SwePub - sökning: WFRF:(Zhang Fangfang)

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1.	Deng, Min, et al. (författare) Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis 2013 Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697- Tidskriftsartikel (refereegranskat)abstract To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
2.	Liu, Yanrong, et al. (författare) Ionic liquids/deep eutectic solvents for CO2 capture: Reviewing and evaluating 2021 Ingår i: Green Energy & Environment. - : Elsevier. - 2468-0257. ; 6:3, s. 314-328 Tidskriftsartikel (refereegranskat)abstract The CO2 solubilities (including CO2 Henry’s constant) in physical- and chemical-based ILs/DESs and the COSMO-RS models describing these properties were comprehensively collected and summarized. The summarized results indicate that chemical-based ILs/DESs are superior to physical-based ILs/DESs for CO2 capture, especially those ILs have functionalized cation and anion, and superbase DESs; some of the superbase DESs have higher CO2 solubilities than those of ILs; the best physical- and chemical-based ILs, as well as physical- and chemical-based DESs are [BMIM][BF4] (4.20 mol kg-1), [DETAH][Im] (11.91 mol kg-1), [L-Arg]-Gly 1:6 (4.92 mol kg-1) and TBD-EG 1:4 (12.90 mol kg-1), respectively. Besides the original COSMO-RS mainly providing qualitative predictions, six corrected COSMO-RS models have been proposed to improve the prediction performance based on the experimental data, but only one model is with universal parameters. The newly determined experimental results were further used to verify the perditions of original and corrected COSMO-RS models. The comparison indicates that the original COSMO-RS qualitatively predicts CO2 solubility for some but not all ILs/DESs, while the quantitative prediction is incapable at all. The original COSMO-RS is capable to predict CO2 Henry’s constant qualitatively for both physical-based ILs and DESs, and quantitative prediction is only available for DESs. For the corrected COSMO-RS models, only the model with universal parameters provides quantitative predictions for CO2 solubility in physical-based DESs, while other corrected models always show large deviations (>83%) compared with the experimental CO2 Henry’s constants.
3.	Yuan, Jun, et al. (författare) Understanding energetic disorder in electron-deficient-core-based non-fullerene solar cells 2020 Ingår i: Science in China Series B. - : SCIENCE PRESS. - 1674-7291 .- 1869-1870. ; 63:8, s. 1159-1168 Tidskriftsartikel (refereegranskat)abstract Recent advances in material design for organic solar cells (OSCs) are primarily focused on developing near-infrared non-fullerene acceptors, typically A-DA D-A type acceptors (where A abbreviates an electron-withdrawing moiety and D, an electron-donor moiety), to achieve high external quantum efficiency while maintaining low voltage loss. However, the charge transport is still constrained by unfavorable molecular conformations, resulting in high energetic disorder and limiting the device performance. Here, a facile design strategy is reported by introducing the "wing" (alkyl chains) at the terminal of the DA D central core of the A-DA D-A type acceptor to achieve a favorable and ordered molecular orientation and therefore facilitate charge carrier transport. Benefitting from the reduced disorder, the electron mobilities could be significantly enhanced for the "wing"-containing molecules. By carefully changing the length of alkyl chains, the mobility of acceptor has been tuned to match with that of donor, leading to a minimized charge imbalance factor and a high fill factor (FF). We further provide useful design strategies for highly efficient OSCs with high FF.
4.	Zhang, Zhibo, et al. (författare) Zinc-based deep eutectic solvent – An efficient carbonic anhydrase mimic for CO2 hydration and conversion 2021 Ingår i: Separation and Purification Technology. - : Elsevier. - 1383-5866 .- 1873-3794. ; 276 Tidskriftsartikel (refereegranskat)abstract Carbonic anhydrase (CA) has demonstrated great potential to mitigate CO2 emissions by enzymatic conversion of CO2, while its commercial implementation is limited by the inherent shortcomings of CA, such as thermal and chemical instability, high sensitivity to the environment, and high cost. To overcome the drawbacks of CA and develop advanced technologies for mitigating CO2 emission, for the first time, mimetic CA (ZnHisGly) with the characteristics of natural CA was designed and synthesized, i.e., zinc-based deep eutectic solvent (DES), to boost CO2 hydration and conversion. The mimetic CA exhibited facile synthesis, high stability, and low cost as the characteristics of DES, and showed better catalytic performance compared to the currently reported mimetic CA. Particularly, its catalytic performance increased greatly with increasing pH and temperatures, which provides promising prospects in the industrial applications of DES-based CA mimics.
5.	Li, Jiajia, et al. (författare) Recent Applications of Ionic Liquids in Quasi-Solid-State Lithium Metal Batteries 2021 Ingår i: Green Chemical Engineering. - : Elsevier. - 2666-9528. ; 2:3, s. 253-265 Forskningsöversikt (refereegranskat)abstract Quasi-solid-state lithium metal batteries are considered as one of the most promising energy storage devices, and the application of ionic liquids (ILs) as a new generation of functionalized electrolyte components in lithium metal batteries has become one of the research focuses. In this review, the very recent research work related to using IL to develop quasi-solid-state electrolytes and their influences on the performances of quasi-solid-state lithium metal batteries were surveyed and summarized, suggesting that the introduction of ILs can improve the ionic conductivity, broaden the electrochemical stability window, and enhance the electrochemical stability of selected electrolytes. Moreover, using ILs to prepare high-performance electrodes with unique microstructures and uniform distribution of fillers were also introduced. The composite quasi-solid-state electrolytes were suggested as the mainstream of electrolytes in the future due to the combination of the advantages of inorganic and polymer quasi-solid-state electrolytes, and their development challenges in high energy and high safety quasi-solid-state lithium metal batteries were also discussed.
