| 1. |
- Loeber, JG, et al.
(författare)
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Neonatal Screening in Europe Revisited: An ISNS Perspective on the Current State and Developments Since 2010
- 2021
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Ingår i: International journal of neonatal screening. - : MDPI AG. - 2409-515X. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- Neonatal screening (NBS) was initiated in Europe during the 1960s with the screening for phenylketonuria. The panel of screened disorders (“conditions”) then gradually expanded, with a boost in the late 1990s with the introduction of tandem mass spectrometry (MS/MS), making it possible to screen for 40–50 conditions using a single blood spot. The most recent additions to screening programmes (screening for cystic fibrosis, severe combined immunodeficiency and spinal muscular atrophy) were assisted by or realised through the introduction of molecular technologies. For this survey, we collected data from 51 European countries. We report the developments between 2010 and 2020 and highlight the achievements reached with the progress made in this period. We also identify areas where further progress can be made, mainly by exchanging knowledge and learning from experiences in neighbouring countries. Between 2010 and 2020, most NBS programmes in geographical Europe matured considerably, both in terms of methodology (modernised) and with regard to the panel of conditions screened (expanded). These developments indicate that more collaboration in Europe through European organisations is gaining momentum. We can only accomplish the timely detection of newborn infants potentially suffering from one of the many rare diseases and take appropriate action by working together.
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| 2. |
- Boyle, R J, et al.
(författare)
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Nocturnal temperature controller laminar airflow for treating atopic asthma : a randomised controlled trial
- 2012
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Ingår i: Thorax. - : BMJ Publishing Group. - 0040-6376 .- 1468-3296. ; 67:3, s. 215-221
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Tidskriftsartikel (refereegranskat)abstract
- Objective To determine whether environmental control using nocturnal temperature controlled laminar airflow (TLA) treatment could improve the quality of life of patients with persistent atopic asthma. Design Randomised, double-blind, placebo-controlled, parallel-group trial. Setting Nineteen European asthma clinics. Participants 312 patients aged 7-70 with inadequately controlled persistent atopic asthma. Main outcome measure Proportion of patients with an increase of >= 0.5 points in asthma quality of life score after 1 year of treatment. Results TLA devices were successfully installed in the bedrooms of 282 (90%) patients included in the primary efficacy analysis. There was a difference in treatment response rate between active (143 of 189, 76%) and placebo (56 of 92, 61%) groups, difference 14.8% (95% CI 3.1 to 26.5, p=0.02).(3) In patients aged >= 12, on whom the study was powered, the difference in response rate was similar-active 106 of 143 (74%), placebo 42 of 70 (60%), difference 14.1% (0.6 to 27.7, p=0.059). There was a difference between groups in fractional exhaled nitric oxide change of -7.1 ppb (-13.6 to -0.7, p=0.03). Active treatment was associated with less increase in cat-specific IgE than placebo. There was no difference in adverse event rates between treatment groups. Conclusion Inhalant exposure reduction with TLA improves quality of life, airway inflammation and systemic allergy in patients with persistent atopic asthma. TLA may be a treatment option for patients with inadequately controlled persistent atopic asthma.
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| 3. |
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| 4. |
- Wannberg A, Mellergård A, Zetterström P, Delaplane R, Grönros M, Karlsson L-E, McGreevy R L
(författare)
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SLAD: A neutron diffractometer for the study of disordered materials
- 1999
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Ingår i: Journal of Neutron Research. - : Overseas Publisher Association. ; 8, s. 133-154
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Tidskriftsartikel (refereegranskat)abstract
- The Studsvik Liquid and Amorpous materials Diffractometer (SLAD)is a neutron diffractometer designed for measurements of the structure factor of liquids, glasses and amorphous materials, for total (i.e. Bragg and diffuse) scattering measurements from powd
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| 6. |
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| 7. |
- Curtis, Maurice A, et al.
(författare)
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Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension.
- 2007
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 315:5816, s. 1243-9
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Tidskriftsartikel (refereegranskat)abstract
- The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.
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| 9. |
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| 10. |
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| 11. |
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| 12. |
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| 13. |
- McGreevy R L, Zetterström P
(författare)
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Reverse Monte Carlo modelling of networl glasses: useful or useless?
- 2001
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Ingår i: Journal of Non-Crystalline Solids. - : ELSEVIER SCIENCE. - 0022-3093. ; 293-295, s. 297-303
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Tidskriftsartikel (refereegranskat)abstract
- It has been ten years since the first reverse Monte Carlo (RMC) modelling study of a glass (vitreous silica) was published. The aim of that early work was twofold: firstly to assess whether the experimental data alone would support the continuous random n
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| 14. |
- Peng, Ru, 1960-, et al.
