| 1. |
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| 2. |
- Ahlqvist-Rastad, Jane, et al.
(författare)
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Erythropoietin therapy and cancer related anaemia : updated Swedish recommendations
- 2007
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Ingår i: Medical Oncology. - : Springer Science and Business Media LLC. - 1357-0560 .- 1559-131X. ; 24:3, s. 267-272
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Tidskriftsartikel (refereegranskat)abstract
- Due to concerns related to treatment with erythropoietin (EPO) and possible negative effects on tumour control, a workshop was organised by the Medical Products Agency of Sweden with the aim to revise national treatment guidelines if needed. In patients with solid tumours, conflicting results have been reported with respect to tumour control and survival. Until further notice it is therefore recommended that EPO should be used restrictively in the treatment of patients with cancer and that the anticipated improvement in quality of life should be evaluated against potential risks.
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| 3. |
- Bolejko, Anetta, et al.
(författare)
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A roller coaster of emotions and sense : coping with the perceived psychosocial consequences of a false-positive screening mammography
- 2014
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Ingår i: Journal of Clinical Nursing. - : John Wiley & Sons. - 0962-1067 .- 1365-2702. ; 23:13-13, s. 2053-2062
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Tidskriftsartikel (refereegranskat)abstract
- Aims and objectives To explore coping with the perceived psychosocial consequences of a false-positive screening mammography. Background Mammographic screening has been found effective to decrease breast cancer (BC) mortality, yet there are adverse effects. Psychosocial consequences of false-positive mammographic screening have mainly been investigated from a population-based perspective. A call for qualitative studies to further explore these consequences has thus been postulated. To date, qualitative studies have elucidated women's experiences following their recall breast examinations, but their coping with perceived psychosocial consequences of a false-positive screening mammography has not yet been explored. Design An explorative qualitative study. Methods Face-to-face interviews were held with a purposive heterogeneous sample of 13 Swedish-speaking women with a false-positive screening mammography. The transcripts were analysed by the use of an inductive content analysis. Results Coping with the perceived psychosocial consequences of a false-positive screening mammography implied a roller coaster of emotion and sense. Women described how they imagined the worst and were in a state of uncertainty feeling threatened by a fatal disease. Conversely, they felt protected, surrounded by their families and being professionally taken care of, which together with perceived sisterhood and self-empowerment evoked strength and hope. Being aware of family responsibility became a crucial matter. Experiencing false-positive screening raised thoughts of thankfulness and reappraisal of life, although an ounce of BC anxiety remained. Consequently, gained awareness about BC screening and values in life surfaced. Conclusions Experiencing a false-positive screening mammography triggers agonising experiences evoking a variety of coping strategies. Provision of screening raises the issue of responsibility for an impact on psychosocial well-being among healthy women. Relevance to clinical practice Gained knowledge might provide a basis for interventions to prevent psychosocial consequences of false-positive mammographic screening and provide support for women with a potentially compromised ability to overcome such consequences.
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| 4. |
- Bolejko, Anetta, et al.
(författare)
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A roller coaster of emotions and sense : coping with the perceived psychosocial consequences of a false-positive screening mammography
- 2014
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Ingår i: Journal of Clinical Nursing. - : John Wiley & Sons. - 0962-1067 .- 1365-2702. ; 23:13-14, s. 2053-2062
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Tidskriftsartikel (refereegranskat)abstract
- Aims and objectives To explore coping with the perceived psychosocial consequences of a false-positive screening mammography. Background Mammographic screening has been found effective to decrease breast cancer (BC) mortality, yet there are adverse effects. Psychosocial consequences of false-positive mammographic screening have mainly been investigated from a population-based perspective. A call for qualitative studies to further explore these consequences has thus been postulated. To date, qualitative studies have elucidated women's experiences following their recall breast examinations, but their coping with perceived psychosocial consequences of a false-positive screening mammography has not yet been explored. Design An explorative qualitative study. Methods Face-to-face interviews were held with a purposive heterogeneous sample of 13 Swedish-speaking women with a false-positive screening mammography. The transcripts were analysed by the use of an inductive content analysis. Results Coping with the perceived psychosocial consequences of a false-positive screening mammography implied a roller coaster of emotion and sense. Women described how they imagined the worst and were in a state of uncertainty feeling threatened by a fatal disease. Conversely, they felt protected, surrounded by their families and being professionally taken care of, which together with perceived sisterhood and self-empowerment evoked strength and hope. Being aware of family responsibility became a crucial matter. Experiencing false-positive screening raised thoughts of thankfulness and reappraisal of life, although an ounce of BC anxiety remained. Consequently, gained awareness about BC screening and values in life surfaced. Conclusions Experiencing a false-positive screening mammography triggers agonising experiences evoking a variety of coping strategies. Provision of screening raises the issue of responsibility for an impact on psychosocial well-being among healthy women.
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| 5. |
- Bolejko, Anetta, et al.
(författare)
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Adaptation to Swedish and further development of the ‘Consequences of Screening – Breast Cancer’ questionnaire : a multimethod study
- 2013
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Ingår i: Scandinavian Journal of Caring Sciences. - : Springer. - 0283-9318 .- 1471-6712. ; 27:2, s. 475-486
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: Experiencing a false-positive screening mammography can cause considerable psychosocial distress. The Consequences of Screening – Breast Cancer questionnaire (COS-BC parts 1 and 2), recently developed in Denmark, is the only condition-specific questionnaire for measuring short- and long-term psychosocial consequences of false-positive mammographic screening. Additional studies are needed to further test the COS-BC before use across cultures. Furthermore, studies have suggested that the consequences of false-positive screening results are partly common across cancer screening settings, although this hypothesis remains largely untested.Objectives: This study (i) assesses content validity of a Swedish version of the COS-BC, (ii) tests whether items expressing long-term consequences of false-positive lung cancer screening results are relevant in a breast cancer screening context and (iii) explores the usefulness of taking results from Rasch analyses of the source version as an aid in questionnaire translation and adaptation.Methods: Following dual-panel translation, content validity was assessed through qualitative interviews with representatives of the target population and the content validity index (CVI). Item locations and Rasch model fit of the source questionnaires were considered in the translation and assessment process.Results: The COS-BC items were generally found relevant and provided coverage of the target construct. Content validity was supported also for nine of 10 lung cancer screening items. Scale CVI values were ≥0.81. Previous Rasch data were useful in facilitating translation and assessing item content validity. The resulting Swedish version of the COS-BC parts 1 and 2 consists of 34 and 23 items, respectively.Conclusion: This study illustrates the value of methodological triangulation and use of data from previous Rasch analyses in questionnaire translation and adaptation. We found support for the hypothesis that consequences of false-positive screening are common across cancer screening settings. Psychometric properties of the Swedish COS-BC remain to be established.