6.	Liu, Huan, et al. (författare) The first human induced pluripotent stem cell line of Kashin–Beck disease reveals involvement of heparan sulfate proteoglycan biosynthesis and PPAR pathway 2022 Ingår i: The FEBS Journal. - : John Wiley & Sons. - 1742-464X .- 1742-4658. ; 289:1, s. 279-293 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE: Kashin-Beck disease (KBD) is an endemic osteochondropathy. Due to a lack of suitable animal or cellular disease models, the research progress on KBD has been limited. Our goal was to establish the first disease-specific human induced pluripotent stem cells (hiPSCs) cellular disease model of KBD, and to explore its etiology and pathogenesis exploiting transcriptome sequencing.METHODS: HiPSCs were reprogrammed from dermal fibroblasts of two KBD and one healthy control donors via integration-free vectors. Subsequently, hiPSCs were differentiated into chondrocytes through three-week culture. Gene expression profiles in KBD, normal primary chondrocytes and hiPSC-derived chondrocytes were defined by RNA sequencing. A Venn diagram was constructed to show the number of shared differentially expressed genes (DEGs) between KBD and normal. Gene oncology and Kyoto Encyclopedia of Genes and Genomes annotations were performed, and six DEGs were further validated in other individuals by real-time quantitative reverse transcription PCR (RT-qPCR).RESULTS: KBD cellular disease models were successfully established by generation of hiPSC lines. Seventeen consistent and significant DEGs present in all compared groups (KBD and normal) were identified. RT-qPCR validation gave consistent results with the sequencing data. Glycosaminoglycan biosynthesis-heparan sulfate/heparin, PPAR signaling pathway and cell adhesion molecules (CAMs) pathways were identified to be significantly altered in KBD.CONCLUSION: Differentiated chondrocytes deriving from KBD-origin hiPSCs provide the first cellular disease model for etiological studies of KBD. This study also provides new sights into the pathogenesis and etiology of KBD and is likely to inform the development of targeted therapeutics for its treatment.
7.	Song, Jiage, et al. (författare) Over 13% Efficient Organic Solar Cells Based on Low-Cost Pentacyclic A-DA D-A-Type Nonfullerene Acceptor 2021 Ingår i: Solar RRL. - : Wiley-Blackwell. - 2367-198X. ; 5:8 Tidskriftsartikel (refereegranskat)abstract Recent studies have almost focused on finding active layer materials with extended pi-conjugation structures for high-performance organic solar cells (OSCs). However, with the extension of conjugate length, the synthesis difficulty and cost of materials will increase. Achieving high efficiency while reducing material costs is a prerequisite for the commercialization of OSCs. Herein, two low-cost A-DA D-A-type (where A and D represent an electron-withdrawing unit and an electron-donating unit, respectively) nonfullerene acceptors (Y25,Y26) are synthesized with pentacyclic fused backbone as the DA D electron-deficient core and 5,6-difluoro-3-(dicyandiamethyl) indigo as the end groups. Compared with classical Y series acceptors with heptacyclic backbone, although Y25 and Y26 own the reduced conjugated length, they still show moderate performance (11.65% and 13.34%), and the cost of synthesis is significantly reduced. Therefore, we provide a new molecular design idea for commercially efficient nonfullerene OSCs acceptors. We also find that adding alkyl chains to the beta site of thiophenes is beneficial to obtaining the reduced energetic disorder, dominant molecular stacking, and desirable morphology, which can facilitate charge carrier transport and prompt higher short-circuit current density (J(sc)) as well as fill factor.
8.	Zhang, Sheng, et al. (författare) Full review : The progress and developing trends of nanosheet-based sensing applications 2021 Ingår i: Coordination chemistry reviews. - : Elsevier BV. - 0010-8545 .- 1873-3840. ; 433, s. 213742-213742 Tidskriftsartikel (refereegranskat)abstract Due to the extremely high area-to-thickness, nanosheets have become one of the rising research fields with vast applications. In comparison with other bulk materials, the 2D structure reveals unique physical (e.g., ultra-thin thickness, high flexibility and stretchability, excellent adhesion, etc.), electrochemical properties (e.g., superior electrical, catalytic properties, etc.) and expected to have immense potential for high-performance sensors. In this review, the state-of-the-art research in nanosheet-based sensing applications are discussed into three subtopics of the electrocatalytic sensor, gas sensor and epidermal sensor.
9.	Zhang, Yanan, et al. (författare) Identifying discriminative features for diagnosis of Kashin-Beck disease among adolescents 2021 Ingår i: BMC Musculoskeletal Disorders. - : BioMed Central. - 1471-2474. ; 22:1 Tidskriftsartikel (refereegranskat)abstract INTRODUCTION: Diagnosing Kashin-Beck disease (KBD) involves damages to multiple joints and carries variable clinical symptoms, posing great challenge to the diagnosis of KBD for clinical practitioners. However, it is still unclear which clinical features of KBD are more informative for the diagnosis of Kashin-Beck disease among adolescent.METHODS: We first manually extracted 26 possible features including clinical manifestations, and pathological changes of X-ray images from 400 KBD and 400 non-KBD adolescents. With such features, we performed four classification methods, i.e., random forest algorithms (RFA), artificial neural networks (ANNs), support vector machines (SVMs) and linear regression (LR) with four feature selection methods, i.e., RFA, minimum redundancy maximum relevance (mRMR), support vector machine recursive feature elimination (SVM-RFE) and Relief. The performance of diagnosis of KBD with respect to different classification models were evaluated by sensitivity, specificity, accuracy, and the area under the receiver operating characteristic (ROC) curve (AUC).RESULTS: Our results demonstrated that the 10 out of 26 discriminative features were displayed more powerful performance, regardless of the chosen of classification models and feature selection methods. These ten discriminative features were distal end of phalanges alterations, metaphysis alterations and carpals alterations and clinical manifestations of ankle joint movement limitation, enlarged finger joints, flexion of the distal part of fingers, elbow joint movement limitation, squatting limitation, deformed finger joints, wrist joint movement limitation.CONCLUSIONS: The selected ten discriminative features could provide a fast, effective diagnostic standard for KBD adolescents.
