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  • Audouze, Karine, et al. (author)
  • Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways : Challenges and Opportunities
  • 2021
  • In: Frontiers in Toxicology. - : Frontiers Media S.A.. - 2673-3080. ; 3
  • Journal article (peer-reviewed)abstract
    • A transformation of regulatory toxicology is underway to meet the demands of testing increasing numbers of chemicals whilst reducing reliance on in vivo models. This transformation requires a shift from chemical safety assessment largely based on direct empirical observation of apical toxicity outcomes in whole organisms to predictive approaches in which outcomes and risks are inferred from accumulated mechanistic understanding. 
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