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- Langhorne, P, et al.
(författare)
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Is stroke unit care portable? A systematic review of the clinical trials
- 2005
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Ingår i: Age and Ageing. - : Oxford University Press (OUP). - 0002-0729 .- 1468-2834. ; 34:4, s. 324-330
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Tidskriftsartikel (refereegranskat)abstract
- Background: It is not known if mobile stroke teams can achieve the good results seen in trials of geographically discrete stroke wards (stroke units). Objective: To establish the effectiveness of mobile stroke teams. Design: Systematic review of controlled clinical trials that compared peripatetic systems of organised stroke care (stroke team care) with alternative hospital services. Methods: Systematic review and meta-analysis (using Cochrane Collaboration methodology and involving the primary trialists). Clinical outcomes included death, dependency, the need for institutional care and measures of the process of care such as the delivery of key investigations and treatments. Results: Six clinical trials (1,085 patients) were identified, five (781 patients) compared some form of stroke team care with conventional care in general medical wards and one (304 patients) compared team care with a comprehensive stroke unit. Compared with care in general wards, stroke team care improved some aspects of the process of care, but clinical outcomes were similar. Compared with a comprehensive stroke unit, stroke team patients were significantly less likely to survive (P< 0.001), return home (P< 0.001) or regain independence (P< 0.0001). Most aspects of the process of care were also poorer than in the stroke unit. Conclusions: Care from a mobile stroke team had no major impact on death, dependency or the need for institutional care. © The Author 2005. Published by Oxford University Press. All rights reserved.
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- Meglinski, IV, et al.
(författare)
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Laser ice scaffolds modeling for tissue engineering
- 2005
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Ingår i: LASER PHYSICS LETTERS. - : John Wiley andamp;amp; Sons, Ltd. - 1612-2011 .- 1612-202X. ; 2:9, s. 465-467
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Tidskriftsartikel (refereegranskat)abstract
- Tissue engineering is one of the most exciting and rapidly growing areas in biomedical engineering that offers vast potential for changing traditional approaches to meeting many pharmaceutics and critical health care needs. Currently the bottle-neck area in this multidisciplmiary field appears to be materials and fabrication technology for the design of artificial extracellular matrices/scaffolds that support culturing and growth of new tissue. We have shown that stable relief structures can be created and maintained in the bulk of ice by continuous s canning with computer-guided IR CO2 laser. The optimal laser beam intensity and fluence rate distribution within the ice sample, as well as the rate of scanning were estimated based on the Monte Carlo model utilized physical/optical properties of ice. The results of numerical simulation are agreed well with the observed experimental results of thermo-coupling measurements and obtained microscopic images.
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- van der Burg, Jorien m, et al.
(författare)
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Increased metabolism in the R6/2 mouse model of Huntington's disease.
- 2008
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Ingår i: Neurobiology of Disease. - : Elsevier BV. - 0969-9961. ; 29:1, s. 41-51
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Tidskriftsartikel (refereegranskat)abstract
- Huntington’s disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is unknown. The aim of this study was to examine body weight changes and weight-regulating factors in HD using the R6/2 mouse model as a tool. We found that R6/2 mice started losing weight at 9 weeks of age. Total locomotor activity was unaltered and caloric intake was not decreased until 11 weeks of age, which led us to hypothesize that increased metabolism might underlie the weight loss. Indeed, oxygen consumption in R6/2 mice was elevated from 6 weeks of age, indicative of an increased metabolism. Several organ systems that regulate weight and metabolism, including the hypothalamus, the stomach and adipose tissue displayed abnormalities in R6/2 mice. Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors.
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