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| 6. |
- Bolejko, Anetta, et al.
(författare)
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Adaptation to Swedish and further development of the 'Consequences of Screening - Breast Cancer' questionnaire : a multimethod study
- 2013
-
Ingår i: Scandinavian Journal of Caring Sciences. - : Springer. - 0283-9318 .- 1471-6712. ; 27:2, s. 475-486
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Tidskriftsartikel (refereegranskat)abstract
- Experiencing a false-positive screening mammography can cause considerable psychosocial distress. The Consequences of Screening - Breast Cancer questionnaire (COS-BC parts 1 and 2), recently developed in Denmark, is the only condition-specific questionnaire for measuring short- and long-term psychosocial consequences of false-positive mammographic screening. Additional studies are needed to further test the COS-BC before use across cultures. Furthermore, studies have suggested that the consequences of false-positive screening results are partly common across cancer screening settings, although this hypothesis remains largely untested. This study (i) assesses content validity of a Swedish version of the COS-BC, (ii) tests whether items expressing long-term consequences of false-positive lung cancer screening results are relevant in a breast cancer screening context and (iii) explores the usefulness of taking results from Rasch analyses of the source version as an aid in questionnaire translation and adaptation.Following dual-panel translation, content validity was assessed through qualitative interviews with representatives of the target population and the content validity index (CVI). Item locations and Rasch model fit of the source questionnaires were considered in the translation and assessment process.The COS-BC items were generally found relevant and provided coverage of the target construct. Content validity was supported also for nine of 10 lung cancer screening items. Scale CVI values were ≥0.81. Previous Rasch data were useful in facilitating translation and assessing item content validity. The resulting Swedish version of the COS-BC parts 1 and 2 consists of 34 and 23 items, respectively. This study illustrates the value of methodological triangulation and use of data from previous Rasch analyses in questionnaire translation and adaptation. We found support for the hypothesis that consequences of false-positive screening are common across cancer screening settings. Psychometric properties of the Swedish COS-BC remain to be established.
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| 7. |
- Bolejko, Anetta, et al.
(författare)
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Prevalence, Long-term Development, and Predictors of Psychosocial Consequences of False-Positive Mammography among Women Attending Population-Based Screening
- 2015
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 24:9, s. 1388-1397
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Cancer screening aims to detect cancer at an asymptomatic stage, although side effects from screening also occur. We investigated the prevalence, longitudinal development, and predictors of psychosocial consequences of false-positive breast cancer screening. METHODS: Three hundred ninety-nine women with false-positive screening mammography responded to the Consequences of Screening-Breast Cancer (COS-BC) questionnaire immediately after a negative diagnosis (free from breast cancer) following recall examination(s) (baseline), and 6 and 12 months later. Age-matched controls (n = 499) with a negative mammogram responded to the COS-BC at the same occasions. Five COS-BC scales (Sense of dejection, Anxiety, Behavioral, Sleep, and Existential values) were used as outcome measures. RESULTS: Women with false-positive mammography had consistently higher prevalence of all five consequences compared with controls (P < 0.001). The prevalences decreased between baseline and 6 months (P < 0.001) but were stable between 6 and 12 months (P ≥ 0.136). Early recall profoundly predicted long-term consequences for all five outcomes (OR, 3.05-10.31), along with dissatisfaction with information at recall (OR, 2.28-2.56), being foreign-born (OR, 2.35-3.71), and lack of social support (OR, 1.13-1.25). CONCLUSION: This 1-year longitudinal study shows that women experience psychosocial consequences of false-positive screening mammography. Early recall should be performed cautiously, and provision of information as well as social support may reduce psychosocial consequences. IMPACT: Although delivery of population-based screening reduces breast cancer mortality, it also raises the issue of its impact on the psychosocial well-being of healthy women. Our findings identify predictors that can be targeted in future efforts to reduce the side effects of mammographic screening.
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| 8. |
- Bolejko, Anetta, et al.
(författare)
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Psychometric properties of a Swedish version of the Consequences of Screening : Breast Cancer questionnaire
- 2014
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Ingår i: Journal of Advanced Nursing. - : John Wiley & Sons. - 0309-2402 .- 1365-2648. ; 70:10, s. 2373-2388
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To evaluate the psychometric properties of a questionnaire addressing psychosocial consequences of false-positive mammographic screening.BACKGROUND: The Consequences of Screening - Breast Cancer and Lung Cancer questionnaires target psychosocial consequences of false-positive cancer screening. The Consequences of Screening - Breast Cancer questionnaire and ten items not considered lung cancer specific from the Lung Cancer questionnaire have been adapted for use in mammographic screening in Sweden, but remain psychometrically untested.DESIGN: Instrument development paper with psychometric cross-sectional and test-retest design.METHODS: Twelve scales of a Swedish questionnaire version were tested by the Rasch model and traditional psychometric methods. Women with false-positive (Group I, n = 640) and negative (Group II, n = 802) screening mammography responded to the study questionnaire and the Nottingham Health Profile during 2009-2011.RESULTS: Iterative analyses resulted in nine scales demonstrating Rasch model fit, but all scales exhibited poor targeting with relatively large floor effects. Corrected item-total correlations exceeded the recommended criterion. Score differences between Groups I and II and correlations with Nottingham Health Profile sections followed an expected pattern. Cronbach's α and test-retest reliability was acceptable for group-level assessments for ten and seven scales, respectively.CONCLUSIONS: Five scales (Sense of dejection, Anxiety, Behavioural, Sleep and Existential values) of the Swedish questionnaire version demonstrated the best psychometric properties. Other scales should be used more cautiously. Although filling an important gap, causes of concern were identified across scales. The questionnaire should therefore be considered for group-level assessments rather than for measurement of individual degrees of psychosocial consequences.
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| 9. |
- Bolejko, Anetta, et al.
