| 1. |
- Pan, Xiong-Fei, et al.
(författare)
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Circulating fatty acids and risk of gestational diabetes mellitus : prospective analyses in China
- 2021
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Ingår i: European Journal of Endocrinology. - : Bioscientifica. - 0804-4643 .- 1479-683X. ; 185:1, s. 87-97
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Tidskriftsartikel (refereegranskat)abstract
- Objective: We aimed to examine prospective associations between circulating fatty acids in early pregnancy and incident gestational diabetes mellitus (GDM) among Chinese pregnant women.Methods: Analyses were based on two prospective nested case-control studies conducted in western China (336 GDM cases and 672 matched controls) and central China (305 cases and 305 matched controls). Fasting plasma fatty acids in early pregnancy (gestational age at enrollment: 10.4 weeks(s.d., 2.0)) and 13.2 weeks (1.0), respectively) were determined by gas chromatography-mass spectrometry, and GDM was diagnosed based on the International Association of Diabetes in Pregnancy Study Groups criteria during 24-28 weeks of gestation. Multiple metabolic biomarkers (HOMA-IR (homeostatic model assessment for insulin resistance), HbA1c, c-peptide, high-sensitivity C-reactive protein, adiponectin, leptin, and blood lipids) were additionally measured among 672 non-GDM controls at enrollment.Results: Higher levels of saturated fatty acids (SFAs) 14:0 (pooled odds ratio, 1.41 for each 1-s.d. increase; 95% CI: 1.25, 1.59) and 16:0 (1.19; 1.05, 1.35) were associated with higher odds of GDM. Higher levels of n-6 polyunsaturated fatty acid (PUFA) 18:2n-6 were strongly associated with lower odds of GDM (0.69; 0.60, 0.80). In non-GDM pregnant women, higher SFAs 14:0 and 16:0 but lower n-6 PUFA 18:2n-6 were generally correlated with unfavorable metabolic profiles.Conclusions: We documented adverse associations of 14:0 and 16:0 but a protective association of 18:2n-6 with GDM among Chinese pregnant women. Our findings highlight the distinct roles of specific fatty acids in the onset of GDM.
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| 2. |
- Yang, Xinping, et al.
(författare)
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Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
- 2016
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Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 164:4, s. 805-817
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Tidskriftsartikel (refereegranskat)abstract
- While alternative splicing is known to diversify the functional characteristics of some genes, the extent to which protein isoforms globally contribute to functional complexity on a proteomic scale remains unknown. To address this systematically, we cloned full-length open reading frames of alternatively spliced transcripts for a large number of human genes and used protein-protein interaction profiling to functionally compare hundreds of protein isoform pairs. The majority of isoform pairs share less than 50% of their interactions. In the global context of interactome network maps, alternative isoforms tend to behave like distinct proteins rather than minor variants of each other. Interaction partners specific to alternative isoforms tend to be expressed in a highly tissue-specific manner and belong to distinct functional modules. Our strategy, applicable to other functional characteristics, reveals a widespread expansion of protein interaction capabilities through alternative splicing and suggests that many alternative "isoforms'' are functionally divergent (i.e., "functional alloforms'').
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| 3. |
- Dai, Wenbin, et al.
(författare)
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Industrial Edge Computing : Enabling Embedded Intelligence
- 2019
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Ingår i: IEEE Industrial Electronics Magazine. - : IEEE. - 1932-4529 .- 1941-0115. ; 13:4, s. 48-56
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Tidskriftsartikel (refereegranskat)abstract
- The term industrial edge computing is used to describe a distributed platform that integrates communication, computation, and storage resources for performing real-time applications that can be directly accessed from the cloud. A step toward the industrial Internet revolution, industrial edge computing is designed to facilitate agile connectivity, real-time control, and data optimization, while enabling intelligent applications, ensuring tight security, and protecting privacy. Industrial edge computing makes use of what is known as edge computing nodes (ECNs), which bridge the gap between the physical world and the digital world by acting as smart gateways for assets, services, and systems. The IEEE P2805 Standards are being developed for defining protocols for self-management, data acquisition, and machine learning through cloud-edge collaboration on ECNs.
