| 1. |
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| 2. |
- Abbafati, Cristiana, et al.
(författare)
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- 2020
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Beets, G., et al.
(författare)
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ECCO Essential Requirements for Quality Cancer Care: Colorectal Cancer. A critical review
- 2017
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Ingår i: Critical Reviews in Oncology Hematology. - : Elsevier BV. - 1040-8428. ; 110, s. 81-93
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Tidskriftsartikel (refereegranskat)abstract
- Background: ECCO essential requirements for quality cancer care (ERQCC) are checklists and explanations of organisation and actions that are necessary to give high-quality care to patients who have a specific tumour type. They are written by European experts representing all disciplines involved in cancer care. ERQCC papers give oncology teams, patients, policymakers and managers an overview of the elements needed in any healthcare system to provide high quality of care throughout the patient journey. References are made to clinical guidelines and other resources where appropriate, and the focus is on care in Europe. Colorectal cancer (CRC) is the second most common cause of cancer death in Europe and has wide variation in outcomes among countries. Increasing numbers of older people are contracting the disease, and treatments for advanced stages are becoming more complex. A growing number of survivors also require specialist support. High-quality care can only be a carried out in specialised CRC units or centres which have both a core multidisciplinary team and an extended team of allied professionals, and which are subject to quality and audit procedures. Such units or centres are far from universal in all European countries. It is essential that, to meet European aspirations for comprehensive cancer control, healthcare organisations implement the essential requirements in this paper, paying particular attention to multidisciplinarity and patient-centred pathways from diagnosis, to treatment, to survivorship. Conclusion: Taken together, the information presented in this paper provides a comprehensive description of the essential requirements for establishing a high-quality CRC service. The ECCO expert group is aware that it is not possible to propose a 'one size fits all' system for all countries, but urges that access to multidisciplinary units or centres must be guaranteed for all those with CRC. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.
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| 4. |
- Farhadfar, Nosha, et al.
(författare)
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Weighty choices : selecting optimal G-CSF doses for stem cell mobilization to optimize yield
- 2020
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Ingår i: Blood Advances. - : AMER SOC HEMATOLOGY. - 2473-9529 .- 2473-9537. ; 4:4, s. 706-716
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Tidskriftsartikel (refereegranskat)abstract
- There are limited data on the effect of donor body mass index (BMI) on peripheral blood stem cell (PBSC) mobilization response to granulocyte colony-stimulating factor (G-CSF), especially in unrelated donors. Obesity has been associated with persistent leukocytosis, elevated circulating progenitor cells, and enhanced stem cell mobilization. Therefore, we hypothesized that adequate collection of CD34(+) cells may be achieved with lower doses (per kilogram of body weight) of G-CSF in donors with higher BMI compared with donors with lower BMI. Using the Center for International Blood and Marrow Transplant Research database, we evaluated the impact of donor BMI on G-CSF-mobilized PBSC yield in healthy unrelated donors. We examined 20 884 PBSC donations collected at National Marrow Donor Program centers between 2006 and 2016. We found significantly higher collection yields in obese and severely obese donors compared with normal and overweight donors. An increase in average daily G-CSF dose was associated with an increase in stem cell yield in donors with normal or overweight BMI. In contrast, an increase in average daily G-CSF dose beyond 780 mu g per day in obese and 900 mg per day in severely obese donors did not increase cell yield. Pain and toxicities were assessed at baseline, during G-CSF administration, and postcollection. Obesity was associated with higher levels of self-reported donation-related pain and toxicities in the pericollection and early postdonation recovery periods. This study suggests a maximum effective G-CSF dose for PBSC mobilization in obese and severely obese donors, beyond which higher doses of G-CSF add no increased yield.
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| 5. |
- Tay, J., et al.
(författare)
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Pre-transplant marital status and hematopoietic cell transplantation outcomes
- 2020
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Ingår i: Current Oncology. - : MULTIMED INC. - 1198-0052 .- 1718-7729. ; 27:6, s. E596-E606
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Tidskriftsartikel (refereegranskat)abstract
- Background Evidence about the impact of marital status before hematopoietic cell transplantation (HCT) on outcomes after HCT is conflicting. Methods We identified patients 40 years of age and older within the Center for International Blood and Marrow Transplant Research registry who underwent HCT between January 2008 and December 2015. Marital status before HCT was declared as one of: married or living with a partner, single (never married), separated or divorced, and widowed. We performed a multivariable analysis to determine the association of marital status with outcomes after HCT. Results We identified 10,226 allogeneic and 5714 autologous HCT cases with, respectively, a median follow-up of 37 months (range: 1-102 months) and 40 months (range: 1-106 months). No association between marital status and overall survival was observed in either the allogeneic (p = 0.58) or autologous (p = 0.17) setting. However, marital status was associated with grades 2-4 acute graft-versus-host disease (GVHD), p < 0.001, and chronic GVHD, p = 0.04. The risk of grades 2-4 acute GVHD was increased in separated compared with married patients [hazard ratio (FIR): 1.13; 95% confidence interval (CI): 1.03 to 1.24], and single patients had a reduced risk of grades 2-4 acute GVHD (FIR: 0.87; 95% CI: 0.77 to 0.98). The risk of chronic GVHD was lower in widowed compared with married patients (FIR: 0.82; 95% CI: 0.67 to 0.99). Conclusions Overall survival after HCT is not influenced by marital status, but associations were evident between marital status and grades 2-4 acute and chronic GVHD. To better appreciate the effects of marital status and social support, future research should consider using validated scales to measure social support and patient and caregiver reports of caregiver commitment, and to assess health-related quality of life together with health care utilization.