(författare)
-
Psychometric properties of a Swedish version of the Consequences of Screening : Breast Cancer questionnaire
- 2014
-
Ingår i: Journal of Advanced Nursing. - : John Wiley & Sons. - 0309-2402 .- 1365-2648. ; 70:10, s. 2373-2388
-
Tidskriftsartikel (refereegranskat)abstract
- AIM: To evaluate the psychometric properties of a questionnaire addressing psychosocial consequences of false-positive mammographic screening. BACKGROUND: The Consequences of Screening--Breast Cancer and Lung Cancer questionnaires target psychosocial consequences of false-positive cancer screening. The Consequences of Screening--Breast Cancer questionnaire and ten items not considered lung cancer specific from the Lung Cancer questionnaire have been adapted for use in mammographic screening in Sweden, but remain psychometrically untested. DESIGN: Instrument development paper with psychometric cross-sectional and test-retest design. METHODS: Twelve scales of a Swedish questionnaire version were tested by the Rasch model and traditional psychometric methods. Women with false-positive (Group I, n = 640) and negative (Group II, n = 802) screening mammography responded to the study questionnaire and the Nottingham Health Profile during 2009-2011. RESULTS: Iterative analyses resulted in nine scales demonstrating Rasch model fit, but all scales exhibited poor targeting with relatively large floor effects. Corrected item-total correlations exceeded the recommended criterion. Score differences between Groups I and II and correlations with Nottingham Health Profile sections followed an expected pattern. Cronbach's α and test-retest reliability was acceptable for group-level assessments for ten and seven scales, respectively. CONCLUSIONS: Five scales (Sense of dejection, Anxiety, Behavioural, Sleep and Existential values) of the Swedish questionnaire version demonstrated the best psychometric properties. Other scales should be used more cautiously. Although filling an important gap, causes of concern were identified across scales. The questionnaire should therefore be considered for group-level assessments rather than for measurement of individual degrees of psychosocial consequences.
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| 10. |
- de Grijs, Richard, et al.
(författare)
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The NGC 5253 star cluster system - I. Standard modelling and infrared-excess sources
- 2013
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 431:3, s. 2917-2932
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Tidskriftsartikel (refereegranskat)abstract
- Using high-resolution Hubble Space Telescope data, we re-examine the fundamental properties (ages, masses and extinction values) of the rich star cluster population in the dwarf starburst galaxy NGC 5253. The gain in resolution compared to previous studies is of order a factor of 2 in both spatial dimensions, while our accessible wavelength range transcends previous studies by incorporation of both near-ultraviolet and near-infrared (IR) passbands. We apply spectral synthesis treatments based on two different simple stellar population model suites to our set of medium-, broad-band and H alpha images to gain an improved physical understanding of the IR-excess flux found for a subset of young clusters (30 of 149). With the caveat that our models are based on fully sampled stellar mass functions, the NGC 5253 cluster population is dominated by a significant number of relatively low-mass (M-cl less than or similar to a few x 10(4) M-circle dot) objects with ages ranging from a few x 10(6) to a few x 10(7) yr, which is in excellent agreement with the starburst age of the host galaxy. The IR-excess clusters are almost all found in this young age range and have masses of up to a few x 10(4) M-circle dot. The IR excess in the relatively low-mass NGC 5253 clusters is most likely caused by a combination of stochastic sampling effects and colour variations due to the presence of either luminous red or pre-main-sequence stars. We also find a small number of intermediate-age (similar to 1 Gyr old), similar to 10(5) M-circle dot clusters, as well as up to a dozen massive, similar to 10 Gyr old globular clusters. Their presence supports the notion that NGC 5253 is a very active galaxy that has undergone multiple episodes of star cluster formation.
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| 11. |
- Duval, Florent, et al.
(författare)
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The Lyman alpha reference sample VI. Lyman alpha escape from the edge-on disk galaxy Mrk 1486
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 587
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Tidskriftsartikel (refereegranskat)abstract
- Context. Recent numerical simulations suggest that the strength of the Lyman alpha (Ly alpha) line of star-forming disk galaxies strongly depends on the inclination at which they are observed: from edge-on to face-on, we expect to see a change from a strongly attenuated Ly alpha line to a strong Ly alpha emission line.Aims. We aim to understand how a strong Ly alpha emission line is able to escape from the low-redshift highly inclined (edge-on) disk galaxy Mrk 1486 (z similar to 0.0338). To our knowledge, this work is the first observational study of Ly alpha transport inside an edge-on disk galaxy.Methods. Using a large set of HST imaging and spectroscopic data, we investigated the interstellar medium (ISM) structure and the dominant source of Ly alpha radiation inside Mrk 1486. Moreover, using a 3D Monte Carlo Ly alpha radiation transfer code, we studied the radiative transfer of Ly alpha and UV continuum photons inside a 3D geometry of neutral hydrogen (HI) and dust that models the ISM structure at the galaxy center. Our numerical simulations predicted the Ly alpha line profile that we then compared to the one observed in the HST/COS spectrum of Mrk 1486.Results. While a pronounced Ly alpha absorption line emerges from the disk of Mrk 1486, very extended Ly alpha structures are observed at large radii from the galaxy center: a large Ly alpha-halo and two very bright Ly alpha regions located slightly above and below the disk plane. The analysis of IFU H alpha spectroscopic data of Mrk 1486 indicates the presence of two bipolar outflowing halos of HI gas at the same location as these two bright Ly alpha regions. Comparing different diagnostic diagrams (such as [OIII](5007)/H beta versus [OI](6300)/H alpha) to photo-and shock-ionization models, we find that the Ly alpha production of Mrk 1486 is dominated by photoionization inside the galaxy disk. From this perspective, our numerical simulations succeed in reproducing the strength and shape of the observed Ly alpha emission line of Mrk 1486 by assuming a scenario in which the Ly alpha photons are produced inside the galaxy disk, travel along the outflowing halos, and scatter on cool HI materials toward the observer.Conclusions. Extended bipolar galactic winds are frequently observed from star-forming disk galaxies. Given the advantage Ly alpha photons take of such outflowing HI materials to easily escape from Mrk 1486, this mechanism may explain the origin of strong Ly alpha emission lines frequently observed from highly inclined galaxies at high-redshift. This therefore challenges the robustness of the expected viewing-angle effect on the Ly alpha properties of star-forming disk galaxies.
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| 12. |
- Eriksson, Mikael, et al.
(författare)
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Identification of Women at High Risk of Breast Cancer Who Need Supplemental Screening
- 2020
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Ingår i: Radiology. - : Radiological Society of North America (RSNA). - 1527-1315 .- 0033-8419. ; 297:2, s. 327-333
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Tidskriftsartikel (refereegranskat)abstract
- Background Mammography screening reduces breast cancer mortality, but a proportion of breast cancers are missed and are detected at later stages or develop during between-screening intervals. Purpose To develop a risk model based on negative mammograms that identifies women likely to be diagnosed with breast cancer before or at the next screening examination. Materials and Methods This study was based on the prospective screening cohort Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA), 2011-2017. An image-based risk model was developed by using the Stratus method and computer-aided detection mammographic features (density, masses, microcalcifications), differences in the left and right breasts, and age. The lifestyle extended model included menopausal status, family history of breast cancer, body mass index, hormone replacement therapy, and use of tobacco and alcohol. The genetic extended model included a polygenic risk score with 313 single nucleotide polymorphisms. Age-adjusted relative risks and tumor subtype specific risks were estimated by using logistic regression, and absolute risks were calculated. Results Of 70 877 participants in the KARMA cohort, 974 incident cancers were sampled from 9376 healthy women (mean age, 54 years ± 10 [standard deviation]). The area under the receiver operating characteristic curve (AUC) for the image-based model was 0.73 (95% confidence interval [CI]: 0.71, 0.74). The AUCs for the lifestyle and genetic extended models were 0.74 (95% CI: 0.72, 0.75) and 0.77 (95% CI: 0.75, 0.79), respectively. There was a relative eightfold difference in risk between women at high risk and those at general risk. High-risk women were more likely to be diagnosed with stage II cancers and with tumors 20 mm or larger and were less likely to have stage I and estrogen receptor-positive tumors. The image-based model was validated in three external cohorts. Conclusion By combining three mammographic features, differences in the left and right breasts, and optionally lifestyle factors and family history and a polygenic risk score, the model identified women at high likelihood of being diagnosed with breast cancer within 2 years of a negative screening examination and in possible need of supplemental screening.