10.	Zhang, Zhibo, et al. (författare) Application and Challenge of Ionic Liquids as Co-solvent for Electro-enzymatic Conversion of CO2 to Methanol 2021 Ingår i: Proceedings of the Chinese Society of Electrical Engineering. - : Chinese Society for Electrical Engineering. - 0258-8013. ; 41:11, s. 3657-3665 Tidskriftsartikel (refereegranskat)abstract Utilization of carbon dioxide (CO2) has attracted great research interests, because CO2 is both a typical greenhouse gas and renewable carbon resource. This review mainly summarized and reviewed the research work linked to the challenges in the enzymatic conversion of CO2, such as NADH regeneration and low CO2 conversion efficiency. Based on the summary on the electro-enzymatic conversion of CO2, ionic liquids for the enzymatic conversion of CO2, and ionic liquids for the electrochemical conversion of CO2, we suggested applying ionic liquids as co-solvent in the enzymatic conversion of CO2 to methanol and coupling it with the reduction of NAD+ to NADH by electrocatalysis, providing a novel pathway for producing methanol from CO2.
11.	Zhang, Zhibo, et al. (författare) Novel artificial ionic cofactors for efficient electro-enzymatic conversion of CO2 to formic acid 2022 Ingår i: Journal of CO2 Utilization. - : Elsevier. - 2212-9820 .- 2212-9839. ; 60 Tidskriftsartikel (refereegranskat)abstract The low yield of enzymatic conversion of CO2 to formic acid as well as the high cost and instability of using the natural cofactor (NADH) hamper the large-scale application of the CO2 enzymatic utilization. To address these issues and to improve the production of formic acid, six bipyridinium-based artificial cofactors were developed for the enzymatic conversion of CO2 and further integrated with the electrocatalytic regeneration of the cofactors for the formic acid production. All of them did show a higher catalytic performance compared to NADH. Particularly, 1,1′-bis(2-(dimethylamino)ethyl)-4,4′-bipyridinium bromine did exhibit the highest catalytic performance with a high formic acid concentration of 4.76 mM in 60 min, which is 47 times higher than that of the natural cofactor NADH and is also currently the highest performance among the reported artificial cofactors in literature. Thermodynamic analysis, electrochemical investigations, and molecular dynamics simulations were performed to clarify the structure-energy relationship of the functional bipyridinium-based salts and to rationalize how it is affected by the different functional groups. This study gives a deep insight into the role of artificial cofactors in enzymatic reactions and can clearly promote the development of novel bioelectrochemical conversion of CO2.
12.	Ai, Chao, et al. (författare) Current Development on Origami/Kirigami‐Inspired Structure of Creased Patterns toward Robotics 2021 Ingår i: Advanced Engineering Materials. - : Wiley. - 1438-1656 .- 1527-2648. ; 23:10, s. 2100473-2100473 Tidskriftsartikel (refereegranskat)abstract Origami/kirigami, the ancient art of paper folding and cutting techniques, has provided considerable inspiration for structural design routes in the engineering and medical fields over the last few decades. The practicability of the methods and concepts of origami/kirigami has been demonstrated in several emerging classes of technologies, e.g., stretchable electronics, deformable devices, self-assembly fabrication, etc. More and more related products are produced pursuing a folding form for better storage, deformation capacity, and multifunction realization. Herein, the innovative creased patterns of origami/kirigami designs are distinguished and discussed, and the four most widely used creased pattern types are introduced, which may potentially provide origami/kirigami related inspiration and additional solutions toward many research fields.
13.	Guo, Xiong, et al. (författare) Kashin-Beck Disease (KBD) 2017 Ingår i: Endemic disease in China. - Beijing : People's Medical Publishing House. - 9787117247139 ; , s. 150-211 Bokkapitel (refereegranskat)
14.	Huang, He, et al. (författare) Material informatics for uranium-bearing equiatomic disordered solid solution alloys 2021 Ingår i: Materials Today Communications. - : Elsevier BV. - 2352-4928. ; 29 Tidskriftsartikel (refereegranskat)abstract Near-equiatomic, multi-component alloys with disordered solid solution phase (DSSP) are associated with outstanding performance in phase stability, mechanical properties and irradiation resistance, and may provide a feasible solution for developing novel uranium-based alloys with better fuel capacity. In this work, we build a machine learning (ML) model of disordered solid solution alloys (DSSAs) based on about 6000 known multicomponent alloys and several materials descriptors to efficiently predict the DSSAs formation ability. To fully optimize the ML model, we develop a multi-algorithm cross-verification approach in combination with the SHapley Additive exPlanations value (SHAP value). We find that the Delta S-C, Lambda, Phi(s), gamma and 1/Omega, corresponding to the former two Hume - Rothery (H - R) rules, are the most important materials descriptors affecting DSSAs formation ability. When the ML model is applied to the 375 uranium-bearing DSSAs, 190 of them are predicted to be the DSSAs never known before. 20 of these alloys were randomly synthesized and characterized. Our predictions are in-line with experiments with 3 inconsistent cases, suggesting that our strategy offers a fast and accurate way to predict novel multi-component alloys with high DSSAs formation ability. These findings shed considerable light on the mapping between the material descriptors and DSSAs formation ability.
15.	Jiang, Chongyang, et al. (författare) Aprotic phosphonium‐based ionic liquid as electrolyte for high CO2 electroreduction to oxalate 2023 Ingår i: AIChE Journal. - : John Wiley & Sons. - 0001-1541 .- 1547-5905. ; 69:2 Tidskriftsartikel (refereegranskat)abstract In this study, a new CO2 electroreduction electrolyte system consisting of tetrabutylphosphonium 4-(methoxycarbonyl) phenol ([P4444][4-MF-PhO]) ionic liquid (IL) and acetonitrile (AcN) was designed to produce oxalate, and the electroreduction mechanism was studied. The results show that using the new IL-based electrolyte, the electroreduction system exhibits 93.8% Faradaic efficiency and 12.6 mA cm−2 partial current density of oxalate at −2.6 V. The formation rate of oxalate is 234.4 μmol cm−2 h−1, which is better than those reported in the literature. The mechanism study using density functional theory (DFT) calculations reveals that [P4444][4-MF-PhO] can effectively activate CO2 molecule through ester and phenoxy double active sites. In addition, in the phosphonium-based ionic environment, the potential barriers of the key intermediates CO2− and C2O42− are reduced by the induced electric field, which greatly facilitates the activation and conversion of CO2 molecule to oxalate.