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| 6. |
- Andritsch, E., et al.
(författare)
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ECCO Essential Requirements for Quality Cancer Care: Soft Tissue Sarcoma in Adults and Bone Sarcoma. A critical review
- 2017
-
Ingår i: Critical Reviews in Oncology Hematology. - : Elsevier BV. - 1040-8428. ; 110, s. 94-105
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Tidskriftsartikel (refereegranskat)abstract
- Background: ECCO essential requirements for quality cancer care (ERQCC) are checklists and explanations of organisation and actions that are necessary to give high-quality care to patients who have a specific tumour type. They are written by European experts representing all disciplines involved in cancer care. ERQCC papers give oncology teams, patients, policymakers and managers an overview of the elements needed in any healthcare system to provide high quality of care throughout the patient journey. References are made to clinical guidelines and other resources where appropriate, and the focus is on care in Europe. Sarcomas - which can be classified into soft tissue and bone sarcomas - are rare, but all rare cancers make up more than 20% of cancers in Europe, and there are substantial inequalities in access to high-quality care. Sarcomas, of which there are many subtypes, comprise a particularly complex and demanding challenge for healthcare systems and providers. This paper presents essential requirements for quality cancer care of soft tissue sarcomas in adults and bone sarcomas. High-quality care must only be carried out in specialised sarcoma centres (including paediatric cancer centres) which have both a core multidisciplinary team and an extended team of allied professionals, and which are subject to quality and audit procedures. Access to such units is far from universal in all European countries. It is essential that, to meet European aspirations for high-quality comprehensive cancer control, healthcare organisations implement the requirements in this paper, paying particular attention to multidisciplinarity and patient-centred pathways from diagnosis and follow-up, to treatment, to improve survival and quality of life for patients. Conclusion: Taken together, the information presented in this paper provides a comprehensive description of the essential requirements for establishing a high-quality service for soft tissue sarcomas in adults and bone sarcomas. The ECCO expert group is aware that it is not possible to propose a 'one size fits all' system for all countries, but urges that access to multidisciplinary teams is guaranteed to all patients with sarcoma. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.
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| 7. |
- Chhabra, Saurabh, et al.
(författare)
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Myeloablative vs reduced-intensity conditioning allogeneic hematopoietic cell transplantation for chronic myeloid leukemia
- 2018
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Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 2:21, s. 2922-2936
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Tidskriftsartikel (refereegranskat)abstract
- Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment of chronic myeloid leukemia (CML). Optimal conditioning intensity for allo-HCT for CML in the era of tyrosine kinase inhibitors (TKIs) is unknown. Using the Center for International Blood and Marrow Transplant Research database, we sought to determine whether reduced-intensity/nonmyeloablative conditioning (RIC) allo-HCT and myeloablative conditioning (MAC) result in similar outcomes in CML patients. We evaluated 1395 CML allo-HCT recipients between the ages of 18 and 60 years. The disease status at transplant was divided into the following categories: chronic phase 1, chronic phase 2 or greater, and accelerated phase. Patients in blast phase at transplant and alternative donor transplants were excluded. The primary outcome was overall survival (OS) after allo-HCT. MAC (n = 1204) and RIC allo-HCT recipients (n = 191) from 2007 to 2014 were included. Patient, disease, and transplantation characteristics were similar, with a few exceptions. Multivariable analysis showed no significant difference in OS between MAC and RIC groups. In addition, leukemia-free survival and nonrelapse mortality did not differ significantly between the 2 groups. Compared with MAC, the RIC group had a higher risk of early relapse after allo-HCT (hazard ratio [HR], 1.85; P = .001). The cumulative incidence of chronic graft-versus-host disease (cGVHD) was lower with RIC than with MAC (HR, 0.77; P = .02). RIC provides similar survival and lower cGVHD compared with MAC and therefore may be a reasonable alternative to MAC for CML patients in the TKI era.
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| 8. |
- DeFilipp, Zachariah, et al.