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| 13. |
- Gallo, Valentina, et al.
(författare)
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Social Inequalities and Mortality in Europe - Results from a Large Multi-National Cohort
- 2012
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:7
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Tidskriftsartikel (refereegranskat)abstract
- Background: Socio-economic inequalities in mortality are observed at the country level in both North America and Europe. The purpose of this work is to investigate the contribution of specific risk factors to social inequalities in cause-specific mortality using a large multi-country cohort of Europeans. Methods: A total of 3,456,689 person/years follow-up of the European Prospective Investigation into Cancer and Nutrition (EPIC) was analysed. Educational level of subjects coming from 9 European countries was recorded as proxy for socioeconomic status (SES). Cox proportional hazard model's with a step-wise inclusion of explanatory variables were used to explore the association between SES and mortality; a Relative Index of Inequality (RII) was calculated as measure of relative inequality. Results: Total mortality among men with the highest education level is reduced by 43% compared to men with the lowest (HR 0.57, 95% C.I. 0.52-0.61); among women by 29% (HR 0.71, 95% C.I. 0.64-0.78). The risk reduction was attenuated by 7% in men and 3% in women by the introduction of smoking and to a lesser extent (2% in men and 3% in women) by introducing body mass index and additional explanatory variables (alcohol consumption, leisure physical activity, fruit and vegetable intake) (3% in men and 5% in women). Social inequalities were highly statistically significant for all causes of death examined in men. In women, social inequalities were less strong, but statistically significant for all causes of death except for cancer-related mortality and injuries. Discussion: In this European study, substantial social inequalities in mortality among European men and women which cannot be fully explained away by accounting for known common risk factors for chronic diseases are reported.
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| 14. |
- Hsiao, Tiger Yu-Yang, et al.
(författare)
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JWST Reveals a Possible z similar to 11 Galaxy Merger in Triply Lensed MACS0647-JD
- 2023
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8205 .- 2041-8213. ; 949:2
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Tidskriftsartikel (refereegranskat)abstract
- MACS0647-JD is a triply lensed z similar to 11 galaxy originally discovered with the Hubble Space Telescope. The three lensed images are magnified by factors of similar to 8, 5, and 2 to AB mag 25.1, 25.6, and 26.6 at 3.5 mu m. The brightest is over a magnitude brighter than other galaxies recently discovered at similar redshifts z > 10 with JWST. Here, we report new JWST imaging that clearly resolves MACS0647-JD as having two components that are either merging galaxies or stellar complexes within a single galaxy. The brighter larger component "A" is intrinsically very blue (ss similar to-2.6 +/- 0.1), likely due to very recent star formation and no dust, and is spatially extended with an effective radius similar to 70 +/- 24 pc. The smaller component "B" (r similar to 20-+ 58 pc) appears redder (ss similar to-2 +/- 0.2), likely because it is older (100-200 Myr) with mild dust extinction (AV similar to 0.1 mag). With an estimated stellar mass ratio of roughly 2:1 and physical projected separation similar to 400 pc, we may be witnessing a galaxy merger 430 million years after the Big Bang. We identify galaxies with similar colors in a high-redshift simulation, finding their star formation histories to be dissimilar, which is also suggested by the spectral energy distribution fitting, suggesting they formed further apart. We also identify a candidate companion galaxy "C" similar to 3 kpc away, likely destined to merge with A and B. Upcoming JWST Near Infrared Spectrograph observations planned for 2023 January will deliver spectroscopic redshifts and more physical properties for these tiny magnified distant galaxies observed in the early universe.
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| 15. |
- Hörberg, Lisa, et al.
(författare)
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Reproducibility of measurements with a semi-automatic software package for the evaluation of rectal cancer
- 2020
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Ingår i: Acta Radiologica. - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 61:5, s. 586-594
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Tidskriftsartikel (refereegranskat)abstract
- Background: Staging of rectal cancer with MRI has major impact on treatment choice and may be of importance in new cancer management strategies such as “wait-and-see” policy. Purpose: To assess the reproducibility of a software package recently developed at our department to measure volumes, apparent diffusion coefficient, and the skewness of apparent diffusion coefficient in lymph nodes and tumors in rectal cancer patients before and after chemoradiation treatment. Material and Methods: This study included 20 consecutive patients with biopsy-verified rectal cancer, in whom MRI staging had been performed both before and after chemoradiation treatment. The diffusion-weighted images were transferred to the software. The volume, apparent diffusion coefficient, and skewness were determined for 93 lymph nodes and 40 tumors. The volumes were compared with manual measurements of the volume of the same lymph nodes and tumors. Results: The agreement in semi-automatic measurements of lymph nodes was very good (ICC = 0.99), and in tumors good (ICC = 0.88). The agreement in manual measurements of lymph nodes was very good (ICC = 0.95) when all lymph nodes were included, but low (ICC = 0.52) if three outliers were excluded. Bland–Altman plots showed clear agreement between manual and semi-automatic measurements in the lymph nodes, but not in measurements of tumors. The values of apparent diffusion coefficient and skewness in tumors differed before and after treatment but did not differ in lymph nodes as a group. Conclusion: The software package showed a high degree of reproducibility in measurements on lymph nodes but requires further development to improve the reproducibility of tumor measurements.
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| 16. |
- Landström, Anna, 1990, et al.
(författare)
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A life cycle approach to business performance measurement systems
- 2018
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Ingår i: Procedia Manufacturing. - : Elsevier BV. - 2351-9789. ; 25, s. 126-133, s. 126-133
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Konferensbidrag (refereegranskat)abstract
- Virtually every company has implemented a Business Performance Measurement System (BPMS) with the purpose of monitoring production and business performance and to execute the corporate strategy at all levels in a company. The purpose of this article is to shed light on common pitfalls related to the practical use of BPMS and further to present a life cycle model with the purpose of introducing structured approach to avoiding the pitfalls. The article contributes to further development of the BPMS life cycle concept and practical examples of how it can be used.