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| 4. |
- Deng, Haoran, et al.
(författare)
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A Decision-Dependent Hydrogen Supply Infrastructure Planning Approach Considering Causality Between Vehicles and Stations
- 2024
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Ingår i: IEEE Transactions on Sustainable Energy. - : Institute of Electrical and Electronics Engineers (IEEE). - 1949-3029 .- 1949-3037. ; 15:3, s. 1914-1932
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Tidskriftsartikel (refereegranskat)abstract
- In the early commercialization stage of hydrogen fuel cell vehicles (HFCVs), reasonable hydrogen supply infrastructure (HSI) planning is a premise for promoting the popularization of HFCVs. However, there is a strong causality between HFCVs and hydrogen refueling stations (HRSs): the planning decisions of HRSs could affect the hydrogen refueling demand of HFCVs, and the growth of demand would in turn stimulate the further investment in HRSs, which is prompted by the chicken-egg conundrum. Meanwhile, there is a cost contradiction between energy planning and hydrogen refueling convenience of HFCVs caused by HRSs siting planning. To this end, this work establishes a multi-network HSI planning model coordinating hydrogen, power, and transportation networks. Then, to reflect the causal relation between HFCVs and HRSs effectively in the early stage of hydrogen infrastructure investment planning without sufficient historical data, hydrogen demand decision-dependent uncertainty (DDU) and a distributionally robust optimization framework are developed. The uncertainty of hydrogen demand is modeled as a Wasserstein ambiguity set with a decision-dependent empirical probability distribution. Subsequently, to reduce the computational complexity caused by the introduction of a large number of scenarios and high-dimensional nonlinear constraints, we developed an improved distribution shaping method and techniques of scenario and variable reduction to derive the solvable form with less computing burden. Finally, the simulation results demonstrate that this method can reduce costs by at least 7.7% compared with traditional methods and will be more effective in large-scale HSI planning issues. Further, we put forward effective suggestions for the policymakers and investors.
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| 5. |
- Du, Rong, et al.
(författare)
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Effective Urban Traffic Monitoring by Vehicular Sensor Networks
- 2015
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Ingår i: IEEE Transactions on Vehicular Technology. - : IEEE Press. - 0018-9545 .- 1939-9359. ; 64:1, s. 273-286
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Tidskriftsartikel (refereegranskat)abstract
- Traffic monitoring in urban transportation systems can be carried out based on vehicular sensor networks. Probe vehicles (PVs), such as taxis and buses, and floating cars (FCs), such as patrol cars for surveillance, can act as mobile sensors for sensing the urban traffic and send the reports to a traffic-monitoring center (TMC) for traffic estimation. In the TMC, sensing reports are aggregated to form a traffic matrix, which is used to extract traffic information. Since the sensing vehicles cannot cover all the roads all the time, the TMC needs to estimate the unsampled data in the traffic matrix. As this matrix can be approximated to be of low rank, matrix completion (MC) is an effective method to estimate the unsampled data. However, our previous analysis on the real traces of taxis in Shanghai reveals that MC methods do not work well due to the uneven samples of PVs, which is common in urban traffic. To exploit the intrinsic relationship between the unevenness of samples and traffic estimation error, we study the temporal and spatial entropies of samples and successfully define the important criterion, i.e., average entropy of the sampling process. A new sampling rule based on this relationship is proposed to improve the performance of estimation and monitoring.With the sampling rule, two new patrol algorithms are introduced to plan the paths of controllable FCs to proactively participate in trafficmonitoring. By utilizing the patrol algorithms for real-data-set analysis, the estimation error reduces from 35% to about 10%, compared with the random patrol or interpolation method in traffic estimation. Both the validity of the exploited relationship and the effectiveness of the proposed patrol control algorithms are demonstrated.
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| 6. |
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| 7. |
- Huang, Ketuan, et al.