(författare)
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Maintenance Tyrosine Kinase Inhibitors Following Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia : A Center for International Blood and Marrow Transplant Research Study
- 2020
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier. - 1083-8791 .- 1523-6536. ; 26:3, s. 472-479
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Tidskriftsartikel (refereegranskat)abstract
- It remains unknown whether the administration of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 after allogeneic hematopoietic cell transplantation (HCT) is associated with improved outcomes for patients with chronic myelogenous leukemia (CML). In this registry study, we analyzed clinical outcomes of 390 adult patients with CML who underwent transplantation between 2007 and 2014 and received maintenance TKI following HCT (n = 89) compared with no TKI maintenance (n = 301), as reported to the Center for International Blood and Marrow Transplant Research. All patients received TKI therapy before HCT. The majority of patients had a disease status of first chronic phase at HCT (n = 240; 62%). The study was conducted as a landmark analysis, excluding patients who died, relapsed, had chronic graft-versus-host disease, or were censored before day +100 following HCT. Of the 89 patients who received TKI maintenance, 77 (87%) received a single TKI and the other 12 (13%) received multiple sequential TKIs. The most common TKIs used for maintenance were dasatinib (n = 50), imatinib (n = 27), and nilotinib (n = 27). As measured from day +100, the adjusted estimates for 5-year relapse (maintenance, 35% versus no maintenance, 26%; P = .11), leukemia-free survival (maintenance, 42% versus no maintenance, 44%; P = .65), or overall survival (maintenance, 61% versus no maintenance, 57%; P = .61) did not differ significantly between patients receiving TKI maintenance or no maintenance. These results remained unchanged in multivariate analysis and were not modified by disease status before transplantation. In conclusion, our data from this day +100 landmark analysis do not demonstrate a significant impact of maintenance TKI therapy on clinical outcomes. The optimal approach to TKI administration in the post-transplantation setting in patients with CML remains undetermined.
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| 9. |
- Dinegdae, Yared, 1981-, et al.
(författare)
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Calibrating ERAPave PP with field performance data
- 2024
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The conventional pavement design approach considers various parameters for the optimization of pavements for the prevailing traffic and environmental conditions. Demands related to technological developments, climate adaptation and infrastructure resilience are expected to influence the way pavements are designed and constructed. For this, better and improved flexible pavement design tools are required. ERAPave performance prediction (PP) which is a mechanistic-empirical (M-E) pavement design tool is currently under development with the goal of addressing the several challenges facing the pavement industry. This paper calibrates the permanent deformation prediction approach in ERAPave PP using pavement performance data from actual field pavements. As traffic volume is observed to have a significant influence on predicted results, separate calibration was performed for medium-to-high-volume and low-volume traffic categories. A global calibration factor is used for this purpose, significantly improving the accuracy of the prediction for both categories. Prediction accuracy can be improved further through the consideration of observed rut depth variability.
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| 10. |
- Dinegdae, Yared, 1981-, et al.
(författare)
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ERAPave PP calibration using field pavement sections
- 2024
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Ingår i: Sammanställning av postrar från Transportforum 2024. - Linköping : Statens väg- och transportforskningsinstitut.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Introduction - ERAPave PPMechanistic-empirical (M-E) pavement performance evaluation toolEmploys enhanced approaches for inputs characterization, pavement response modeling and performance evaluationPredicts distresses such as permanent deformation, fatigue cracking, frost heave and studded tire wearUnder consideration by the Swedish and Norwegian Transport Administration as a possible successor to existing methods
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| 11. |
- Dinegdae, Yared, 1981-, et al.
(författare)
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Evaluation of ERAPave PP permanent deformation models using APT
- 2023
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Ingår i: International Journal on Road Materials and Pavement Design. - : Taylor & Francis. - 1468-0629 .- 2164-7402. ; 25:sup1, s. 95-111
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Tidskriftsartikel (refereegranskat)abstract
- Permanent deformation is one of the failure modes considered in the analysis and design of flexible pavements. ERAPave performance prediction (PP) which is a mechanistic empirical (ME) pavement design tool utilises two distinct models for the prediction of permanent deformation in the bound and unbound granular layers including subgrade. This paper aims to calibrate these models using pavement response and performance data from accelerated pavement testing (APT) structures. Material properties such as layer modulus were established through an optimisation that involves both falling weight deflectometer (FWD) and pavement response measurements. Based on the predicted performance results, a separate set of calibration was performed for permanent deformation development in moist and wet moisture conditions. The calibrated models have resulted in predictions that are in good agreement with observed performances. Furthermore, the model parameters successfully captured the initial densification behaviour and the associated sensitivity with axle load level.
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| 12. |
- Dinegdae, Yared, 1981-, et al.