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| 17. |
- Landström, Anna, 1990, et al.
(författare)
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Present state analysis of BPMS in large manufacturing companies
- 2016
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Ingår i: Proceedings from PMA 2016, 10th conference of the Performance Measurement Association 26-29 June 2016 Edinburgh, Scotland.
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Konferensbidrag (refereegranskat)abstract
- The purpose of this article is to empirically investigate the present state of the performance measurement systems (PMS) at 7 sites of 6 different large Swedish manufacturingcompanies. The methodology has both a bottom-up and a top-down perspective. Important findings are that the PMSs are very similar in how they function but differ a lot in what ismeasured.
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| 18. |
- Landström, Anna, et al.
(författare)
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Present state analysis of business performance measurement systems in large manufacturing companies
- 2016
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Ingår i: PMA Conference 2016 PMA2016. - Edinburgh, United Kingdom. ; , s. 26-29
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Konferensbidrag (refereegranskat)abstract
- The purpose of this article is to empirically investigate the present state of the performance measurement systems (PMS) at 7 sites of 6 different large Swedish manufacturing companies. The methodology has both a bottom-up and a top-down perspective. Important findings are that the PMSs are very similar in how they function but differ a lot in what is measured.
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| 19. |
- Leufkens, Anke M, et al.
(författare)
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Educational level and risk of colorectal cancer in EPIC with specific reference to tumor location
- 2011
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Ingår i: International Journal of Cancer. - New York : Wiley-Blackwell. - 0020-7136 .- 1097-0215. ; 130:3, s. 622-630
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Tidskriftsartikel (refereegranskat)abstract
- Existing evidence is inconclusive on whether socioeconomic status (SES) and educational inequalities influence colorectal cancer (CRC) risk, and whether low or high SES/educational level is associated with developing CRC. The aim of our study was to investigate the relationship between educational level and CRC. We studied data from 400,510 participants in the EPIC (European Prospective Investigation into Cancer and Nutrition) study, of whom 2,447 developed CRC (colon: 1,551, rectum: 896, mean follow-up 8.3 years). Cox proportional hazard regression analysis stratified by age, gender and center, and adjusted for potential confounders were used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI). Relative indices of inequality (RII) for education were estimated using Cox regression models. We conducted separate analyses for tumor location, gender and geographical region. Compared with participants with college/university education, participants with vocational secondary education or less had a nonsignificantly lower risk of developing CRC. When further stratified for tumor location, adjusted risk estimates for the proximal colon were statistically significant for primary education or less (HR 0.73, 95%CI 0.57–0.94) and for vocational secondary education (HR 0.76, 95%CI 0.58–0.98). The inverse association between low education and CRC risk was particularly found in women and Southern Europe. These associations were statistically significant for CRC, for colon cancer and for proximal colon cancer. In conclusion, CRC risk, especially in the proximal colon, is lower in subjects with a lower educational level compared to those with a higher educational level. This association is most pronounced in women and Southern Europe.
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| 20. |
- Lindblom, Ulrika, et al.
(författare)
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Aspiration as a late complication after accelerated versus conventional radiotherapy in patients with head and neck cancer
- 2016
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Ingår i: Acta Oto-Laryngologica. - : Taylor & Francis. - 0001-6489 .- 1651-2251. ; 136:3, s. 304-311
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Tidskriftsartikel (refereegranskat)abstract
- Conclusion Neck dissection after radiotherapy increased the risk of aspiration as a late effect in a sub-sample of patients treated for head and neck cancer in the ARTSCAN study. Patients treated with accelerated fractionation (AF) developed aspiration, with or without coughing, more frequently than patients treated with conventional fractionation (CF). Objectives A long-term follow-up study was conducted to determine the frequency of aspiration as a late effect in patients with head and neck cancer treated with AF or CF. Method One-hundred and eight patients were recruited from two centres of the Swedish multi-centre study, ARTSCAN, where AF and CF were compared. Patients with positive lymph nodes were treated with neck dissection after completing radiotherapy. The follow-up was performed at a median of 65 months after initiation of radiotherapy and included an ENT and a videofluoroscopic examination. Results Aspiration was found in 51/108 (47%) and silent aspiration in 34/96 (35%) patients. Neck dissection (n = 47 patients) was significantly associated with both aspiration and silent aspiration. Aspiration was more common among patients treated with AF (34/61; 56%) compared to CF (17/47; 36%; p = 0.053). Silent aspiration was also more common after AF (24/54; 44%) than after CF (10/42; 24%; p = 0.052).
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| 21. |
- Lindblom, Ulrika, et al.
(författare)
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Radiation-induced trismus in the ARTSCAN head and neck trial.
- 2014
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Ingår i: Acta Oncologica. - : Informa Healthcare. - 1651-226X .- 0284-186X. ; 53:5, s. 620-627
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Tidskriftsartikel (refereegranskat)abstract
- Trismus, a well-known sequelae after treatment of head and neck cancer, decreases a patient's oral function and quality of life. The main objectives of this study were to: 1) investigate the long-term prevalence of radiation-induced trismus in patients treated for head and neck cancer according to two different fractionation schedules; and 2) model a dose-response relationship for trismus. Material and methods. Patients were recruited from the Swedish ARTSCAN trial, a prospective randomised multicentre study comparing conventional and accelerated fractionation. A total of 124 patients agreed to a clinical ENT examination 21-127 months (median 66 months) after beginning radiation therapy. Trismus-related scores were assessed using the EORTC H&N35 Quality of Life questionnaire. The TheraBite(®) range of motion scale was used to measure maximal interincisal distance. The dose-response relationship for structures important for mastication and the temporomandibular joints was investigated by normal tissue complication probability modelling. Results. No significant differences in patient-reported trismus or maximal interincisal distance were found between the two trial arms. Patient-reported moderate to high scores regarding trismus increased from 3% at the start of radiation therapy to 25% at the long-term follow-up. Maximal interincisal distance correlated significantly with patient-reported scores of trismus. The best dose-response fit to the endpoint data was found for the dose to the ipsilateral masseter. Conclusions. Trismus is a persistent complication after radiotherapy with 3D-conformal radiation therapy. We found no difference between the severity and prevalence of trismus between conventional and accelerated fractionation, but a significant correlation between the absorbed dose to the mastication structures and opening of the mouth. Further prospective studies may determine whether a reduced dose to structures important for mastication using intensity-modulated radiation therapy will reduce problems with trismus.
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| 22. |
- Linton, Peter, et al.