(författare)
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Crystal structure and phase transformation in Ni53Mn 25Ga22 shape memory alloy from 20 K to 473 K
- 2005
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 87:11
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Tidskriftsartikel (refereegranskat)abstract
- The crystal structures, magnetic structures, and phase transformation of the off-stoichiometric Ni53 Mn25 Ga22 were studied by neutron powder diffraction at different temperatures. It is shown that Ni53 Mn25 Ga22 has a tetragonal I4/mmm structure from 20 K to 403 K. An abrupt jump in unit-cell volume around room temperature, corresponding to an endothermic peak in the differential scanning calorimetry curve, was observed. This indicates a pretransformation in the martensitic phase of Ni53 Mn25 Ga22, which is completely different from the phase transformation in the stoichiometric Ni2 MnGa. The sequence of structural transformation in Ni53 Mn25 Ga22 is closely related to its intrinsic temperature-dependent magnetic structure. © 2005 American Institute of Physics.
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| 15. |
- Peng, Yongmei, et al.
(författare)
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Fatty acid composition of diet, cord blood and breast milk in Chinese mothers with different dietary habits.
- 2009
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Ingår i: Prostaglandins, leukotrienes, and essential fatty acids. - : Elsevier BV. - 1532-2823 .- 0952-3278. ; 81:5-6, s. 325-30
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Tidskriftsartikel (refereegranskat)abstract
- The influence of two different dietary patterns on maternal fatty acid (FA) intake on the composition of umbilical cord blood plasma phospholipids and transitional breast milk was investigated. A 7-day dietary record was completed in the last trimester of pregnancy by women living in an inland and a coastal area of south-eastern China. The FA composition in maternal diet was calculated using the 2002 Chinese food composition database. Cord blood and transitional breast milk samples were collected and their FA composition was analyzed by capillary gas-liquid chromatography. Mothers in the coastal area showed higher intake of long-chain polyunsaturated FA (LCPUFA) including docosahexaenoic acid (DHA, 22:6omega) and eicosapentaenoic acid (EPA,20:5omega3) but lower linoleic acid (LA, 18:2omega6) and alpha-linolenic acid (ALA, 18:3omega3) than the mothers in the inland area. The intake of arachidonic acid (AA, 20:4omega6) did not differ between the two areas. LA, ALA, AA and DHA in breast milk of day 5 reflected the maternal diet except that the EPA content in breast milk at day 5 was similar for the areas. LA, ALA and AA were lower and EPA higher in umbilical cord plasma phospholipids in infants from the costal compared to the inland area. There were significant differences in maternal intakes of FA confirming different dietary habits, which influenced the FA composition of cord plasma phospholipids and transitional breast milk. Since FA influence gene expression the found variation implies that the long-term follow-up of this cohort will be interesting.
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| 19. |
- Tangeraas, T, et al.
(författare)
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Performance of Expanded Newborn Screening in Norway Supported by Post-Analytical Bioinformatics Tools and Rapid Second-Tier DNA Analyses
- 2020
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Ingår i: International journal of neonatal screening. - : MDPI AG. - 2409-515X. ; 6:3, s. 51-
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Tidskriftsartikel (refereegranskat)abstract
- In 2012, the Norwegian newborn screening program (NBS) was expanded (eNBS) from screening for two diseases to that for 23 diseases (20 inborn errors of metabolism, IEMs) and again in 2018, to include a total of 25 conditions (21 IEMs). Between 1 March 2012 and 29 February 2020, 461,369 newborns were screened for 20 IEMs in addition to phenylketonuria (PKU). Excluding PKU, there were 75 true-positive (TP) (1:6151) and 107 (1:4311) false-positive IEM cases. Twenty-one percent of the TP cases were symptomatic at the time of the NBS results, but in two-thirds, the screening result directed the exact diagnosis. Eighty-two percent of the TP cases had good health outcomes, evaluated in 2020. The yearly positive predictive value was increased from 26% to 54% by the use of the Region 4 Stork post-analytical interpretive tool (R4S)/Collaborative Laboratory Integrated Reports 2.0 (CLIR), second-tier biochemical testing and genetic confirmation using DNA extracted from the original dried blood spots. The incidence of IEMs increased by 46% after eNBS was introduced, predominantly due to the finding of attenuated phenotypes. The next step is defining which newborns would truly benefit from screening at the milder end of the disease spectrum. This will require coordinated international collaboration, including proper case definitions and outcome studies.
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| 20. |
- Zetterström, Olle, 1940-, et al.