(författare)
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Implementation of energy-based models for pavement performance evaluation : Summary of results
- 2023
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Currently operational pavement design systems utilize empirical relationships to predict the long-term performance of pavement structures. These weak empirical couplings define the pavement response to environmental and traffic loads. The Swedish Transport Administration in close collaboration with the pavement industry has initiated a multi-year program with the aim of developing and implementing advanced models for Swedish conditions. The implementation of the program was carried out in phases and during these phases different activities were executed. This report presents and summarizes the main findings of the implementation project. The summary includes the development and enhancement of advanced material models and the incorporation of these models into a windows-based pavement analysis tool. Material models that are developed on the basis of micromechanics and mixture morphology are utilized for the prediction of asphalt mixture properties such as viscosity, shear modulus, phase angle, scalar modulus, creep rate and dynamic modulus. These material models account for factors such as temperature and rate of loading and are verified for a number of Swedish mixtures. The windows-based pavement analysis tool was developed using an interactive and dynamic Python programming language and incorporates energy-based methods for the prediction of rutting and cracking. The tool incorporates features for the prediction of pavement temperature profile and the integration of axle load spectra (ALS). The developed and enhanced material models have been observed to provide reasonable and acceptable predictions while the Windows-based pavement analysis tool is observed to be stable andefficient. The analysis of different scenarios has shown that the linear elastic analysis (LEA) based cracking model provides predictions that are reasonable. The finite element method (FEM) based cracking and rutting models, on the other hand, are observed to deliver results that are over exaggerated and unacceptable. To improve further the accuracy of predicted results, it is strongly recommended that both the rutting and cracking predictive models should be verified, calibrated and validated for Swedish conditions.
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| 13. |
- Dinegdae, Yared, 1981-, et al.
(författare)
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Structural response analysis of concrete pavement
- 2024
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Cement concrete or concrete pavements are an integral part of the road network in many countries. In the United States, concrete pavements comprise approximately 45% of the road network. In comparison, the share in Sweden is almost negligible. In 2007, the Swedish Transport Administration (Trafikverket) initiated in close collaboration with the paving industry a field project with the aim of building knowledge and understanding on the structural response of concrete pavements.This report aims to characterize the structural response of a concrete pavement under varying traffic and environmental conditions. This is achieved by utilizing in-situ strains, stresses and deflections measured over an extended period of time from a concrete test slab. The structural responses and environmental conditions were measured using strain gauges, geophones, soil pressure cells and temperature measuring sensors. These instruments were installed at different locations of interest within the concrete slab. Loading was applied using dynamic falling weights and heavy trucks that travel at different speed levels. The strain measurements from the heavy truck were used to establish a relationship between applied axle load level and induced strain at various location of the slab. The analyses have shown that the structural response of concrete pavements is highly dependent on both environmental and traffic loadings. It has also been observed that strain levels are speed dependent, slow-moving trucks inducing a higher magnitude of longitudinal and transverse strainsunder the wheel at the bottom of the slab. Increase in truck axle load level is also observed to increase the amount of induced strain for all the locations considered. It is important to further validate the experimental results with a numerical analysis that involve multi layered linear elastic analysis (MLEA) and finite element method (FEM). This allows to enhance the predictive models of the existing Swedish concrete pavement design method.
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| 14. |
- Dinegdae, Yared, 1981-, et al.
(författare)
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Toward a Comprehensive Pavement Reliability Analysis Approach
- 2023
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Ingår i: Transportation Research Record. - : Sage Publications. - 0361-1981 .- 2169-4052. ; 2677:7, s. 680-692
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Tidskriftsartikel (refereegranskat)abstract
- Reliability has been incorporated in pavement design tools to account for input variability influence on predicted performance. As they are not based on a probabilistic method of uncertainty propagation, the reliability analysis methodologies that are currently implemented in pavement performance tools lack rigor and robustness. This paper investigates the potential of three reliability analysis methodologies for pavement application: the Pavement ME reliability analysis methodology, Monte Carlo simulation (MCS), and the first-order reliability method (FORM). The MCS and FORM involve a response surface method for the generation of a second-order surrogate model. The investigation was performed using inputs and performance data from accelerated pavement testing structures. Inputs that were identified as significant were characterized as random variables and their associated variability was established using measured structural and material properties. Pavement performance with respect to rutting was predicted using the ERAPave performance prediction tool, while MCS was used to generate the actual variability of the distress. The reliability analysis results have shown that a comprehensive reliability analysis methodology is required that effectively captures input variabilities and the error associated with surrogate models.
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| 15. |
- Inamoto, Y., et al.
(författare)
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Non-Graft-versus-Host Disease Ocular Complications after Hematopoietic Cell Transplantation: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation
- 2019
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Ingår i: Biology of Blood and Marrow Transplantation. - : Elsevier BV. - 1083-8791. ; 25:5, s. E145-E154
-
Tidskriftsartikel (refereegranskat)abstract
- Non-graft-versus-host disease (GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT) but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplantation physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. We summarize the incidence, risk factors, screening, prevention, and treatment of individual complications and generate evidence-based recommendations. Baseline ocular evaluation before HCT should be considered in all patients who undergo HCT. Follow-up evaluations should be considered according to clinical signs and symptoms and risk factors. Better preventive strategies and treatments remain to be investigated for individual ocular complications after HCT. Both transplantation physicians and ophthalmologists should be knowledgeable about nonGVHD ocular complications and provide comprehensive collaborative team care. (C) 2018 American Society for Blood and Marrow Transplantation.