16.	Li, Fangfang, et al. (författare) Combination of CO2 electrochemical reduction and biomass gasification for producing methanol : A techno-economic assessment 2024 Ingår i: Energy Conversion and Management. - : Elsevier Ltd. - 0196-8904 .- 1879-2227. ; 307 Tidskriftsartikel (refereegranskat)abstract Combining CO2 electrochemical reduction (CO2R) and biomass gasification for producing methanol (CH3OH) is a promising option to increase the carbon efficiency, reduce total production cost (TPC), and realize the utilization of byproducts of CO2R system, but its viability has not been studied. In this work, systematic techno-economic assessments for the processes that combined CO2R to produce CO/syngas/CH3OH with biomass gasification were conducted and compared to stand-alone biomass gasification and CO2R processes, to identify the benefits and analyze the commercialization potential of different pathways under current and future conditions. The results demonstrated that the process that combined biomass gasification with CO2R to CO represents a viable pathway with a competitive TPC of 0.39 €/kg-CH3OH under the current condition. For all the combined cases, electricity usage for CO2R accounts for 36–76% of total operating cost, which plays a key role for TPC. Sensitivity analysis confirmed that the process that combined biomass gasification with CO2R to CO is sensitive to the price of electricity, while both CO2R performance and prices of stack and electricity are important for the processes that combined with CO2R to syngas/CH3OH.
17.	Li, Fangfang, et al. (författare) Combination of CO2 electrochemical reduction and biomass gasification for producing methanol: A techno-economic assessment 2024 Ingår i: Energy Conversion and Management. - : Elsevier. - 0196-8904 .- 1879-2227. ; 307 Tidskriftsartikel (refereegranskat)abstract Combining CO2 electrochemical reduction (CO2R) and biomass gasification for producing methanol (CH3OH) is a promising option to increase the carbon efficiency, reduce total production cost (TPC), and realize the utilization of byproducts of CO2R system, but its viability has not been studied. In this work, systematic techno-economic assessments for the processes that combined CO2R to produce CO/syngas/CH3OH with biomass gasification were conducted and compared to stand-alone biomass gasification and CO2R processes, to identify the benefits and analyze the commercialization potential of different pathways under current and future conditions. The results demonstrated that the process that combined biomass gasification with CO2R to CO represents a viable pathway with a competitive TPC of 0.39 €/kg-CH3OH under the current condition. For all the combined cases, electricity usage for CO2R accounts for 36–76% of total operating cost, which plays a key role for TPC. Sensitivity analysis confirmed that the process that combined biomass gasification with CO2R to CO is sensitive to the price of electricity, while both CO2R performance and prices of stack and electricity are important for the processes that combined with CO2R to syngas/CH3OH.
18.	Li, Fangfang, et al. (författare) Efficient and Reversible Chemisorption of Carbon Dioxide with Dianionic-Functionalized Ionic Liquid-Based Solvents 2020 Ingår i: Energy & Fuels. - : American Chemical Society (ACS). - 0887-0624 .- 1520-5029. ; 34:7, s. 8526-8533 Tidskriftsartikel (refereegranskat)abstract Developing carbon dioxide (CO2) capture technologies has caused worldwide interest because of the baneful influence of CO2 on climate change as a main greenhouse gas. Ionic liquids (ILs) are considered as potential absorbents for CO2 capture because of their unique properties compared with current amine-based solvents. In this work, new dianionic-functionalized IL-based solvents, bi(1,8-diazabicyclo[5.4.0]undec-7-ene) dimethylhydantoin/ethylene glycol ([(DBUH)(2)][Dhyd]/EG), were designed and prepared for efficient and reversible chemisorption of CO2. Among the absorbents, [(DBUH)(2)][Dhyd]/EG with a mass ratio of 5:5 exhibited not only a high CO2 absorption capacity of 0.11 g CO2 /g absorbent at 20 degrees C and 0.10 MPa but also good recyclability. Spectroscopic characterizations and simulation calculations confirmed that the superior CO2 capacity may be attributed to the simultaneous reaction of CO(2 )with both the [Dhyd](2)- anion and deprotonated EG. The excellent CO2 absorption and regeneration performance imply that [(DBUH)(2)][Dhyd]/EG solvents may have great industrial application potentials.
19.	Li, Fangfang, et al. (författare) Energy, Cost, and Environmental Assessments of Methanol Production via Electrochemical Reduction of CO2 from Biosyngas 2023 Ingår i: ACS Sustainable Chemistry and Engineering. - : American Chemical Society. - 2168-0485. ; 11:7, s. 2810-2818 Tidskriftsartikel (refereegranskat)abstract Electrochemical reduction of CO2 removed from biosyngas into value-added methanol (CH3OH) provides an attractive way to mitigate climate change, realize CO2 utilization, and improve the overall process efficiency of biomass gasification. However, the economic and environmental feasibilities of this technology are still unclear. In this work, economic and environmental assessments for the stand-alone CO2 electrochemical reduction (CO2R) toward CH3OH with ionic liquid as the electrolyte and the integrated process that combined CO2R with biomass gasification were conducted systematically to identify key economic drivers and provide technological indexes to be competitive. The results demonstrated that costs of investment associated with CO2R and electricity are the main contributors to the total production cost (TPC). Integration of CO2R with CO2 capture/purification and biomass gasification could decrease TPC by 28%-66% under the current and future conditions, highlighting the importance of process integration. Energy and environmental assessment revealed that the energy for CO2R dominated the main energy usage and CO2 emissions, and additionally, the energy structure has a great influence on environmental feasibility. All scenarios could provide climate benefits over the conventional coal-to-CH3OH process if renewable sources are used for electricity generation.
