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Sökning: WFRF:(Wu Yunjun)

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1.
  • Wang, Hui, et al. (författare)
  • A novel Schiff base derivative: Synthesis, two-photon absorption properties and application for bioimaging
  • 2018
  • Ingår i: Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy. - : PERGAMON-ELSEVIER SCIENCE LTD. - 1386-1425 .- 1873-3557. ; 198, s. 304-308
  • Tidskriftsartikel (refereegranskat)abstract
    • A novel donor-pi-acceptor-pi-donor type (D-pi-A-pi-D) Schiff base derivative (L) has been designed and synthesized. The structure of L is confirmed by single-crystal X-ray diffraction analysis as well. The photophysical properties of compound L were comprehensively investigated by using both experimental and theoretical methods. The results indicate that L exhibits large Stokes shift and moderate two-photon action (2PA) cross-section in the near infrared (NIR) region. Furthermore, the confocal microscopy imaging study demonstrates that compound L could penetrate into cells and target the cellular mitochondria compartment. Due to its low cytotoxicity, compound L provides a promising tool for directly lighting up the mitochondria compartment in living HepG2 cells. (C) 2018 Elsevier B.V. All rights reserved.
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2.
  • Wang, Hui, et al. (författare)
  • A water-soluble "turn-on" fluorescent probe for specifically imaging mitochondria viscosity in living cells
  • 2018
  • Ingår i: Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy. - : PERGAMON-ELSEVIER SCIENCE LTD. - 1386-1425 .- 1873-3557. ; 203, s. 127-131
  • Tidskriftsartikel (refereegranskat)abstract
    • Rational design of water-soluble probes for mitochondrial viscosity in practical biological applications remains a challenge. Herein, we described a novel hydro soluble benzothiazole salt derivative MitoSN, which exhibits specifically response and singular sensitivity to the mitochondria viscosity in living Hela cells. MitoSN displays an excellent fluorescence enhancement (ca. 35-fold) with the increase of the viscosity in the water-glycerol system. Moreover, confocal microscopy indicates that MitoSN is sensitive to the local viscosity and selectively stains mitochondria, the body of zebrafish as well. Importantly, MitoSN is capable to identify the viscosity difference of mitochondria in normal and nystatin treated Hela cells. The work provides a useful tool to monitor the changes of viscosity in the mitochondrial microenvironment. (C) 2018 Elsevier B.V. All rights reserved.
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  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Wang, Hui (2)
Hu, Zhang-Jun (2)
Kong, Lin (2)
Fang, Bin (2)
Li, Xiangzi (2)
Wu, Yunjun (2)
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Uvdal, Kajsa (1)
Yu, Yan (1)
Li, Di (1)
Zhou, Le (1)
Feng, Zhijun (1)
Xiao, Lufei (1)
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Linköpings universitet (2)
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Engelska (2)
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Naturvetenskap (2)
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2018 (2)

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