| 1. |
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| 2. |
- Menkveld, Albert J., et al.
(författare)
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Nonstandard Errors
- 2024
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Ingår i: JOURNAL OF FINANCE. - : Wiley-Blackwell. - 0022-1082 .- 1540-6261. ; 79:3, s. 2339-2390
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Tidskriftsartikel (refereegranskat)abstract
- In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty-nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.
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| 3. |
- Zhao, Yunlong, et al.
(författare)
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Stable Alkali Metal Ion Intercalation Compounds as Optimized Metal Oxide Nanowire Cathodes for Lithium Batteries
- 2015
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Ingår i: Nano letters (Print). - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 15:3, s. 2180-2185
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Tidskriftsartikel (refereegranskat)abstract
- Intercalation of ions in electrode materials has been explored to improve the rate capability in lithium batteries and supercapacitors, due to the enhanced diffusion of Li+ or electrolyte cations. Here, we describe a synergistic effect between crystal structure and intercalated ion by experimental characterization and ab initio calculations, based on more than 20 nanomaterials: five typical cathode materials together with their alkali metal ion intercalation compounds A-M-O (A = Li, Na, K, Rb; M = V, Mo, Co, Mn, Fe-P). Our focus on nanowires is motivated by general enhancements afforded by nanoscale structures that better sustain lattice distortions associated with charge/discharge cycles. We show that preintercalation of alkali metal ions in V-O and Mo-O yields substantial improvement in the Li ion charge/discharge cycling and rate, compared to A-Co-O, A-Mn-O, and A-Fe-P-O. Diffraction and modeling studies reveal that preintercalation with K and Rb ions yields a more stable interlayer expansion, which prevents destructive collapse of layers and allow Li ions to diffuse more freely. This study demonstrates that appropriate alkali metal ion intercalation in admissible structure can overcome the limitation of cyclability as well as rate capability of cathode materials, besides, the preintercalation strategy provides an effective method to enlarge diffusion channel at the technical level, and more generally, it suggests that the optimized design of stable intercalation compounds could lead to substantial improvements for applications in energy storage.
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| 4. |
- Bian, Wenjie, et al.
(författare)
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Diffusion behavior of Se(IV) and Re(VII) in biotite: effects of dry density and ionic strength
- 2023
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Ingår i: Journal of Radioanalytical and Nuclear Chemistry. - : Springer Nature. - 0236-5731 .- 1588-2780. ; 332:11, s. 4413-4425
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Tidskriftsartikel (refereegranskat)abstract
- Biotite is an important adsorption carrier in the constituent minerals of Beishan granite. In this work, the effects of compaction density and ionic strength on the diffusion behavior of Se(IV) and Re(VII) in biotite were studied by capillary in-diffusion method and diffusion cell through-diffusion method. When the compaction density decreases or the ionic strength increases, the apparent diffusion coefficient increases, and its values range between 10–11 and 10–9 m2/s. The relationship between De and εacc, ionic strength and εacc was fitted using Archie's law and compared with the parameters of other researchers.
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| 5. |
- Dai, Helong, et al.