20.	Li, Fangfang, et al. (författare) Ionic liquids for CO2 electrochemical reduction 2021 Ingår i: Chinese Journal of Chemical Engineering. - : Elsevier. - 1004-9541 .- 2210-321X. ; 31, s. 75-93 Forskningsöversikt (refereegranskat)abstract Electrochemical reduction of CO2 is a novel research field towards a CO2-neutral global economy and combating fast accelerating and disastrous climate changes while finding new solutions to store renewable energy in value-added chemical and fuels. Ionic liquids (ILs), as medium and catalysts (or supporting part of catalysts) have been given wide attention in the electrochemical CO2 reduction reaction (CO2RR) due to their unique advantages in lowering overpotential and improving the product selectivity, as well as their designable and tunable properties. In this review, we have summarized the recent progress of CO2 electro-reduction in IL-based electrolytes to produce higher-value chemicals. We then have highlighted the unique enhancing effect of ILs on CO2RR as templates, precursors, and surface functional moieties of electrocatalytic materials. Finally, computational chemistry tools utilized to understand how the ILs facilitate the CO2RR or to propose the reaction mechanisms, generated intermediates and products have been discussed.
21.	Li, Fangfang, et al. (författare) Rotten Eggs Revaluated: Ionic Liquids and Deep Eutectic Solvents for Removal and Utilization of Hydrogen Sulfide 2022 Ingår i: Industrial & Engineering Chemistry Research. - : American Chemical Society (ACS). - 0888-5885 .- 1520-5045. ; 61:7, s. 2643-2671 Forskningsöversikt (refereegranskat)abstract Hydrogen sulfide (H2S) is highly toxic and one of the problematic impurities in industrial gas streams, calling for H2S removal down to single-digit ppm levels to protect health and environment, and not to harm to the downstream processes. Here, we discuss the recent developments and challenges of current H2S removal technologies. Furthermore, we present a comprehensive review of H2S removal in ionic liquids (ILs), IL-based solvents/adsorbents/membranes, and deep eutectic solvents (DESs) due to their unique advantages. We analyze theoretical studies to better understand the microscopic details behind H2S removal. We discuss new research on IL/DES-based H2S removal processes from an industrial perspective. Finally, we summarize the utilization of H2S in IL/DES-based systems for the recovery of sulfur and hydrogen, and synthesis of value-added chemicals. This review will provide both general and in-depth knowledge of the achievements, difficulties, and research priorities in developing novel ILs/DESs for efficient and sustainable H2S removal and utilization.
22.	Li, Yihao, et al. (författare) c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/beta-Catenin/Axin2 Pathway 2016 Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 76:11, s. 3364-3375 Tidskriftsartikel (refereegranskat)abstract The molecular underpinnings of aggressive breast cancers remain mainly obscure. Here we demonstrate that activation of the transcription factor c-Myb is required for the prometastatic character of basal breast cancers. An analysis of breast cancer patients led us to identify c-Myb as an activator of Wnt/beta-catenin signaling. c-Myb interacted with the intracellular Wnt effector beta-catenin and coactivated the Wnt/beta-catenin target genes Cyclin D1 and Axin2. Moreover, c-Myb controlled metastasis in an Axin2-dependent manner. Expression microarray analyses revealed a positive association between Axin2 and c-Myb, a target of the proinflammatory cytokine IL1 beta that was found to be required for IL1 beta-induced breast cancer cell invasion. Overall, our results identified c-Myb as a promoter of breast cancer invasion and metastasis through its ability to activate Wnt/beta-catenin/Axin2 signaling. (C) 2016 AACR.
23.	Li, Yangshuo, et al. (författare) Electrochemical CO2 reduction with ionic liquids: review and evaluation 2023 Ingår i: Industrial Chemistry & Materials. - : Royal Society of Chemistry. - 2755-2608 .- 2755-2500. ; 1:3, s. 410-430 Forskningsöversikt (refereegranskat)abstract The increasing CO2 emission, as the chief culprit causing numerous environmental problems, could be addressed by the electrochemical CO2 reduction (CO2R) to the added-value carbon-based chemicals. Ionic liquids (ILs) as electrolytes and co-catalysts have been widely studied to promote CO2R owing to their unique advantages. Among the potential products of CO2R, those only containing one carbon atom, named C1 products, including CO, CH3OH, CH4, and syngas, are easier to achieve than others. In this study, we first summarized the research status on CO2R to these C1 products, and then, the state-of-the-art experimental results were used to evaluate the economic potential and environmental impact. Considering the rapid development in CO2R, future scenarios with better CO2R performances were reasonably assumed to predict the future business for each product. Among the studied C1 products, the research focuses on CO, where satisfactory results have been achieved. The evaluation shows that producing CO via CO2R is the only profitable route at present. CH3OH and syngas of H2/CO (1 : 1) as the targeted products can become profitable in the foreseen future. In addition, the life cycle assessment (LCA) was used to evaluate the environmental impact, showing that CO2R to CH4 is the most environmentally friendly pathway, followed by the syngas of H2/CO (2 : 1) and CO, and the further improvement of the CO2R performance can make all the studied C1 products more environmentally friendly. Overall, CO is the most promising product from both economic and environmental impact aspects.