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| 16. |
- Inamoto, Y., et al.
(författare)
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Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT
- 2019
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Ingår i: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 54:5, s. 648-661
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Tidskriftsartikel (refereegranskat)abstract
- Non-graft-vs.-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment, and ocular toxicities associated with medications. We have summarized incidence, risk factors, screening, prevention and treatment of individual complicastions and generated evidence-based recommendations. Baseline ocular evaluation before HCT should be considered in all patients who undergo HCT. Follow-up evaluations should be considered according to clinical symptoms, signs and risk factors. Better preventive strategies and treatments remain to be investigated for individual ocular complications after HCT. Both transplant physicians and ophthalmologists should be knowledgeable of non-GVHD ocular complications and provide comprehensive collaborative team care.
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| 17. |
- Jagadeesh, Deepa, et al.
(författare)
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Outcomes of rituximab‐BEAM versus BEAM conditioning regimen in patients with diffuse large B cell lymphoma undergoing autologous transplantation
- 2020
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Ingår i: Cancer. - : WILEY. - 0008-543X .- 1097-0142. ; 126:10, s. 2279-2287
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Although rituximab-based high-dose therapy is frequently used in diffuse large B cell lymphoma (DLBCL) patients undergoing autologous hematopoietic cell transplantation (auto-HCT), data supporting the benefits are not available. Herein, we report the impact of rituximab-based conditioning on auto-HCT outcomes in patients who have DLBCL. METHODS Using the Center for International Blood and Marrow Transplant Research (CIBMTR) registry, 862 adult DLBCL patients undergoing auto-HCT between 2003 and 2017 using BEAM (BCNU, etoposide, cytarabine, melphalan) conditioning regimen were included. All patients received frontline rituximab-containing chemoimmunotherapy and had chemosensitive disease pre-HCT. Early chemoimmunotherapy failure was defined as not achieving complete remission (CR) after frontline chemoimmunotherapy or relapse within 1 year of initial diagnosis. The primary outcome was overall survival (OS). RESULTS The study cohort was divided into 2 groups: BEAM (n = 667) and R-BEAM (n = 195). On multivariate analysis, no significant difference was seen in OS (P = .83) or progression-free survival (PFS) (P = .61) across the 2 cohorts. No significant association between the use of rituximab and risk of relapse (P = .15) or nonrelapse mortality (P = .12) was observed. Variables independently associated with lower OS included older age at auto-HCT (P < .001), absence of CR at auto-HCT (P < .001) and early chemoimmunotherapy failure (P < .001). Older age (P < .0002) and non-CR pre-HCT (P < .0001) were also associated with inferior PFS. There was no significant difference in early infectious complications between the 2 cohorts. CONCLUSION In this large registry analysis of DLBCL patients undergoing auto-HCT, the addition of rituximab to the BEAM conditioning regimen had no impact on transplantation outcomes. Older age, absence of CR pre auto-HCT, and early chemoimmunotherapy failure were associated with inferior survival.
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| 18. |
- Kalaria, Raj, et al.
(författare)
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The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact.
- 2024
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Ingår i: Alzheimer's & dementia : the journal of the Alzheimer's Association. - 1552-5279.
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Tidskriftsartikel (refereegranskat)abstract
- Two of every three persons living with dementia reside in low- and middle-income countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of global dementia care costs occur in high-income countries (HICs), with dementia research predominantly focusing on HICs. This imbalance necessitates LMIC-focused research to ensure that characterization of dementia accurately reflects the involvement and specificities of diverse populations. Development of effective preventive, diagnostic, and therapeutic approaches for dementia in LMICs requires targeted, personalized, and harmonized efforts. Our article represents timely discussions at the 2022 Symposium on Dementia and Brain Aging in LMICs that identified the foremost opportunities to advance dementia research, differential diagnosis, use of neuropsychometric tools, awareness, and treatment options. We highlight key topics discussed at the meeting and provide future recommendations to foster a more equitable landscape for dementia prevention, diagnosis, care, policy, and management in LMICs. HIGHLIGHTS: Two-thirds of persons with dementia live in LMICs, yet research and costs are skewed toward HICs. LMICs expect dementia prevalence to more than double, accompanied by socioeconomic disparities. The 2022 Symposium on Dementia in LMICs addressed advances in research, diagnosis, prevention, and policy. The Nairobi Declaration urges global action to enhance dementia outcomes in LMICs.
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| 19. |
- Kanate, Abraham S., et al.
