| 1. |
- Li, Xiaobin, et al.
(author)
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Knowledge graph based OPC UA information model automatic construction method for heterogeneous devices integration
- 2024
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In: Robotics and Computer-Integrated Manufacturing. - : Elsevier BV. - 0736-5845 .- 1879-2537. ; 88
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Journal article (peer-reviewed)abstract
- Emergent manufacturing paradigms, including ubiquitous manufacturing, social manufacturing, and agile manufacturing, facilitate the advancement of the manufacturing industry. However, these paradigms suffer from the difficulty of interoperability due to the heterogeneity of field devices and diverse communication protocols. The OLE for Process Control Unified Architecture (OPC UA) technique, which is featured with cross-platform, is considered as the pivotal technology for addressing this issue. However, there still exist a large number of heterogeneous devices which do not support OPC UA protocol. The communication protocols of these heterogeneous devices need to be converted into OPC UA based on information model, nevertheless, the manual construction of OPC UA information model is cumbersome and inefficient. In this paper, an integrated architecture based on reasoning over the OPC UA information model is proposed to realize rapid integration of heterogeneous devices to achieve interoperability. To realize the proposed integrated architecture, an automatic device information model construction method is developed simultaneously. The method first identifies the type of the newly accessed device based on the character-level TextCNN (CTCNN) model, which utilizes the word sequence extracted from the corresponding device data frame as input. Subsequently an open-world knowledge completion model is adopted to link the unseen entities in the device data frame to the information model knowledge graph(KG) to support the information model automatic construction for unknown device. For evaluation purpose, two industrial datasets are constructed and the results demonstrate the feasibility and effectiveness of the proposed method.
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| 2. |
- Ulfarsson, Elfar, et al.
(author)
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Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells : A novel therapeutic approach
- 2005
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In: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 11:13, s. 4674-4680
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Journal article (peer-reviewed)abstract
- Craniopharyngioma is a rare benign intracranial epithelial tumor that, however, often recurs and sometimes kills the affected patients, one-third of which are children. In many cases, the patients acquire growth hormone deficiency and postoperatively need substitution. Generally, growth hormone promotes local release of insulin-like growth factor I (IGF-I), which in turn activates the IGF-I receptor (IGF-IR) if present. Together, these circumstances raise the question whether IGF-IR may be involved in craniopharyngioma growth. To address this issue, we analyzed phenotypically well-characterized primary low-passage craniopharyngioma cell lines from nine different patients for IGF-IR expression and IGF-I dependency. Two of the cell lines showed no/very low expression of the receptor and was independent on IGF-I, whereas five cell lines exhibited a strong expression and was clearly contingent on IGF-I. The two remaining cell lines had low receptor expression and IGF-I dependency. Upon treatment with an IGF-IR inhibitor, cells with high IGF-IR expression responded promptly with decreased Akt phosphorylation followed by growth arrest. These responses were not seen in cells with no/very low receptor expression. Growth of cell lines with tow IGF-IR expression was only slightly affected by IGF-IR inhibition. Taken together, our data suggest that IGF-IR may be involved in the growth of a subset of craniopharyngiomas and points to the possibility of the involvement of IGF-IR inhibitors as a treatment modality to obtain complete tumor-free conditions before growth hormone substitution. © 2005 American Association for Cancer Research.
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