(författare)
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Genetic variants and Expression of Cytochrome p450 Oxidoreductase Predict Postoperative Survival in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma
- 2019
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Ingår i: Journal of Cancer. - : IVYSPRING INT PUBL. - 1837-9664. ; 10:6, s. 1453-1465
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Tidskriftsartikel (refereegranskat)abstract
- Our current study investigates the prognostic values of genetic variants and mRNA expression of cytochrome p450 oxidoreductase (POR) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). A total of 19 candidate single nucleotide polymorphisms (SNPs) located in the exons of POR were genotyped using Sanger sequencing from 476 HBV-related HCC patients who underwent hepatectomy between 2003 and 2013. The mRNA expression of POR in 212 patients with HBV-related HCC was obtained from GSE14520 dataset. Survival analysis was performed to investigate the association of POR variants and mRNA expression with overall survival (OS) and recurrence-free survival (RFS). Nomograms were used to predict the prognosis of HBV-related HCC patients. Gene set enrichment analysis (GSEA) was used to investigate the mechanism of POR in HBV-related HCC prognosis. The polymorphism POR-rs1057868 was significantly associated with HBV-related HCC OS (CT/TT vs. CC, hazard ratio [HR] = 0.69, 95% confidence interval [CI] = [0.54, 0.88], P = 0.003), but not significantly associated with RFS (CT/TT vs. CC, P = 0.378). POR mRNA expression was also significantly associated with HBV-related HCC OS (high vs. low, HR = 0.61, 95% CI = [0.38, 0.97], P= 0.036), but not significantly associated with the RFS (high vs. low, P = 0.201). Two nomograms were developed to predict the HBV-related HCC OS. Furthermore, GSEA suggests that multiple gene sets were significantly enriched in liver cancer survival and recurrence, as well as POR-related target therapy in the liver. In conclusion, our study suggests that POR-rs1057868 and mRNA expression may serve as a potential postoperative prognosis biomarker in HBV-related HCC.
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| 8. |
- Liao, Xiwen, et al.
(författare)
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Comprehensive investigation of key biomarkers and pathways in hepatitis B virus-related hepatocellular carcinoma
- 2019
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Ingår i: Journal of Cancer. - : IVYSPRING INT PUBL. - 1837-9664. ; 10:23, s. 5689-5704
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Our study is aim to explore potential key biomarkers and pathways in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) using genome-wide expression profile dataset and methods. Methods: Dataset from the GSE14520 is used as the training cohort and The Cancer Genome Atlas dataset as the validation cohort. Differentially expressed genes (DEGs) screening were performed by the limma package. Gene set enrichment analysis (GSEA), weighted gene co-expression network analysis (WGCNA), gene ontology, the Kyoto Encyclopedia of Genes and Genomes, and risk score model were used for pathway and genes identification. Results: GSEA revealed that several pathways and biological processes are associated with hepatocarcinogenesis, such as the cell cycle, DNA repair, and p53 pathway. A total of 160 DEGs were identified. The enriched functions and pathways of the DEGs included toxic substance decomposition and metabolism processes, and the P450 and p53 pathways. Eleven of the DEGs were identified as hub DEGs in the WGCNA. In survival analysis of hub DEGs, high expression of PRC1 and TOP2A were significantly associated with poor clinical outcome of HBV-related HCC, and shown a good performance in HBV-related HCC diagnosis. The prognostic signature consisting of PRC1 and TOP2A also doing well in the prediction of HBV-related HCC prognosis. The diagnostic and prognostic values of PRC1 and TOP2A was confirmed in TCGA HCC patients. Conclusions: Key biomarkers and pathways identified in the present study may enhance the comprehend of the molecular mechanisms underlying hepatocarcinogenesis. Additionally, mRNA expression of PRC1 and TOP2A may serve as potential diagnostic and prognostic biomarkers for HBV-related HCC.
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| 9. |
- Liao, Xiwen, et al.