(författare)
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Blockade of CD27/CD70 pathway to reduce the generation of memory T cells and markedly prolong the survival of heart allografts in presensitized mice
- 2011
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Ingår i: Transplant Immunology. - : Elsevier BV. - 1878-5492 .- 0966-3274. ; 24:4, s. 195-202
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Tidskriftsartikel (refereegranskat)abstract
- Background: Alloreactive memory T cells are a major obstacle to transplantation acceptance due to their capacity for accelerated rejection. Methods: C57BL/6 mice that had rejected BALB/c skin grafts 4 weeks earlier were used as recipients. The recipient mice were treated with anti-CD154/LFA-1 with or without anti-CD70 during the primary skin transplantation and anti-CD154/LFA-1 or not during the secondary transplantation of BALB/c heart. We evaluated the impact of combinations of antibody-mediated blockade on the generation of memory T cells and graft survival after fully MHC-mismatched transplantations. Results: One month after the primary skin transplantation, the proportions of CD4(+) memory T cells/CD4(+) T cells and CD8(+)memory T cells/CD8(+) T cells in the anti-CD154/LFA-1 combination group were 47.32 +/- 428% and 23.18 +/- 2.77%, respectively. In the group that included anti-CD70 treatment, the proportions were reduced to 34.10 +/- 2.71% and 12.19 +/- 3.52% (P<0.05 when comparing the proportion of memory T cells between the two groups). The addition of anti-CD70 to the treatment regimen prolonged the mean survival time following secondary heart transplantation from 10 days to more than 90 days (P<0.001). Furthermore, allogenic proliferation of recipient splenic T cells and graft-infiltrating lymphocytes were significantly decreased. Meanwhile, the proportion of regulatory T cells was increased to 9.46 +/- 1.48% on day 100 post-transplantation (P<0.05). Conclusions: The addition of anti-CD70 to the anti-CD154/LFA-1 combination given during the primary transplantation reduced the generation of memory T cells. This therapy regimen provided a potential means to alleviate the accelerated rejection mediated by memory T cells during secondary heart transplantation and markedly prolong the survival of heart allografts. (C) 2011 Elsevier B.V. All rights reserved.
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| 6. |
- Han, Yanting, et al.
(författare)
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Green preparation of antibacterial shape memory foam based on bamboo cellulose nanofibril and waterborne polyurethane for adaptive relief of plantar pressure
- 2024
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Ingår i: International Journal of Biological Macromolecules. - : Elsevier BV. - 0141-8130 .- 1879-0003. ; 256
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Tidskriftsartikel (refereegranskat)abstract
- This study developed an aqueous solution blending and freeze-drying method to prepare an antibacterial shape memory foam (WPPU/CNF) based on waterborne PHMG-polyurethane and cellulose nanofibers derived from bamboo in response to the increasing demand for environmentally friendly, energy conserving, and multifunctional foams. The obtained WPPU/CNF composite foam has a highly porous network structure with well-dispersed CNFs forming hydrogen bonds with the WPPU matrix, which results in a stable and rigid cell skeleton with enhanced mechanical properties (80 KPa) and anti-abrasion ability. The presence of guanidine in the polyurethane chain endowed the WPPU/CNF composite foam with an instinctive and sustained antibacterial ability against Escherichia coli and Staphylococcus aureus. The WPPU/CNF composite foam exhibited a water-sensitive shape memory function in a cyclic shape memory program because of the chemomechanical adaptability of the hydrogen-bonded network of CNFs in the elastomer matrix. The shape-fixation ratio for local compression reached 95 %, and the shape-recovery rate reached 100 %. This allows the WPPU/CNF pad prototype to reversibly adjust the undulation height to adapt to plantar ulcers, which can reduce the local plantar pressure by 60 %. This study provides an environmentally friendly strategy for cellulose-based composite fabrication and enriches the design and application of intelligent foam devices.
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| 7. |
- Kang, Xiangpeng, et al.
(författare)
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Isatis tinctoria L. combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice
- 2010
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Ingår i: Transplant Immunology. - : Elsevier BV. - 1878-5492 .- 0966-3274. ; 23:1-2, s. 34-39
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Tidskriftsartikel (refereegranskat)abstract
- Memory T cells present a unique challenge in transplantation. Although memory T cells express robust immune responses to invading pathogens. they may be resistant to the effects of immunosuppressive therapies used to prolong graft survival. In previous studies, we found that compound K. the synthesized analogue of highly unsaturated fatty acids from Isatis tinctoria L., reduced acute cardiac allograft rejection in mice (Wang et al., 2009 [1]). Here, we further investigated the effect of compound K on cardiac allograft rejection in alloantigen-primed mice. We found that compound K significantly inhibited CD4(+) and CD8(+) memory T cells proliferation in a mixed lymphocyte reaction (MLR). In vivo, compound K combined with anti-CD154 and anti-LFA-1 monoclonal antibodies (mAbs) significantly extended the survival time of heart grafts in alloantigen-primed mice with no obvious toxic side effects. Furthermore, our data suggests that compound K works by reducing the expression of both IL-2 and IFN-gamma within the graft rather than enhancing expression of regulatory T cells (Tregs). Compound K can also inhibit the alloresponses of memory T cells, while increasing the proportion of CD4(+) memory T cells in the spleen of the recipients and significantly reducing the level of alloantibodies in the serum. Our study highlights the unique immune effects of compound K that may be further explored for clinical use in extending the survival of transplant grafts. (C) 2010 Elsevier B.V. All rights reserved.