(författare)
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Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors
- 2016
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 127:7, s. 938-947
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Tidskriftsartikel (refereegranskat)abstract
- We evaluated 917 adult lymphoma patients who received haploidentical (n = 185) or HLA-matched unrelated donor (URD) transplantation either with (n = 241) or without antithymocyte globulin (ATG; n = 491) following reduced-intensity conditioning regimens. Haploidentical recipients received posttransplant cyclophosphamide-based graft-versus-host disease (GVHD) prophylaxis, whereas URD recipients received calcineurin inhibitor-based prophylaxis. Median follow-up of survivors was 3 years. The 100-day cumulative incidence of grade III-IV acute GVHD on univariate analysis was 8%, 12%, and 17% in the haploidentical, URD without ATG, and URD with ATG groups, respectively (P = .44). Corresponding 1-year rates of chronic GVHD on univariate analysis were 13%, 51%, and 33%, respectively (P < .001). On multivariate analysis, grade III-IV acute GVHD was higher in URD without ATG (P = .001), as well as URD with ATG (P = .01), relative to haploidentical transplants. Similarly, relative to haploidentical transplants, risk of chronic GVHD was higher in URD without ATG and URD with ATG (P < .0001). Cumulative incidence of relapse/progression at 3 years was 36%, 28%, and 36% in the haploidentical, URD without ATG, and URD with ATG groups, respectively (P = .07). Corresponding 3-year overall survival (OS) was 60%, 62%, and 50% in the 3 groups, respectively, with multivariate analysis showing no survival difference between URD without ATG (P = .21) or URD with ATG (P = .16), relative to haploidentical transplants. Multivariate analysis showed no difference between the 3 groups in terms of nonrelapse mortality (NRM), relapse/progression, and progression-free survival (PFS). These data suggest that reduced-intensity conditioning haploidentical transplantation with posttransplant cyclophosphamide does not compromise early survival outcomes compared with matched URD transplantation, and is associated with significantly reduced risk of chronic GVHD.
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| 20. |
- Lawler, M., et al.
(författare)
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The European Cancer Patient's Bill of Rights, update and implementation 2016
- 2016
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Ingår i: Esmo Open. - : Elsevier BV. - 2059-7029. ; 1:6
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Tidskriftsartikel (refereegranskat)abstract
- In this implementation phase of the European Cancer Patient's Bill of Rights (BoR), we confirm the following three patient-centred principles that underpin this initiative: 1. The right of every European citizen to receive the most accurate information and to be proactively involved in his/her care. 2. The right of every European citizen to optimal and timely access to a diagnosis and to appropriate specialised care, underpinned by research and innovation. 3. The right of every European citizen to receive care in health systems that ensure the best possible cancer prevention, the earliest possible diagnosis of their cancer, improved outcomes, patient rehabilitation, best quality of life and affordable health care. Agree our high-level goal. The vision of 70% longterm survival for patients with cancer in 2035, promoting cancer prevention and cancer control and the associated progress in ensuring good patient experience and quality of life. Establish the major mechanisms to underpin its delivery. (1) The systematic and rigorous sharing of best practice between and across European cancer healthcare systems and (2) the active promotion of Research and Innovation focused on improving outcomes; (3) Improving access to new and established cancer care by sharing best practice in the development, approval, procurement and reimbursement of cancer diagnostic tests and treatments. Work with other organisations to bring into being a Europe based centre that will (1) systematically identify, evaluate and validate and disseminate best practice in cancer management for the different countries and regions and (2) promote Research and Innovation and its translation to maximise its impact to improve outcomes.
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| 21. |
- Lawler, M., et al.
(författare)
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The European Code of Cancer Practice
- 2021
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Ingår i: Journal of Cancer Policy. - : Elsevier BV. - 2213-5383. ; 28
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Tidskriftsartikel (refereegranskat)abstract
- There are considerable disparities between the quality of cancer care and clinical outcomes for cancer patients in different European countries, regions, hospitals and communities. These have persisted despite the introduction of many European and National Cancer Plans, an extensive portfolio of clinical guidelines and the existence of evidence based guidelines for the good practice in planning cancer healthcare systems. We describe the European Code of Cancer Practice which is a citizen and patient-centred accessible widely disseminated statement of the core requirements for good clinical cancer practice. The Code sets out 10 key overarching Rights of what a patient should expect from their healthcare system each supported by a plain language explanation. The Rights highlight the importance of equal access to affordable and optimal cancer care, good quality information about an individual patient's disease and treatment and about the quality and outcomes of the cancer service they will use. Specialised multidisciplinary cancer care teams, shared decision-making, research and innovation, a focus on quality of life, the integration of supportive and palliative care within oncology are all emphasised. There is a need for a systematic approach to supporting cancer survivors with a survivorship care plan including their rehabilitation, reintegration into society and return to work where appropriate without discrimination. The Code has been co-produced by a team of cancer patients, patient advocates and cancer professionals to bridge the gap between clinical guidelines, healthcare policies and patients' everyday experience. It is robustly evidence-based and supported by a comprehensive review of the medical literature and evidence for good clinical practice. The Code is strongly endorsed by Europe's professional and patient cancer organisations and the European Commission.
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| 22. |
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| 23. |
- Radivoyevitch, Tomas, et al.
