| 1. |
- Füvesi, Judit, et al.
(författare)
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Proteomics of Cerebrospinal Fluid for Biomarker Discovery in Multiple Sclerosis
- 2013
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Ingår i: Clinical Laboratory International (CLI). - Brussels, Belgium : PanGlobal Media. - 1373-1580. ; 37, s. 29-31
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Tidskriftsartikel (refereegranskat)abstract
- The discovery of reliable biomarkers, which are eligible for the prediction of both disease progression and response to treatment, means a great challenge in the management of multiple sclerosis (MS), a devastating disease of the central nervous system. The results of recent proteomic findings from the cerebrospinal fluid of MS patients hold promise of finding ideal biomarkers in the near future.
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| 2. |
- Schutzer, Steven E., et al.
(författare)
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Gray Matter Is Targeted in First-Attack Multiple Sclerosis
- 2013
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:9, s. e66117-
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Tidskriftsartikel (refereegranskat)abstract
- The cause of multiple sclerosis (MS), its driving pathogenesis at the earliest stages, and what factors allow the first clinical attack to manifest remain unknown. Some imaging studies suggest gray rather than white matter may be involved early, and some postulate this may be predictive of developing MS. Other imaging studies are in conflict. To determine if there was objective molecular evidence of gray matter involvement in early MS we used high-resolution mass spectrometry to identify proteins in the cerebrospinal fluid (CSF) of first-attack MS patients (two independent groups) compared to established relapsing remitting (RR) MS and controls. We found that the CSF proteins in first-attack patients were differentially enriched for gray matter components (axon, neuron, synapse). Myelin components did not distinguish these groups. The results support that gray matter dysfunction is involved early in MS, and also may be integral for the initial clinical presentation.
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