(författare)
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Integrated analysis of competing endogenous RNA network revealing potential prognostic biomarkers of hepatocellular carcinoma
- 2019
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Ingår i: Journal of Cancer. - : Ivyspring International Publisher. - 1837-9664. ; 10:14, s. 3267-3283
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The goal of our study is to identify a competing endogenous RNA (ceRNA) network using dysregulated RNAs between HCC tumors and the adjacent normal liver tissues from The Cancer Genome Atlas (TCGA) datasets, and to investigate underlying prognostic indicators in hepatocellular carcinoma (HCC) patients. Methods: All of the RNA- and miRNA-sequencing datasets of HCC were obtained from TCGA, and dysregulated RNAs between HCC tumors and the adjacent normal liver tissues were investigated by DESeq and edgeR algorithm. Survival analysis was used to confirm underlying prognostic indicators. Results: In the present study, we constructed a ceRNA network based on 16 differentially expressed genes (DEGs), 7 differentially expressed microRNAs and 34 differentially expressed long non-coding RNAs (DELs). Among these dysregulated RNAs, three DELs (AP002478.1, HTR2A-AS1, and ERVMER61-1) and six DEGs (enhancer of zeste homolog 2 [EZH2], kinesin family member 23 [KIF23], chromobox 2 [CBX2], centrosomal protein 55 [CEP55], cell division cycle 25A [CDC25A], and claspin [CLSPN]) were used for construct a prognostic signature for HCC overall survival (OS), and performed well in HCC OS (adjusted P<0.0001, adjusted hazard ratio = 2.761, 95% confidence interval = 1.838-4.147). Comprehensive survival analysis demonstrated that this prognostic signature may be act as an independent prognostic indicator of HCC OS. Functional assessment of these dysregulated DEGs in the ceRNA network and gene set enrichment of this prognostic signature suggest that both were enriched in the biological processes and pathways of the cell cycle, cell division and cell proliferation. Conclusions: Our current study constructed a ceRNA network for HCC, and developed a prognostic signature that may act as an independent indicator for HCC OS.
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| 10. |
- Wang, Xinping, et al.
(författare)
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Nature of three episodes of Paleoproterozoic magmatism (2180 Ma, 2115 Ma and 1890 Ma) in the Liaoji belt, North China with implications for tectonic evolution
- 2017
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Ingår i: Precambrian Research. - : Elsevier BV. - 0301-9268. ; 298, s. 252-267
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Tidskriftsartikel (refereegranskat)abstract
- Three episodes of Paleoproterozoic magmatism with distinctively different nature in the Liaoji belt of the Eastern North China Craton are discussed here: the 2200–2140 Ma Liaoji A-type granites, the 2160–2110 Ma Haicheng mafic sills and the ∼1890 Ma Qingchengzi I-type granites. The Mafeng monzogranitic pluton, representative of the Liaoji A-type granites, gives a SIMS U-Pb zircon age of 2181 ± 6 Ma (n = 20, MSWD = 4.3). The Qingchengzi plagiogranitic pluton, representative of the Qingchengzi I-type granites, gives a SIMS U-Pb zircon age of 1891 ± 10 Ma (n = 8, MSWD = 1.8). The Mafeng monzogranites are high in Fe, Ti, K but low in Mg, Al and Ca. They have high abundance of total REEs (ΣREE = 213–346 ppm). They are relatively depleted in feldspar-compatible elements (e.g., Eu and Sr) and HFSEs (e.g., Nb, Ta, P and Ti). They have high 10000 × Ga/Al ratios of 3.19–3.61 and Zr + Nb + Ce + Y concentrations of 472–656 ppm, which are typical for A-type granite. The Qingchengzi plagiogranites have relatively high Al, Ca, Na but low Fe, Ti and K contents. They have low abundance of total REEs (ΣREE = 17.6–21.6 ppm). They are enriched in LILEs (e.g., Ba, K and Sr) but depleted in HFSEs (e.g., Nb, Ta, P, Ti and Y). These features, combined with extremely high Sr/Y ratios (327–413), are comparable with those of typical modern adakites. The Liaoji A-type granites show a source same to that of the Haicheng mafic sills and they originated from the Archean subcontinental lithospheric mantle plus with contamination from the Archean granites. However, the Qingchengzi I-type granites are interpreted to originate from subducted oceanic crust with significant contributions from sediments. The Liaoji A-type granites and the coeval bimodal volcanism in the Liaohe Group as well as the Haicheng mafic sills may represent episodic magmatism which was related to a protracted intra-continental rifting caused by lithospheric extension. The ca. 1890 Ma Qingchengzi I-type granites and coexisting S-type granites as well as the coeval regional metamorphism are favored to represent an active continental magmatism linked to Paleoproterozoic subduction.