(författare)
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Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma
- 2018
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Ingår i: Leukemia Research. - : Elsevier BV. - 0145-2126 .- 1873-5835. ; 74, s. 130-136
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Tidskriftsartikel (refereegranskat)abstract
- Background: Exposures to DNA-damaging drugs and ionizing radiations increase risks of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).Methods: 9028 recipients of hematopoietic cell autotransplants (1995-2010) for Hodgkin lymphoma (HL; n=916), non-Hodgkin lymphoma (NHL; n=3546) and plasma cell myeloma (PCM; n=4566), reported to the CIBMTR, were analyzed for risk of subsequent AML or MDS.Results: 335 MDS/ AML cases were diagnosed posttransplant (3.7%). Variables associated with an increased risk for AML or MDS in multivariate analyses were: (1) conditioning with total body radiation versus chemotherapy alone for HL (HR=4.0; 95% confidence interval [1.4, 11.6]) and NHL (HR=2.5 [1.1, 2.5]); (2) >= 3 versus 1 line of chemotherapy for NHL (HR=1.9 [1.3, 2.8]); and (3) subjects with NHL transplanted in 2005-2010 versus 1995-1999 (HR=2.1 [1.5, 3.1]). Using Surveillance, Epidemiology and End Results (SEER) data, we found risks for AML/ MDS in HL, NHL and PCM to be 5-10 times the background rate. In contrast, relative risks were 10-50 for AML and approximately 100 for MDS in the autotransplant cohort.Conclusions: There are substantial risks of AML and MDS after autotransplants for HL, NHL and PCM.
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| 24. |
- Rahman, Mohammad Shafiqur, 1978-, et al.
(författare)
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A model for the permanent deformation behavior of the unbound layers of pavements
- 2021
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Ingår i: Proceedings Eleventh International Conference on the Bearing Capacity of Roads, Railways and Airfields. - London : CRC Press. - 9781003222880 ; , s. 277-287
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This article presents a model for the permanent deformation (PD) behavior of unbound granular materials (UGMs) used in the base and subbase layers of pavement struc- tures. The model was developed based on multistage (MS) repeated load triaxial (RLT) test- ing. This is essentially a modified version of a previously developed model to better suit to field conditions in a simple and effective manner. The model was calibrated for eight com- monly used UGMs using MSRLT tests with a range of moisture contents. For validation, the calibrated models were used to predict the PD behavior of three of the UGMs in MSRLT tests with stress levels and moisture contents different from those used during the calibrations. This model showed better quality of fit when compared with another widely used PD model. The model was further tested successfully for field conditions by capturing the PD behavior of an instrumented pavement test section in a controlled environment using a heavy vehicle simu- lator (HVS) based accelerated pavement testing (APT). Inputs for calibrating the model were based on the readings from the instrumentations. The parameters of the model were adjusted to match the measured data with the predictions. Based on these results for various design conditions, some ranges of values of the material parameters of the model were suggested.
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| 25. |
- Zhu, Jiqing, 1987-, et al.
(författare)
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Durability assessment of bio-extended bituminous binders by rheological characterisation after long-term ageing
- 2024
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Ingår i: 8th E&E (Eurasphalt & Eurobitume) Congress, Budapest, Hungary, 19-12 June, 2024.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The pursuit of sustainable road infrastructure is prompting extensive research into the utilization of bio-extended bituminous binders. This paper investigates the durability of bio-extended bituminous binders (both unmodified and polymer-modified) containing a plant-based bio-oil, aiming to assess their long-term performance. The research employed laboratory-scale tests and advanced rheological techniques to evaluate viscoelastic properties of the binders after long-term ageing. Accelerated ageing protocols were used to simulate prolonged exposure to environmental factors, including the Rolling Thin Film Oven Test (RTFOT) and Pressure Ageing Vessel (PAV) test. Dynamic Shear Rheometer (DSR) tests measured the shear modulus and phase angle of the binders under various conditions while Bending Beam Rheometer (BBR) tests measured the flexural creep stiffness at different low temperatures. Various performance indicators and specification parameters were analysed for the investigated binders regarding their resistance to both fatigue cracking at intermediate temperatures and thermal cracking at low temperatures.The results indicate that the bio-extended binders passed all the analysed criteria after RTFOT+PAV ageing. Using the investigated bio-oil in bituminous binders had largely a positive effect on the ΔTc and did not affect the standard performance low-temperature grade significantly. The bio-extended binders followed the same relationships between several durability-related performance indicators as the reference binders did. Certain slight negative effects could be noticed at low temperatures when the bio-oil content was high, but a further verification on the asphalt mixture scale will be necessary to assess if these effects are significant enough to impact the asphalt mixture performance in practical applications.
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| 26. |
- Zhu, Jiqing, 1987-, et al.