24.	Lin, Xialu, et al. (författare) Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes 2019 Ingår i: Journal of Applied Toxicology. - : John Wiley & Sons. - 0260-437X .- 1099-1263. ; 39:2, s. 343-353 Tidskriftsartikel (refereegranskat)abstract Deoxynivalenol (DON) and T-2 toxin are prevalent mycotoxin contaminants in the food and feed stuffs worldwide, with non-negligible co-contamination and co-exposure conditions. Meanwhile, they are considerable risk factors for Kashin-Beck disease, a chronic endemic osteochondropathy. The aim of this study was to investigate the individual and combined cytotoxicity of DON and T-2 toxin on proliferating human C-28/I2 and newborn rat primary costal chondrocytes by MTT assay. Four molar concentration combination ratios of DON and T-2 toxin were used, 1:1 for R1 mixture, 10:1 for R10, 100:1 for R100 and 1000:1 for R1000. The toxicological interactions were quantified by the MixLow method. DON, T-2 toxin, and their mixtures all showed a clear dose-dependent toxicity for chondrocytes. The cytotoxicity of T-2 toxin was 285-fold higher than DON was in human chondrocytes, and 22-fold higher in the rat chondrocytes. The combination of DON and T-2 toxin was significantly synergistic at middle and high level concentrations of R10 mixtures in rat chondrocytes, but significantly antagonistic at the low concentrations of R100 mixtures in both cells and at the middle concentrations of R1000 mixtures in rat chondrocytes. These results indicated that the combined toxicity was influenced by the cell sensitivity for toxins, the difference between the combination ratio and equitoxic ratio, the concentrations and other factors.
25.	Liu, Yanrong, et al. (författare) Recent progress on electrochemical reduction of CO2 to methanol 2020 Ingår i: Current Opinion in Green and Sustainable Chemistry. - : Elsevier. - 2452-2236. ; 23, s. 10-17 Forskningsöversikt (refereegranskat)abstract Methanol is a future energy carrier because of its high volume-specific energy density and a significant intermediate for many bulk chemicals. Electrochemical reduction (ECR) is a promising method to fabricate methanol (CH3OH) from carbon dioxide (CO2) where electrocatalyst, reactor configuration and electrode play an essential role. In this review, seven types of electrocatalysts, i.e., metal alloys, metal oxides, metal chalcogenides and carbides, metal-organic complexes, metal-free, pyridine and MOF-based electrocatalyts, as well as the effect of reactor configuration and electrode were comprehensively summarized. Finally, challenges and perspectives on developing electrocatalysts were highlighted.
26.	Liu, Yi, et al. (författare) Self-Assembly at a Macroscale Using Aerodynamics 2022 Ingår i: Applied Sciences. - : MDPI AG. - 2076-3417. ; 12:15, s. 7676-7676 Tidskriftsartikel (refereegranskat)abstract Intuitive self-assembly devices are of great significance to the emerging applications of self-assembly theory. In this paper, a novel intuitive device with an aerodynamic system is fabricated for the self-assembly experiment. Table tennis balls were used as the objects to be assembled during the self-assembly process. To understand more about the system, two experiments were designed—the directed assembly experiment was conducted to organize a specific structure and to explore the influences of environmental variables, and the indirect assembly experiment repeated with the “bottom-up” self-organization process and expressed the characteristics of “the optimization” and “the emergence” in the self-organization process. This article expressed a novel self-assembly approach at a macroscale and created a new choice or idea for the structural design and the optimization method.
27.	Metaferia, Wondwosen, et al. (författare) GaAsP Nanowires Grown by Aerotaxy 2016 Ingår i: Nano Letters. - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 16:9, s. 5701-5707 Tidskriftsartikel (refereegranskat)abstract We have grown GaAsP nanowires with high optical and structural quality by Aerotaxy, a new continuous gas phase mass production process to grow III-V semiconductor based nanowires. By varying the PH3/AsH3 ratio and growth temperature, size selected GaAs1-xPx nanowires (80 nm diameter) with pure zinc-blende structure and with direct band gap energies ranging from 1.42 to 1.90 eV (at 300 K), (i.e., 0 ≤ x ≤ 0.43) were grown, which is the energy range needed for creating tandem III-V solar cells on silicon. The phosphorus content in the NWs is shown to be controlled by both growth temperature and input gas phase ratio. The distribution of P in the wires is uniform over the length of the wires and among the wires. This proves the feasibility of growing GaAsP nanowires by Aerotaxy and results indicate that it is a generic process that can be applied to the growth of other III-V semiconductor based ternary nanowires.
28.	Song, Luying, et al. (författare) Synthesis of Two-Dimensional Metal-Organic Frameworks via Dehydrogenation Reactions on a Cu(111) Surface 2020 Ingår i: The Journal of Physical Chemistry C. - : AMER CHEMICAL SOC. - 1932-7447 .- 1932-7455. ; 124:23, s. 12390-12396 Tidskriftsartikel (refereegranskat)abstract Metal-organic frameworks prepared on surfaces (SMOFs) have been considered to have potential applications in various research fields. Traditionally, the SMOFs are prepared by coadsorbing organic ligands and metal atoms on surfaces. In this article, we successfully construct the SMOFs via the dehydrogenation reactions of aromatic amines on the Cu(111) surfaces. The dehydrogenated nitrogen radicals interact with the copper adatoms, forming the N-Cu-N bonds. Combining with the scanning tunneling microscopy and the density functional theory calculations, we obtain the structural models of the SMOFs.
29.	Wang, Xi, et al. (författare) Gene expression signature in endemic osteoarthritis by microarray analysis 2015 Ingår i: International Journal of Molecular Sciences. - Basel, Switzerland : MDPI. - 1661-6596 .- 1422-0067. ; 16:5, s. 11465-11481 Tidskriftsartikel (refereegranskat)abstract Kashin-Beck Disease (KBD) is an endemic osteochondropathy with an unknown pathogenesis. Diagnosis of KBD is effective only in advanced cases, which eliminates the possibility of early treatment and leads to an inevitable exacerbation of symptoms. Therefore, we aim to identify an accurate blood-based gene signature for the detection of KBD. Previously published gene expression profile data on cartilage and peripheral blood mononuclear cells (PBMCs) from adults with KBD were compared to select potential target genes. Microarray analysis was conducted to evaluate the expression of the target genes in a cohort of 100 KBD patients and 100 healthy controls. A gene expression signature was identified using a training set, which was subsequently validated using an independent test set with a minimum redundancy maximum relevance (mRMR) algorithm and support vector machine (SVM) algorithm. Fifty unique genes were differentially expressed between KBD patients and healthy controls. A 20-gene signature was identified that distinguished between KBD patients and controls with 90% accuracy, 85% sensitivity, and 95% specificity. This study identified a 20-gene signature that accurately distinguishes between patients with KBD and controls using peripheral blood samples. These results promote the further development of blood-based genetic biomarkers for detection of KBD.