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| 11. |
- Wang, Yong, et al.
(författare)
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Inclusion Engineering in Medium Mn Steels : Effect of Hot-Rolling Process on the Deformation Behaviors of Oxide and Sulfide Inclusions
- 2022
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Ingår i: Metallurgical and materials transactions. B, process metallurgy and materials processing science. - : Springer Nature. - 1073-5615 .- 1543-1916. ; 53:4, s. 2182-2197
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Tidskriftsartikel (refereegranskat)abstract
- Medium Mn steel (MMS) is a new category of the third-generation advanced high strength steel (3rd AHSS) which is developed in the recent 1-2 decades due to a unique trade-off of strength and ductility. Thus, this steel grade has a wide application potential in different fields of industry. The current work provides a fundamental study of the effect of hot-rolling on the inclusion deformation inMMSincluding a varied 7 to 9 mass pctMn. Specifically, the deformation behavior of different types of inclusions (i.e., Mn(S,Se), liquid oxide (MnSiO3), MnAl2O4, and complex oxy-sulfide) was investigated. The results show that both MnSiO3 and Mn(S,Se) are soft inclusions which are able to be deformed during the hot-rolling process but MnAl2O4 does not. The aspect ratio of soft inclusions increases significantly from as-cast to hot-rolling conditions. When the maximum size of different inclusions is similar, Mn(S,Se) deforms more than MnSiO3 does. This is due to a joint influence of physical parameters including Young's modulus, coefficient of thermal expansion (α), etc. However, when the maximum size of one type of inclusion (e.g., MnSiO3) is much larger than another one (e.g., Mn(S,Se)), this maximum size of soft inclusions plays a dominant role than other factors. In addition, the deformation behavior of dual-phase inclusion depends on the major phase, i.e., either oxide or sulfide. Last but not least, empirical correlations between the reduction ratio of the thickness of plate, grain size, and aspect ratio of oxide and sulfide inclusions after hot-rolling are provided quantitatively. This work aims to contribute to the 'inclusion engineering' concept in the manufacturing of new generation AHSS.
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| 12. |
- Xu, Weidong, et al.
(författare)
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Iodomethane-Mediated Organometal Halide Perovskite with Record Photoluminescence Lifetime
- 2016
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Ingår i: ACS Applied Materials and Interfaces. - : AMER CHEMICAL SOC. - 1944-8244 .- 1944-8252. ; 8:35, s. 23181-23189
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Tidskriftsartikel (refereegranskat)abstract
- Organometallic lead halide perovskites are excellent light harvesters for high-efficiency photovoltaic devices. However, as the key component in these devices, a perovskite thin film with good morphology and minimal trap states is still difficult to obtain. Herein we show that by incorporating a low boiling point alkyl halide such as iodomethane (CH3I) into the precursor solution, a perovskite (CH3NH3PbI3-xClx) film with improved grain size and orientation can be easily achieved. More importantly, these films exhibit a significantly reduced amount of trap states. Record photoluminescence lifetimes of more than 4 mu s are achieved; these lifetimes are significantly longer than that of pristine CH3NH3PbI3-xClx films. Planar heterojunction solar cells incorporating these CH3I-mediated perovskites have demonstrated a dramatically increased power conversion efficiency compared to the ones using pristine CH3NH3PbI3-xClx. Photoluminescence, transient absorption, and microwave detected photoconductivity measurements all provide consistent evidence that CH3I addition increases the number of excitons generated and their diffusion length, both of which assist efficient carrier transport in the photovoltaic device. The simple incorporation of alkyl halide to enhance perovskite surface passivation introduces an important direction for future progress on high efficiency perovskite optoelectronic devices.