(författare)
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Experimental analysis and predictive modelling of linear viscoelastic response of asphalt mixture under dynamic shear loading
- 2022
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Ingår i: Construction and Building Materials. - : Elsevier. - 0950-0618 .- 1879-0526. ; 328
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Tidskriftsartikel (refereegranskat)abstract
- The use of predictive models can facilitate the inclusion of shear parameters in asphalt mixture evaluation and design processes. Unlike more extensively studied tension–compression models, the currently existing shear model, the Hirsch model, has unrealistic constants, particularly for the prediction of phase angle. Aiming at an improved predictive model in shear, this study employs a simple shear apparatus to experimentally analyse the linear viscoelastic properties of asphalt mixtures for road paving. Master curves were constructed and compared between different asphalt mixtures. Additionally, the test results were also analysed in the Black space and the Cole-Cole space. The dynamic shear response of asphalt mixtures was thereafter modelled on the basis of the Hirsch model. As the original model for phase angle prediction was found to be unrealistic, a particular focus in this study was put on identifying realistic empirical relationships for predicting the phase angle of asphalt mixtures in shear. More reliable shear test results of asphalt mixtures were used to calibrate the model, and extra test data were utilized to validate the calibrated model. It is indicated that the predictive model after calibration could deliver results of greatly improved accuracy, especially at the high-frequency and low-frequency ends. The analysis and modelling also leads to realistic empirical relationships for predicting the phase angle of asphalt mixtures in shear. The experimental verification confirms the good prediction accuracy of the calibrated model and proposed empirical relationships.
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| 27. |
- Zhu, Jiqing, 1987-, et al.
(författare)
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Investigation on Ageing Behaviour of Bio-Extended Bituminous Binders and Asphalt Mixtures for Sustainable Road Infrastructure
- 2024
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Ingår i: Transport Research Arena (TRA), Dublin, Ireland, 15 - 18 April, 2024.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper investigates the use of a plant-based bio-oil in bituminous binders as a partial replacement of petroleum-based bitumen for asphalt mixtures. Its effects on the ageing behaviour of bituminous binders and asphalt mixtures are studied. A total of six bituminous binders and their asphalt mixtures were prepared and analysed in laboratory, including three different binder formulations with varying percentages of bio-oil and their respective reference binders. Both the bituminous binders and asphalt mixtures were subjected to ageing protocols in laboratory. Softening point test, rheological and dynamic mechanical analyses were conducted to evaluate the changes in properties of the materials before and after ageing. The results indicate that the mechanical properties of aged binders and mixtures show very similar relationships as between the fresh materials, but the relationships after ageing are at changed levels due to the laboratory conditioning. This supports further studies to verify their functional performance in asphalt pavements.
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| 28. |
- Zhu, Jiqing, 1987-, et al.
(författare)
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Koldioxidavtryck av biobindemedel för asfalt : beräkningar från vagga till beläggningar
- 2024
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Ingår i: Sammanställning av referat från Transportforum 2024. - Linköping : Statens väg- och transportforskningsinstitut. ; , s. 411-412
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Bitumen används ofta som bindemedel i asfaltbeläggningar. Den relativt höga miljöpåverkan relaterade till användningen av bitumen medför dock utmaningar för asfaltbranschen, såsom beroende av icke-förnybara resurser, hög energiförbrukning och utsläpp av växthusgaser. Forskare undersöker användningen av förnybara biooljor, som de från sojabönor, rapsfrön, skogen och spillolja, som partiella ersättningar för att mildra dessa problem. Biooljor från växter är särskilt lovande på grund av deras hållbarhet och tillgänglighet. De hjälper till att minska asfaltbranschens beroende av fossila resurser och kan i vissa fall även förbättra bindemedels egenskaper som flexibilitet och vidhäftning till stenmaterial. Att bedöma deras långsiktiga hållbarhet och klimatpåverkan i asfaltbeläggningar kräver dock en utvärdering av koldioxidavtryck över olika faser av livscykeln. I denna studie genomförs en livscykelanalys (LCA) för asfaltbeläggningar tillverkade med bituminösa bindemedel som innehåller en växtbaserad bioolja från ett bioraffinaderi. Analysen fokuserar på koldioxidavtrycket. Beräkningar utförs ”från vagga till beläggningar” och omfattar utvinning och bearbetning av råmaterial i asfaltbeläggningar, transporter, tillverkning av asfalt, utläggning, och packningsarbete. Syftet med denna studie är att utvärdera kolavtrycket för de undersökta biobindemedlen och bedöma deras potentiella fördelar. För beläggningar med två asfaltlager som använder det undersökta biobindemedlet, visar denna LCA-studie att minskningen av GWP på grund av inflöde av biogent kol kan utgöra över 50% av den fossila GWP:n. Däremot har påverkan av utflöde och eventuellt utsläpp av biogent kol från det studerade systemet under senare livscykelfaser inte analyserats på grund av brist på tillgängliga data och metodik. Återanvändbarhet, återvinningsbarhet och långsiktig nedbrytbarhet hos biobindemedlet behöver fortfarande utvärderas i framtida studier för att täcka den fullständiga biogena kolflödet.
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