30.	Wang, Zhiyu, et al. (författare) Interfacial Modification of Lithium Metal Anode by Boron Nitride Nanosheets Ingår i: ACS Nano. - 1936-086X. ; 18:4, s. 3531-3541 Tidskriftsartikel (refereegranskat)abstract Metallic lithium (Li) is the most attractive anode for Li batteries because it holds the highest theoretical specific capacity (3860 mA h g -1) and the lowest redox potential (-3.040 V vs SHE). However, the poor interface stability of the Li anode, which is caused by the high reactivity and dendrite formation of metallic Li upon cycling, leads to undesired electrochemical performance and safety issues. While two-dimensional boron nitride (BN) nanosheets have been utilized as an interfacial layer, the mechanism on how they stabilize the Li-electrolyte interface remains elusive. Here, we show how BN nanosheet interlayers suppress Li dendrite formation, enhance Li ion transport kinetics, facilitate Li deposition, and reduce electrolyte decomposition. We show through both simulation and experimental data that the desolvation process of a solvated Li ion within the interlayer nanochannels kinetically favors Li deposition. This process enables long cycling stability, reduced voltage polarization, improved interface stability, and negligible volume expansion. Their application as an interfacial layer in symmetric cells and full cells that display significantly improved electrochemical properties is also demonstrated. The knowledge gained in this study provides both critical insights and practical guidelines for designing a Li metal anode with significantly improved performance.
31.	Zhang, Baoshan, et al. (författare) The psychological process of stereotyping : Content, forming, internalizing, mechanisms, effects, and interventions 2023 Ingår i: Frontiers in Psychology. - : Frontiers Media S.A.. - 1664-1078. ; 13 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
32.	Zhang, Lei, et al. (författare) A window–space-directed assembly strategy for the construction of supertetrahedron-based zeolitic mesoporous metal–organic frameworks with ultramicroporous apertures for selective gas adsorption 2021 Ingår i: Chemical Science. - : Royal Society of Chemistry. - 2041-6520 .- 2041-6539. ; 12:16, s. 5767-5773 Tidskriftsartikel (refereegranskat)abstract Despite their scarcity due to synthetic challenges, supertetrahedron-based metal–organic frameworks (MOFs) possess intriguing architectures, diverse functionalities, and superb properties that make them in‑demand materials. Employing a new window–space-directed assembly strategy, a family of mesoporous zeolitic MOFs have been constructed herein from corner-shared supertetrahedra based on homometallic or heterometallic trimers [M3(OH/O)(COO)6] (M3 = Co3, Ni3 or Co2Ti). These MOFs consisted of close-packed truncated octahedral cages possessing a sodalite topology and large β-cavity mesoporous cages (~22 Å diameter) connected by ultramicroporous apertures (~5.6 Å diameter). Notably, the supertetrahedron-based sodalite topology MOF composed with the Co2Ti trimer exhibited high thermal and chemical stability as well as the ability to efficiently separate acetylene (C2H2) from carbon dioxide (CO2).
33.	Zhang, Long, et al. (författare) Signaling interplay between transforming growth factor-beta receptor and PI3K/AKT pathways in cancer 2013 Ingår i: TIBS -Trends in Biochemical Sciences. Regular ed.. - : Elsevier BV. - 0968-0004 .- 1362-4326. ; 38:12, s. 612-620 Forskningsöversikt (refereegranskat)abstract The transforming growth factor (TGF)-beta and phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signaling pathways are used in cells to control numerous responses, including proliferation, apoptosis, and migration. TGF-beta is known for its cytostatic effect's in premalignant states and its pro-oncogenic activity in advanced cancers. The pro-cell survival response exerted by growth-factor-mediated activation of PI3K/AKT has been linked to stimulation of tumor formation. Both TGF-beta receptor and PI3K/AKT pathways were initially modeled as linear signaling conduits. Although early studies suggested that these two pathways might counteract each other in balancing cell survival, emerging evidence has uncovered multiple modes of intricate signal integration and obligate collaboration in driving cancer progression. These new insights provide the rationale for exploring their dual targeting in cancer.
34.	Zhang, Wei, et al. (författare) Recombination dynamics in aerotaxy-grown Zn-doped GaAs nanowires 2016 Ingår i: Nanotechnology. - : IOP Publishing. - 0957-4484 .- 1361-6528. ; 27:45 Tidskriftsartikel (refereegranskat)abstract In this paper we have investigated the dynamics of photo-generated charge carriers in a series of aerotaxy-grown GaAs nanowires (NWs) with different levels of Zn doping. Time-resolved photo-induced luminescence and transient absorption have been employed to investigate radiative (band edge transition) and non-radiative charge recombination processes, respectively. We find that the photo-luminescence (PL) lifetime of intrinsic GaAs NWs is significantly increased after growing an AlGaAs shell over them, indicating that an AlGaAs shell can effectively passivate the surface of aerotaxy-grown GaAs NWs. We observe that PL decay time as well as PL intensity decrease with increasing Zn doping, which can be attributed to thermally activated electron trapping with the trap density increased due to the Zn doping level.