(författare)
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In Situ Observation of the Genesis of Mesoporous Silica SBA-15 : Dynamics on Length Scales from 1 nm to 1 mu m
- 2009
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 25:8, s. 4685-4691
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Tidskriftsartikel (refereegranskat)abstract
- We report on the mechanism of growth of mesoporous silica (SBA-15, plane group p6m). In situ studies of the formation using ultrasmall angle X-ray scattering (USAXS) and small-angle X-ray scattering (SAXS) covering length scales from 5 to 10000 A, complemented with UV-vis and transmission electron microscopy (TEM), provide unique data on particle growth coupled with information regarding the progression of the mesostructure formation and the micellar evolution.
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| 23. |
- Nabizadeh, Armin, et al.
(författare)
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A search for high-redshift direct-collapse black hole candidates in the PEARLS north ecliptic pole field
- 2024
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 683
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Tidskriftsartikel (refereegranskat)abstract
- Direct-collapse black holes (DCBHs) of mass ∼ 104-105 M⊙ that form in HI-cooling halos in the early Universe are promising progenitors of the greater than or similar to 109 M⊙ supermassive black holes that fuel observed z greater than or similar to 7 quasars. Efficient accretion of the surrounding gas onto such DCBH seeds may render them sufficiently bright for detection with the JWST up to z ≈ 20. Additionally, the very steep and red spectral slope predicted across the ≈ 1-5 μm wavelength range of the JWST/NIRSpec instrument during their initial growth phase should make them photometrically identifiable up to very high redshifts. In this work, we present a search for such DCBH candidates across the 34 arcmin2 in the first two spokes of the JWST cycle-1 PEARLS survey of the north ecliptic pole time-domain field covering eight NIRCam filters down to a maximum depth of ∼ 29 AB mag. We identify two objects with spectral energy distributions consistent with the Pacucci et al. (2016) DCBH models. However, we also note that even with data in eight NIRCam filters, objects of this type remain degenerate with dusty galaxies and obscured active galactic nuclei over a wide range of redshifts. Follow-up spectroscopy would be required to pin down the nature of these objects. Based on our sample of DCBH candidates and assumptions on the typical duration of the DCBH steep-slope state, we set a conservative upper limit of less than or similar to 5x10-4 comoving Mpc-3 (cMpc-3) on the comoving density of host halos capable of hosting DCBHs with spectral energy distributions similar to the Pacucci et al. (2016) models at z ≈ 6-14.
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| 24. |
- Olsson, Åsa, et al.
(författare)
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Overweight in relation to tumour size and axillary lymph node involvement in postmenopausal breast cancer patients-differences between women invited to vs. not invited to mammography in a randomized screening trial.
- 2009
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Ingår i: Cancer Epidemiology. - : Elsevier BV. - 1877-7821. ; 33:1, s. 41532-41532
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Overweight is associated with advanced stage at diagnosis in breast cancer patients. This could be explained by specific tumour characteristics or tumour promoting factors in the obese, but a diagnostic delay could also be of importance. Mammographic screening has caused a change towards diagnosis of less advanced tumours. This study investigates invitation to mammographic screening and the association between overweight and tumour size/axillary lymph node involvement at breast cancer diagnosis in postmenopausal women. METHODS: In 1976 a randomized mammographic screening trial, inviting 50% of all women aged 45-69 was set up in Malmö, Sweden. The present analysis examined overweight (body mass index >or=25) as a determinant for large tumours (>20mm) and axillary lymph node involvement in postmenopausal women. These associations were studied separately in patients diagnosed prior to the mammographic screening trial, in invited women and in non-invited subjects (controls). In all, 2478 postmenopausal women were diagnosed with invasive breast cancer in these groups between 1961 and 1991. Logistic regression analysis allowed adjustment for other potential determinants of tumours size and axillary lymph node involvement. RESULTS: In women diagnosed before the onset of the screening trial and in women not invited to mammography in the trial (controls), overweight was positively associated with large tumour size and axillary node involvement. There was no statistically significant association between overweight and these factors in women invited to mammographic screening. CONCLUSION: Invitation to mammographic screening may be particularly important for overweight postmenopausal women in order to detect breast tumours early.
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| 25. |
- Ottosson, Sandra, 1981-, et al.
(författare)
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Weight loss and Body Mass Index in relation to aspiration in patients treated for head and neck cancer : a long-term follow-up
- 2014
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Ingår i: Supportive Care in Cancer. - : Springer. - 0941-4355 .- 1433-7339. ; 22:9, s. 2361-2369
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Persistent severe swallowing dysfunction with aspiration is a common and sometimes overlooked sequelae after treatment for squamous cell carcinoma of the head and neck (SCCHN) and may impact food intake and nutritional status. More knowledge is needed to increase the understanding of severe swallowing dysfunction as a risk factor for persistent nutritional deteriorations in SCCHN survivors. The purpose of the study was to investigate weight loss and body mass index (BMI) in relation to pharyngeal swallowing function in a long-term perspective in patients after SCCHN treatment.METHODS: Data from 101 patients were available for the analyses. Swallowing function was assessed by videofluoroscopy at a mean of 71.6 months after the start of radiotherapy (RT). Percent weight change (calculated with weight at the start of RT as the reference) and BMI at follow-up were the primary nutritional measures.RESULTS: Aspiration was present in 48 of 101 patients (48 %). Patients with aspiration had a significantly higher mean weight loss and a lower BMI (-10.9 % and 23.1, respectively) at follow-up compared with patients without aspiration (-2.8 % and 26.0, respectively). Patients with aspiration were unable to gain weight after 23 months. Only ten of 101 patients (10 %) were underweight at follow-up.CONCLUSIONS: Swallowing dysfunction with aspiration was related to long-term weight loss and reduced BMI. Few patients were underweight despite the high prevalence of swallowing dysfunction.
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| 26. |
- Roger, Kevin, et al.
(författare)
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Superswollen Microemulsions Stabilized by Shear and Trapped by a Temperature Quench
- 2011
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 27:17, s. 10447-10454
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Tidskriftsartikel (refereegranskat)abstract
- We studied the solubilization of oil in the C16E8/hexadecane/H2O system. Close to the phase inversion temperature (PIT), the system, at equilibrium, can form either homogeneous states (i.e., microemulsions) at high surfactant concentrations or three-phase states at lower concentrations. We show that, under gentle shear, at a line we named the clearing boundary (CB), located a few degrees below the PIT, the system is homogeneous regardless of the surfactant concentration. We relate this shift of the microemulsion boundary to shear-induced disruption of the asymmetric bicontinuous structure. Although this state quickly relaxes to equilibrium when shear is stopped, we show that is still possible to trap it into a metastable state through a temperature quench. This method is the sub-PIT emulsification that we described in a previous work (Roger et al. Langmuir 2010, 26, 3860-3867).