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| 13. |
- Yang, Bo, et al.
(författare)
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Opportunistic multichannel access with decentralized channel state information
- 2015
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Ingår i: Wireless Communications & Mobile Computing. - : Wiley. - 1530-8669 .- 1530-8677. ; 15:2, s. 322-339
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Tidskriftsartikel (refereegranskat)abstract
- This paper considers multiaccess control for the uplink in orthogonal frequency division multiple access wireless networks. To avoid the extensive information exchange associated with centralized approaches, we formulate the decentralized access control problem with the contention power constraint as a Bayesian game, mapping time-varying channel state information into contention strategies. By exploiting the problem structure, a strategy where users access the channels with probability one if the observed channel gain is above a predetermined threshold is shown to be optimal. It is also shown that the energy consumption of the threshold strategy will not exceed that of randomized strategies. The game is then equivalently reformulated as one of finding the threshold value in a distributed manner, and the existence and uniqueness of Bayesian Nash equilibria is established. A distributed algorithm based on Lagrange duality is proposed to approach the unique equilibrium, and the algorithm is shown to be globally stable. In a homogeneous system, the performance loss of the proposed scheme is proved to be bounded compared with a centralized channel allocation scheme. Contrary to other proposals, our method allows for heterogeneous channel state information and achieves a comparable throughput with reduced power.
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| 14. |
- Yang, Bo, et al.
(författare)
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Threshold-based Multichannel Access with Energy Constraint
- 2010
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Ingår i: 2010 IEEE International Conference on Communications. - 9781424464043
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Konferensbidrag (refereegranskat)abstract
- This paper considers multiaccess control for the uplink in orthogonal-frequency-division-multiple-access (OFDMA) wireless networks. To avoid extensive information exchange with the access point in centralized approaches, we propose a distributed threshold-based scheme, where each user accesses multiple channels simultaneously based on a comparison between measured channel gains and a channel gain threshold. Each user will adapts its channel gain threshold based on local measurements of collision on each channel and the energy consumption for channel contention. The problem is formulated as a constrained non-cooperative game. We show existence and uniqueness of the Nash equilibrium. A gradient-based algorithm is proposed to update the channel gain threshold. Furthermore, the convergence of this algorithm is proved. In addition, for heterogeneous systems, our proposed scheme can maintain multiuser diversity gains considering the time-varying channel gain and energy consumption. Compared with peer distributed OFDMA schemes and random channel selection algorithms, our proposed schemes reduce overhead and achieve a higher throughput.
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| 15. |
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| 16. |
- Yang, Ziwen, et al.
(författare)
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Adaptive Estimation for Environmental Monitoring Using an Autonomous Underwater Vehicle
- 2023
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Ingår i: 2023 62nd IEEE Conference on Decision and Control, CDC 2023l, CDC 2023. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 2521-2528
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Konferensbidrag (refereegranskat)abstract
- This paper considers the problem of monitoring and adaptively estimating an environmental field, such as temperature or salinity, using an autonomous underwater vehicle (AUV). The AUV moves in the field and persistently measures environmental scalars and its position in its local coordinate frame. The environmental scalars are approximately linearly distributed over the region of interest, and an adaptive estimator is designed to estimate the gradient. By orthogonal decomposition of the velocity of the AUV, a linear time-varying system is equivalently constructed, and the sufficient conditions on the motion of the AUV are established, under which the global exponential stability of the estimation error system is rigorously proved. Furthermore, an estimate of the exponential convergence rate is given, and a reference trajectory that maximizes the estimate of the convergence rate is obtained for the AUV to track. Numerical examples verify the stability and efficiency of the system.
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