35.	Zhang, Zhibo, et al. (författare) Electrochemically driven efficient enzymatic conversion of CO2 to formic acid with artificial cofactors 2021 Ingår i: Journal of CO2 Utilization. - : Elsevier. - 2212-9820 .- 2212-9839. ; 52 Tidskriftsartikel (refereegranskat)abstract Enzymatic reduction of CO2 to formic acid with the enzyme formate dehydrogenase (FDH) and a cofactor is a promising method for CO2 conversion and utilization. However, the natural cofactor nicotinamide adenine dinucleotide (NADH) shows some drawbacks such as a low reduction efficiency and forms isomers or dimers (1,6 - NADH or NAD dimer) in the regeneration reaction. To overcome them and to improve the production of formic acid, in this work, the artificial cofactors, i.e., the bipyridinium-based salts of methyl viologen (MV2+), 1,1’-dicarboxymethyl-4,4’-bipyridinium bromine (DC2+), and 1,1’-diaminoethyl-4,4’-bipyridinium bromine (DA2+), were used to replace NADH, and the effect of different functional groups on the electrochemical regeneration and catalytic performance in the enzymatic reaction was studied systematically. Also, studies using the natural cofactor NADH were carried out for comparison. It was found that the cofactor with amino groups showed the highest catalytic efficiency (kcat/Km) of 0.161 mM-1min-1, which is 536 times higher than that of the natural cofactor NADH. Molecular Dynamics simulations were conducted to give further molecular insight into the behavior of the cofactors. Analyzing the free energy profiles of the complexes between CO2 in the FDH active site with different artificial cofactors indicated that the artificial cofactor with the amino groups had the highest affinity for CO2, being consistent with the experimental observations.
36.	Zhu, Can, et al. (författare) Tuning the electron-deficient core of a non-fullerene acceptor to achieve over 17% efficiency in a single-junction organic solar cell 2020 Ingår i: Energy & Environmental Science. - : ROYAL SOC CHEMISTRY. - 1754-5692 .- 1754-5706. ; 13:8, s. 2459-2466 Tidskriftsartikel (refereegranskat)abstract Finding effective molecular design strategies to enable efficient charge generation and small energy loss is among the long-standing challenges in developing high performance non-fullerene organic solar cells (OSCs). Recently, we reported Y-series non-fullerene acceptors with an electron-deficient-core-based fused structure (typically Y6), opening a new door to achieve high external quantum efficiency (∼80%) while maintaining low energy loss (∼0.57 eV). On this basis, further reducing the energy losses and ultimately improving the performance of OSCs has become a research hotspot. In this paper, we design and synthesize a new member of the Y-series acceptor family, Y18, which adopts a fused benzotriazole segment with unique luminescence properties as its electron-deficient core. Compared to Y6, the benzotriazole-based acceptor Y18 exhibits extended optical absorption and higher voltage. Consequently, the device delivers a promising power conversion efficiency of 16.52% with a very low energy loss of 0.53 eV. Further device optimization by exploiting a ternary blend strategy allowed us to achieve a high efficiency of 17.11% (certified as 16.76% by NREL). Y18 may become one of the most important candidate materials for its broader absorption spectra and higher voltage of Y18 (compared to Y6) in the OSCs field.
37.	Zhu, Fangfang, et al. (författare) A logarithmic bottom boundary layer model for the unsteady and non-uniform swash flow 2022 Ingår i: Coastal Engineering. - : Elsevier BV. - 0378-3839. ; 172 Tidskriftsartikel (refereegranskat)abstract This paper presents a bottom boundary layer model for the unsteady and non-uniform flow in the swash zone, by extending the momentum integral method so as to include spatial gradients. The developed model is further incorporated into a hydrodynamic model based on the Nonlinear Shallow Water Equations. Two swash zone cases are examined to investigate the effect of the inclusion of spatial gradients. In the first of the two, boundary layer development under non-breaking periodic waves formulated by Carrier and Greenspan (1958) is investigated (wave-driven swash). Results show that the spatial gradients have the most pronounced effect in the lower swash, and in the region just seaward. In both these regions the spatial gradients enhance (diminish) onshore (offshore) bed shear stress, thus potentially contributing to onshore sediment transport under non-breaking waves. The second case investigated is the Kikkert et al. (2012) dam-break swash event (bore-driven swash). The model results are qualitatively and quantitatively accurate when compared against the laboratory measurements, and the velocities in the later backwash agree more closely with the measurements than those of Briganti et al. (2011). Results show that the inclusion of spatial gradients also favours onshore sediment transport in the lower swash. In addition, the bottom boundary layer is more fully developed in the uprush tip, resulting in smaller bed shear stress in the upper swash. The extended momentum integral method thus appears to capture more comprehensively the swash boundary layer, and the approach, therefore, offers a way forward in more accurate reproduction of swash dynamics in computational modelling.
38.	Zhu, Fangfang, et al. (författare) Investigation of Momentum Correction Factor in the Swash Flow 2022 Ingår i: Journal of Waterway, Port, Coastal and Ocean Engineering. - 0733-950X. ; 148:6 Tidskriftsartikel (refereegranskat)abstract Swash flows are commonly modeled using the nonlinear shallow water equations (NSWEs). In the derivation of the NSWEs, directly from depth-averaging the Navier-Stokes equations, a so-called momentum correction factor, β, emerges. In this study we present a numerical model of the NSWEs that includes β, which is allowed to vary in space and time, and feedback onto the flow. We apply this model to a swash flow, by making use of the vertical flow structure calculated by use of the log-law boundary layer and free flow region. We thereby examine its influence on the swash-flow predictions of a dam-break swash event described in the literature. The numerical results show that the momentum correction factor has a significant effect on the shoreline motion, and flow adjacent to the shoreline, which results in an overprediction of the shoreline with respect to the standard (β = 1, NSWE) approach. Given that consideration of β should yield a more complete description of the swash dynamics, the implication is that the log-law boundary layer model does not describe the flow structure in the swash tip region well. The implication of this is that to achieve accurate modeling at the flow uprush tip, at which point the largest bed shear stresses are typically exerted, a different submodel is required in that vicinity. Equally, it suggests that classical NSWEs also cannot describe the flow at the tip well, and that accurate prediction is achieved despite this inherent deficiency.

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