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| 27. |
- Rydberg, Claes-Erik, 1972-, et al.
(författare)
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Detection of isolated Population III stars with the James Webb Space Telescope
- 2013
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 429:4, s. 3658-3664
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Tidskriftsartikel (refereegranskat)abstract
- The first Population III stars are predicted to form in minihaloes at z approximate to 10-30. The James Webb Space Telescope (JWST), tentatively scheduled for launch in 2018, will probably be able to detect some of the first galaxies, but whether it will also be able to detect the first stars remains more doubtful. Here, we explore the prospects of detecting an isolated Population III star or a small cluster of Population III stars down to z = 2 in either lensed or unlensed fields. Our calculations are based on realistic stellar atmospheres and take into account the potential flux contribution from the surrounding HII region. We find that unlensed Population III stars are beyond the reach of JWST, and that even lensed Population III stars will be extremely difficult to detect. However, the main problem with the latter approach is not necessarily that the lensed stars are too faint, but that their surface number densities are too low. To detect even one 60 M-circle dot Population III star when pointing JWST through the galaxy cluster MACS J0717.5+3745, the lensing cluster with the largest Einstein radius detected so far, the cosmic star formation rate of Population III stars would need to be approximately an order of magnitude higher than predicted by the most optimistic current models.
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| 28. |
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| 29. |
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| 30. |
- Wersäll, Carl, et al.
(författare)
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Stiffness of Ballastless Railway Embankments Determined by Repetitive Static Plate Load Tests
- 2023
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Ingår i: Transportation Infrastructure Geotechnology. - : Springer Nature. - 2196-7202 .- 2196-7210. ; 10:6, s. 1032-1049
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Tidskriftsartikel (refereegranskat)abstract
- In the repetitive static plate load test, a plate is loaded in two cycles where the second loading cycle provides a modulus denoted Ev2. When calculating the stiffness of a railway embankment, Young’s modulus is often assumed to be equal to Ev2 throughout the embankment. This approach, however, provides inaccurate results, mainly due to soil nonlinearity and the influence of confinement stress. Currently, there exists no method to account for these aspects to derive reliable deformation properties of embankments. Occasionally, correction factors are applied to Ev2, resulting in crude estimations. In this study, plate load tests were simulated in PLAXIS 2D using the Hardening Soil Model and calibrated against four field tests, conducted on crushed rock-fill sub-ballast. The calibrated soil properties were applied in finite element simulations of railway embankments with ballastless slab-track systems. Based on the results of finite element analyses, a semi-empirical approach is proposed, which considers confinement stress through a hyperbolic stress–strain relationship. Soil properties for compacted rock-fill with particle grading 0–150 mm were assumed through the results of the calibrated finite element analyses and the method was verified against 43 plate load tests. This semi-empirical method is more accurate than assuming a constant Young’s modulus, while maintaining simplicity and ease of use.
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| 31. |
- Wersäll, Carl, et al.
(författare)
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Är Ev2-modulen något att räkna med? : Utförande och tillämpning
- 2023
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Ingår i: Bygg och Teknik. - : Byggteknikförlaget. - 0281-658X .- 2002-8350. ; :1, s. 40-45
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Statiskt plattbelastningsförsök är en av de mest tillförlitliga metoderna för packningskontroll men styvheten som erhålls – även kallad bärighet – ska ses som en empirisk parameter som inte direkt kan översättas till jordmaterialets egenskaper i driftskedet. Detta eftersom plattbelastning utförs vid en betydligt högre spänningsnivå och med en mindre belastningsyta än för de flesta konstruktioner. Ofta används Ev2-modulen som ett direkt mått på E-modulen i beräkningar utan att ta hänsyn till jordens spännings- och töjningsberoende egenskaper. I denna artikel utforskas vad Ev2-modulen egentligen motsvarar och hur den kan användas till att beräkna deformationer. Med hjälp av mätresultat och FEM-simuleringar har en förenklad semi-empirisk metod utvecklats för att beräkna elastiska deformationer i driftskedet utifrån de resultat som erhålls i ett plattbelastningsförsök
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| 32. |
- Wilkins, Stephen M., et al.
(författare)
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First Light And Reionization Epoch Simulations (FLARES) VII : The star formation and metal enrichment histories of galaxies in the early Universe
- 2023
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press. - 0035-8711 .- 1365-2966. ; 518:3, s. 3935-3948
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Tidskriftsartikel (refereegranskat)abstract
- The star formation and metal enrichment histories of galaxies - at any epoch - constitute one of the key properties of galaxies, and their measurement is a core aim of observational extragalactic astronomy. The lack of deep rest-frame optical coverage at high redshift has made robust constraints elusive, but this is now changing thanks to JWST. In preparation for the constraints provided by JWST, we explore the star formation and metal enrichment histories of galaxies at z = 5-13 using the First Light And Reionization Epoch Simulations (FLARES) suite. Built on the EAGLE model, the unique strategy of FLARES allows us to simulate galaxies with a wide range of stellar masses (and luminosities) and environments. While we predict significant redshift evolution of average ages and specific star formation rates, our core result is mostly a flat relationship of age and specific star formation rate with stellar mass. We also find that galaxies in this epoch predominantly have strongly rising star formation histories, albeit with the normalization dropping with redshift and stellar mass. In terms of chemical enrichment, we predict a strong stellar mass-metallicity relation present at z = 10 and beyond alongside significant a-enhancement. Finally, we find no large-scale environmental dependence of the relationship between age, specific star formation rate, or metallicity with stellar mass.
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| 33. |
- Windhorst, Rogier A., et al.
(författare)
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JWST PEARLS. Prime extragalactic areas for reionization and lensing science : project overview and first results
- 2023
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Ingår i: Astronomical Journal. - : Institute of Physics (IOP). - 0004-6256 .- 1538-3881. ; 165:1
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Tidskriftsartikel (refereegranskat)abstract
- We give an overview and describe the rationale, methods, and first results from NIRCam images of the JWST “Prime Extragalactic Areas for Reionization and Lensing Science” (PEARLS) project. PEARLS uses up to eight NIRCam filters to survey several prime extragalactic survey areas: two fields at the North Ecliptic Pole (NEP); seven gravitationally lensing clusters; two high redshift protoclusters; and the iconic backlit VV 191 galaxy system to map its dust attenuation. PEARLS also includes NIRISS spectra for one of the NEP fields and NIRSpec spectra of two high-redshift quasars. The main goal of PEARLS is to study the epoch of galaxy assembly, active galactic nucleus (AGN) growth, and First Light. Five fields—the JWST NEP Time-Domain Field (TDF), IRAC Dark Field, and three lensing clusters—will be observed in up to four epochs over a year. The cadence and sensitivity of the imaging data are ideally suited to find faint variable objects such as weak AGN, high-redshift supernovae, and cluster caustic transits. Both NEP fields have sightlines through our Galaxy, providing significant numbers of very faint brown dwarfs whose proper motions can be studied. Observations from the first spoke in the NEP TDF are public. This paper presents our first PEARLS observations, their NIRCam data reduction and analysis, our first object catalogs, the 0.9–4.5 μm galaxy counts and Integrated Galaxy Light. We assess the JWST sky brightness in 13 NIRCam filters, yielding our first constraints to diffuse light at 0.9–4.5 μm. PEARLS is designed to be of lasting benefit to the community.
