally similar species within sites. Between late-mid and late succession, there was no further increase in species richness, but a significant increase in functional alpha diversity, suggesting that functionally redundant species were replaced by functionally more dissimilar species. Functional turnover between stages was higher than predicted, and higher than within-stage turnover, indicating that different assembly processes act at different successional stages. 4. Synthesis. Analysis of spatial and temporal turnover in different facets of diversity suggests that deterministic processes generate biodiversity during post-disturbance ecosystem development and that the relative importance of assembly processes has changed over time. Trait-mediated abiotic filtering appears to play an important role in community assembly during the early and early-mid stages of arable-to-grassland succession, whereas the relative importance of competitive exclusion appears to have increased towards the later successional stages. Phylogenetic diversity provided a poor reflection of functional diversity and did not contribute to inferences about underlying assembly processes. Functionally deterministic assembly suggests that it may be possible to predict future post-disturbance changes in biodiversity, and associated ecosystem attributes, on the basis of species’ functional traits but not phylogeny.
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| 22. |
- Reusch, Simeon, et al.
(författare)
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Candidate Tidal Disruption Event AT2019fdr Coincident with a High-Energy Neutrino
- 2022
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 128:22
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Tidskriftsartikel (refereegranskat)abstract
- The origins of the high-energy cosmic neutrino flux remain largely unknown. Recently, one high-energy neutrino was associated with a tidal disruption event (TDE). Here we present AT2019fdr, an exceptionally luminous TDE candidate, coincident with another high-energy neutrino. Our observations, including a bright dust echo and soft late-time x-ray emission, further support a TDE origin of this flare. The probability of finding two such bright events by chance is just 0.034%. We evaluate several models for neutrino production and show that AT2019fdr is capable of producing the observed high-energy neutrino, reinforcing the case for TDEs as neutrino sources.
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