(författare)
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Comparable morning versus evening administration of once-daily mometasone furoate dry powder inhaler
- 2008
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Ingår i: Respiratory Medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 102:10, s. 1406-1411
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Tidskriftsartikel (refereegranskat)abstract
- Background: The control of daytime and nighttime symptoms is an important measure of effectiveness of asthma therapy, especially, when administered once-daily. Objective: To evaluate the efficacy of evening and morning administrations of mometasone furoate administered via a dry powder inhaler (MF-DPI) 400 μg once-daily (QD) to show equivalence. Methods: Open-label, randomized, parallel-group study in adult patients with mild to moderate asthma with a ≥3-month history of ICS use. Patients received MF-DPI 400 μg QD either in the morning (AM) or evening (PM) for 12 weeks. The primary measure was the change in asthma symptoms from baseline to week 12. Secondary outcomes included response to treatment, adherence, inhaler device evaluation, use of rescue medication, urinary cortisol levels, and differential white blood cell count. Results: A total of 1537 patients were randomized, the efficacy population comprised 543 and 479 patients in the MF-DPI QD morning and evening groups, respectively. Mean improvements from baseline in daytime symptom scores at week 12 with morning and evening administration of MF-DPI 400 μg were -0.11 ± 0.59 and -0.12 ± 0.68, respectively (95% CI, -0.095 to 0.061) and the corresponding improvements in nighttime symptom scores were -0.08 ± 0.59 and -0.07 ± 0.50, respectively (95% CI, -0.067 to 0.068). Use of rescue medication was the same in both groups (1 puff/day). MF-DPI QD was well tolerated regardless of time of administration. Conclusions: This open-label study did not identify differences between morning and evening dosing of MF-DPI 400 μg QD. A better effect of evening dosing compared to morning dosing found in previous double-blind placebo-controlled studies could not be confirmed. © 2008 Elsevier Ltd. All rights reserved.
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| 21. |
- Zetterström, Olle, 1940-, et al.
(författare)
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Improved asthma control with budesonide/formeterol in a single inhaler, compared with budesonide alone
- 2001
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Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 18:2, s. 262-268
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Tidskriftsartikel (refereegranskat)abstract
- Budesonide/formoterol in a single inhaler was compared with budesonide alone, and with concurrent administration of budesonide and formoterol from separate inhalers, in patients with asthma, not controlled with inhaled glucocorticosteroids alone. In this 12-week, double-blind, randomized, double-dummy study, 362 adult asthmatics (forced expiratory volume in one second 73.8% of predicted, inhaled glucocorticosteroid dose 960 ╡g╖day-1) received single inhaler budesonide/formoterol (Symbicort « Turbuhaler «) 160/4.5 ╡g, two inhalations b.i.d., or corresponding treatment with budesonide, or budesonide plus formoterol via separate inhalers. There was a greater increase in morning peak expiratory flow (PEF) with single-inhaler (35.7 L╖min-1) and separate-inhaler (32.0 L╖min-1) budesonide and formoterol, compared with budesonide alone (0.2 L╖min-1, p<0.001, both comparisons), the effect was apparent after 1 day (p<0.001 versus budesonide, both comparisons). Similarly, evening PEF, use of rescue medication, total asthma symptom scores and percentage of symptom-free days improved more with both single inhaler and separate inhaler therapy than with budesonide alone, as did asthma control days (~15% more, p<0.001 versus budesonide, both comparisons, with a marked increase in the first week). All treatments were well tolerated and the adverse event profile was similar in all three treatment groups. It is concluded that single inhaler therapy with budesonide and formoterol is a clinically effective and well-tolerated treatment for patients with asthma that is not fully controlled by inhaled glucocorticosteroids alone.
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| 22. |
- Zetterström, Oskar, et al.
(författare)
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Reducing the Dispersion of Periodic Structures with Twist and Polar Glide Symmetries
- 2017
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- In this article, a number of guiding structures are proposed which take advantage of higher symmetries to vastly reduce the dispersion. These higher symmetries are obtained by executing additional geometrical operations to introduce more than one period into the unit cell of a periodic structure. The specific symmetry operations employed here are a combination of p-fold twist and polar glide. Our dispersion analysis shows that a mode in a structure possessing higher symmetries is less dispersive than in a conventional structure. It is also demonstrated that, similar to the previously studied Cartesian glide-symmetric structures, polar glide-symmetric structures also exhibit a frequency independent response. Promising applications of these structures are leaky-wave antennas which utilize the low frequency dependence.
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| 23. |
- Zetterström, Olle, et al.