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| 34. |
- Zackrisson, Björn, 1954-, et al.
(författare)
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Biological Response, in vitro, to Pulsed High-dose Rate Electrons from a Clinical Accelerator
- 1991
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Ingår i: Acta Oncologica. - Oslo, Norway : Scandinavian University Press. - 0284-186X .- 1651-226X. ; 30:6, s. 747-751
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Tidskriftsartikel (refereegranskat)abstract
- Several studies of biological response to ionizing radiation of high absorbed dose rates have been performed, often with conflicting results. The aim of this study was to establish whether a difference between irradiation at high dose rates and at more conventional dose rates could be verified. Pulsed 50 MeV electrons from a clinical accelerator were used both for the high dose rate experiments (mean dose rate: 3.8 x 10(2) Gy/s) and the reference experiments (mean dose rate: 9.6 x 10(-2) Gy/s). In this study V-79 cells were irradiated in vitro. The experiments were carried out under both oxic and anoxic conditions. No significant difference in relative biological effectiveness (RBE) or oxygen enhancement ratio (OER) was observed at the different dose rates investigated.
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| 35. |
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| 36. |
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| 37. |
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| 38. |
- Zackrisson, Martin, et al.
(författare)
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Scan-o-matic: High-Resolution Microbial Phenomics at a Massive Scale
- 2016
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Ingår i: G3: Genes, Genomes, Genetics. - : Oxford University Press (OUP). - 2160-1836. ; 6:9, s. 3003-3014
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Tidskriftsartikel (refereegranskat)abstract
- The capacity to map traits over large cohorts of individuals—phenomics—lags far behind the explosive development in genomics. For microbes, the estimation of growth is the key phenotype because of its link to fitness. We introduce an automated microbial phenomics framework that delivers accurate, precise, and highly resolved growth phenotypes at an unprecedented scale. Advancements were achieved through the introduction of transmissive scanning hardware and software technology, frequent acquisition of exact colony population size measurements, extraction of population growth rates from growth curves, and removal of spatial bias by reference-surface normalization. Our prototype arrangement automatically records and analyzes close to 100,000 growth curves in parallel. We demonstrate the power of the approach by extending and nuancing the known salt-defense biology in baker’s yeast. The introduced framework represents a major advance in microbial phenomics by providing high-quality data for extensive cohorts of individuals and generating well-populated and standardized phenomics databases
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| 39. |
- Zackrisson, Malin, 1974, et al.
(författare)
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Structure, dynamics, and rheology of concentrated dispersions of poly(ethylene glycol)-grafted colloids.
- 2006
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Ingår i: Physical review. E, Statistical, nonlinear, and soft matter physics. - 1539-3755. ; 73:1 Pt 1
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Tidskriftsartikel (refereegranskat)abstract
- A comprehensive experimental study of the dynamics and rheology of concentrated aqueous dispersions of poly(ethylene glycol)-grafted colloidal spheres is reported. The study focuses on good solvent conditions, for which excluded-volume interactions dominate. At high concentrations a glass transition is evident from the nondecaying component of the intensity correlation function measured with three-dimensional dynamic light scattering. Results for the linear viscoelastic and steady shear rheology on approaching the glass transition correlate well with the slowing of the diffusive dynamics; in particular, at, or close to, the concentration where the dynamics becomes nonergodic, the dispersions acquire a low-frequency plateau in the elastic shear modulus as well as a yield stress. The overall behavior of the dispersions conforms to that of hard-sphere dispersions; however, some qualitative differences are observed in the evolution of the dynamics and rheology with increasing concentration near the glass transition.
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| 40. |
- Zackrisson, Mats, et al.
(författare)
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Sustainability Performance Indicators at Shop Floor Level in Large Manufacturing Companies
- 2017
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Ingår i: The 24th CIRP Conference on Life Cycle Engineering. - : Elsevier. ; 61, s. 457-462
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Konferensbidrag (refereegranskat)abstract
- This article investigates sustainability in the performance measurement systems of Swedish manufacturing companies. It builds on a previous study that documents relatively few direct environmental indicators at shop floor level, which raises questions about possible indirect links between existing indicators and the environment that could be used to improve the environmental aspect of company's sustainability ambitions. A method for identifying and categorizing indirect links to sustainability issues was defined and used. The results suggest that at shop floor level 90% of the indicators have at least an indirect relation to one or more of the sustainability dimensions economy, environment and social, of which 26% are at least indirectly related to the environmental dimension. Despite the many indirect connections, participating companies perceive a need to improve sustainability indicators and some ideas are suggested.
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| 41. |
- Zackrisson, Sophia, et al.
(författare)
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Rate of over-diagnosis of breast cancer 15 years after end of Malmö mammographic screening trial: follow-up study.
- 2006
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Ingår i: BMJ. - 0959-8138. ; 332:7543, s. 689-691
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Tidskriftsartikel (refereegranskat)abstract
- Objective To evaluate the rate of over-diagnosis of breast cancer 15 years after the end of the Malmo mammographic screening trial. Design Follow-up Study. Setting Malmo, Sweden. Subjects 42 283 women aged 45-69 years at randomisation. Interventions Screening for breast cancer with mammography or not (controls). Screening was offered at end of randomisation design to both groups aged 45-54 at randomisation but not to groups aged 55-69 at randomisation. Main outcome measures Rate of over-diagnosis of breast cancer (in situ and invasive), calculated as incidence in the invited and control groups, during period of randomised design (period 1), during period randomised design ended (period 2), and at end of follow-up. Results In women aged 55-69 years at randomisation the relative rates of over-diagnosis of breast cancer (95% confidence intervals) were 1.32 (1.14 to 1.53) for period 1, 0.92 (0.79 to 1.06) for period 2, and 1.10 (0.99 to 1.22) at the end of follow-up. Conclusion Conclusions on over-diagnosis of breast cancer in the Malmo mammographic screening trial can be drawn mainly in women aged 55-69 years at randomisation whose control groups were never screened. Fifteen years after die trial ended the rate of over-diagnosis of breast cancer was 10% in this age group.
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