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| 8. |
- Liu, Ming, et al.
(författare)
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A High-End Reconfigurable Computation Platform for Nuclear and Particle Physics Experiments
- 2011
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Ingår i: Computing in science & engineering (Print). - 1521-9615 .- 1558-366X. ; 13:2, s. 52-63
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Tidskriftsartikel (refereegranskat)abstract
- A high-performance computation platform based on field-programmable gate arrays targets nuclear and particle physics experiment applications. The system can be constructed or scaled into a supercomputer-equivalent size for detector data processing by inserting compute nodes into advanced telecommunications computing architecture (ATCA) crates. Among the case study results are that one ATCA crate can provide a computation capability equivalent to hundreds of commodity PCs for Hades online particle track reconstruction and Cherenkov ring recognition.
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| 9. |
- Liu, Ming, et al.
(författare)
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ATCA-based Computation Platform for Data Acquisition and Triggering in Particle Physics Experiments
- 2008
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Ingår i: 2008 INTERNATIONAL CONFERENCE ON FIELD PROGRAMMABLE AND LOGIC APPLICATIONS, VOLS 1 AND 2. ; , s. 287-292
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Konferensbidrag (refereegranskat)abstract
- An ATCA-based computation platform for data acquisition and trigger applications in nuclear and particle physics experiments has been developed. Each Compute Node (CN) which appears as a Field Replaceable Unit (FRU) in an ATCA shelf, features 5 Xilinx Virtex-4 FX60 FPGAs and up to 10 GBytes DDR2 memory. Connectivity is provided with 8 optical links and 5 Gigabit Ethernet ports, which are mounted on each board to receive data from detectors and forward results to outer shelves or PC farms with attached mass storage. Fast point-to-point on-board interconnections between FPGAs as well as the full-mesh shelf backplane provide flexibility and high bandwidth to partition algorithms and correlate results among them. The system represents a highly reconfigurable and scalable solution for multiple applications.
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| 10. |
- Qiu, Renxi, et al.
(författare)
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Towards Robust Personal Assistant Robots: Experience Gained in the SRS Project
- 2012
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Ingår i: IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), 2012. - : IEEE. - 9781467317375 ; , s. 1651-1657
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Konferensbidrag (refereegranskat)abstract
- SRS is a European research project for building robust personal assistant robots using ROS (Robotic Operating System) and Care-O-bot (COB) 3 as the initial demonstration platform. In this paper, experience gained while building the SRS system is presented. A main contribution of the paper is the SRS autonomous control framework. The framework is divided into two parts. First, it has an automatic task planner, which initialises actions on the symbolic level. The planner produces proactive robotic behaviours based on updated semantic knowledge. Second, it has an action executive for coordination actions at the level of sensing and actuation. The executive produces reactive behaviours in well-defined domains. The two parts are integrated by fuzzy logic based symbolic grounding. As a whole, they represent the framework for autonomous control. Based on the framework, several new components and user interfaces are integrated on top of COB's existing capabilities to enable robust fetch and carry in unstructured environments. The implementation strategy and results are discussed at the end of the paper.
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| 11. |
- Wang, Feng, et al.