(författare)
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The whole story : Treatment outcomes with Symbicort®
- 2002
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Ingår i: Respiratory Medicine. - 0954-6111 .- 1532-3064. ; 96:SUPPL. 1
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Forskningsöversikt (refereegranskat)abstract
- Asthma is a chronic inflammatory disorder of the airways that has a considerable socioeconomic impact. Asthma management guidelines have been introduced to help provide better long-term control of asthma. Although recommended guidelines may increase the direct medication costs, the overall direct costs of asthma may be reduced due to fewer exacerbations. In addition, indirect costs due to lost productivity and mortality are reduced and patients have an improved quality of life. Inhaled corticosteroids are first-line therapy in the treatment of persistent asthma. Against this background, we have assessed the cost-effectiveness of Symbicort® (budesonide and formoterol in a single inhaler), a treatment that provides better control of asthma compared with budesonide alone. While the prescribing costs of Symbicort® were found to be higher than for budesonide alone, these were partially offset by reduced costs due to fewer asthma exacerbations and a reduced need for other medications. Combined long-term therapy with budesonide and formoterol also improves patient quality of life compared with budesonide alone. Two other factors associated with asthma treatment success and cost-effectiveness are patient/physician education and good patient adherence to prescribed therapy. The introduction of a single inhaler that is easy to use in simple treatment regimens may improve patient adherence to prescribed medication, thus resulting in improved asthma control and fewer exacerbations. Treatment with Symbicort® is more cost-effective than treatment with budesonide alone. © 2002 Elsevier Science Ltd.
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| 24. |
- Zetterström, Olle, 1940-, et al.
(författare)
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The whole story : treatment outcomes with Symbicort?
- 2002
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Ingår i: Respiratory Medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 96:Supplement A, s. 29-35
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Tidskriftsartikel (refereegranskat)abstract
- Asthma is a chronic inflammatory disorder of the airways that has a considerable socioeconomic impact. Asthma management guidelines have been introduced to help provide better long-term control of asthma. Although recommended guidelines may increase the direct medication costs, the overall direct costs of asthma may be reduced due to fewer exacerbations. In addition, indirect costs due to lost productivity and mortality are reduced and patients have an improved quality of life. Inhaled corticosteroids are first-line therapy in the treatment of persistent asthma. Against this background, we have assessed the cost-effectiveness of Symbicort(R) (budesonide and formoterol in a single inhaler), a treatment that provides better control of asthma compared with budesonide alone. While the prescribing costs of Symbicort(R) were found to be higher than for budesonide alone, these were partially offset by reduced costs due to fewer asthma exacerbations and a reduced need for other medications. Combined long-term therapy with budesonide and formoterol also improves patient quality of life compared with budesonide alone. Two other factors associated with asthma treatment success and cost-effectiveness are patient/physician education and good patient adherence to prescribed therapy. The introduction of a single inhaler that is easy to use in simple treatment regimens may improve patient adherence to prescribed medication, thus resulting in improved asthma control and fewer exacerbations. Treatment with Symbicort(R) is more cost-effective than treatment with budesonide alone.
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| 25. |
- Zetterström P, Dahlborg U, Delaplane R G, Howells W S
(författare)
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Neutron diffraction studies of liquid iso-propanol
- 1991
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Ingår i: Physica Scripta. ; 44, s. 56-62
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Tidskriftsartikel (refereegranskat)abstract
- The structure of deuterated liquid iso-propanol has been studied with neutron diffraction at the LAD diffractometer at the ISIS spallation source. Measurements were performed at temperatures 190, 220, 250 and 275 K. To correctfor inelastic effects a model
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| 26. |
- Zetterström, P., et al.
(författare)
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Nanoscale defect clusters in metallic glasses
- 2007
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Ingår i: Journal of Physics. - : IOP Publishing. - 0953-8984 .- 1361-648X. ; 19:37, s. 376217-
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Tidskriftsartikel (refereegranskat)abstract
- The reverse Monte Carlo method was used to obtain three-dimensional discrete distributions of constitutional atoms in melt-spun CuZr and CuZrTi metallic glasses from neutron and x-ray diffraction data. It was found that the icosahedral short-range order is less stable in the CuZr binary alloy than in the Ti-doped ternary alloy. The present investigation also provides evidence on the medium-range order, characterized by some nanoscale clusters of defects, in the metallic-glassy state.
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| 27. |
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| 28. |
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| 29. |
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| 30. |
- Zetterström, R, et al.
(författare)
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Vårdbehov och vårdeffektivitet
- 1979
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 76, s. 711-12
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Tidskriftsartikel (refereegranskat)
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