(författare)
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The major histocompatibility complex (MHC) of the secondary transplant tissue donor influences the cross-reactivity of alloreactive memory cells.
- 2011
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Ingår i: Scandinavian Journal of Immunology. - : Wiley. - 1365-3083 .- 0300-9475. ; 73, s. 190-197
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Tidskriftsartikel (refereegranskat)abstract
- Memory cells are currently thought to be a major barrier to tolerance induction in transplantation. However, whether alloreactive memory cells resulting from a primary transplant have cross-reactivity in a second transplant is unclear. Here, we used skin transplantation from BALB/c mice donors to pre-sensitize C(57) BL/6 (B6) mice. One month later, several strains of mice (including BALB/c, DBA/2, NOD, C3H and B6 mice) were chosen as donors to construct a memory model of heterotopic cardiac transplantation. The higher degree of MHC mismatch to sensitizing MHC resulted in longer Median survival times (MSTs, BALB/c 3.63 days VS C3H 6.08 days). 3.5 days after cardiac transplantation, compared with the BALB/c and DBA/2 groups, in the groups of NOD and C3H, the infiltration of inflammatory cells in the grafts, the proportion and proliferation of memory cells in spleens, and the function of allogeneic antibodies decreased significantly. The varying degrees of MHC mismatch between the primary and secondary donors influenced the intensity of alloreactive memory cell function, the higher degree of MHC mismatch resulted in better tolerance during secondary transplantation, and these may be related to the changed activation, proliferation and function of the alloreactive memory cells.
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| 12. |
- Xiao, Jun, et al.
(författare)
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The Design of Augmented Reality-Based Learning System Applied in U-Learning Environment
- 2016
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Ingår i: E-Learning and Games. - Cham : Springer. - 9783319402581 - 9783319402598 ; , s. 27-36
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Konferensbidrag (refereegranskat)abstract
- The easy and widely accessibility of Internet resources makes it possible to support learning almost anywhere at any time through powerful mobile technologies, and facilitate ubiquitous learning (u-learning) to grow in use and popularity. Augmented Reality (AR) can be recognized as a key technology that can be used in the U-learning environment to increase learning effect and improve learning experience. This paper designs an integrated model of U-learning, based on which we have also developed an augmented reality technology based learning system named as “Starry Sky Exploration—Eight Planets of Solar System”; an analysis on its implementation is reported and the AR learning system applicable for U-learning environment is found effective and practical.
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| 13. |
- Yang, Zhenlin, et al.
(författare)
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Structural basis of ligand binding modes at the neuropeptide Y Y-1 receptor
- 2018
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 556:7702, s. 520-524
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Tidskriftsartikel (refereegranskat)abstract
- Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology(1,2). The NPY-Y receptor system has emerged as one of the most complex networks with three peptide ligands (NPY, peptide YY and pancreatic polypeptide) binding to four receptors in most mammals, namely the Y-1, Y-2, Y-4 and Y-5 receptors, with different affinity and selectivity(3). NPY is the most powerful stimulant of food intake and this effect is primarily mediated by the Y-1 receptor (Y1R)(4). A number of peptides and small-molecule compounds have been characterized as Y1R antagonists and have shown clinical potential in the treatment of obesity(4), tumour(1) and bone loss(5). However, their clinical usage has been hampered by low potency and selectivity, poor brain penetration ability or lack of oral bioavailability(6). Here we report crystal structures of the human Y1R bound to the two selective antagonists UR-MK299 and BMS-193885 at 2.7 and 3.0 angstrom resolution, respectively. The structures combined with mutagenesis studies reveal the binding modes of Y1R to several structurally diverse antagonists and the determinants of ligand selectivity. The Y1R structure and molecular docking of the endogenous agonist NPY, together with nuclear magnetic resonance, photo-crosslinking and functional studies, provide insights into the binding behaviour of the agonist and for the first time, to our knowledge, determine the interaction of its N terminus with the receptor. These insights into Y1R can enable structure-based drug discovery that targets NPY receptors.
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